$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

전이성 대장암에 대한 면역치료의 최신 지견
Recent Progress in Immunotherapy for Metastatic Colorectal Cancer 원문보기

Journal of digestive cancer research, v.10 no.2, 2022년, pp.65 - 73  

김성중 (조선대학교 의과대학 내과학교실) ,  이준 (조선대학교 의과대학 내과학교실)

Abstract AI-Helper 아이콘AI-Helper

A breakthrough in immunotherapy has changed the outlook for metastatic colorectal cancer (mCRC) treatment as the immune surveillance evasion mechanism of tumor cells has been continuously elucidated. Immune checkpoint inhibitors (ICI), such as pembrolizumab, nivolumab, and ipilimumab, which block im...

주제어

참고문헌 (42)

  1. Hong, Seri, Won, Young-Joo, Lee, Jae Jun, Jung, Kyu-Won, Kong, Hyun-Joo, Im, Jeong-Soo, Seo, Hong Gwan. Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2018. Cancer research and treatment : official journal of Korean Cancer Association, vol.53, no.2, 301-315.

  2. Siegel, Rebecca L., Miller, Kimberly D., Fedewa, Stacey A., Ahnen, Dennis J., Meester, Reinier G. S., Barzi, Afsaneh, Jemal, Ahmedin. Colorectal cancer statistics, 2017. CA: A Cancer Journal for Clinicians, vol.67, no.3, 177-193.

  3. Heinemann, V., von Weikersthal, L.F., Decker, T., Kiani, A., Vehling-Kaiser, U., Al-Batran, S.E., Heintges, T., Lerchenmuller, C., Kahl, C., Seipelt, G., Kullmann, F., Stauch, M., Scheithauer, W., Hielscher, J., Scholz, M., Muller, S., Link, H., Niederle, N., Rost, A., Hoffkes, H.G., Moehler, M., Lindig, R.U., Modest, D.P., Rossius, L., Kirchner, T., Jung, A., Stintzing, S.. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. The Lancet. Oncology, vol.15, no.10, 1065-1075.

  4. Van Cutsem, Eric, Köhne, Claus-Henning, Láng, István, Folprecht, Gunnar, Nowacki, Marek P., Cascinu, Stefano, Shchepotin, Igor, Maurel, Joan, Cunningham, David, Tejpar, Sabine, Schlichting, Michael, Zubel, Angela, Celik, Ilhan, Rougier, Philippe, Ciardiello, Fortunato. Cetuximab Plus Irinotecan, Fluorouracil, and Leucovorin As First-Line Treatment for Metastatic Colorectal Cancer: Updated Analysis of Overall Survival According to Tumor KRAS and BRAF Mutation Status. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.29, no.15, 2011-2019.

  5. Wei, Spencer C., Duffy, Colm R., Allison, James P.. Fundamental Mechanisms of Immune Checkpoint Blockade Therapy. Cancer discovery, vol.8, no.9, 1069-1086.

  6. Sinicrope, Frank A., Sargent, Daniel J.. Molecular Pathways: Microsatellite Instability in Colorectal Cancer: Prognostic, Predictive, and Therapeutic Implications. Clinical Cancer research : an official journal of the American Association for Cancer Research, vol.18, no.6, 1506-1512.

  7. Comprehensive molecular characterization of human colon and rectal cancer. Nature, vol.487, no.7407, 330-337.

  8. Toh, James W.T., de Souza, Paul, Lim, Stephanie H., Singh, Puneet, Chua, Wei, Ng, Weng, Spring, Kevin J.. The Potential Value of Immunotherapy in Colorectal Cancers: Review of the Evidence for Programmed Death-1 Inhibitor Therapy. Clinical colorectal cancer, vol.15, no.4, 285-291.

  9. Le, Dung T., Uram, Jennifer N., Wang, Hao, Bartlett, Bjarne R., Kemberling, Holly, Eyring, Aleksandra D., Skora, Andrew D., Luber, Brandon S., Azad, Nilofer S., Laheru, Dan, Biedrzycki, Barbara, Donehower, Ross C., Zaheer, Atif, Fisher, George A., Crocenzi, Todd S., Lee, James J., Duffy, Steven M., Goldberg, Richard M., de la Chapelle, Albert, Koshiji, Minori, Bhaijee, Feriyl, Huebner, Thomas, Hruban, Ralph H., Wood, Laura D., Cuka, Nathan, Pardoll, Drew M., Papadopoulos, Nickolas, Kinzler, Kenneth W., Zhou, Shibin, Cornish, Toby C., Taube, Janis M., Anders, Robert A., Eshleman, James R., Vogelstein, Bert, Diaz Jr., Luis A.. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. The New England journal of medicine, vol.372, no.26, 2509-2520.

  10. Le, Dung T., Kavan, Petr, Kim, Tae Won, Burge, Matthew E., Van Cutsem, Eric, Hara, Hiroki, Boland, Patrick McKay, Van Laethem, Jean-Luc, Geva, Ravit, Taniguchi, Hiroya, Crocenzi, Todd S., Sharma, Manish, Atreya, Chloe Evelyn, Diaz, Luis A., Liang, Li Wen, Marinello, Patricia, Dai, Tong, O'Neil, Bert H.. KEYNOTE-164: Pembrolizumab for patients with advanced microsatellite instability high (MSI-H) colorectal cancer.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.36, no._suppl15, 3514-3514.

  11. Le, Dung T., Kim, Tae Won, Van Cutsem, Eric, Geva, Ravit, Jäger, Dirk, Hara, Hiroki, Burge, Matthew, O’Neil, Bert, Kavan, Petr, Yoshino, Takayuki, Guimbaud, Rosine, Taniguchi, Hiroya, Elez, Elena, Al-Batran, Salah-Eddin, Boland, Patrick M., Crocenzi, Todd, Atreya, Chloe E., Cui, Yi, Dai, Tong, Marinello, Patricia, Diaz Jr, Luis A., André, Thierry. Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.38, no.1, 11-19.

  12. Andre, Thierry, Shiu, Kai-Keen, Kim, Tae Won, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis J. A., Smith, Denis Michel, Garcia-Carbonero, Rocio, Benavides, Manuel, Gibbs, Peter, De La Fouchardiere, Christelle, Rivera, Fernando, Elez, Elena, Bendell, Johanna C., Le, Dung T., Yoshino, Takayuki, Yang, Ping, Farooqui, Mohammed Zulfiqar Husain, Marinello, Patricia, Diaz, Luis A.. Pembrolizumab versus chemotherapy for microsatellite instability-high/mismatch repair deficient metastatic colorectal cancer: The phase 3 KEYNOTE-177 Study.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.38, no.18, LBA4-LBA4.

  13. Overman, Michael J, McDermott, Ray, Leach, Joseph L, Lonardi, Sara, Lenz, Heinz-Josef, Morse, Michael A, Desai, Jayesh, Hill, Andrew, Axelson, Michael, Moss, Rebecca A, Goldberg, Monica V, Cao, Z Alexander, Ledeine, Jean-Marie, Maglinte, Gregory A, Kopetz, Scott, André, Thierry. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. The Lancet. Oncology, vol.18, no.9, 1182-1191.

  14. Overman, Michael J., Lonardi, Sara, Wong, Ka Yeung Mark, Lenz, Heinz-Josef, Gelsomino, Fabio, Aglietta, Massimo, Morse, Michael A., Van Cutsem, Eric, McDermott, Ray, Hill, Andrew, Sawyer, Michael B., Hendlisz, Alain, Neyns, Bart, Svrcek, Magali, Moss, Rebecca A., Ledeine, Jean-Marie, Cao, Z. Alexander, Kamble, Shital, Kopetz, Scott, André, Thierry. Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.36, no.8, 773-779.

  15. Lenz, Heinz-Josef, Van Cutsem, Eric, Luisa Limon, Maria, Wong, Ka Yeung Mark, Hendlisz, Alain, Aglietta, Massimo, García-Alfonso, Pilar, Neyns, Bart, Luppi, Gabriele, Cardin, Dana B., Dragovich, Tomislav, Shah, Usman, Abdullaev, Sandzhar, Gricar, Joseph, Ledeine, Jean-Marie, Overman, Michael James, Lonardi, Sara. First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.40, no.2, 161-170.

  16. Ali, Siraj Mahamed, Gay, Laurie M., Elvin, Julia Andrea, Vergilio, Jo-Anne, Ramkissoon, Shakti H., Suh, James, Severson, Eric Allan, Daniel, Sugganth, Killian, Jonathan Keith, Schrock, Alexa Betzig, Chung, Jon, Frampton, Garrett Michael, Fabrizio, David, Albacker, Lee A., Miller, Vincent A., Corona, Robert John, Ross, Jeffrey S.. MSI-high and MSI-stable colorectal carcinomas (CRC): A comprehensive genomic profiling (CGP) study.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.36, no._suppl15, 3574-3574.

  17. Akbay, Esra A., Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H., Christensen, Camilla L., Mikse, Oliver R., Cherniack, Andrew D., Beauchamp, Ellen M., Pugh, Trevor J., Wilkerson, Matthew D., Fecci, Peter E., Butaney, Mohit, Reibel, Jacob B., Soucheray, Margaret, Cohoon, Travis J., Janne, Pasi A., Meyerson, Matthew, Hayes, D. Neil, Shapiro, Geoffrey I., Shimamura, Takeshi, Sholl, Lynette M., Rodig, Scott J., Freeman, Gordon J., Hammerman, Peter S., Dranoff, Glenn, Wong, Kwok-Kin. Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors. Cancer discovery, vol.3, no.12, 1355-1363.

  18. Yang, Hannah, Lee, Won Suk, Kong, So Jung, Kim, Chang Gon, Kim, Joo Hoon, Chang, Sei Kyung, Kim, Sewha, Kim, Gwangil, Chon, Hong Jae, Kim, Chan. STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade. The Journal of clinical investigation, vol.129, no.10, 4350-4364.

  19. Pozzi, Chiara, Cuomo, Alessandro, Spadoni, Ilaria, Magni, Elena, Silvola, Alessio, Conte, Alexia, Sigismund, Sara, Ravenda, Paola Simona, Bonaldi, Tiziana, Zampino, Maria Giulia, Cancelliere, Carlotta, Di Fiore, Pier Paolo, Bardelli, Alberto, Penna, Giuseppe, Rescigno, Maria. The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death. Nature medicine, vol.22, no.6, 624-631.

  20. Fukuoka, Shota, Hara, Hiroki, Takahashi, Naoki, Kojima, Takashi, Kawazoe, Akihito, Asayama, Masako, Yoshii, Takako, Kotani, Daisuke, Tamura, Hitomi, Mikamoto, Yuichi, Hirano, Nami, Wakabayashi, Masashi, Nomura, Shogo, Sato, Akihiro, Kuwata, Takeshi, Togashi, Yosuke, Nishikawa, Hiroyoshi, Shitara, Kohei. Regorafenib Plus Nivolumab in Patients With Advanced Gastric or Colorectal Cancer: An Open-Label, Dose-Escalation, and Dose-Expansion Phase Ib Trial (REGONIVO, EPOC1603). Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.38, no.18, 2053-2061.

  21. Cousin, Sophie, Cantarel, Coralie, Guegan, Jean-Philippe, Gomez-Roca, Carlos, Metges, Jean-Philippe, Adenis, Antoine, Pernot, Simon, Bellera, Carine, Kind, Michèle, Auzanneau, Céline, Le Loarer, Francois, Soubeyran, Isabelle, Bessede, Alban, Italiano, Antoine. Regorafenib-Avelumab Combination in Patients with Microsatellite Stable Colorectal Cancer (REGOMUNE): A Single-arm, Open-label, Phase II Trial. Clinical Cancer research : an official journal of the American Association for Cancer Research, vol.27, no.8, 2139-2147.

  22. Bendell, Johanna C., Bang, Yung-Jue, Chee, Cheng Ean, Ryan, David P., McRee, Autumn Jackson, Chow, Laura Q., Desai, Jayesh, Wongchenko, Matthew, Yan, Yibing, Pitcher, Bethany, Foster, Paul, Cha, Edward, Grossman, William, Kim, Tae Won. A phase Ib study of safety and clinical activity of atezolizumab (A) and cobimetinib (C) in patients (pts) with metastatic colorectal cancer (mCRC).. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.36, no._suppl4, 560-560.

  23. Eng, Cathy, Kim, Tae Won, Bendell, Johanna, Argilés, Guillem, Tebbutt, Niall C, Di Bartolomeo, Maria, Falcone, Alfredo, Fakih, Marwan, Kozloff, Mark, Segal, Neil H, Sobrero, Alberto, Yan, Yibing, Chang, Ilsung, Uyei, Anne, Roberts, Louise, Ciardiello, Fortunato, Ahn, JB, Asselah, J, Badarinath, S, Baijal, S, Begbie, S, Berry, S, Canon, JL, Carbone, RG, Cervantes, A, Cha, YJ, Chang, K, Chaudhry, A, Chmielowska, E, Cho, SH, Chu, D, Couture, F, Cultrera, J, Cunningham, D, Van Cutsem, E, Cuyle, PJ, Davies, J, Dowden, S, Dvorkin, M, Ganju, V, Garcia, RV, Kerr, R, Kim, TY, King, K, Kortmansky, J, Kozloff, M, Lam, KO, Lee, J, Lee, AS, Lesperance, B, Luppi, G, Ma, B, Maiello, E, Mandanas, R, Marshall, J, Marx, G, Mullamitha, S, Nechaeva, M, Park, JO, Pavlakis, N, Ponce, CG, Potemski, P, Raouf, S, Reeves, J, Segal, N, Siena, S, Smolin, A, Streb, JO, Strickland, A, Szutowicz-Zielinska, E, Tabernero, JM, Tan, B, Valera. Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial. The Lancet. Oncology, vol.20, no.6, 849-861.

  24. Pfirschke, C., Engblom, C., Rickelt, S., Cortez-Retamozo, V., Garris, C., Pucci, F., Yamazaki, T., Poirier-Colame, V., Newton, A., Redouane, Y., Lin, Y.J., Wojtkiewicz, G., Iwamoto, Y., Mino-Kenudson, M., Huynh, T.G., Hynes, R.O., Freeman, G.J., Kroemer, G., Zitvogel, L., Weissleder, R., Pittet, M.J.. Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity, vol.44, no.2, 343-354.

  25. Herting, Cameron J., Farren, Matthew R., Tong, Yan, Liu, Ziyue, O’Neil, Bert, Bekaii-Saab, Tanios, Noonan, Anne, McQuinn, Christopher, Mace, Thomas A., Shaib, Walid, Wu, Christina, El-Rayes, Bassel F., Shahda, Safi, Lesinski, Gregory B.. A multi-center, single-arm, phase Ib study of pembrolizumab (MK-3475) in combination with chemotherapy for patients with advanced colorectal cancer: HCRN GI14-186. Cancer immunology, immunotherapy : CII, vol.70, no.11, 3337-3348.

  26. Ree, Anne Hansen, Hamre, Hanne, Kersten, Christian, Hofsli, Eva, Guren, Marianne Grønlie, Sorbye, Halfdan, Johansen, Christin, Negård, Anne, Flatmark, Kjersti, Meltzer, Sebastian. Repeat sequential oxaliplatin-based chemotherapy (FLOX) and nivolumab versus FLOX alone as first-line treatment of microsatellite-stable (MSS) metastatic colorectal cancer (mCRC): Initial results from the randomized METIMMOX study.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.39, no.15, 3556-3556.

  27. Gong, Xiaomei, Li, Xuefei, Jiang, Tao, Xie, Huikang, Zhu, Zhengfei, Zhou, Fei, Zhou, Caicun. Combined Radiotherapy and Anti-PD-L1 Antibody Synergistically Enhances Antitumor Effect in Non-Small Cell Lung Cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, vol.12, no.7, 1085-1097.

  28. Sharabi, Andrew B., Nirschl, Christopher J., Kochel, Christina M., Nirschl, Thomas R., Francica, Brian J., Velarde, Esteban, Deweese, Theodore L., Drake, Charles G.. Stereotactic Radiation Therapy Augments Antigen-Specific PD-1–Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen. Cancer immunology research, vol.3, no.4, 345-355.

  29. Parikh, Aparna Raj, Clark, Jeffrey William, Wo, Jennifer Yon-Li, Yeap, Beow Y, Allen, Jill N., Blaszkowsky, Lawrence Scott, Ryan, David P., Giantonio, Bruce J., Weekes, Colin D., Zhu, Andrew X., Van Seventer, Emily E., Matlack, Lauren, Foreman, Bronwen, Ly, Leilana, Drapek, Lorraine C., Ting, David Tsai, Corcoran, Ryan Bruce, Hong, Theodore S.. A phase II study of ipilimumab and nivolumab with radiation in microsatellite stable (MSS) metastatic colorectal adenocarcinoma (mCRC).. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.37, no.15, 3514-3514.

  30. Parikh, Aparna R., Szabolcs, Annamaria, Allen, Jill N., Clark, Jeffrey W., Wo, Jennifer Y., Raabe, Michael, Thel, Hannah, Hoyos, David, Mehta, Arnav, Arshad, Sanya, Lieb, David J., Drapek, Lorraine C., Blaszkowsky, Lawrence S., Giantonio, Bruce J., Weekes, Colin D., Zhu, Andrew X., Goyal, Lipika, Nipp, Ryan D., Dubois, Jon S., van Seventer, Emily E., Foreman, Bronwen E., Matlack, Lauren E., Ly, Leilana, Meurer, Jessica A., Hacohen, Nir, Ryan, David P., Yeap, Beow Y., Corcoran, Ryan B., Greenbaum, Benjamin D., Ting, David T., Hong, Theodore S.. Radiation Therapy Enhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial. Nature cancer, vol.2, no.11, 1124-1135.

  31. Thibodeau SN, French AJ, Cunningham JM, et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res 1998;58:1713-1718. 

  32. Mathiak, Micaela, Rütten, Arno, Mangold, Elisabeth, Fischer, Hans-Peter, Ruzicka, Thomas, Friedl, Waltraut, Propping, Peter, Kruse, Roland. Loss of DNA Mismatch Repair Proteins in Skin Tumors From Patients With Muir-Torre Syndrome and MSH2 or MLH1 Germline Mutations: Establishment of Immunohistochemical Analysis as a Screening Test. The American journal of surgical pathology, vol.26, no.3, 338-343.

  33. Lemery, Steven, Keegan, Patricia, Pazdur, Richard. First FDA Approval Agnostic of Cancer Site - When a Biomarker Defines the Indication. The New England journal of medicine, vol.377, no.15, 1409-1412.

  34. McGranahan, Nicholas, Furness, Andrew J. S., Rosenthal, Rachel, Ramskov, Sofie, Lyngaa, Rikke, Saini, Sunil Kumar, Jamal-Hanjani, Mariam, Wilson, Gareth A., Birkbak, Nicolai J., Hiley, Crispin T., Watkins, Thomas B. K., Shafi, Seema, Murugaesu, Nirupa, Mitter, Richard, Akarca, Ayse U., Linares, Joseph, Marafioti, Teresa, Henry, Jake Y., Van Allen, Eliezer M., Miao, Diana, Schilling, Bastian, Schadendorf, Dirk, Garraway, Levi A., Makarov, Vladimir, Rizvi, Naiyer A., Snyder, Alexandra, Hellmann, Matthew D., Merghoub, Taha, Wolchok, Jedd D., Shukla, Sachet A., Wu, Catherine J., Peggs, Karl S., Chan, Timothy A., Hadrup, Sine R., Quezada, Sergio A., Swanton, Charles. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science, vol.351, no.6280, 1463-1469.

  35. Schrock, A.B., Ouyang, C., Sandhu, J., Sokol, E., Jin, D., Ross, J.S., Miller, V.A., Lim, D., Amanam, I., Chao, J., Catenacci, D., Cho, M., Braiteh, F., Klempner, S.J., Ali, S.M., Fakih, M.. Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer. Annals of oncology : official journal of the European Society for Medical Oncology, vol.30, no.7, 1096-1103.

  36. Chen, Eric X., Jonker, Derek J., Loree, Jonathan M., Kennecke, Hagen F., Berry, Scott R., Couture, Felix, Ahmad, Chaudhary E., Goffin, John R., Kavan, Petr, Harb, Mohammed, Colwell, Bruce, Samimi, Setareh, Samson, Benoit, Abbas, Tahir, Aucoin, Nathalie, Aubin, Francine, Koski, Sheryl L., Wei, Alice C., Magoski, Nadine M., Tu, Dongsheng, O’Callaghan, Chris J.. Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer : The Canadian Cancer Trials Group CO.26 Study. JAMA oncology, vol.6, no.6, 1-8.

  37. Loibl, Sibylle, Sinn, Bruno Valentin, Karn, Thomas, Untch, Michael, Sinn, Hans-Peter, Weber, Karsten Ernst, Hanusch, Claus, Huober, Jens Bodo, Staib, Peter, Lorenz, Ralf, Blohmer, Jens Uwe, Marmé, Frederik, Schmitt, Wolfgang D, Rhiem, Kerstin, van Mackelenbergh, Marion, Fasching, Peter A., Wu, Song, Higgs, Brandon W., Schneeweiss, Andreas, Denkert, Carsten. Exome analysis of oncogenic pathways and tumor mutational burden (TMB) in triple-negative breast cancer (TNBC): Results of the translational biomarker program of the neoadjuvant double-blind placebo controlled GeparNuevo trial.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.37, no.15, 509-509.

  38. Yoon, Harry H., Jin, Zhaohui, Kour, Oudom, Kankeu Fonkoua, Lionel Aurelien, Shitara, Kohei, Gibson, Michael K., Prokop, Larry J., Moehler, Markus, Kang, Yoon-Koo, Shi, Qian, Ajani, Jaffer A.. Association of PD-L1 Expression and Other Variables With Benefit From Immune Checkpoint Inhibition in Advanced Gastroesophageal Cancer : Systematic Review and Meta-analysis of 17 Phase 3 Randomized Clinical Trials. JAMA oncology, vol.8, no.10, 1456-.

  39. Ettinger, David S., Wood, Douglas E., Aisner, Dara L., Akerley, Wallace, Bauman, Jessica, Chirieac, Lucian R., D'Amico, Thomas A., DeCamp, Malcolm M., Dilling, Thomas J., Dobelbower, Michael, Doebele, Robert C., Govindan, Ramaswamy, Gubens, Matthew A., Hennon, Mark, Horn, Leora, Komaki, Ritsuko, Lackner, Rudy P., Lanuti, Michael, Leal, Ticiana A., Leisch, Leah J., Lilenbaum, Rogerio, Lin, Jules, Loo Jr, Billy W., Martins, Renato, Otterson, Gregory A., Reckamp, Karen, Riely, Gregory J., Schild, Steven E., Shapiro, Theresa A., Stevenson, James, Swanson, Scott J., Tauer, Kurt, Yang, Stephen C., Gregory, Kristina, Hughes, Miranda. Non-Small Cell Lung Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN, vol.15, no.4, 504-535.

  40. Fuchs, Charles S., Doi, Toshihiko, Jang, Raymond Woo-Jun, Muro, Kei, Satoh, Taroh, Machado, Manuela, Sun, Weijing, Jalal, Shadia Ibrahim, Shah, Manish A., Metges, Jean-Philippe, Garrido, Marcelo, Golan, Talia, Mandala, Mario, Wainberg, Zev A., Catenacci, Daniel V.T., Bang, Yung-Jue, Wang, Jiangdian, Koshiji, Minori, Dalal, Rita P., Yoon, Harry H.. KEYNOTE-059 cohort 1: Efficacy and safety of pembrolizumab (pembro) monotherapy in patients with previously treated advanced gastric cancer.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol.35, no._suppl15, 4003-4003.

  41. Masarwy, Razan, Kampel, Liyona, Horowitz, Gilad, Gutfeld, Orit, Muhanna, Nidal. Neoadjuvant PD-1/PD-L1 Inhibitors for Resectable Head and Neck Cancer : A Systematic Review and Meta-analysis. JAMA otolaryngology-- head & neck surgery, vol.147, no.10, 871-.

  42. Endo, Eisei, Okayama, Hirokazu, Saito, Katsuharu, Nakajima, Shotaro, Yamada, Leo, Ujiie, Daisuke, Kase, Koji, Fujita, Shotaro, Endo, Hisahito, Sakamoto, Wataru, Saito, Motonobu, Saze, Zenichiro, Momma, Tomoyuki, Ohki, Shinji, Mimura, Kosaku, Kono, Koji. A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair–Deficient/Microsatellite Instability-High Colorectal Cancer. Molecular cancer research, vol.18, no.9, 1402-1413.

저자의 다른 논문 :

관련 콘텐츠

오픈액세스(OA) 유형

GOLD(Hybrid)

저자가 APC(Article Processing Charge)를 지불한 논문에 한하여 자유로운 이용이 가능한, hybrid 저널에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로