[논문]네트워크 약리학을 이용한 소양증을 동반한 피부 염증에 대한 지실(枳實)의 잠재적 치료기전 탐색

서광일; 김준동; 김병현; 김규석; 남혜정; 김윤범

doi:10.6114/jkood.2022.35.4.075

네트워크 약리학을 이용한 소양증을 동반한 피부 염증에 대한 지실(枳實)의 잠재적 치료기전 탐색
Analysis of Potential Active Ingredients and Treatment Mechanism of Ponciri Fructus Immaturus for Dermatitis Accompanied by Pruritus Using Network Pharmacology 원문보기

韓方眼耳鼻咽喉皮膚科學會誌 = The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, v.35 no.4, 2022년, pp.75 - 94

서광일 (경희대학교 한의과대학 안이비인후피부과학교실) , 김준동 (경희대학교 한의과대학 안이비인후피부과학교실) , 김병현 (경희대학교 한의과대학 안이비인후피부과학교실) , 김규석 (경희대학교 한의과대학 안이비인후피부과학교실) , 남혜정 (경희대학교 한의과대학 안이비인후피부과학교실) , 김윤범 (경희대학교 한의과대학 안이비인후피부과학교실)

Abstract ▼ AI-Helper

Objectives : To identify the active ingredient of Poncirus Trifoliata Immaturus and to explore the mechanism expected to potentially act on dermatitis accompanied by pruritus. Methods : We conducted the network pharmacological analysis. We selected effective ingredients among the active compounds of Poinciri Fructus Immaturus. We found the target protein of the selected active ingredient, disease(dermatitis accompanied by pruritus) and fexofenadine. Then we established the network between the proteins which Poinciri Fructus Immaturus and fexofenadine intersected with disease respectively, and the coregene was also extracted. After that, the active pathways in the human body involving the groups and coregenes were searched. Results : Total of 7 active ingredients were selected, and 202 target proteins were collected. There were 756 proteins related to inflammatory skin disease accompanied by pruritus, and 75 proteins were related to fexofenadine. 42 proteins crossed by Poinciri Fructus Immaturus with a disease, and 31 proteins crossed by fexofenadine with a disease. 12 proteins were found as a coregene from the proteins that cross Poinciri Fructus Immaturus and disease. Coregenes are involved in 'Nitric-oxide synthase regulator activity', 'Epidermal growth factor receptor signaling pathway'. 2 groups that extracted are invloved in 'Fc receptor signaling pathway', 'Central carbon metabolism in cancer', 'Phosphatidylinositol 3-kinase complex, class IB', and 'omega-hydroxylase P450 pathway'. Conclusion : It is expected that Poinciri Fructus Immaturus will be able to show direct or indirect anti-pruritus and anti-inflammatory effects on skin inflammation accompanied by pruritus in the future. And it is also expected to have a synergy effect with fexofenadine on skin disease.

주제어

표/그림 (8)

그림 Fig. 1. Network between Active Ingredients of Compounds(Ponciri Fructus) and Target Proteins
표 Table 1. Active Compounds of Ponciri Fructus Immaturus
그림 Fig. 3. (A) PPI Network of Intersection Targets between Compounds(Ponciri Fructus) and Disease(Dermatitis or Eczema with Pruritus) Node 42, Edge 90; STRING (B) PPI Network of Intersection Targets between Drugs(Fexofenadine) and Disease(Dermatitis or Eczema with Pruritus) Node 30, Edge 85; STRING
그림 Fig. 2. Venn Diagram Showing Intersection Targets between Compounds(Poinciri Fructus), Disease(Dermatitis and Eczema with Pruritus, DEI) and Drugs(Fexofenadine)
그림 Fig. 4. Total Protein-Protein Network and Modules Including Coregene Selected through cytoNCA and MCODE Plugin between Compounds(Ponciri Fructus) and Disease(Dermatitis or Eczema with Pruritus) (A) Cluster 1, Score : 6.750 Node : 9 Edge : 27 (B) Cluster 2, Score : 3.000 Node : 15 Edge : 3
표 Table 2. MCODE Analysis of Intersection Targets between Compounds(Fructus Arctii) and Disease(Dermatitis or Eczema with Pruritus)
표 Table 3. Coregenes of PPI Network of Intersection Targets between Compounds(Ponciri Fructus) and Disease(Dermatitis or Eczema with Pruritus)
그림 Fig. 5. (A) GO Analysis of Module in PPI Network of Intersection Targets between Coregenes of Compounds(Ponciri Fructus) and Disease(Dermatitis or Eczema with Pruritus); BP, KEGG Pathway (B) GO Analysis of Intersection Targets between Compounds(Ponciri Fructus), Disease (Dermatitis or Eczema with Pruritus) and Drugs; Cluster 1, Analyzed by MCODE Plugin (C) GO Analysis of Module in PPI Network of Intersection Targets between Coregenes of Compounds(Ponciri Fructus) and Disease(Dermatitis or Eczema with Pruritus); Cluster 2, Analyzed by MCODE Plugin (D) GO Terms and KEGG Pathway Analysis of Coregenes between Compounds(Ponciri Fructus) and Drug(Fexofenadine)

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