[논문]제2형 당뇨병 환자에서 혈당강하제와 보중익기탕 병용 투여가 혈당 변화에 미치는 영향 및 안전성 연구

오승현; 정우녕; 송미령; 노지원; 안영민; 안세영; 이병철

doi:10.22246/jikm.2023.44.3.354

제2형 당뇨병 환자에서 혈당강하제와 보중익기탕 병용 투여가 혈당 변화에 미치는 영향 및 안전성 연구
A Retrospective Study of the Safety and Effect of Co-administration of Glucose-lowering Medication and Bojungikgi-tang on Blood Glucose Level in Patients with Type 2 Diabetes Mellitus 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.44 no.3, 2023년, pp.354 - 365

오승현 (경희대학교 대학원 임상한의학과) , 정우녕 (경희대학교 대학원 임상한의학과) , 송미령 (경희대학교 한의과대학 부속병원 신장내분비내과교실) , 노지원 (경희대학교 한의과대학 부속병원 신장내분비내과교실) , 안영민 (경희대학교 대학원 임상한의학과) , 안세영 (경희대학교 대학원 임상한의학과) , 이병철 (경희대학교 대학원 임상한의학과)

Abstract ▼ AI-Helper

Objective: This study aimed to assess the safety and effect on glucose level of Bojungikgi-tang in patients with type 2 diabetes mellitus. Methods: To review patients' clinical characteristics and laboratory tests retrospectively, we investigated 15 hospitalized patients with type 2 diabetes mellitus who took Bojungikgi-tang at Kyung Hee University Korean Medical Hospital for at least one day between January 2012 and December 2022. The blood glucose levels, including fasting blood sugar (FBS), 2-hour postprandial glucose (PP2) levels, and glycated hemoglobin level, were collected to determine the effect of the Bojungikgi-tang on blood sugar changes. Furthermore, to evaluate the safety of Bojungikgi-tang, hepatic function and renal function tests were implemented, including aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltransferase, blood urea nitrogen, creatinine, and Modification of Diet in Renal Disease estimated glomerular filtration rate. Results: When Bojungikgi-tang and a standard treatment for diabetes were administered for patients with type 2 diabetes, it was confirmed that there were no statistically significant changes in FBS and PP2 levels in the analysis of each medication taken. There was no significant difference in the safety profile after taking Bojungikgi-tang. Conclusions: The combined administration of Bojungikgi-tang with standard hypoglycemic medication for patients with type 2 diabetes may not affect blood glucose levels and safety.

주제어

표/그림 (13)

표 Table 1. Composition of Bojungikgi-tang
그림 Fig. 1. Participant disposition. T2DM : type 2 diabetes mellitus
표 Table 2. Baseline Demographics and Clinical Characteristics
표 Table 3. Details of the Participants
표 Table 4. Type of Hypoglycemic Treatment
그림 Fig. 2. Change in blood glucose after co-administration of Bojungikgi-tang and hypoglycemic agents. FBS : fasting blood sugar, PP2 : 2 hours post-prandial plasma glucose
그림 Fig. 3. Change in 2-hours postprandial glucose levels in subgroups. PP2 : 2 hours post-prandial plasma glucose, HbA1c : glycated Hemoglobin
표 Table 5. Change in Blood Sugar Test Before and After Taking of Bojungikgi-tang
그림 Fig. 4. Change in HbA1c level after co-administration
표 Table 6. Change in Blood Sugar Test in Subgroups Before and After Taking of Bojungikgi-tang
표 Table 7. Change in Blood Sugar Test Before and After Taking of Bojungikgi-tang by Period
표 Table 8. Change in HbA1c Level after Administration of Bojungikgi-tang
표 Table 9. Change in Liver and Kidney Function after Administration of Bojungikgi-tang

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