[논문]Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial

Yang, Yi; Wang, Hong; Zhang, Ming; Shi, Mengxue; Yang, Cailing; Ni, Qiang; Wang, Qi; Li, Jing; Wang, Xuemei; Zhang, Chen; Li, Zhi

doi:10.1016/j.jgr.2021.09.001

[국내논문] Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial 원문보기

Journal of ginseng research = 高麗人參學會誌, v.46 no.4, 2022년, pp.543 - 549

Yang, Yi (Health Management Center, Tianjin Third Central Hospital) , Wang, Hong (General Practice Department, Tianjin Third Central Hospital) , Zhang, Ming (Nutrition Department, Tianjin Third Central Hospital) , Shi, Mengxue (Health Management Center, Tianjin Third Central Hospital) , Yang, Cailing (Food and Drug Safety Evaluation Center, Comprehensive Testing Center of Chinese Academy of Inspection and Quarantine) , Ni, Qiang (Health Management Center, Tianjin Third Central Hospital) , Wang, Qi (Health Management Center, Tianjin Third Central Hospital) , Li, Jing (Laboratory Department, Tianjin Third Central Hospital) , Wang, Xuemei (Scientific Research Center, Conbio Technology Group Co., Ltd.) , Zhang, Chen (Scientific Research Center, Conbio Technology Group Co., Ltd.) , Li, Zhi (Scientific Research Center, Conbio Technology Group Co., Ltd.)

Abstract ▼ AI-Helper

Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue.

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표/그림 (7)

표 Table 1 Subjective physical strength rating scale.
그림 Fig. 1. Screening process of subjects.
표 Table 2 Comparison of equilibrium between the two groups before the test(x±SD).
표 Table 3 Comparison of general conditions in the two groups before and after the test.
표 Table 4 Changes of efficacy indicators before and after the test (x±SD).
표 Table 5 Comparison of blood pressure and heart rate before, after and during the test (x±SD).
표 Table 6 Changes of blood routine, urine routine and blood biochemical indexes before and after the food test (x±SD).

참고문헌 (28)

1 Yan B. Liu Y. Shi A. Wang Z. Aa J. Huang X. Liu Y. Investigation of the antifatigue effects of Korean ginseng on professional athletes by gas chromatography-time-of-flight-mass spectrometry-based metabolomics J AOAC Int 101 2018 701 707 10.5740/jaoacint.17-0220 28927488

상세보기
2 Oyagi A. Ogawa K. Kakino M. Hara H. Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice BMC Compl Alternative Med 10 2010 10.1186/1472-6882-10-45

상세보기
3 Cabral De Oliveira A.C. Perez A.C. Prieto J.G. Duarte I.D.G. Alvarez A.I. Protection of Panax ginseng in injured muscles after eccentric exercise J Ethnopharmacol 97 2005 10.1016/j.jep.2004.10.029

상세보기
4 Voces J. Cabral de Oliveira A.C. Prieto J.G. Vila L. Perez A.C. Duarte I.D. Alvarez A.I. Ginseng administration protects skeletal msucle from oxidative stress induced by acute exercise in rats Braz J Med Biol Res 37 2004 10.1590/S0100-879X2004001200012

상세보기
5 Kim S.H. Park K.S. Chang M.J. Sung J.H. Effects of Panax ginseng extract on exercise-induced oxidative stress J Sports Med Phys Fit 45 2005
6 Jovanovski E. Jenkins A. Dias A.G. Peeva V. Sievenpiper J. Arnason J.T. Rahelic D. Josse R.G. Vuksan V. Effects of Korean red ginseng (Panax ginseng C.A. Mayer) and its isolated ginsenosides and polysaccharides on arterial stiffness in healthy individuals Am J Hypertens 23 2010 10.1038/ajh.2010.5

상세보기
7 Qi B. Liu L. Zhang H. Zhou G.X. Wang S. Duan X.Z. Bai X.Y. Wang S.M. Zhao D.Q. Anti-fatigue effects of proteins isolated from Panax quinquefolium J Ethnopharmacol 153 2014 10.1016/j.jep.2014.02.045

상세보기
8 Evans R.K. Knight K.L. Draper D.O. Parcell A.C. Effects of warm-up before eccentric exercise on indirect markers of muscle damage Med Sci Sports Exerc 34 2002 10.1097/00005768-200212000-00006

상세보기
9 Dolezal B.A. Potteiger J.A. Jacobsen D.J. Benedict S.H. Muscle damage and resting metabolic rate after acute resistance exercise with an eccentric overload Med Sci Sports Exerc 32 2000 10.1097/00005768-200007000-00003

상세보기
10 Hartz A.J. Bentler S. Noyes R. Hoehns J. Logemann C. Sinift S. Butani Y. Wang W. Brake K. Ernst M. Randomized controlled trial of Siberian ginseng for chronic fatigue Psychol Med 34 2004 10.1017/S0033291703008791

상세보기
11 Krishnan R.K. Evans W.J. Kirwan J.P. Impaired substrate oxidation in healthy elderly men after eccentric exercise J Appl Physiol 94 2003 10.1152/japplphysiol.00746.2002

상세보기
12 Choi K.T. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer Acta Pharmacol Sin 29 2008 10.1111/j.1745-7254.2008.00869.x

상세보기
13 Genlan Y. Yaping Z. Liufeng O. Kexuan Z. Yunan Z. Research progress on anti-fatigue effect of ginseng J Chem Inf Model 10 2015 1174 1177 10.13935/j.cnki.sjzx.150844
14 Qian Y. Kaiyuan S. Yongfen L. Xuguang L. Shuguang Y. Hongfa X. Yong H. A study on the effects of tonifying prescription and clearing prescription of Chinese herbs on anti-physical fatigue Chinese J Sport Med 18 1999 300 304
15 Anhui X. Hongjun W. Fengwen G. Yu Y. Liqiang W. Rui Z. Chunyan L. Experimental study on the promoting motion fatigue recover of the cordyceps militaris extract on the chemical indicators in blood of human Lishizhen Med Mater Medica Reseach 21 2010 2481 2483 10.3969/j.issn.1008-0805.2010.10.027
16 Surong X. The human feeding study on relieving physical fatigue of multi-vitamins amino acid functional beverage 2016 Lanzhou University
17 Zhang L. Chen X. Cheng Y. Chen Q. Tan H. Son D. Chang D. Bian Z. Fang H. Xu H. Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial J Ginseng Res 43 2019 676 683 10.1016/j.jgr.2019.05.006 31695571

원문보기 상세보기
18 Hilkens L. Bock J.D. Kretzers J. Alwine F.M.K. Esther G.F.-V. Petra A.M.J.S. Astrid M.H.H. Luc J.C.V.L. Jan-Willem V.D. Whey protein supplementation does not accelerate recovery from a single bout of eccentric exercise J Sports Sci 2020 10.1080/02640414.2020.1820184

상세보기
19 Shi Z. Li Y. A review of ginsenosides regulating glucocorticoid receptor pathway 2021 Chinese Archives of Traditional Chinese Medicine
20 Kim J. Lee H. Kang K.S. Chun K.H. Hwang G.S. Protective effect of Korean Red Ginseng against glucocorticoid-induced osteoporosis in vitro and in vivo Journal of Ginseng Research 39 2015 46 53 10.1016/j.jgr.2014.06.001 25535476

원문보기 상세보기
21 Ahtiainen J.P. Lehti M. Hulmi J.J. Kraemer W.J. Alen M. Nyman K. Selänne H. Pakarinen A. Komulainen J. Kovanen V. Recovery after heavy resistance exercise and skeletal muscle androgen receptor and insulin-like growth factor-I isoform expression in strength trained men J Strength Condit Res 25 2011 767 777 10.1519/JSC.0b013e318202e449

상세보기
22 Pengfei L. Baoxin F. Wenyuan S. Weiying Z. Pifang Z. Guoqiang S. Comparative study of three different incremental exercises for evaluating aerobic capacity of cyclist on a cycle ergometer China Sport Sci Technol 46 2010 123 125
23 Caslin H.L. Abebayehu D. Qayum A.A. Haque T.T. Taruselli M.T. Paez P.A. Pondicherry N. Barnstein B.O. Hoeferlin L.A. Chalfant C.E. Lactic acid inhibits lipopolysaccharide-induced mast cell function by limiting glycolysis and ATP availability J Immunol 203 2019 453 464 10.4049/jimmunol.1801005 31160535

상세보기
24 Junwei W. The campare study of 4 weeks fixed load and incremental load on college students' aerobic capacity effect 2016 Jilin Uniersity
25 Liu R. Wu L. Du Q. Ren J.W. Chen Q.H. Li D. Mao R.X. Liu X.R. Li Y. Small molecule oligopeptides isolated from walnut (juglans regia L.) and their anti-fatigue effects in mice Molecules 24 2018 45 10.3390/molecules24010045

상세보기
26 Sung W.S. Kang H.R. Jung C.Y. Park S.S. Lee S.H. Kim E.J. Efficacy of Korean red ginseng (Panax ginseng) for middle-aged and moderate level of chronic fatigue patients: a randomized, double-blind, placebo-controlled trial Compl Ther Med 48 2020 102246 10.1016/j.ctim.2019.102246

상세보기
27 Hong M. Lee Y.H. Kim S. Suk K.T. Bang C.S. Yoon J.H. Baik G.H. Kim D.J. Kim M.J. Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease J Ginseng Res 40 2016 203 210 10.1016/j.jgr.2015.07.006 27616896

원문보기 상세보기
28 Yoon S.J. Kim S.K. Lee N.Y. Choi Y.R. Kim H.S. Gupta H. Youn G.S. Sung H. Shin M.J. Suk K.T. Effect of Korean red ginseng on metabolic syndrome J Ginseng Res 45 2021 380 389 10.1016/j.jgr.2020.11.002 34025131

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