$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

침향(沈香)의 국내외 연구동향과 본초학에 대한 문헌고찰
Agarwood's Domestic and International Research Trends and Literature Review of Herbal Medicine 원문보기

大韓本草學會誌 = The Korea journal of herbology, v.38 no.6, 2023년, pp.1 - 27  

정광호 (IAA국제침향협회 연구소) ,  조우진 (IAA국제침향협회 연구소)

Abstract AI-Helper 아이콘AI-Helper

Objectives : To investigate the modern research achievements of agarwood and its association with the efficacy of herbal medicine based on the in vivo and in vitro activities of volatile compounds detected in agarwood. Methods : Databases such as PubMed and ScienceOn were searched for medicinal in v...

주제어

표/그림 (5)

참고문헌 (257)

  1. Lee SY, Mohamed R. The origin and domestication?of Aquilaria, an important agarwood-producing?genus. Agarwood: science behind the fragrance.?2016 : 1-20. doi:10.1007/978-981-10-0833-7_1? 

  2. Lopez-Sampson A, Page, T. History of use and?trade of agarwood. Economic botany. 2018 ; 72(1) :?107-29. doi:10.1007/s12231-018-9408-4? 

  3. Alam J, Mujahid M, Rahman MA, Akhtar J, Khalid?M, Jahan Y, et al. An insight of pharmacognostic?study and phytopharmacology of Aquilaria agallocha.?Journal of Applied Pharmaceutical Science. 2015 ;?5(8) : 173-81. doi:10.7324/JAPS.2015.50827? 

  4. Hashim YZ, Kerr PG, Abbas P, Salleh HM.?Aquilaria spp.(agarwood) as source of health beneficial?compounds: A review of traditional use,?phytochemistry and pharmacology. Journal of?Ethnopharmacology. 2016 ; 189 : 331-60. doi:10.1016/j.jep.2016.06.055? 

  5. Boncho-hak. Seoul : Young-Lim Press. 2020 : 392.? 

  6. Yuan H, Ma Q, Ye L, Piao G. The traditional medicine?and modern medicine from natural products.?Molecules. 2016 ; 21(5). doi:10.3390/molecules21050559? 

  7. Park S, Kim H. Study on marker component and?skin efficacy of Aquilaria Malaccensis agarwood?extract. Jounal of The Korean Society of cosmetology.?2019 ; 25(3) : 685-93.? 

  8. Lee HY, Lee IC, Kwak JH, Kim TH. Evaluation of?free radical scavenging and pancreatic lipase inhibitory?effects of Aquilaria agallocha extracts. Korean Journal?of Food Preservation. 2015 ; 22(3) : 437-42. doi:10.11002/kjfp.2015.22.3.437? 

  9. Shin KH, Choi KY, Cho SY, Ahn DK, Park SK.?GC-MS Analysis of chemical constituents from?various agarwood. The Korea Journal of Herbology.?2011 ; 26(1) : 7-12. doi:10.6116/kjh.2011.26.1.007? 

  10. Park HD, Weon HW. The effect of agarwood?inhalation using an electric incense burner on stress and brain waves. Journal of the Korea?Academia-Industrial cooperation Society. 2021 ;?22(3) : 536-45. doi:10.5762/kais.2021.22.3.536? 

  11. Jung KH, Lee KJ. A comparative analysis of the?volatile components of agarwood from Vietnam?and other regions. Asian Journal of Beauty and?Cosmetology. 2022 ; 20(4) : 481-98. doi:10.20402/ajbc.2022.0076? 

  12. Ahn S, Ma CT, Choi JM, An S, Lee M, Le THV, et?al. Adiponectin-secretion-promoting?phenylethylchromones from the agarwood of?Aquilaria malaccensis. J Nat Prod. 2019 ; 82(2) :?259-64. doi:10.1021/acs.jnatprod.8b00635? 

  13. Inoue E, Shimizu Y, Masui R, Tsubonoya T,?Hayakawa T, Sudoh K. Agarwood inhibits histamine?release from rat mast cells and reduces scratching?behavior in mice: Effect of agarwood on histamine?release and scratching behavior. J Pharmacopuncture.?2016 ; 19(3) : 239-45. doi:10.3831/KPI.2016.19.025? 

  14. Hwang YL, Kim KY, Yu SN, Park KI, Ahn SC.?Evaluation of immunomodulatory and biological?effects of Aquilaria crassna extracts. The Journal?of Herbal Formula Science. 2022 ; 30(4) : 249-57.?doi:10.14374/HFS.2022.30.4.249? 

  15. Kim YH, Lee EJ, Song BK, Kim HK. Studies on the?antiallergic effect of Aquillariae Lignum. Journal of?Korean Oriental Medicine. 1997 ; 18(2) : 167-87.? 

  16. Kim MS, Hwang HI, Lee YR, Kim HW, Park JK.?The effects of Lentinula edodes and Aquilariae?agallocha extracts combination on the repair of?UVA-damaged DNA and DNCB-induced allergic?dermatitis. The Korean Journal of Food And?Nutrition. 2015 ; 28(5) : 759-65. doi:10.9799/ksfan.2015.28.5.759? 

  17. Kim CK, Jeong SJ, Kim HM. Antiallergic effect of?Aquilariae Lignum. Yakhak Hoeji. 1997 ; 41(2) :?255-9.? 

  18. Wang CH, Peng DQ, Liu YY, Wu YL, Guo P, Wei?JH. Anti-asthmatic effect of agarwood alcohol extract in mice and its mechanism. Zhongguo?Zhong Yao Za Zhi. 2021 ; 46(16) : 4214-21.?doi:10.19540/j.cnki.cjcmm.20210520.704? 

  19. Alamil JMR, Xenaki D, Manandhar B, Paudel KR,?Hansbro PM, Oliver BG, et al. Agarwood oil?nanoemulsion attenuates production of?lipopolysaccharide (LPS)-induced proinflammatory?cytokines, IL-6 and IL-8 in human bronchial?epithelial cells. Experimental and Clinical Sciences.?2023 ; 22 : 681-5. doi:10.17179/excli2023-6282? 

  20. Li W, Cai CH, Dong WH, Guo ZK, Wang H, Mei?WL, Dai HF. 2-(2-phenylethyl)chromone derivatives?from Chinese agarwood induced by artificial?holing. Fitoterapia. 2014 ; 98 : 117-23. doi:10.1016/j.fitote.2014.07.011? 

  21. Li W, Cai CH, Guo ZK, Wang H, Zuo WJ, Dong WH,?et al. Five new eudesmane-type sesquiterpenoids?from Chinese agarwood induced by artificial?holing. Fitoterapia. 2015 ; 100 : 44-9. doi:10.1016/j.fitote.2014.11.010? 

  22. Singh BR, Sinha DK, Or VK, Vadhana P, Bhardwaj?M, Saraf A, et al. Antimicrobial activity of agarwood?oil against multiple-drug-resistant (MDR) microbes?of clinical, food and environmental origin. Curr?Drug Discov Technol. 2020 ; 17(3) : 348-56.?doi:10.2174/1570163816666190125163536? 

  23. Chen H, Yang Y, Xue J, Wei J, Zhang Z, Chen H.?Comparison of compositions and antimicrobial?activities of essential oils from chemically stimulated?agarwood, wild agarwood and healthy Aquilaria?sinensis (Lour.) gilg trees. Molecules. 2011 ; 16(6)?: 4884-96. doi:10.3390/molecules16064884? 

  24. Han JS, Shin, D.H. Antimicrobial activity of?Lysimachia clethroides duby extracts on foodborne microorganisms. Korean Journal of Food?Science and Technology. 2001 ; 33(6) : 774-83.?doi:10.1016/j.phymed.2022.153935? 

  25. Xia L, Li W, Wang H, Chen H, Cai C, Yang L, et al.?LC-MS guided identification of dimeric 2-(2-?phenylethyl)chromones and sesquiterpene-2-(2-phenylethyl)chromone conjugates from agarwood?of Aquilaria crassna and their cytotoxicity.?Fitoterapia. 2019 ; 138 : 104349. doi:10.1016/j.fitote.2019.104349? 

  26. He D, Dong WH, Li W, Yang L, Yuan JZ, Gai CJ,?et al. LC-MS-guided isolation of 2-(2-phenylethyl)?chromone dimers from red soil agarwood of?Aquilaria crassna. Fitoterapia. 2022 ; 158 : 105162.?doi:10.1016/j.fitote.2022.105162? 

  27. Liu YY, Chen DL, Yu ZX, Can-Hong W, Feng J,?Meng Y, Wei JH. New 2-(2-phenylethyl) chromone?derivatives from agarwood and their inhibitory?effects on tumor cells. Natural product research.?2020 ; 34(12) : 1721-7. doi:10.1080/14786419.2018.1528591? 

  28. Zhao YM, Yang L, Kong FD, Dong WH, Li W,?Chen HQ, et al. Three new 5,6,7,8-tetrahydro2-(2-phenylethyl)chromones and one new dimeric?2-(2-phenylethyl)chromone from agarwood of?Aquilaria crassna Pierre ex Lecomte in Laos. Nat?Prod Res. 2021 ; 35(14) : 2295-302. doi:10.1080/14786419.2019.1672066? 

  29. Dahham SS, Tabana YM, Iqbal MA, Ahamed MB,?Ezzat MO, Majid AS, Majid AM. The anticancer,?antioxidant and antimicrobial properties of the?sesquiterpene beta-caryophyllene from the essential?oil of Aquilaria crassna. Molecules. 2015 ; 20(7) :?11808-29. doi:10.3390/molecules200711808? 

  30. Chen L, Liu Y, Li Y, Yin W, Cheng Y. Anti-cancer?effect of sesquiterpene and triterpenoids from?agarwood of Aquilaria sinensis. Molecules. 2022 ;?27(16) : 5350. doi:10.3390/molecules27165350? 

  31. Gunasekera SP, Kinghorn AD, Cordell GA,?Farnsworth NR. Plant anticancer agents. XIX?Constituents of Aquilaria malaccensis. J Nat Prod.?1981 ; 44(5) : 569-72. doi:10.1021/np50017a010? 

  32. Dahham SS, Hassan LE, Ahamed MB, Majid AS,?Majid AM, Zulkepli NN. In vivo toxicity and?antitumor activity of essential oils extract from?agarwood (Aquilaria crassna). BMC Complement?Altern Med. 2016 ; 16(1) : 1-11. doi:10.1186/s12906-016-1210-1? 

  33. Hashim YZ, Phirdaous A, Azura A. Screening of?anticancer activity from agarwood essential oil.?Pharmacognosy Res. 2014 ; 6(3) : 191-4. doi:10.4103/0974-8490.132593? 

  34. Huang XL, Cai D, Gao P, Wang JG, Cheng YX.?Aquilariperoxide A, a sesquiterpene dimer from?agarwood of Aquilaria sinensis with dual antitumor?and antimalarial effects. J Org Chem. 2023 ;?88(13) : 8352-9. doi:10.1021/acs.joc.3c00372? 

  35. Huang XL, Zhou YT, Yan YM, Cheng YX.?Sesquiterpenoid-chromone heterohybrids from?agarwood of Aquilaria sinensis as potent specific?Smad3 phosphorylation inhibitors. The Journal of?Organic Chemistry. 2022 ; 87(12) : 7643-8.?doi:10.1021/acs.joc.2c00145? 

  36. Kim YC, Lee EH, Lee YM, Kim HK, Song BK, Lee?EJ, Kim HM. Effect of the aqueous extract of?Aquilaria agallocha stems on the immediate?hypersensitivity reactions. J Ethnopharmacol.?1997 ; 58(1) : 31-8. doi:10.1016/s0378-8741(97)00075-5? 

  37. Wang SL, Tsai YC, Fu SL, Cheng MJ, Chung MI, Chen JJ. 2-(2-Phenylethyl)-4 H-chromen-4-one?derivatives from the resinous wood of Aquilaria?sinensis with anti-inflammatory effects in?LPS-induced macrophages. Molecules. 2018 ; 23(2)?: 289. doi:10.3390/molecules23020289? 

  38. Huo HX, Gu YF, Sun H, Zhang YF, Liu WJ, Zhu?ZX, et al. Anti-inflammatory 2-(2-phenylethyl)?chromone derivatives from Chinese agarwood.?Fitoterapia. 2017 ; 118 : 49-55. doi:10.1016/j.fitote.2017.02.009? 

  39. Yu Z, Wang C, Zheng W, Chen D, Liu Y, Yang Y,?Wei J. Anti-inflammatory 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones from agarwood of?Aquilaria sinensis. Bioorg Chem. 2020 ; 99 :?103789. doi:10.1016/j.bioorg.2020.103789? 

  40. Yang ZH, Fang HB, Tao CT, Jiao YB, Cheng YX.?Eight new 2-(2-phenylethyl)chromone derivatives?from agarwood of Aquilaria sinensis with antiinflammatory activity. Fitoterapia. 2023 ; 169 :?105564. doi:10.1016/j.fitote.2023.105564? 

  41. Liu YY, Chen DL, Wei JH, Feng J, Zhang Z, Yang?Y, Zheng W. Four new 2-(2-Phenylethyl)chromone?derivatives from Chinese agarwood produced via?the whole-tree agarwood-inducing technique.?Molecules. 2016 ; 21(11) : 1433. doi:10.3390/molecules21111433? 

  42. Zhu Z, Gu Y, Zhao Y, Song Y, Li J, Tu P.?GYF-17, a chloride substituted 2-(2-phenethyl)-chromone, suppresses LPS-induced inflammatory?mediator production in RAW264.7 cells by inhibiting?STAT1/3 and ERK1/2 signaling pathways. Int?Immunopharmacol. 2016 ; 35 : 185-92. doi:10.1016/j.intimp.2016.03.044? 

  43. Huo HX, Gu YF, Zhu ZX, Zhang YF, Chen XN,?Guan PW, et al. LC-MS-guided isolation of antiinflammatory 2-(2-phenylethyl)chromone dimers?from Chinese agarwood (Aquilaria sinensis).?Phytochemistry. 2019 ; 158 : 46-55. doi:10.1016/j.phytochem.2018.11.003? 

  44. Zhang S, Xie Y, Song L, Wang Y, Qiu H, Yang Y,?et al. Seven new 2-(2-phenylethyl) chromone?derivatives from agarwood of Aquilaria agallocha?with inhibitory effects on nitric oxide production.?Fitoterapia. 2022 ; 159 : 105177. doi:10.1016/j.fitote.2022.105177? 

  45. Yu ZX, Wang CH, Chen DL, Liu YY, Wei JH. Antiinflammatory sesquiterpenes from agarwood?produced via whole-tree agarwood-inducing?technique of Aquilaria sinensis. Zhongguo Zhong?Yao Za Zhi. 2019 ; 44(19) : 4196-202. doi:10.19540/j.cnki.cjcmm.20190723.201? 

  46. Chen Y, Chen N, Wang J, Li S. Effects of Baimuxinol?on the inflammation and oxidative stress of?LPS-induced RAW264.7 macrophages via regulating?the NF-kappaB/IkappaBalpha and Nrf2/ARE?signaling pathway. Acta Biochim Pol. 2023 ; 70(1)?: 77-82. doi:10.18388/abp.2020_6208? 

  47. Xie Y, Song L, Li C, Yang Y, Zhang S, Xu H, et al.?Eudesmane-type and agarospirane-type?sesquiterpenes from agarwood of Aquilaria?agallocha. Phytochemistry. 2021 ; 192 : 112920.?doi:10.1016/j.phytochem.2021.112920? 

  48. Zhou H, Li XY, Fang HB, Jiang HZ, Cheng YX.?Five new sesquiterpenoids from agarwood of?Aquilaria sinensis. Beilstein J Org Chem. 2023 ;?19(1) : 998-1007. doi:10.3762/bjoc.19.75? 

  49. Ma CT, Ly TL, Le THV, Tran TVA, Kwon SW, Park?JH. Sesquiterpene derivatives from the agarwood of?Aquilaria malaccensis and their anti-inflammatory?effects on NO production of macrophage RAW?264.7 cells. Phytochemistry. 2021 ; 183 : 112630.?doi:10.1016/j.phytochem.2020. 112630? 

  50. Yuan JZ, Yang YL, Li W, Yang L, Dai HF, Mandi?A, et al. Zizaane-type sesquiterpenoids and their?rearranged derivatives from agarwood of an Aquilaria plant. Molecules. 2021 ; 27(1) : 198. doi:10.3390/molecules27010198? 

  51. Yadav DK, Mudgal V, Agrawal J, Maurya AK,?Bawankule DU, Chanotiya CS, et al. Molecular?docking and ADME studies of natural compounds?of agarwood oil for topical anti-inflammatory?activity. Curr Comput Aided Drug Des. 2013 ; 9(3)?: 360-70. doi:10.2174/1573409911309030012? 

  52. Alamil JMR, Paudel KR, Chan Y, Xenaki D,?Panneerselvam J, Singh SK, et al. Rediscovering the?therapeutic potential of agarwood in the management?of chronic inflammatory Diseases. Molecules. 2022?; 27(9) : 3038. doi:10.3390/molecules27093038? 

  53. Tian CP, Song YL, Xu HT, Niu SQ, Wu ZH, Shen?LQ. Composition analysis,antioxidative and?antibacterial activities comparison of agarwood oils?extracted by supercritical and steam distillation.?Zhongguo Zhong Yao Za Zhi. 2019 ; 44(18) :?4000-8. doi:10.19540/j.cnki.cjcmm.20190629.302? 

  54. Jung I. Evaluation of β-selinene absorption rate?and antioxidant effect of Chimhyang-hwan fermented?with lactic acid bacteria. Journal of Industrial?Innovation [Internet]. 2023 ; 39(2) : 143-50.?doi:10.22793/indinn.2023.39.2.013? 

  55. Wang MR, Li W, Luo S, Zhao X, Ma CH, Liu SX.?GC-MS Study of the chemical components of?different Aquilaria sinensis (Lour.) Gilgorgans and?agarwood from different asian countries. Molecules.?2018 ; 23(9) : 2168. doi:10.3390/molecules 23092168 

  56. Ma S HM, Fu Y, Qiao M, Li Y. How closely induced?agarwood's biological activity resemble that of wild?agarwood? Molecules. 2023 ; 28(7) : 2922. doi:10.3390/molecules28072922? 

  57. Seo JH, Park DJ, Lee SY, Cho HS, Jin MH.?Neuraminidase-inhibition activity of nodakenetin?from Gongjin-dan fermented by lactic acid bacteria.?Microbiol Biotechnol Lett. 2020 ; 48(3) : 303-9.?doi:10.4014/mbl.2001.01015? 

  58. Shibata S, Sugiyama T, Uekusa Y, Masui R,?Narukawa Y, Kiuchi F. Five new 2-(2-phenylethyl)?chromone derivatives from agarwood. J Nat Med.?2020 ; 74(3) : 561-70. doi:10.1007/s11418-020-01410-z? 

  59. Sugiyama T, Narukawa Y, Shibata S, Masui R,?Kiuchia F. New 2-(2-phenylethyl)chromone?derivatives and inhibitors of phosphodiesterase?(PDE) 3A from agarwood. Nat Prod Commun. 2016?; 11(6) : 795-7.? 

  60. Sugiyama T, Narukawa Y, Shibata S, Masui R,?Kiuchi F. Three new 5,6,7,8-tetrahydroxy-5,6,?7,8-tetrahydrochromone derivatives enantiomeric?to agarotetrol from agarwood. J Nat Med. 2018 ;?72(3) : 667-74. doi:10.1007/s11418-018-1201-2? 

  61. Kuamsub S, Singthong P, Chanthasri W,?Chobngam N, Sangkaew W, Hemdecho S, et al.?Improved lipid profile associated with daily?consumption of Tri-Sura-Phon in healthy?overweight volunteers: An open-label, randomized?controlled trial. Evid Based Complement Alternat?Med. 2017 ; 2017 : 2687173. doi:10.1155/2017/2687173? 

  62. Zhang H, Ma JL, Chang C, Ta H, Zhao YF, Shi?SP, et al. Gastroprotective 2-(2-phenylethyl)?chromone-sesquiterpene hybrids from the resinous?wood of Aquilaria sinensis (Lour.) Gilg. Bioorganic?Chemistry. 2023 ; 133 : 106396. doi:10.1016/j.bioorg.2023.106396? 

  63. Zhou YB. [Pharmacological actions of lignum?Aquilariae Resinatum (Aquilaria agallocha Roxb.) on the smooth muscle of intestines]. Zhong Yao?Tong Bao. 1988 ; 13(6) : 40-2, 64.? 

  64. Ma J, Huo H, Zhang H, Wang L, Meng Y, Jin F, et?al. 2-(2-phenylethyl) chromone-enriched extract of?the resinous heartwood of Chinese agarwood?(Aquilaria sinensis) protects against taurocholic?acid-induced gastric epithelial cells apoptosis?through Perk/eIF2α/CHOP pathway.?Phytomedicine. 2022 ; 98 : 153935. doi:10.1016/j.phymed.2022. 153935? 

  65. Wang C, Peng D, Liu Y, Wu Y, Guo P, Wei J. Agarwood?alcohol extract protects against gastric ulcer by?inhibiting oxidation and inflammation. Evid Based?Complement Alternat Med. 2021 ; 2021. doi:10.1155/2021/9944685? 

  66. Verkman A, Tradtrantip L, Ko E, Verkman A.?Antidiarrheal Efficacy and Cellular Mechanisms of a Thai Herbal Remedy. 2014. doi:10.1371/journal.pntd.0002674? 

  67. Li H, Qu Y, Zhang J, Zhang J, Gao W. Spasmolytic?activity of Aquilariae Lignum Resinatum extract on gastrointestinal motility involves muscarinic?receptors, calcium channels and NO release. PharmBiol. 2018 ; 56(1) : 559-66. doi:10.1080/13880209.2018.1492000? 

  68. Liao G, Mei WL, Dong WH, Li W, Wang P, Kong?FD, et al. 2-(2-Phenylethyl)chromone derivatives in?artificial agarwood from Aquilaria sinensis.?Fitoterapia. 2016 ; 110 : 38-43. doi:10.1016/j.fitote.2016.01.011? 

  69. Mi CN, Mei WL, Wang H, Yang L, Dong WH, Gai?CJ, et al. Four new guaiane sesquiterpenoids from?agarwood of Aquilaria filaria. Fitoterapia. 2019 ;?135 : 79-84. doi:10.1016/j.fitote.2019.04.007? 

  70. Yang L, Yang YL, Dong WH, Li W, Wang P, Cao X,?et al. Sesquiterpenoids and 2-(2-phenylethyl)?chromones respectively acting as α-glucosidase?and tyrosinase inhibitors from agarwood of an Aquilaria plant. Journal of Enzyme Inhibition and?Medicinal Chemistry. 2019 ; 34(1) : 853-62. doi:10.1080/14756366.2019.1576657? 

  71. Yang L YY, Dong WH, Li W, Wang P, Cao X, Yuan?JZ, Chen HQ, Mei WL, Dai HF. Sesquiterpenoids?and 2-(2-phenylethyl)chromones respectively acting?as α-glucosidase and tyrosinase inhibitors from?agarwood of an Aquilaria plant. J Enzyme Inhib?Med Chem 2019 ; 34(1) : 853-62. doi:10.1080/14756366.2019.1576657? 

  72. Ji SY, Lee H, Hwangbo H, Kim MY, Kim DH, Park?BS, et al. Agarwood pill enhances immune function?in cyclophosphamide-induced immunosuppressed?mice. Biotechnology and Bioprocess Engineering.?2023 ; 28(1) : 63-73. doi:10.1007/s12257-022-0345-9? 

  73. Ji SY, Hwangbo H, Lee H, Koo YT, Kim JS, Lee?KW, et al. Immunostimulatory activity of agarwood?through activation of MAPK signaling pathway in?RAW 264.7 murine macrophages. Journal of Life?Science. 2021 ; 31(8) : 745-54. doi:10.5352/JLS.2021.31.8.745? 

  74. Guo R, Li J, Gu Y, Li Y, Li S, Gao X, et al. GYF-21, an epoxide 2?(2?phenethyl)?chromone derivative,?suppresses dysfunction of B cells mainly via?inhibiting BAFF activated signaling pathways. International Immunopharmacology. 2019 ; 67 :?473-82. doi:10.1016/j.intimp.2018. 12.048? 

  75. Guo R, Zhao YF, Li J, Gu YF, Huo HX, Li SS, et?al. GYF-21, an Epoxide 2-(2-phenethyl)-chromone?derivative, suppresses innate and adaptive immunity?via inhibiting STAT1/3 and NF-kappaB signaling?pathways. Front Pharmacol. 2017 ; 8 : 281. doi:10.3389/fphar.2017.00281? 

  76. Zhu Z, Zhao Y, Huo H, Gao X, Zheng J, Li J, Tu?P. HHX-5, a derivative of sesquiterpene from?Chinese agarwood, suppresses innate and adaptive?immunity via inhibiting STAT signaling pathways.?Eur J Pharmacol. 2016 ; 791 : 412-23. doi:10.1016/j.ejphar.2016.09.023? 

  77. Wang H, Hu J, Hu J, Chen Q, Shang N, Liu M, et?al. Antidepressant effect of 4-Butyl-alphaagarofuran via HPA axis and serotonin system.?Brain Res Bull. 2023 ; 198 : 3-14. doi:10.1016/j.brainresbull.2023.04.003? 

  78. Huong DTL, Dat NT, Van Minh C, Kang JS, Kim?YH. Monoamine oxidase inhibitors from Aquilaria?agallocha. The Korean Society of Pharmacognosy.?2002 ; 8(1) : 30-3.? 

  79. Okugawa H, Ueda R, Matsumoto K, Kawanishi K,?Kato A. Effect of jinkoh-eremol and agarospirol?from agarwood on the central nervous system in?mice. Planta Med. 1996 ; 62(1): 2-6. doi:10.1055/s-2006-957784? 

  80. Ueda JY, Imamura L, Tezuka Y, Tran QL, Tsuda?M, Kadota S. New sesquiterpene from Vietnamese?agarwood and its induction effect on brain-derived?neurotrophic factor mRNA expression in vitro.?Bioorg Med Chem. 2006 ; 14(10) : 3571-4. doi:10.1016/j.bmc.2006.01.023? 

  81. Hu JP, Wang WJ, Chen H, Li YW, Fan JH, Li Y.?Pharmacokinetics, tissue distribution, and excretion?of buagafuran in rats. J Asian Nat Prod Res. 2011?; 13(3) : 205-14. doi:10.1080/10286020.2010.550881? 

  82. Castro KP, Ito M. Individual and combined?inhalational sedative effects in mice of low molecular?weight aromatic compounds found in agarwood?aroma. Molecules. 2021 ; 26(5) : 1320. doi:10.3390/molecules26051320? 

  83. Gong B, Wang CH, Wu YL, Liu YY, Wei JH. Anxiolytic?and antidepressant effects of agarwood inhalation?and its mechanism. Zhongguo Zhong Yao Za Zhi.?2023 ; 48(4) : 1023-31. doi:10.19540/j.cnki.cjcmm.20221027.401? 

  84. Wang S, Wang C, Yu Z, Wu C, Peng D, Liu X, et al.?Agarwood essential oil ameliorates restrain stress-induced anxiety and depression by inhibiting HPA?axis hyperactivity. Int J Mol Sci. 2018 ; 19(11) :?3468. doi:10.3390/ijms19113468? 

  85. Wang S, Wang C, Peng D, Liu X, Wu C, Guo P,?Wei J. Agarwood essential oil displays sedativehypnotic effects through the GABAergic system.?Molecules. 2017 ; 22(12) : 2190. doi:10.3390/molecules22122190? 

  86. Miyoshi T, Ito M, Kitayama T, Isomori S, Yamashita?F. Sedative effects of inhaled benzylacetone and?structural features contributing to its activity. Biol?Pharm Bull. 2013 ; 36(9) : 1474-81. doi:10.1248/bpb.b13-00250? 

  87. Wang C, Gong B, Liu Y, Chen D, Wu Y, Wei J.?Agarwood essential oil inhalation exerts antianxiety?and antidepressant effects via the regulation of?Glu/GABA system homeostasis. Biomed Rep. 2023?; 18(2) : 16. doi:10.3892/br.2023.1598? 

  88. Chen X, Wang C, He Q, Feng J, Chen D, Wei J, Liu?Y. Chemical composition and potential properties in?mental Illness (anxiety, depression and insomnia) of?agarwood essential oil : A review. Molecules. 2022?; 27(14): 4528. doi :10.3390/molecules 27144528? 

  89. Dong M, Du H, Li X, Zhang L, Wang X, Wang Z,?Jiang H. Discovery of biomarkers and potential?mechanisms of agarwood incense smoke intervention?by untargeted metabolomics and network?pharmacology. Drug Des Devel Ther. 2022 ; 16:?265-78. doi:10.2147/DDDT.S348028? 

  90. Wang C, Wang Y, Gong B, Wu Y, Chen X, Liu Y,?Wei J. Effective components and molecular mechanismof agarwood essential oil inhalation and the sedative?and hypnotic effects based on GC-MS- Qtof and?molecular docking. Molecules. 2022 ; 27(11) : 3483.? 

  91. Okugawa H, Ueda R, Matsumoto K, Kawanishi K,?Kato A. Effects of agarwood extracts on the central nervous system in mice. Planta Med. 1993 ; 59(1)?: 32-6. doi:10.1055/s-2006-959599? 

  92. Tanaka J, Uchimura N, Hashizume Y, Shirakawa?S, Satomura T, Ohyama T, et al. Effects of aroma on sleep and biological rhythms. Psychiatry Clin?Neurosci. 2002 ; 56(3) : 299-300. doi:10.1046/j.1440-1819.2002.00984.x? 

  93. Kao WY, Hsiang CY, Ho SC, Ho TY, Lee KT.?Novel serotonin-boosting effect of incense smoke?from Kynam agarwood in mice: The involvement of?multiple neuroactive pathways. J Ethnopharmacol.?2021 ; 275 : 114069. doi:10.1016/j.jep.2021.114069 

  94. Takemoto H, Ito M, Shiraki T, Yagura T, Honda G.?Sedative effects of vapor inhalation of agarwood?oil and spikenard extract and identification of their?active components. Journal of natural medicines.?2008 ; 62 : 41-6. doi:10.1007/s11418-007-0177-0 

  95. Lai Y, Hua L, Yang J, Xu J, Chen J, Zhang S, et?al. The effect of Chinese agarwood essential oil?with cyclodextrin inclusion against PCPA-induced?insomnia rats. Molecules. 2023 ; 28(2) : 635.?doi:10.3390/molecules28020635? 

  96. Park H, Weon H. The effect of agarwood inhalation?on adults stress and brain-waves. Journal of?Wellness. 2022 ; 17(2) : 205-14. doi:10.21097/ksw.2022.5.17.2.205? 

  97. Kankaynar M, Ceyhun HA, Baran A, Sulukan E,?Yildirim S, Bolat I, et al. The anxiolytic and circadian?regulatory effect of agarwood water extract and its?effects on the next generation; zebrafish modelling.?Comp Biochem Physiol C Toxicol Pharmacol. 2023?; 269 : 109621. doi:10.1016/j.cbpc. 2023.109621? 

  98. Wang C, Wang S, Peng D, Yu Z, Guo P, Wei J.?Agarwood extract mitigates intestinal injury in?Fluorouracil-induced mice. Biol Pharm Bull. 2019?; 42(7) : 1112-9. doi:10.1248/bpb.b18-00805? 

  99. Zheng H, Gao J, Man S, Zhang J, Jin Z, Gao W.?The protective effects of Aquilariae Lignum Resinatum?extract on 5-Fuorouracil-induced intestinal mucositis?in mice. Phytomedicine. 2019 ; 54 : 308-17. doi:10.1016/j.phymed.2018.07.006? 

  100. Yang DL, Mei WL, Zeng YB, Guo ZK, Zhao YX,?Wang H, et al. 2-(2-phenylethyl)chromone?derivatives in Chinese agarwood "Qi-Nan" from?Aquilaria sinensis. Planta Med. 2013 ; 79(14) :?1329-34. doi:10.1055/s-0033-1350647? 

  101. Liao G, Mei WL, Kong FD, Li W, Yuan JZ, Dai?HF. 5, 6, 7, 8-Tetrahydro-2-(2-phenylethyl)?chromones from artificial agarwood of Aquilaria?sinensis and their inhibitory activity against?acetylcholinesterase. Phytochemistry. 2017 ; 139?: 98-108. doi:10.1016/j.phytochem.2017.04.011? 

  102. Yang DL, Wang H, Guo ZK, Dong WH, Mei WL,?Dai HF. A new 2-(2-phenylethyl) chromone?derivative in Chinese agarwood 'Qi-Nan' from?Aquilaria sinensis. Journal of Asian natural?products research. 2014 ; 16(7) : 770-6.?doi:10.1080/10286020.2014.896342? 

  103. Yang Y, Chen HQ, Kong FD, Zhou LM, Li W, Dong?WH, et al. Dimeric sesquiterpenoid-4H-chromone?derivatives from agarwood of Aquilaria crassna and their cytotoxicity. Phytochemistry. 2018 ;?145 : 207-13. doi:10.1016/j.phytochem.2017.08.007? 

  104. Yang Y, Mei WL, Kong FD, Chen HQ, Li W, Chen?ZB, Dai HF. Four new bi-2-(2-phenylethyl)?chromone derivatives of agarwood from Aquilaria?crassna. Fitoterapia. 2017 ; 119 : 20-5. doi:10.1016/j.fitote.2017.03.008? 

  105. Xiang P, Mei W, Chen H, Kong F, Wang H, Liao?G, et al. Four new bi-phenylethylchromones from?artificial agarwood. Fitoterapia. 2017 ; 120 :?61-6. doi:10.1016/j.fitote.2017.05.012? 

  106. Xiang P, Dong WH, Cai CH, Li W, Zhou LM, Dai?HF, et al. Three new dimeric 2-(2-phenylethyl)?chromones from artificial agarwood of Aquilaria?sinensis. Nat Prod Res. 2021 ; 35(21) : 3592-8.?doi:10.1080/14786419.2020.1716345? 

  107. Wang HN, Mei WL, Dong WH, Kong FD, Li W,?Yuan JZ, Dai HF. Two new 2-(2-Hydroxy-2-?phenylethyl)chromens from agarwood originating?from Aquilaria crassna. J Asian Nat Prod Res.?2018 ; 20(2) : 122-7. doi:10.1080/10286020.2017.1379998? 

  108. Kuang T, Chen HQ, Wang H, Kong FD, Cai CH,?Dong WH, et al. UPLC-MS-guided isolation of?single ether linkage dimeric 2-(2-phenylethyl)?chromones from Aquilaria sinensis. RSC Adv.?2019 ; 9(30) : 17025-34. doi:10.1039/c9ra02597a? 

  109. Li W, Yang YL, Yang L, Wang H, Dong WH, Cai?CH, et al. New sesquiterpenoids bearing 11-methyl?ester group of agarwood. Fitoterapia. 2020 ; 143?: 104557. doi:10.1016/j.fitote.2020.104557? 

  110. Shao H, Mei WL, Kong FD, Dong WH, Gai CJ, Li?W, et al. Sesquiterpenes of agarwood from Gyrinops?salicifolia. Fitoterapia. 2016 ; 113 : 182-7. doi:10.1016/j.fitote.2016.07.015? 

  111. Li W, Liao G, Dong WH, Kong FD, Wang P, Wang?H, et al. Sesquiterpenoids from Chinese agarwood?induced by artificial holing. Molecules. 2016 ;?21(3) : 274. doi:10.3390/molecules21030274? 

  112. Wang HN, Dong WH, Huang SZ, Li W, Kong FD,?Wang H, et al. Three new sesquiterpenoids from?agarwood of Aquilaria crassna. Fitoterapia. 2016?; 114 : 7-11. doi:10.1016/j.fitote.2016.07.014? 

  113. Arai MA, Yamaguchi Y, Ishibashi M. Total?synthesis of agalloside, isolated from Aquilaria?agallocha, by the 5-O-glycosylation of flavan.?Org Biomol Chem. 2017 ; 15(23) : 5025-32.?doi:10.1039/c7ob01004d? 

  114. Xiao WJ, Chen HQ, Wang H, Cai CH, Mei WL,?Dai HF. New secondary metabolites from the?endophytic fungus Fusarium sp. HP-2 isolated?from "Qi-Nan" agarwood. Fitoterapia. 2018 ; 130?: 180-3. doi:10.1016/j.fitote.2018.08.008? 

  115. Han M, Zhang H, Hu M, Sun W, Li Z, Cao G, et?al. Inhalation administration of agarwood incense rescues scopolamine-induced learning and memory?impairment in mice. Front Pharmacol. 2021 ; 12?: 821356. doi:10.3389/fphar.2021.821356? 

  116. Lee MJ, Jang M, Bae CS, Park KS, Kim HJ, Lee S,?et al. Effects of oriental medicine Kyung- Ok-Ko on uterine abnormality in hyperandrogenized rats.?Rejuvenation Research. 2016 ; 19(6) : 456-66.?doi:10.1089/rej.2015.1787? 

  117. De Rubis G, Paudel KR, Manandhar B, Singh SK,?Gupta G, Malik R, et al. Agarwood oil?nanoemulsion attenuates cigarette smoke-induced?inflammation and oxidative stress markers in?BCi-NS1. 1 Airway Epithelial Cells. Nutrients.?2023 ; 15(4) : 1019. doi:10.3390/nu15041019? 

  118. Hwang JH, Jung HW. TA pharmacopuncture as a primary and independent treatment for frequent?sprains occurring over 9 months in a patient with?needle sickness: Case report. Medicine. 2018 ;?97(45).? 

  119. Hwang WD. A report on clinical application of?chenxiang about chronic renal failure. The Journal?of Internal Korean Medicine. 2004 ; 25(2) : 368-78.? 

  120. Shivanand P, Arbie NF, Krishnamoorthy S,?Ahmad N. Agarwood-the fragrant molecules of a wounded tree. Molecules. 2022 ; 27(11) : 3386.?doi:10.3390/molecules27113386? 

  121. Kim HM. Antiallergy drugs from oriental?medicines. Oriental Pharmacy and Experimental?Medicine. 2000 ; 1(1) : 1-7.? 

  122. Wang Y, Hussain M, Jiang Z, Wang Z, Gao J, Ye F,?et al. Aquilaria species (Thymelaeaceae) distribution,?volatile and non-volatile phytochemicals,?pharmacological uses, agarwood grading system,?and induction methods. Molecules. 2021 ; 26(24)?: 7708.? 

  123. Yu M, He QQ, Chen XQ, Feng J, Wie JH, Liu YY.?Chemical and bioactivity diversity of 2-(2- phenylethyl) chromones in Agarwood: A review.?Chemistry & Biodiversity. 2022 ; 19(12) :?e202200490. doi:10.1002/cbdv.202200490? 

  124. Wang S, Yu Z, Wang C, Wu C, Guo P, Wei J.?Chemical constituents and pharmacological activity?of agarwood and Aquilaria plants. Molecules.?2018 ; 23(2) : 342.? 

  125. Li W, Chen HQ, Wang H, Mei WL, Dai HF. Natural?products in agarwood and Aquilaria plants:?Chemistry, biological activities and biosynthesis.?Natural product reports. 2021 ; 38(3) : 528-65.?doi:10.1039/d0np00042f? 

  126. Jeong HJ, Hong SH, Kim HM. Oriental medicines?with anti-anaphylactic effect. Oriental Pharmacy?and Experimental Medicine. 2004 ; 4(3) : 125-36.? 

  127. Shamsi-Baghbanan H, Sharifian A, Esmaeili S,?Minaei B. Hepatoprotective herbs, avicenna?viewpoint. Iranian Red Crescent Medical Journal.?2014 ; 16(1).? 

  128. Shivanand P, Arbie NF, Krishnamoorthy S,?Ahmad N. Agarwood-the fragrant molecules of a wounded tree. Molecules. 2022 ; 27(11) : 3386.?doi:10.3390/molecules27113386? 

  129. Lee SH, Kim, Y. I., Yang, G. Y., Kim, J. H., Heo,?Y. K., & Lee, H. The literatural study on prescription?about low back pain. Journal of Haehwa Medicine.?2007 ; 16(1) : 41-59.? 

  130. Cho SH, & Jeong, J. H. The literatual study on the external medical treatment of Menorrhalgia?and Leucorrhea for gynecologic condition. Journal?of Haehwa Medicine. 2000 ; 9(1) : 319-35.? 

  131. Lee MS, Lee JH, Yoon TK, Lee JC, Lee BK. Study on?the "Moschus substitute for Aquilariae Resinatum?Lignum or Aucklandiae Radix" of Gongjin-Dan in?the classic literature. Official Journal of The?Korean Medicine Society For The Herbal Formula?Study. 2015 ; 23(2) : 235-43. doi:10.14374/HFS.2015.23.2.235? 

  132. Li QQ, Wang G, Huang F, Banda M, Reed E.?Antineoplastic effect of β-elemene on prostate cancer cells and other types of solid tumour cells.?Journal of Pharmacy and Pharmacology. 2010 ;?62(8) : 1018-27. doi:10.1111/j.2042-7158.2010.01135.x? 

  133. Dai ZJ, Tang W, Lu WF, Gao J, Kang HF, Ma?XB, et al. Antiproliferative and apoptotic effects?of β-elemene on human hepatoma HepG2 cells.?Cancer Cell International. 2013 ; 13(1) : 1-10.?doi:10.1186/1475-2867-13-27? 

  134. Li X, Wang G, Zhao J, Ding H, Cunningham C,?Chen F, et al. Antiproliferative effect of β- elemene?in chemoresistant ovarian carcinoma cells is?mediated through arrest of the cell cycle at the?G2-M phase. Cellular and Molecular Life Sciences?CMLS. 2005 ; 62 : 894-904. doi:10. 1007/s00018-005-5027-1? 

  135. Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu?YH. Anti-tumor effect of β-elemene in?glioblastoma cells depends on p38 MAPK activation.?Cancer letters. 2008 ; 264(1) : 127-34. doi:10.1016/j.canlet.2008.01.049? 

  136. Wang G, Li X, Huang F, Zhao J, Ding H, CunninghamC, et al. Antitumor effect of β-elemene in non- small-cell lung cancer cells is mediated via?induction of cell cycle arrest and apoptotic cell death.?Cellular and Molecular Life Sciences CMLS. 2005?; 62 : 881-93. doi:10. 1007/s00018-005-5017-3? 

  137. Chen P, Li X, Zhang R, Liu S, Xiang Y, Zhang?M, et al. Combinative treatment of β-elemene?and cetuximab is sensitive to KRAS mutant?colorectal cancer cells by inducing ferroptosis and?inhibiting epithelial-mesenchymal transformation. Theranostics. 2020 ; 10(11) : 5107. doi:10.7150/thno.44705? 

  138. Zheng F, Tang Q, Zheng X, Wu J, Huang H,?Zhang H, Hann SS. Inactivation of Stat3 and?crosstalk of miRNA155-5p and FOXO3a contribute?to the induction of IGFBP1 expression by betaelemene in human lung cancer. Experimental &?molecular medicine. 2018 ; 50(9) : 1-14. doi:10.1038/s12276-018-0146-6? 

  139. Guan C, Liu W, Yue Y, Jin H, Wang X, Wang XJ.?Inhibitory effect of β-elemene on human breast cancer cells. International journal of clinical and?experimental pathology. 2014 ; 7(7) : 3948.? 

  140. Wu J, Tang Q, Yang L, Chen Y, Zheng F, Hann?SS. Interplay of DNA methyltransferase 1 and?EZH2 through inactivation of Stat3 contributes to?β-elemene-inhibited growth of nasopharyngeal?carcinoma cells. Scientific Reports. 2017 ; 7(1):?509. doi :10.1038/s41598-017-00626-6? 

  141. Qureshi MZ, Attar R, Romero MA, Sabitaliyevich?UY, Nurmurzayevich SB, Ozturk O, et al.?Regulation of signaling pathways by β-elemene?in cancer progression and metastasis. Journal of?cellular biochemistry. 2019 ; 120(8): 12091-100.?doi:10.1002/jcb.28624? 

  142. Lee RX, Li QQ, Reed E. β-elemene effectively?suppresses the growth and survival of both?platinum-sensitive and-resistant ovarian tumor?cells. Anticancer research. 2012 ; 32(8) : 3103-13.? 

  143. Li QQ, Wang G, Liang H, Li JM, Huang F,?Agarwal PK, et al. β-Elemene promotes cisplatin-induced cell death in human bladder cancer and?other carcinomas. Anticancer research. 2013 ;?33(4) : 1421-8.? 

  144. Zhang SY, Li XB, Hou SG, Sun Y, Shi YR, Lin?SS. Cedrol induces autophagy and apoptotic cell?death in A549 non-small cell lung carcinoma?cells through the P13K/Akt signaling pathway,?the loss of mitochondrial transmembrane potential?and the generation of ROS. International Journal?of Molecular Medicine. 2016 ; 38(1) : 291-9.?doi:10.3892/ijmm.2016.2585? 

  145. Chien JH, Chang KF, Lee SC, Lee CJ, Chen YT,?Lai HC, et al. Cedrol restricts the growth of?colorectal cancer in vitro and in vivo by inducing?cell cycle arrest and caspase-dependent apoptotic?cell death. International Journal of Medical?Sciences. 2022 ; 19(13): 1953. doi:10.7150/ijms.77719? 

  146. Chang KF, Huang XF, Chang JT, Huang YC, Weng?JC, Tsai NM. Cedrol suppresses glioblastoma?progression by triggering DNA damage and?blocking nuclear translocation of the androgen?receptor. Cancer letters. 2020 ; 495 : 180-90.?doi:10.1016/j.canlet.2020.09.007? 

  147. Jin S, Park J, Yun HJ, Oh YN, Oh S, Choi YH, et?al. Cedrol, a sesquiterpene isolated from Juniperus?chinensis, inhibits human colorectal tumor growth?associated through downregulation of?minichromosome maintenance proteins. Journal?of Cancer Prevention. 2022 ; 27(4) : 221.?doi:10.15430/JCP.2022.27.4.221? 

  148. Yun HJ, Jin S, Park J, Lee EW, Lee HT, Choi?YH, et al. Induction of cell cycle arrest, apoptosis,?and reducing the expression of MCM proteins in?human lung carcinoma A549 cells by cedrol,?isolated from Juniperus chinensis. Journal of?Microbiology and Biotechnology. 2022 ; 32(7)?: 918. doi:10.4014/jmb.2205.05012? 

  149. Mishra SK, Bae YS, Lee YM, Kim JS, Oh SH, KimHM. Sesquiterpene alcohol cedrol chemosensitizes?human cancer cells and suppresses cell proliferation?by destabilizing plasma membrane lipid rafts.?Frontiers in cell and developmental biology. 2021?; 8 : 571676. doi: 10.3389/fcell.2020.571676? 

  150. Dahham SS, Tabana YM, Iqbal MA, Ahamed MB,?Ezzat MO, Majid AS, Majid AM. The anticancer,?antioxidant and antimicrobial properties of the?sesquiterpene β-caryophyllene from the essential?oil of Aquilaria crassna. Molecules. 2015 ; 20(7) :?11808-29. doi:10.3390/molecules200711808? 

  151. Chung KS, Hong JY, Lee JH, Lee HJ, Park JY,?Choi JH, et al. β-caryophyllene in the essential?oil from chrysanthemum boreale induces G1?phase cell cycle arrest in human lung cancer cells.?Molecules. 2019 ; 24(20) : 3754. doi:10.3390/molecules24203754? 

  152. Jung JI, Kim EJ, Kwon GT, Jung YJ, Park T,?Kim Y, et al. β-Caryophyllene potently inhibits?solid tumor growth and lymph node metastasis of?B16F10 melanoma cells in high-fat diet-induced?obese C57BL/6N mice. Carcinogenesis. 2015 ;?36(9) : 1028-39. doi:10.1093/carcin/bgv076? 

  153. Bommareddy A, Knapp K, Nemeth A, Steigerwalt?J, Landis T, Vanwert AL, et al. Alpha-Santalol, a component of sandalwood oil inhibits migration?of breast cancer cells by targeting the β-catenin?pathway. Anticancer Research. 2018 ; 38(8) :?4475-80. doi:10.21873/anticanres.12750? 

  154. Kaur M, Agarwal C, Singh RP, Guan X, Dwivedi C,?Agarwal R. Skin cancer chemopreventive agent, α-santalol, induces apoptotic death of human?epidermoid carcinoma A431 cells via caspase?activation together with dissipation of mitochondrial membrane potential and cytochrome c release.?Carcinogenesis. 2005 ; 26(2) : 369-80. doi:10.1093/carcin/bgh325? 

  155. Shin Y, Lee Y. Cytotoxic activity from Curcuma?zedoaria through mitochondrial activation on ovarian cancer cells. Toxicological research. 2013?; 29 : 257-61. doi:10.5487/TR.2013.29.4.257? 

  156. Grover M, Behl T, Virmani T, Sanduja M,?Makeen HA, Albratty M, et al. Exploration of?cytotoxic potential of longifolene/junipene isolated?from Chrysopogon zizanioides. Molecules. 2022 ;?27(18) : 5764. doi:10.3390/molecules27185764? 

  157. Garlet Q, Pires L, Silva D, Spall S, Gressler L,?Burger M, et al. Effect of (+)-dehydrofukinone on GABA A receptors and stress response in fish?model. Brazilian Journal of Medical and?Biological Research. 2015 ; 49(1) : e4872.?doi:10.1590/ 1414-431X20154872? 

  158. Garlet QI, Souza CF, Rodrigues P, Descovi SN,?Martinez-Rodriguez G, Baldisserotto B,?Heinzmann BM. GABAa receptor subunits?expression in silver catfish (Rhamdia quelen) brain?and its modulation by Nectandra grandiflora Nees?essential oil and isolated compounds. Behavioural?Brain Research. 2019 ; 376 : 112178. doi:10.1016/j.bbr.2019.112178? 

  159. Garlet QI, Rodrigues P, Barbosa LB, Londero AL,?Mello CF, Heinzmann BM. Nectandra grandiflora?essential oil and its isolated sesquiterpenoids?minimize anxiety-related behaviors in mice?through GABAergic mechanisms. Toxicology and?Applied Pharmacology. 2019 ; 375 : 64-80. doi:10.1016/j.taap.2019.05.003? 

  160. Kagawa D, Jokura H, Ochiai R, Tokimitsu I,?Tsubone H. The sedative effects and mechanism?of action of cedrol inhalation with behavioral?pharmacological evaluation. Planta medica. 2003?; 69(07) : 637-41. doi:10.1055/s-2003-41114? 

  161. Zhang K, Lu J, Yao L. Involvement of the dopamine?D1 receptor system in the anxiolytic effect of cedrol?in the elevated plus maze and light-dark box?tests. Journal of pharmacological sciences. 2020 ;?142(1) : 26-33. doi:10.1016/ j.jphs.2019.11.004? 

  162. Yada Y, Sadachi H, Nagashima Y, Suzuki T.?Overseas survey of the effect of cedrol on the?autonomic nervous system in three countries.?Journal of Physiological Anthropology. 2007 ; 26(3)?: 349-54. doi:10.2114/jpa2.26.349? 

  163. Hwang ES, Kim HB, Lee S, Kim MJ, Kim KJ,?Han G, et al. Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced?depression. Behavioural brain research. 2020 ;?380 : 112439. doi:10.1016/j.bbr.2019.112439? 

  164. Johnson A, Stewart A, El-Hakim I, Hamilton TJ.?Effects of super-class cannabis terpenes beta-caryophyllene and alpha-pinene on zebrafish?behavioural biomarkers. Scientific Reports. 2022?; 12(1) : 17250. doi:10.1038/s41598-022-21552-2? 

  165. Moo CL, Yang SK, Osman MA, Yuswan MH, Loh?JY, Lim WM, et al. Antibacterial Activity and?Mode of Action of β-caryophyllene on Bacillus?cereus. Polish journal of microbiology. 2020 ;?69(1) : 49-54. doi:10.33073/pjm-2020-007? 

  166. Oh I, Yang WY, Park J, Lee S, Mar W, Oh K-B,?Shin J. In vitro Na+/K+-ATPase inhibitory?activity and antimicrobial activity of sesquiterpenes?isolated from Thujopsis dolabrata. Archives of?pharmacal research. 2011 ; 34 : 2141-7. doi:10.1007/s12272-011-1218-5? 

  167. Rahman MS, Ahad A, Saha SK, Hong J, Kim?KH. Antibacterial and phytochemical properties?of Aphanamixis polystachya essential oil. Analitycal?Science & Technology. 2017 ; 30(3). doi:10.5806/AST.2017.30.3.113? 

  168. Yagi S, Babiker R, Tzanova T, Schohn H.?Chemical composition, antiproliferative, antioxidant?and antibacterial activities of essential oils from?aromatic plants growing in Sudan. Asian Pacific?journal of tropical medicine. 2016 ; 9(8) :?763-70. doi:10.1016/j.apjtm.2016.06.009? 

  169. da Silva GNS, Pozzatti P, Rigatti F, Horner R,?Alves SH, Mallmann CA, Heinzmann BM.?Antimicrobial evaluation of sesquiterpene α-curcumene and its synergism with imipenem.?Journal of Microbiology, Biotechnology & Food?Sciences. 2015 ; 4(5). doi:10.15414/jmbfs.2015.4.5.434-436? 

  170. Sieniawska E, Sawicki R, Golus J, Swatko-Ossor?M, Ginalska G, Skalicka-Wozniak K. Nigella?damascena L. essential oil-a valuable source of β-elemene for antimicrobial testing. Molecules. 2018?; 23(2) : 256. doi:10.3390/molecules23020256? 

  171. Zhou Y, Jia L, Zhang G, Chen G, Zhou D, Shi X,?et al. Cedrol-loaded dissolvable microneedles based?on flexible backing for promoting hair growth.?Expert Opinion on Drug Delivery. 2023 : 1-10.?doi:10.1080/17425247.2023.2244413? 

  172. Zhang Y, Han L, Chen SS, Guan J, Qu FZ, Zhao?YQ. Hair growth promoting activity of cedrol?isolated from the leaves of Platycladus orientalis.?Biomedicine & Pharmacotherapy. 2016 ; 83 :?641-7. doi:10.1016/j.biopha.2016.07.022? 

  173. Deng Y, Huang F, Wang J, Zhang Y, Zhang Y,?Su G, Zhao Y. Hair growth promoting activity of cedrol nanoemulsion in C57BL/6 mice and its?bioavailability. Molecules. 2021 ; 26(6) : 1795.?doi:10.3390/molecules26061795? 

  174. Zhang Y, Wang J, Qu F, Zhang , Su G, Zhao Y.?Hair growth promotion effect of cedrol cream and?its dermatopharmacokinetics. RSC advances. 2018 ;?8(73) : 42170-8. doi:10.1039/C8RA08667B? 

  175. Chen SS, Zhang Y, Lu QL, Lin Z, Zhao Y.?Preventive effects of cedrol against alopecia in?cyclophosphamide-treated mice. Environmental?Toxicology and Pharmacology. 2016 ; 46 : 270-6.?doi:10.1016/j.etap.2016.07.020? 

  176. Dong W, Wang S, Qian W, Li S, Wang P. Cedrol?alleviates the apoptosis and inflammatory response?of IL-1β-treated chondrocytes by promoting miR-542-5p expression. In Vitro Cellular & Developmental?Biology-Animal. 2021 ; 57 : 962-72. doi:10.1007/s11626-021-00620-3? 

  177. Aati H, El-Gamal A, Kayser O. Chemical composition?and biological activity of the essential oil from?the root of Jatropha pelargoniifolia Courb. native?to Saudi Arabia. Saudi pharmaceutical journal.?2019 ; 27(1) : 88-95. doi:10.1016/j.jsps.2018.09.001? 

  178. Alizadeh M, Jalal M, Hamed K, Saber A,?Kheirouri S, Pourteymour Fard Tabrizi F, Kamari?N. Recent updates on anti-inflammatory and?antimicrobial effects of furan natural derivatives.?Journal of Inflammation Research. 2020 : 451-63.?doi:10.2147/JIR.S262132? 

  179. Moghrovyan A, Parseghyan L, Sevoyan G,?Darbinyan A, Sahakyan N, Gaboyan M, et al.?Antinociceptive, anti-inflammatory, and cytotoxic?properties of Origanum vulgare essential oil, rich?with β-caryophyllene and β-caryophyllene oxide.?Korean J Pain. 2022 ; 35 : 140-51. doi:10.3344/kjp.2022.35.2.140? 

  180. Tambe Y, Tsujiuchi H, Honda G, Ikeshiro Y,?Tanaka S. Gastric cytoprotection of the non- steroidal anti-inflammatory sesquiterpene, β-caryophyllene. Planta medica. 1996 ; 62(05) : 469-70. doi:10.1055/s-2006-957942? 

  181. Yeom JE, Kim SK, Park SY. Regulation of the gut?microbiota and inflammation by β-caryophyllene?extracted from cloves in a dextran sulfate sodium-induced colitis mouse model. Molecules. 2022 ;?27(22) : 7782. doi:10.3390/ molecules27227782? 

  182. Cho JY, Kim HY, Kim SK, Park JHY, Lee HJ,?Chun HS. β-Caryophyllene attenuates dextran?sulfate sodium-induced colitis in mice via?modulation of gene expression associated mainly?with colon inflammation. Toxicology reports.?2015 ; 2 : 1039-45. doi:10.1016/j.toxrep.2015.07.018? 

  183. de Oliveira CC, de Oliveira CV, Grigoletto J, Ribeiro?LR, Funck VR, Grauncke ACB, et al. Anticonvulsant?activity of β-caryophyllene against?pentylenetetrazol-induced seizures. Epilepsy &?behavior. 2016 ; 56 : 26-31. doi:10.1016/j.yebeh.2015.12.040? 

  184. Mallmann MP, Mello FK, Neuberger B, da Costa?Sobral KG, Fighera MR, Royes LFF, et al.?Beta-caryophyllene attenuates short-term recurrent?seizure activity and blood-brain-barrier breakdown?after pilocarpine-induced status epilepticus in?rats. Brain Research. 2022 ; 1784 : 147883.?doi:10.1016/j.brainres.2022.147883? 

  185. Garlet QI, da Costa Pires L, Milanesi LH, Marafiga?JR, Baldisserotto B, Mello CF, Heinzmann BM.?(+)-Dehydrofukinone modulates membrane potential?and delays seizure onset by GABAa receptormediated mechanism in mice. Toxicology and Applied?Pharmacology. 2017 ; 332 : 52-63. doi:10.1016/j.taap.2017.07.010? 

  186. Segat GC, Manjavachi MN, Matias DO, Passos?GF, Freitas CS, Costa R, Calixto JB. Antiallodynic?effect of β-caryophyllene on paclitaxel-induced?peripheral neuropathy in mice. Neuropharmacology.?2017 ; 125 : 207-19. doi:10.1016/j.neuropharm.2017.07.015? 

  187. Aguilar-Avila DS, Flores-Soto ME, Tapia-Vazquez C, Pastor-Zarandona OA, Lopez-Roa RI, ViverosParedes JM. β-Caryophyllene, a natural?sesquiterpene, attenuates neuropathic pain and?depressive-like behavior in experimental diabetic?mice. Journal of medicinal food. 2019 ; 22(5) :?460-8. doi: 10.1089/jmf.2018.0157? 

  188. Sakhaee MH, Sayyadi SAH, Sakhaee N, Sadeghnia?HR, Hosseinzadeh H, Nourbakhsh F, Forouzanfar?F. Cedrol protects against chronic constriction?injury-induced neuropathic pain through inhibiting?oxidative stress and inflammation. Metabolic Brain?Disease. 2020 ; 35 : 1119-26. doi:10.1007/ s11011-020-00581-8? 

  189. Wang G, Ma W, Du J. β-Caryophyllene (BCP)?ameliorates MPP+ induced cytotoxicity. Biomedicine?& Pharmacotherapy. 2018 ; 103 : 1086-91.?doi:10.1016/j.biopha.2018.03.168? 

  190. Chavez-Hurtado P, Gonzalez-Castaneda RE,?Beas-Zarate C, Flores-Soto ME, Viveros-Paredes?JM. β-Caryophyllene reduces DNA oxidation and?the overexpression of glial fibrillary acidic protein?in the prefrontal cortex and hippocampus of D-galactose-induced aged BALB/c mice. Journal of Medicinal Food. 2020 ; 23(5) : 515-22. doi:10.?1089/jmf.2019.0111? 

  191. Kim S, Lee S, Hong C, Cho S, Park M, Choi I.?Antifungal effect of elemol and eudesmol from?Cryptomeria japonica essential oil against?Trichophyton rubrum. Academia Journal of?Agricultural Research. 2016 ; 4(8) : 511-7. doi:10.15413/ajar.2016.0182? 

  192. Mukai A, Takahashi K, Ashitani T. Antifungal?activity of longifolene and its autoxidation products.?European Journal of Wood and Wood Products.?2018 ; 76 : 1079-82. doi:10.1007/s00107-017-1281-9? 

  193. Ryu JS, Cho HI, Won JH, Jeon MN, Kwon OS,?Won BM, et al. Anti-aging effects of cedrol and?collagen-derived peptide. Journal of the Society?of Cosmetic Scientists of Korea. 2015 ; 41(3) :?229-35. doi:10.15230/SCSK.2015.41.3.229? 

  194. Jin MH, Park SG, Hwang YL, Lee MH, Jeong NJ,?Roh SS, et al. Cedrol enhances extracellular matrix?production in dermal fibroblasts in a MAPK-dependent manner. Annals of Dermatology. 2012?; 24(1) : 16-21. doi:10.5021/ad.2012.24.1.16? 

  195. Woo HJ, Yang JY, Kwon HJ, Kim HW, Kim S-H,?Kim J-B. Comparative transcriptome analysis of?caryophyllene-treated Helicobacter pylori. 2021 ;?49(3) : 440-8. doi:10.48022/mbl.2107.07001? 

  196. Woo HJ, Yang JY, Lee MH, Kim HW, Kwon HJ, Park?M, et al. Inhibitory effects of β-caryophyllene on Helicobacter pylori infection in vitro and in vivo.?International journal of molecular sciences. 2020 ; 21(3) : 1008. doi:10.3390/ijms21031008? 

  197. Ozek G, Schepetkin IA, Yermagambetova M, Ozek?T, Kirpotina LN, Almerekova SS, et al. Innate?immunomodulatory activity of cedrol, a component?of essential oils isolated from Juniperus species.?Molecules. 2021 ; 26(24) : 7644. doi:10.3390/molecules26247644? 

  198. Baradaran Rahimi V, Askari VR. A mechanistic?review on immunomodulatory effects of selective?type two cannabinoid receptor β-caryophyllene.?Biofactors. 2022 ; 48(4) : 857-82. doi:10.1002/biof.1869? 

  199. Eller F, Vander Meer R, Behle R, Flor-Weiler L,?Palmquist DE. Bioactivity of cedarwood oil and?cedrol against arthropod pests. Environmental?entomology. 2014 ; 43(3) : 762-6. doi:10.1603/EN13270? 

  200. Mukai A, Takahashi K, Ashitani T. Natural?autoxidation of longifolene and anti-termite activities?of the products. Journal of Wood Science. 2017 ;?63(4) : 360-8. doi:10.1007/s10086-017-1637-0? 

  201. Yoo HJ, Jwa SK. Efficacy of β-caryophyllene for?periodontal disease related factors. Archives of?oral biology. 2019 ; 100 : 113-8. doi:10.1016/j.archoralbio.2019.02.015? 

  202. Yoo HJ, Jwa SK. Inhibitory effects of β-caryophyllene on Streptococcus mutans biofilm.?Archives of oral biology. 2018 ; 88 : 42-6.?doi:10.1016/j.archoralbio.2018.01.009? 

  203. Zhao Y, Li M, Guo J, Fang J, Geng R, Wang Y,?et al. Cedrol, a major component of cedarwood oil,?ameliorates high-fat diet-induced obesity in mice.?Molecular Nutrition & Food Research. 2023 :?2200665. doi:10.1002/mnfr.202200665? 

  204. Franco-Arroyo NN, Viveros-Paredes JM, ZepedaMorales ASM, Roldan E, Marquez-Aguirre AL,?Zepeda-Nuno JS, et al. β-Caryophyllene, a dietary?cannabinoid, protects against metabolic and?immune dysregulation in a diet-induced obesity mouse model. Journal of Medicinal Food. 2022 ;?25(10) : 993-1002. doi:10.1089/jmf.2021.0166? 

  205. Okugawa H, Ueda R, Matsumoto K, Kawanishi?K, Kato A. Effect of α-santalol and β-santalol?from sandalwood on the central nervous system?in mice. Phytomedicine. 1995 ; 2(2) : 119-26.?doi:10. 1016/S0944-7113(11)80056-5? 

  206. Yang HO, Suh DY, Han BH. Isolation and?characterization of platelet-activating factor?receptor binding antagonists from Biota orientalis.?Planta medica. 1995 ; 61(01) : 37-40. doi:10.1055/s-2006-957995? 

  207. Hsu HC, Yang WC, Tsai WJ, Chen CC, Huang?HY, Tsai YC. α-Bulnesene, a novel PAF receptor?antagonist isolated from Pogostemon cablin.?Biochemical and Biophysical Research?Communications. 2006 ; 345(3) : 1033-8. doi:10.1016/j.bbrc.2006.05.006? 

  208. Chang HJ, Kim JM, Lee JC, Kim WK, Chun HS.?Protective effect of β-caryophyllene, a natural?bicyclic sesquiterpene, against cerebral ischemic?injury. Journal of medicinal food. 2013 ; 16(6) :?471-80. doi:10.1089/jmf.2012.2283? 

  209. Hu Q, Zuo T, Deng L, Chen S, Yu W, Liu S, et al.?β-Caryophyllene suppresses ferroptosis induced by?cerebral ischemia reperfusion via activation of?the NRF2/HO-1 signaling pathway in MCAO/R?rats. Phytomedicine. 2022 ; 102 : 154112. doi:10.1016/j.phymed.2022.154112? 

  210. Zhang Y, Liu Y, Peng F, Wei X, Hao H, Li W,?Zhao Y. Cedrol from ginger alleviates rheumatoid?arthritis through dynamic regulation of intestinal?microenvironment. Food & Function. 2022 ;?13(22) : 11825-39. doi:10.1039/d2fo01983c 

  211. Zhang Y, Shen J, Zhao J, Guan J, Wei X, Miao?D, et al. Cedrol from ginger ameliorates?rheumatoid arthritis via reducing inflammation?and selectively inhibiting JAK3 phosphorylation.?Journal of agricultural and food chemistry. 2021?; 69(18) : 5332-43. doi:10.1021/acs.jafc.1c00284? 

  212. Wang J, Chen S, Zhang Ym, Guan J, Su GY,?Ding M, et al. Anti-inflammatory and analgesic?activity based on polymorphism of cedrol in mice.?Environmental Toxicology and Pharmacology.?2019 ; 68 : 13-8. doi:10.1016/j.etap.2019.02.005? 

  213. Dekic M, Radulovic N, Stojanovic N, Mladenovic?M. Analgesic activity of dehydrofukinone,?sesquiterpene ketone from Senecio nemorensis?L.(Asteraceae). Facta Universitatis, Series: Physics,?Chemistry and Technology. 2018 ; 16(1) : 119.? 

  214. Gushiken LFS, Beserra FP, Hussni MF, Gonzaga?MT, Ribeiro VP, De Souza PF, et al. Beta-caryophyllene as an antioxidant, anti-inflammatory?and re-epithelialization activities in a rat skin?wound excision model. Oxidative Medicine and?Cellular Longevity. 2022 ; 2022. doi:10.1155/2022/9004014? 

  215. Koyama S, Purk A, Kaur M, Soini HA, Novotny?MV, Davis K, et al. Beta-caryophyllene enhances?wound healing through multiple routes. PloS one.?2019 ; 14(12) : e0216104. doi:10.1371/journal.pone.0216104? 

  216. Astani A, Reichling J, Schnitzler P. Screening for?antiviral activities of isolated compounds from?essential oils. Evidence-based complementary and?alternative medicine. 2011 ; 2011. doi:10.1093/ecam/nep187? 

  217. Tarumi W, Shinohara K. Olfactory exposure to β-caryophyllene increases testosterone levels in women's saliva. Sexual Medicine. 2020 ; 8(3) :?525-31. doi:10.1016/j.esxm.2020.06.001? 

  218. Wang C, Hao R, Peng B, Chang J, Chen S, Chen?Y, et al. Dissolvable hyaluronic acid microneedles?loaded with β-Elemene for the treatment of?psoriasis. Frontiers in Pharmacology. 2022 ; 13 :?1067051. doi:10.3389/fphar.2022.1067051? 

  219. Han NR, Moon PD, Ryu KJ, Jang JB, Kim HM,?Jeong HJ. β-eudesmol suppresses allergic?reactions via inhibiting mast cell degranulation.?Clinical and Experimental Pharmacology and?Physiology. 2017 ; 44(2) : 257-65. doi:10.1111/1440-1681.12698? 

  220. Hori E, Shojaku H, Watanabe N, Kawasaki Y,?Suzuki M, De Araujo MF, et al. Effects of direct?cedrol inhalation into the lower airway on brain?hemodynamics in totally laryngectomized subjects.?Autonomic Neuroscience. 2012 ; 168(1-2) : 88-92.?doi:10.1016/j.autneu.2012.01.010? 

  221. Kar N, Chakraborty S, De AK, Ghosh S, Bera T.?Development and evaluation of a cedrol-loaded?nanostructured lipid carrier system for in vitro and?in vivo susceptibilities of wild and drug resistant?Leishmania donovani amastigotes. European Journal?of Pharmaceutical Sciences. 2017 ; 104 : 196-211.?doi:10.1016/j.ejps.2017.03.046? 

  222. Al Mansouri S, Ojha S, Al Maamari E, Al Ameri?M, Nurulain SM, Bahi A. The cannabinoid?receptor 2 agonist, β-caryophyllene, reduced?voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice.?Pharmacology Biochemistry and Behavior. 2014 ;?124 : 260-8. doi:10.1016/j.pbb.2014.06.025? 

  223. Sukmawan YP, Anggadiredja K, Adnyana IK.?Anti-neuropathic pain mechanistic study on A.?conyzoides essential oil, Precocene II, caryophyllene, or longifolene as single agents and in combination?with pregabalin. CNS & Neurological DisordersDrug Targets (Formerly Current Drug Targets-CNS?& Neurological Disorders). 2023 ; 22(6) : 924-31.?doi:10.2174/1871527321666220418121329? 

  224. Ahn SS, Yeo H, Jung E, Ou S, Lee YH, Lim Y,?Shin SY. β-Caryophyllene Ameliorates 2, 4-?Dinitrochlorobenzene-Induced Atopic Dermatitis?through the Downregulation of Mitogen-Activated?Protein Kinase/EGR1/TSLP Signaling Axis.?International Journal of Molecular Sciences. 2022?; 23(23) : 14861. doi:10.3390/ijms232314861? 

  225. Akutsu T, Tanaka S, Murakami Y, Nakajima K,?Nagashima Y, Yada Y, et al., editors. Effect of the?natural fragrance "cedrol" on dopamine metabolismin the lateral hypothalamic area of restrained?rats: A microdialysis study. International Congress?Series ; 2006 ; 1287 : 195-200. Elsevier.? 

  226. Adefegha SA, Oboh G, Olopade EO. β- caryophyllene improves sexual performance via?modulation of crucial enzymes relevant to erectile?dysfunction in rats. Toxicological Research. 2021 ;?37 : 249-60. doi:10.1007/s43188-020-00061-2? 

  227. Cho H-I, Hong J-M, Choi J-W, Choi H-S, Kwak?JH, Lee D-U, et al. β-Caryophyllene alleviates?D-galactosamine and lipopolysaccharide-induced?hepatic injury through suppression of the TLR4?and RAGE signaling pathways. European Journal?of Pharmacology. 2015 ; 764 : 613-21. doi:10.1016/j.ejphar.2015.08.001? 

  228. Forouzanfar F, Pourbagher-Shahri AM, Ghazavi?H. Evaluation of antiarthritic and antinociceptive?effects of cedrol in a rat model of arthritis. Oxidative Medicine and Cellular Longevity. 2022?; 2022 : 494365. doi:10.1155/2022/4943965? 

  229. Baldissera MD, Souza CF, Grando TH, Doleski?PH, Boligon AA, Stefani LM, Monteiro SG.?Hypolipidemic effect of β-caryophyllene to treat?hyperlipidemic rats. Naunyn-Schmiedeberg's archives?of pharmacology. 2017 ; 390 : 215-23. doi:10.1007/s00210-016-1326-3? 

  230. Sun W, Kim DH, Byon CH, Choi HI, Park JS, Bae?EH, et al. β-elemene attenuates renal fibrosis in?the unilateral ureteral obstruction model by?inhibition of STAT3 and Smad3 signaling via?suppressing MyD88 expression. International Journal?of Molecular Sciences. 2022 ; 23(10) : 5553. doi:10.3390/ijms23105553? 

  231. Xu C, Jin SQ, Jin C, Dai ZH, Wu YH, He GL, et?al. Cedrol, a Ginger-derived sesquiterpineol,?suppresses estrogen-deficient osteoporosis by?intervening NFATc1 and reactive oxygen species.?International Immunopharmacology. 2023 ; 117 :?109893. doi:10.1016/j.intimp.2023.109893? 

  232. Scandiffio R, Geddo F, Cottone E, Querio G,?Antoniotti S, Gallo MP, et al. Protective effects of?(E)-β-caryophyllene (BCP) in chronic inflammation.?Nutrients. 2020 ; 12(11) : 3273. doi:10.3390/nu12113273? 

  233. Jin KS, Lee JY, Hyun SK, Kim BW, Kwon HJ.?Juniperus chinensis and the functional compounds,?cedrol and widdrol, ameliorate α-melanocyte?stimulating hormone-induced melanin formation?in B16F10 cells. Food Science and Biotechnology.?2015 ; 24 : 611-8. doi:10.1007/s10068-015-0080-5? 

  234. Lee HJ. Pharmacological action of linalool,?oleanolic acid and β-caryophyllene on gene?expression and production of mucin from goblet?cells in respiratory epithelium. Yakhak Hoeji.?2017 ; 61(2) : 75-82. doi:10.17480/psk.2017.61.2.75? 

  235. Takeda A, Watanuki E, Koyama S. Effects of?inhalation aromatherapy on symptoms of sleep?disturbance in the elderly with dementia. Evidence-Based Complementary and Alternative Medicine.?2017 ; 2017. doi:10.1155/2017/1902807? 

  236. Zhang R, Tian A, Zhang H, Zhou Z, Yu H, Chen?L. Amelioration of experimental autoimmune?encephalomyelitis by β-elemene treatment is?associated with Th17 and Treg cell balance. Journal?of Molecular Neuroscience. 2011 ; 44 : 31-40.?doi:10.1007/s12031-010-9483-1? 

  237. Chakraborty S, Kar N, Kumari L, De A, Bera T.?Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound?48/80-induced mast cell degranulation and?anaphylactic shock in mice. International journal?of nanomedicine. 2017 : 4849-68. doi:10.2147/IJN.S132114? 

  238. Ghelardini C, Galeotti N, Mannelli LDC, Mazzanti?G, Bartolini A. Local anaesthetic activity of β- caryophyllene. Il Farmaco. 2001 ; 56(5-7) : 387-9.?doi: 10.1016/s0014-827x(01)01092-8? 

  239. Kim ST. Mucin production and secretion. Korean?Journal of Otorhinolaryngology-Head and Neck?Surgery. 2005 ; 48(5) : 556-62.? 

  240. Clinical practice guideline of Korean Medicine - Irritable bowel syndrome. Korea : National Institute?for Korean Medicine Development; 2022. 32.? 

  241. Lee SH. Literature review of gonorrhea. The Journal?of Internal Korean Medicine. 1994 ; 15(2) : 369.? 

  242. Han JY, Choo MS. Drug treatment for lower urinary?tract symptoms. Journal of the Korean Medical?Association. 2011 ; 54(6) : 637-45. doi:10.5124/jkma.2011.54.6.637? 

  243. Ma CT, Ly TL, Van Le TH, Tran TVA, Kwon SW,?Park JH. Sesquiterpene derivatives from the?agarwood of Aquilaria malaccensis and their anti-inflammatory effects on NO production of macrophage?RAW 264.7 cells. Phytochemistry. 2021 ; 183 :?112630. doi:10.1016/j.phytochem.2020.112630? 

  244. Huo HX, Gu YF, Zhu ZX, Zhang YF, Chen XN,?Guan PW, et al. LC-MS-guided isolation of?anti-inflammatory 2-(2-phenylethyl) chromone?dimers from Chinese agarwood (Aquilaria sinensis).?Phytochemistry. 2019 ; 158 : 46-55. doi:10.1016/j.phytochem.2018.11.003? 

  245. Clinical practice guideline of Korean Medicine,?Functional dyspepsia: Ministry of Health and?Welfare of Korea ; National Institute for Korean?Medicine Development ; 2021. 252.? 

  246. Ahn SW. The systematic of medicinal herb books?and the development history of medicinal herb?study. Korean Journal of Oriental Medicine. 2005?; 11(1) : 19-32.? 

  247. Kim HS, Lee SI, Jeong JK. Systemic review on the research trend of Gastrodiae rhizoma and?relationship between the herbology and KCDcode. The Korea Journal of Herbology. 2016 ;?31(2) : 21-37. doi:10.6116/kjh.2016.31.2.21.? 

  248. Kim HS, Jeong JK, Lee SI. The literature study?of research trend of Menthae Herba and relationship?between the Herbology and KCD-code. The Korea?Journal of Herbology. 2015 ; 30(5) : 29-43.?doi:10.6116/kjh.2015.30.5.29.? 

  249. Jang IW, Jeong JK, Kim HS, Lee SI. The?literature study of research trend of Alismatis Rhizoma and relationship between the Herbology?and KCD. The Korea Journal of Herbology. 2016?; 31(2) : 47-62. doi:10.6116/kjh.2016.31.2.47? 

  250. Kim HJ, Choi GY, Kim C, Lee GS, Kim JH, Lee?SH, et al. Survey on revision and complements?for the current curriculum of Herbology. The Journal?of Korean Medicine. 2009 ; 30(4) : 118-28.?doi:10.6116/kjh.2018.33.5.39? 

  251. KNTP(Korean Traditional Knowledge Portal)?[Online]. Korean Intellectual Property Office.?Available from: https://www.koreantk.com/.? 

  252. Naef R. The volatile and semi-volatile constituents?of agarwood, the infected heartwood of Aquilaria?species: a review. Flavour and Fragrance Journal.?2011 ; 26(2) : 73-87. doi:10.1002/ffj.2034? 

  253. Marini M, Vittori E, Hollemborg J, Mattoli S.?Expression of the potent inflammatory cytokines,?granulocyte-macrophage-colony-stimulating?factor and interleukin-6 and interleukin-8, in?bronchial epithelial cells of patients with asthma.?Journal of Allergy and Clinical Immunology. 1992 ;?89(5) : 1001-9. doi:10.1016/0091-6749(92)90223-o? 

  254. Lowy FD. Staphylococcus aureus infections. New?England journal of medicine. 1998 ; 339(8) :?520-32. doi:10.1056/NEJM199808203390806? 

  255. Liew HJ. A study on agarwood as a medi-food?material in the food service. Food Service Industry?Journal. 2022 ; 18(1) : 33-9. doi:10.22509/kfsa.2022.18.1.003? 

  256. de Cassia Da Silveira e Sa R, Andrade LN, De Sousa?DP. Sesquiterpenes from essential oils and anti-inflammatory activity. Natural product communications.?2015 ; 10(10) : 1934578X1501001033.? 

  257. World Health Organization. WHO International?Standard Terminologies on Traditional Medicine?in the Western Pacific Region. Manila : WHO?Regional Office for the Western Pacific. 2007:?54, 96, 168, 172, 216, 217, 218, 224. 

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로