[논문]불면증에 대한 한방 족욕요법의 무작위 대조군 임상연구 현황 : CNKI를 중심으로

권찬영; 이보람; 이경은

doi:10.22246/jikm.2023.44.4.726

불면증에 대한 한방 족욕요법의 무작위 대조군 임상연구 현황 : CNKI를 중심으로
Randomized Controlled Clinical Trials of Warm Herbal Foot Bath Therapy for Insomnia: A Literature Review Based on the CNKI 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.44 no.4, 2023년, pp.726 - 740

권찬영 (동의대학교 한의과대학 한방신경정신과학교실) , 이보람 (한국한의학연구원 한의과학연구부) , 이경은 (동의대학교부속한방병원)

초록
AI-Helper

목적: 이 연구의 목적은 불면증에 대한 한방 족욕요법의 연구 동향을 검토하는 것이다. 방법: 관련 연구의 수집을 위해 CNKI에서 검색을 수행하여, 2023년 8월 29일까지 발표된 연구를 검토하였다. 불면증 환자를 대상으로 한방 족욕요법과 수면제를 비교한 무작위 대조군 임상시험 만을 분석에 포함하였다. 포함된 연구들의 방법론적 질은 Cochrane risk-of-bias assessment tool을 사용하여 평가하였다. 메타분석의 결과는 위험비(risk ratios, RRs)와 평균차(mean differences, MDs) 및 그 95% 신뢰구간(confidence intervals, CIs)으로 제시되었다. 결과: 총 11편의 무작위 대조군 임상시험이 포함되었다. 분석 결과, 한방 족욕요법은 벤조디아제핀계 약물과 비교하여 유의하게 더 높은 총유효율(RR, 1.25; 95% CI, 1.15 to 1.36; I²=25%)과 개선된 피츠버그 수면의 질 지수(Pittsburgh Sleep Quality Index, PSQI) 총 점수(MD, -3.10; 95% CI, -4.24 to -1.95; I²=73%)를 보였다. 또한, 벤조디아제핀계 약물에 한방 족욕요법을 병용한 경우, 벤조디아제핀계 약물을 단독으로 사용한 것과 비교하여 유의하게 더 높은 총유효율(RR, 1.15; 95% CI, 1.04 to 1.27; I²=0%)과 개선된 PSQI 총 점수(MD, -2.23; 95% CI, -4.09 to -0.38; I²=80%)을 보였다. 네트워크 분석을 통해 한방 족욕요법에 포함된 약재를 분석하고 시각화한 결과, 4개의 클러스터가 발견되었으며, 핵심 약재는 야교등과 산조인이었다. 포함된 연구들의 방법론적 질은 전반적으로 낮았다. 결론: 이 연구는 불면증 개선에 있어서 단독요법 또는 병행치료로서의 한방 족욕요법이 효과적이라는 제한된 수준의 근거를 보여준다. 이 연구의 발견은 향후 한국에서 시행할 한방 족욕요법 연구의 기초자료로 활용될 수 있을 것이다.

Abstract ▼ AI-Helper

Objectives: This review investigated the research on warm herbal foot bath therapy (WHFT) for insomnia. Methods: A search was conducted on the China National Knowledge Infrastructure (CNKI) database to collect relevant studies published up to August 29, 2023. Randomized controlled trials (RCTs) comparing WHFT and sleeping pills in patients with insomnia were included. The methodological quality of the included studies was assessed using the Cochrane risk-of-bias assessment tool. The results of the meta-analysis were presented as risk ratios (RRs) or mean differences (MDs) and their 95% confidence intervals (CIs). Results: A total of 11 RCTs were included. WHFT as monotherapy resulted in a significantly higher total effective rate (TER) (RR, 1.25; 95% CI, 1.15 to 1.36; I2=25%) and an improved Pittsburgh Sleep Quality Index (PSQI) global sore (MD, -3.10; 95% CI, -4.24 to -1.95; I2=73%) compared to benzodiazepines. Additionally, WHFT as a combined therapy with benzodiazepines resulted in a significantly higher TER (RR, 1.15; 95% CI, 1.04 to 1.27; I2=0%) and an improved PSQI global score (MD, -2.23; 95% CI, -4.09 to -0.38; I2=80%) compared to benzodiazepines alone. In network analysis visualizing the components of HWFT, four clusters were discovered, and Polygoni Multiflori Ramuls and Ziziphi Spinosae Semen were the key herbs used in WHFT. Overall, the methodological quality of the included studies was poor. Conclusions: There was limited evidence that WHFT as a monotherapy or combined therapy was effective in improving insomnia. The findings can be used as basic data for future WHFT research in South Korea.

주제어

표/그림 (7)

그림 Fig. 1. PRISMA flow diagram of this study. HWFT : herbal warm foot bath therapy, RCT : randomized controlled clinical trial
표 Table 1. Characteristics of Included Studies
그림 Fig. 2. Results of risk of bias graph and summary. '+' indicates low risk of bias, '-' indicates high risk of bias, and '?' indicates unclear risk of bias.
표 Table 2. Details of HWFT for Insomnia
그림 Fig. 3. Network map of herbs for HWFT. Red, green, blue, and yellow represent each cluster.
그림 Fig. 4. Meta-analysis on HWFT as monotherapy: (a) total effective rate, (b) global score of the Pittsburgh sleep quality index, (c) incidence of adverse events. HWFT : herbal warm foot bath therapy
그림 Fig. 5. Meta-analysis on HWFT as combined therapy: (a) total effective rate, (b) global score of the Pittsburgh sleep quality index. HWFT : herbal warm foot bath therapy

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표제어: PCR

동의어: Packet Collision Rate

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