[논문]구리 기반 표면코팅 및 산화수에 따른 항균·항바이러스 특성

고상원

doi:10.14478/ace.2023.1073

구리 기반 표면코팅 및 산화수에 따른 항균·항바이러스 특성
Copper-based Surface Coatings and Antimicrobial Properties Dependent on Oxidation States 원문보기

공업화학 = Applied chemistry for engineering, v.34 no.5, 2023년, pp.479 - 487

초록
AI-Helper

구리(Cu)는 저렴한 비용으로 용이하게 도입이 가능하여 다양한 소재 표면에 살균 코팅제로 쓰이고 있다. 자연적 산화 반응이 구리의 효능을 손상시키지 않아 장기간 노출 조건에서도 항균 성능을 유지할 수 있다. 더 나아가 구리 화합물은 그람 음성균 및 그람 양성균 뿐만 아니라, 병원성 효모, 외피 보유 및 외피 미보유 타입의 바이러스에 대해 모두 폭넓은 살균 효과를 보인다. 구리 코팅 표면의 접촉 살균은 구리의 침투로 단백질 변성을 일으키고 세포막 손상으로 뉴클레오티드 및 세포질 등의 내용물이 용출되게 한다. 또한 구리 산화환원 활성에 의한 활성 산소종 생성으로 효소작용을 억제하고 DNA를 파괴하여 세포를 영구적으로 손상시킨다. 구리는 안정한 금속 성질 때문에 나노입자, 이온, 복합물, 합금 등의 여러 형태로 쓰이고 있으며 코팅 방법이 다양하다. 본 총설에서는 구리 이온과 구리 산화물의 대표적인 표면 도입 방법을 살펴보고 구리 산화수에 따른 항균·항바이러스 특성을 다루고자 한다.

Abstract ▼ AI-Helper

Copper is cost-effective and abundantly available as a biocidal coating agent for a wide range of material surfaces. Natural oxidation does not compromise the efficacy of copper, allowing it to maintain antimicrobial activity under prolonged exposure conditions. Furthermore, copper compounds exhibit a broad spectrum of antimicrobial activity against pathogenic yeast, both enveloped and non-enveloped types of viruses, as well as gram-negative and gram-positive bacteria. Contact killing of copper-coated surfaces causes the denaturation of proteins and damage to the cell membrane, leading to the release of essential components such as nucleotides and cytoplasm. Additionally, redox-active copper generates reactive oxygen species (ROS), which cause permanent cell damage through enzyme deactivation and DNA destruction. Owing to its robust stability, copper has been utilized in diverse forms, such as nanoparticles, ions, composites, and alloys, resulting in the creation of various coating methods. This mini-review describes representative coating processes involving copper ions and copper oxides on various material surfaces, highlighting the antibacterial and antiviral properties associated with different oxidation states of copper.

주제어

표/그림 (7)

그림 Figure 1. Illustration of antimicrobial mechanism of Cu based surface coatings. (a) Dissolution of Cu from coated surfaces, (b) disruption of membrane and loss of cytoplasmic content, c) generation of ROS, and (d) degradation of DNA.
그림 Figure 2. Chemical modification of cellulose for anchoring Cu ions.
그림 Figure 3. (a) Antiviral activities against bacteriophage Φ6 and Qβ. (b) One-month antiviral activity against the bacteriophage Qβ. Reprinted with permission from [33], Shigetoh et al., ACS Appl. Mater. Interfaces, 15, 20398 (2023). © 2023 American Chemical Society.
그림 Figure 4. (a) Roll-to-roll sonochemical pilot installation. (b) Image of a filter composed from the CuO-coated media. Reprinted with permission from [40], Gedanken et al., ACS Appl. Mater. Interfaces, 14, 24850 (2022). © 2022 American Chemical Society.
그림 Figure 5. Images of Cu2O/PU coated doorkonb. Reprinted with permission from [44]. Ducker et al., ACS Appl. Mater. Interfaces, 12, 34723 (2020). © 2020 American Chemical Society.
표 Table 1. Antimicrobial Activity of Various Substrates Coated with Cu Nanoparticles or Cu Ions
표 Table 1. Continued

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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