[논문]소아 식욕부진에 대한 삼령백출산(蔘苓白朮散)의 효과: 체계적 문헌고찰 및 메타분석

이해솔; 이선행; 장규태; 이보람

doi:10.7778/jpkm.2023.37.1.1

소아 식욕부진에 대한 삼령백출산(蔘苓白朮散)의 효과: 체계적 문헌고찰 및 메타분석
Effects of Samryungbaekchul-san on Childhood Anorexia: A Systematic Review and Meta-Analysis 원문보기

大韓韓方小兒科學會誌 = The journal of pediatrics of Korean medicine, v.37 no.1, 2023년, pp.1 - 14

이해솔 (한국한의학연구원 임상연구협력팀) , 이선행 (경희대학교 한의과대학 소아과학교실) , 장규태 (경희대학교 한의과대학 소아과학교실) , 이보람 (한국한의학연구원 한의과학연구부)

Abstract ▼ AI-Helper

Objectives This study aimed to evaluate the effect of Samryungbaekchul-san on childhood anorexia. Methods We searched 11 English, Korean, Chinese, and Japanese databases for studies published up to May 30, 2022. Randomized controlled trials (RCTs) assessing the effect of Samryungbaekchul-san on childhood anorexia were included. In the meta-analysis, relative risk (RR) and 95% confidence intervals (CI) were indicated as dichotomous variables, and mean difference (MD) or standardized mean difference (SMD) and 95% CIs were indicated as continuous variables. Results We included 12 RCTs with 1345 participants. The Samryungbaekchul-san treatment group had a significantly higher total effective rate (TER) than that of the western medicine control group (RR 1.42, 95% CI 1.23-1.64, I2 = 0%). The combined Samryungbaekchul-san and western medicine treatment group had significantly higher TER (RR 1.31, 95% CI 1.23 to 1.40, I2 = 0%) and levels of neuropeptide Y (SMD 0.93, 95% CI 0.47-1.39, I2 = 70%) and ghrelin (SMD 1.45, 95% CI 1.14-1.76, I2 = 0%) than those of the western medicine alone group. Additionally, leptin levels were significantly lower in the combined treatment group (SMD -1.19, 95% CI -1.88 to -0.51, I2 = 86%) compared with the western medicine alone group, although statistical heterogeneity was substantial. Conclusions Samryungbaekchul-san may be effective for childhood anorexia. However, owing to limitations such as high clinical heterogeneity between the studies, unclear risks of biases, and insufficient reports of adverse events and follow-ups, well-designed RCTs with a low risk of bias are needed in the future.

주제어

표/그림 (5)

그림 Figure 1. A flow diagram of the literature screening and selection processes AMED: Allied and Complementary Medicine Database, CENTRAL: Cochrane Central Register of Controlled Trials, CNKI: China National Knowledge Infrastructure, KISS: Koreanstudies Information Service System, OASIS: Oriental Medicine Advanced Searching Integrated System.
표 Table 1. Clinical Characteristics of the Included Studies
그림 Figure 2. Forest plot of total effective rate: Samryungbaekchul-san versus western medicine treatment CI: confidence interval, HM: herbal medicine, WM: western medicine.
그림 Figure 3. Forest plot of total effective rate: Samryungbaekchul-san plus western medicine treatment versus western medicine treatment alone CI: confidence interval, HM: herbal medicine, WM: western medicine.
그림 Figure 4. Risk of bias summary Low, unclear, and high risk, respectively, are represented with the following symbols: "+", "?", and "-".

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