[논문]표준 치료를 받고 있는 제2형 당뇨병 환자에서 혈당강하제와 평위산 및 향사평위산 병용 투여가 혈당에 미치는 영향 및 안정성 연구

정우녕; 오승현; 송미령; 노지원; 안영민; 안세영; 이병철

doi:10.22246/jikm.2023.44.4.661

표준 치료를 받고 있는 제2형 당뇨병 환자에서 혈당강하제와 평위산 및 향사평위산 병용 투여가 혈당에 미치는 영향 및 안정성 연구
Assessment of Combined Administration of Hypoglycemic Agents and Herbal Extracts (Pyeongwi-san or HyangsaPyongwi-san) on Blood Glucose Levels in Type 2 Diabetes Mellitus: A Retrospective Study 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.44 no.4, 2023년, pp.661 - 674

정우녕 (경희대학교 대학원 임상한의학과) , 오승현 (경희대학교 대학원 임상한의학과) , 송미령 (경희대학교 한의과대학 부속병원 신장내분비내과교실) , 노지원 (경희대학교 한의과대학 부속병원 신장내분비내과교실) , 안영민 (경희대학교 한의과대학 부속병원 신장내분비내과교실) , 안세영 (경희대학교 한의과대학 부속병원 신장내분비내과교실) , 이병철 (경희대학교 한의과대학 부속병원 신장내분비내과교실)

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Abstract: This retrospective study delved into the effects and safety considerations associated with the concomitant usage of hypoglycemic agents and herbal extracts, specifically Pyeongwi-san (PWS) or HyangsaPyongwi-san (HSPWS) in the context of type 2 diabetes mellitus management. Methods: The investigation involved 38 inpatients with type 2 diabetes mellitus who received PWS or HSPWS treatment at Kyung Hee University Korean Medical Hospital from January 2012 to December 2022. By investigating clinical attributes and conducting laboratory assessments, this study aimed to discern the impact of these herbal extracts on blood glucose levels, encompassing fasting blood sugar (FBS) and mean 2-hour postprandial glucose (PP2) levels. Furthermore, the safety profile of the herbal extracts was assessed by comparing liver function indicators, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (GGT), alongside kidney function markers, such as blood urea nitrogen (BUN) and creatinine (Cr). Results: Following the administration of the herbal extracts, no statistically significant alterations in FBS and mean PP2 levels emerged compared to the baseline levels. Notably, the safety evaluation revealed no significant differences in liver and kidney function parameters following herbal extract administration. Conclusion: The results of this research indicate that using PWS or HSPWS alongside hypoglycemic medications could be a beneficial additional method for addressing digestive symptoms in individuals with type 2 diabetes mellitus. Notably, this combination seems to have no negative interactions with other drugs.

주제어

표/그림 (8)

표 Table 1. Composition of Herbal Extracts
그림 Fig. 1. Participant disposition. T2DM : type 2 diabetes mellitus, PWS : Pyeongwi-san, HSPWS : HyangsaPyeongwi-san
표 Table 2. Baseline Demographics and Clinical Characteristics
표 Table 3. Comparison of Blood Glucose before and after Administration of Pyeongwi-san or HyangsaPyeongwi-san with Hypoglycemic Agents
그림 Fig. 2. Change in glucose levels before and after administration of Pyeongwi-san or HyangsaPyeongwi-san and hypoglycemic agents. PWS : Pyeongwi-san, HSPWS : HyangsaPyeongwi-san, N.S. : not significant
표 Table 4. Subgroup Analyses of Blood Glucose before and after Taking Pyeongwi-san or Hyangsa Pyeongwi-san according to Different Type of Oral Hypoglycemic Agent
그림 Fig. 3. Change in glucose levels before and after administration of Pyeongwi-san or HyangsaPyeongwi-san and hypoglycemic agents according to different type of oral hypoglycemic agent.
표 Table 5. Comparison of Liver and Kidney Function before and after Administration of Pyeongwi-san or HyangsaPyeongwi-san with Hypoglycemic Agents

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