[논문]류마티스 관절염 백서 모델에서 작약감초부자탕의 효과: 체계적 문헌고찰 및 메타분석

김채연; 이상현; 황만석

doi:10.18325/jkmr.2023.33.3.79

류마티스 관절염 백서 모델에서 작약감초부자탕의 효과: 체계적 문헌고찰 및 메타분석
Effects of Jakyakkamchobuja-tang on Rheumatoid Arthritis in Rat Model: Systemic Review and Meta-Analysis 원문보기

Journal of Korean Medicine Rehabilitation : JKMR = 한방재활의학과학회지, v.33 no.3, 2023년, pp.79 - 96

김채연 (부산대학교 한의학전문대학원) , 이상현 (부산대학교 대학원 한의학과) , 황만석 (부산대학교 한의학전문대학원)

Abstract ▼ AI-Helper

Objectives This study was designed to review the effect of Jakyakkamchobuja-tang on rat model with rheumatoid arthritis. Methods We used seven databases (PubMed, EMBASE, Cochrane CENTRAL, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, National Digital Science Library) from their inception to May 2023 without language restrictions. Systematic Review Centre for Laboratory Animal Experimentation's tool was used to evaluate the risk of bias. RevMan software (V5.4) was used for the meta-analysis. Results Five studies were selected following our inclusion criteria. The arthritis index decreased significantly (standardized mean difference=-2.06; 95% confidence interval=-3.07 to -1.04; p<0.0001) in Jakyakkamchobuja-tang group. Also, serum cytokines in serum and paw swelling degree decreased in Jakyakkamchobuja-tang group. Conclusions Jakyakkamchobuja-tang may be effective in treating rheumatoid arthritis. Although there is a limitation that the design of drug dosage varies between papers, it can be expected to be applied as an alternative to Western medicine, and it is believed to contribute to the standardization of herbal treatment for rheumatoid arthritis.

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표/그림 (14)

그림 Fig. 1. Flowchart of the literature screening and selection process. CENTRAL: Cochrane CENTRAL, OASIS: Oriental Medicine Advanced Searching Integrated System, KISS: Korean studies Information Service System, NDSL: National Digital Science Library, CNKI: China National Knowledge Infrastructure.
표 Table I. Characteristics of Included Studies
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그림 Fig. 2. Graphical representation of the risk of bias of the included studies.
그림 Fig. 3. Risk of bias summary of the included studies.
그림 Fig. 4. Forest plot of arthritis index between SGFD group and control group. SGFD: shaoyao gancao fuzi decoction, Std.: standardized, SD: standard deviation, CI: confidence interval, df: degree of freedom.
그림 Fig. 5. Forest plot of inflammatory cytokines in serum between SGFD group and control group. IL: interleukin, SGFD: shaoyao gancao fuzi decoction, Std.: standardized, SD: standard deviation, CI: confidence interval, df: degree of freedom.
그림 Fig. 6. Forest plot of paw swelling degree between SGFD group and control group. SGFD: shaoyao gancao fuzi decoction, Std.: standardized, SD: standard deviation, CI: confidence interval, df: degree of freedom.

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