[논문]오공(蜈蚣) 추출물의 태아 기형 및 모체 독성 마우스 시험

이정민; 송준호; 이숭인; 기현준; 신인식; 김성호; 문창종; 김중선; 이지혜

doi:10.14374/hfs.2023.31.1.21

[국내논문] 오공(蜈蚣) 추출물의 태아 기형 및 모체 독성 마우스 시험
Embryotoxic and Teratogenic Effects of Scolopendra Water Extract in Mice 원문보기

大韓韓醫學方劑學會誌 = Herbal formula science, v.31 no.1, 2023년, pp.21 - 28

이정민 (전남대학교 수의과대학) , 송준호 (충북대학교 자연과학대학 생물학과) , 이숭인 (동신대학교 한의과대학) , 기현준 (전남대학교 수의과대학) , 신인식 (전남대학교 수의과대학) , 김성호 (전남대학교 수의과대학) , 문창종 (전남대학교 수의과대학) , 김중선 (전남대학교 수의과대학) , 이지혜 (세명대학교 한의과대학)

Abstract ▼ AI-Helper

Objective : Scolopendra, a dried body of Scolopendra subspinipes mutilans, is one of Korean medicine. Several reports revealed that Scolopendra has therapeutic effects for arthritis, neuroinflammatory diseases and neuropathic pain. However, the fetal adaptive response or teratogenicity associated with administration of Scolopendra is unclear. Therefore, this study aimed to investigate the fetal toxicity effects that were induced following oral administration of Scolopendra water extract (SWE) in pregnant mice. Methods : The pregnant mice were administrated SWE at dosed of 0, 100, 500 and 1000 mg/kg/day during gestation day 0-18. The mortality, body weight and clinical signs of pregnant mice were observed throughout experimental period. Also, the mortality and malformations in foetus were examined. Results : No meaningful changes were observed in the mortality and clinical signs of pregnant mice between the normal control group and SWE administrated groups. Additionally, there are no significant changes in fetal mortalities, and malformations by SWE administration. conclusion : These results suggest that oral exposure to SWE during pregnancy at oral dosages up to 1000 mg/kg/day did not induce teratogenic toxicity in regard to fetal mortality and morphology.

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표/그림 (6)

그림 Fig. 1. Main target, efficacy, and prescription in Traditional Korean Medicine correlation network of Scolopendra using Oriental Medicine Advanced Searching Integrated System (OASIS)^⁹⁾
그림 Fig. 2. Experimental protocol for Scolopendra water extract (SWE) administration in pregnant mice.
표 Table 1. Mortality in Pregnant Mice
표 Table 2. Mortality in Fetuses
표 Table 3. Outside Deformity in Fetuses
그림 Fig. 3. Fetal skeletal formations in pregnant mice that received 1000 mg/kg/day Scolopendra water extract (SWE). There was no significant difference in the fetal skeletal structure between control and treatment mice. (A, B) Fetal skeleton stained with Alizarin red S-Alcian blue staining in the experimental group that was orally administered 1000 mg/kg/day SWE. (C) The forelimb skeleton reveals complete ossification. (D) The vertebral column and sternum show complete ossification in all vertebrae and ribs.

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