[논문]불면증 관련 천연물 추출물의 특허 동향 분석

이정경; 강성현; 권찬영

doi:10.7231/jon.2022.33.3.287

[국내논문] 불면증 관련 천연물 추출물의 특허 동향 분석
Natural Product-Based Products for Sleep Improvement: Analysis of Patent Status in Korea 원문보기

동의신경정신과학회지 = Journal of oriental neuropsychiatry, v.33 no.3, 2022년, pp.287 - 299

이정경 (동의대학교 한의과대학 한의학과) , 강성현 (동의대학교 한의과대학 한의학과) , 권찬영 (동의대학교 한의과대학 한방신경정신과)

Abstract ▼ AI-Helper

Objectives: The purpose of this study was to analyze the trend of natural product-based products for sleep improvement in Korean patents, to enhance the development and application of natural-products for sleep disorder in terms of Korean medicine. Methods: We collected patent data using the KIPRIS database and ScienceON database. Two authors independently screened patents that potentially met the criteria, and assessed full texts of screened patents for eligibility. Included patents were analyzed, quantitatively as well as qualitatively. Results: A total of 60 patents were selected 2008-July 2022. The number of patents have been on the rise since 2017, and reached 12 in 2018. Companies have registered the most patents, followed by the Industry-University Cooperation Foundation. Zizyphi semen (n=6), Lactuca sativa L. (n=5), Valeriana fauriei/officinalis (n=4), Poria cocos (n=4) were frequently used herbs among 60 patents. Twenty-one patents (35%) included medicinal herbs with sleep improving effects. Among 60 patents, alcohol extraction (70%) was mostly used, followed by water immersion (50%), and hot water extraction (48.3%). Conclusions: Analysis results showed that various Korean medicine herbs, are being used for natural-products for sleep disorder. The results will be helpful towards inventing new patents using Korean medicine, developing natural product extracts for sleep improvement, and extending the range of these products in clinical use.

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표/그림 (11)

그림 Fig. 1. Flow diagram of patent selection process.
그림 Fig. 2. Number of natural product-based products for sleep improvement by year.
표 Table 1. Number of Natural Product-Based Products for Sleep Improvement by Each Main Patentee
표 Table 2. Model of Experiment and Method of Extraction of Included Patents
그림 Fig. 3 Percentage of patents by number of its constituents.
표 Table 2. Continued 1
표 Table 3. Frequency of Constituents Used for Patents
표 Table 4. Classification of Constituents Used for Patent
그림 Table 5. Attributive Channel Theory of Constituents
그림 Fig. 4 Distribution of constituents by its characteristics.
그림 Fig. 5. Distribution of constituents by its taste.

참고문헌 (36)

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA: American Psychiatric Association; 2013.
Health Insurance Review & Assessment Service. Healthcare Bigdata Hub, 'Statistics of Diseases'. [cited 2022 Jul]. Available from: http://opendata.hira.or.kr/op/opc/olap4thDsInfo.do
National Institute for Korean Medicine Development (NIKOM). Clinical Practice Guideline of Korean Medicine for Insomnia Disorder. 2021. Available from: https://nikom .or.kr/nckm /m odule/p racticeG uide/view.do?guide_idx164&progress&mds_code&disease_code&gubun&code_gubunmds&agency&continent&sortField&sortType&languagekor&search_typeall&search_text%EB%B6%88%EB%A9%B4%EC%9E%A5%EC%95%A0&viewPage1&guide_idx&progress_jq&title&disease_code_etc1&agency_jq& country&release_date&menu_idx14
Chung SH, Youn SY. Optimizing the Pharmacological Treatment for Insomnia. J Sleep Med. 2016;13(1):1-7.

상세보기
Vgontzas AN, Kales A, Bixler EO. Benzodiazepine side effects: role of pharmacokinetics and pharmacodynamics. Pharmacology. 1995;51:205-223.

상세보기
Muzammil M, Satish S, Gafoor H. A Systematic Review on Natural Sedative and Hypnotics. Int J Pharm Sci Rev Res. 2020;60(1):94-98.
The co-textbook publishing committee of Korean oriental medicine school. The oriental neuropsychiatry. Maver; 2018.
Maust DT, Solway E, Clark SJ, Kirch M, Singer DC, Malani P. Prescription and Nonprescription Sleep Product Use Among Older Adults in the United States. Am J Geriatr Psychiatry. 2019;27(1):32-41.

상세보기
Kim KB. The importance of patent trend and preceding technology search in R&D subject of state. Korea electronics association. 2006;26(9):35-36.
The co-textbook publishing committee of Korean oriental medicine school. The herbal medicine. Younglimsa; 2011.
Huvist Pharm. Co., Ltd., Chungnam University-Industry cooperation foundation. A composition for improving sleep containing extract of Protaetia brevitarsis seulensis larvae. 102020077714. 2020.
Korean Institute of Korean Medicine (KIOM). Composition for the prevention, improvement or treatment of sleep disorders comprising a Faxinus rhynchophylla Hance extract as an active ingredient. 1020180123840. 2018.
Koo DL, Kim JH. The Physiology of Normal Sleep. Hanyang Medical Reviews. 2013;33:190-196.

상세보기
Avidan A. Review of Sleep Medicine. 4th ed. Elsevier; 2017.
Leger D, Morin CM, Uchiyama M, Hakimi Z, Cure S, Walsh JK. Chronic insomnia, quality-of-life, and utility scores: Comparison with good sleepers in a cross-sectional international survey. Sleep Medicine. 2012;13(1):43-51.

상세보기
National Institute of Food and Drug Safety Evaluation. Adults: No more than 4 cups of coffee and 2 cans of beverages per day. [cited 2022 Aug]. Available from: https://www.nifds.go.kr/brd/m_21/view.do?seq12790
National Center for Mental Health. 2017 Mental health technology development project performance analysis and management system establishment; 2017.
National Research Foundation of Korea (NRF). The im - pact of coronavirus pandemic on industry and culture. NRF Issue Report; 2021.
Woo WS. Natural Product Chemistry Research Method (revision). Seoul National University Press. 2013.
Franks F. Freeze-drying of bioproducts: putting principles into practice. European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 1998;45(3): 221-229.

상세보기
Wilhelm RS, Hermann MB. Esters, Organic. Ullmann's Encyclopedia of Industrial Chemistry;2005.
U.S.Department of Health and Human Services. Toxicological profile for n-hexane. U.S.Goverment Printing Office;1999 Jul. Available from: https://www.atsdr.cdc.gov/toxprofiles/tp113.pdf
Seo JW. Information on the development of fragrances and substances containing Jeju tangerine extracts that help sleep. 1020200087959. 2020.
Zelda Therapeutics Operations PTY LTD. Sleep Disorder Composition and Treatment. 1020207001714. 2020.
Cao JX, Zhang QY, Cui SY, Cui XY, Zhang J, Zhang YH, et al. Hypnotic effect of jujubosides from Semen Ziziphi Spinosae. Journal of Ethnopharmacology. 2010;130(1): 163-166.

상세보기
Zhou QH, Zhou XL, Xu MB, Jin TY, Rong PQ, Zheng GQ, et al. Suanzaoren Formulae for Insomnia: Updated Clinical Evidence and Possible Mechanisms. Front Pharmacol. 2018 Feb 9;9:76.
Jung SH, Kim JH, Lee HG, Jang HH, Kim TH, Lyu YS, et al. A Comparison Research of Eastern and Western Medication on the Insomnia. Journal of Oriental Neuropsychiatry. 2009;20(3):65-88.
Yakoot M, Helmy S, Fawal K. Pilot study of the efficacy and safety of lettuce seed oil in patients with sleep disorders. Int J Gen Med. 2011;4:451-456.

상세보기
Shinjyo N, Waddell G, Green J. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20967323.
Doctor BM. Combination of valerian root extract and lavender oil for the treatment of sleep disorders. 102017003954. 2017.
Benslab Corporation. Sleep disorder improvement and sleep induction composition. 1020160053430. 2016.
Via Biotech Corporation. Creation of oriental medicine for improvement and individuality of Gu Gi-ja's work. 1020160064775. 2016.
Lee WY, Jeong GH. Combination Tendency Analysis on Herbal Formula to Treat Insomnia Focused on Zizyphi spinosi Semen. Herbal Formula Science. 2014;22(1):33-45.

원문보기 상세보기
World Intellectual Property Organization (WIPO). Word Intellectual Property Indicators; 2020.
Lee JG. The importance of using patent information and patent trend in biotechnology field. Intellectual Property 21. 2005.. Available from: https://www.bioin.or.kr/board.do?num119648&cmdview&bidsystem
Song MY, Kim HJ, Choi HS. A study on the Analysis of Patent information in the Korean Medicine -Focused on International Patent Classification. Korean Journal of Oriental Medicine. 2005;11(2):67-96.

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