[논문]네트워크 약리학을 통한 황기의 항비만 효능 및 작용기전 예측 연구

김미혜

doi:10.6116/kjh.2023.38.1.45.

네트워크 약리학을 통한 황기의 항비만 효능 및 작용기전 예측 연구
Prediction of functional molecular machanism of Astragalus membranaceus on obesity via network pharmacology analysis 원문보기

大韓本草學會誌 = The Korea journal of herbology, v.38 no.1, 2023년, pp.45 - 53

김미혜 (우석대학교 한의과대학 의생명과학교실)

Abstract ▼ AI-Helper

Objectives : Network pharmacology-based research is one of useful tool to predict the possible efficacy and molecular mechanisms of natural materials with multi compounds-multi targeting effects. In this study, we investigated the functional underlying mechanisms of Astragalus membranaceus Bunge (AM) on its anti-obesity effects using a network pharmacology analysis. Methods : The constituents of AM were collected from public databases and its target genes were gathered from PubChem database. The target genes of AM were compared with the gene set of obesity to find the correlation. Then, the network was constructed by Cytoscape 3.9.1. and functional enrichment analysis was conducted to predict the most relevant pathway of AM. Results : The result showed that AM network contained the 707 nodes and 6867 edges, and 525 intersecting genes were exhibited between AM and obesity gene set, indicating that high correlation with the effects of AM on obesity. Based on GO biological process and KEGG Pathway, 'Response to lipid', 'Cellular response to lipid', 'Lipid metabolic process', 'Regulation of chemokine production', 'Regulation of lipase activity', 'Chemokine signaling pathway', 'Regulation of lipolysis in adipocytes' and 'PPAR signaling pathway' were predicted as functional pathways of AM on obesity. Conclusions : AM showed high relevance with the lipid metabolism related with the chemokine production and lipolysis pathways. This study could be a basis that AM has promising effects on obesity via network pharmacology analysis.

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표/그림 (5)

표 Table 1. List of the compounds from Astragalus membranaceus with the PubChem ID.
표 Table 2. List of common genes of Astragalus membranaceus and obesity gene sets.
그림 Fig. 1. (A) Network of AM with 707 nodes and 6867 edges. (B) Veen diagram of intersection targets between AM network and the gene sets of obesity disease. (C) Network of common genes of AM and obesity.
그림 Fig. 2. Biological processes related to targets of AM using GO Process database.
그림 Fig. 3. Biological processes related to targets of AM using KEGG Pathways database.

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