[논문]이상지질혈증에 대한 택사탕(澤瀉湯)의 효과 : 체계적 문헌 고찰 및 메타 분석

이영서; 허태영; 김경민

doi:10.22246/jikm.2023.44.3.485

이상지질혈증에 대한 택사탕(澤瀉湯)의 효과 : 체계적 문헌 고찰 및 메타 분석
The Effect of Taeksa-tang for Dyslipidemia: A Systematic Review and Meta-Analysis 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.44 no.3, 2023년, pp.485 - 505

이영서 (동의대학교 부속 한방병원 한방내과) , 허태영 (동의대학교 부속 한방병원 한방내과) , 김경민 (동의대학교 부속 한방병원 한방내과)

Abstract ▼ AI-Helper

Objective: The purpose of this study is to assess the effectiveness and safety of using Taeksa-tang for dyslipidemia through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: The search was conducted using keywords such as "dyslipidemia", "hyperlipidemia", "taeksa tang", "zexie tang", and "takusha to" in 12 databases (Pubmed, Cochrane, Embase, ScienceDirect, CNKI, Wanfang, CiNii, RISS, KISS, ScienceON, OASIS, and DBpia) on April 13, 2023. There were no limits on the publication period and language. Cochrane's risk of bias (RoB) was used to evaluate the quality of the studies. A meta-analysis was conducted according to the outcome measurements such as total effective rate (TER), total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and adverse effects, using the Review Manager web. Results: A total of 9 RCTs were selected. In evaluating the RoB, 2 studies mentioning the random sequence generation, 1 study conducting double blindness, and 8 studies without missing values were evaluated as low risk, while 1 study without mentioning the random sequence generation was evaluated as high risk. All other parts were evaluated as unclear risk. The treatment group (Taeksa-tang or Taeksa-tang-gagam) showed more statistically significant effects compared to the control group (Western medicine or Chinese patent medicine) in TER (RR : 1.24, 95% CI 1.15 to 1.34, P<0.00001), TC (MD : -1.12, 95% CI -1.68 to -0.56, P<0.0001), TG (MD : -1.08, 95% CI -1.65 to -0.51, P=0.0002), HDL-C (MD : 0.63, 95% CI 0.34 to 0.93, P<0.0001), LDL-C (MD : -0.81, 95% CI -1.10 to -0.53, P<0.00001). In addition, the treatment group showed lower adverse effects compared to the control group (RR : 0.30, 95% CI 0.12 to 0.74, P=0.008). Conclusion: This study suggests that Taeksa-tang is effective and safe to use for treating dyslipidemia. However, due to the low quality of the included studies, more clinical studies need to be conducted in the future to increase the possibility of clinical use.

주제어

표/그림 (10)

그림 Fig. 1. Flow chart of selection process.
표 Table 1. Summary of 9 Included Studies
표 Table 2. Composition of Taeksa-tang, Taeksa-tang-gagam used in 9 Included Studies
그림 Fig. 2. Graph and summary of risk of bias.
그림 Fig. 3. Result of meta-analysis for total effective rate.
그림 Fig. 4. Result of meta-analysis for total cholesterol.
그림 Fig. 5. Result of meta-analysis for triglyceride.
그림 Fig. 6. Result of meta-analysis for high density lipoprotein cholesterol.
그림 Fig. 7. Result of meta-analysis for low density lipoprotein cholesterol.
그림 Fig. 8. Result of meta-analysis for adverse effects.

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