[논문]네트워크 약리학 기반 대황목단피탕(大黃牧丹皮湯)의 건선 조절 효능 및 작용 기전 예측

권빛나; 김동욱; 양갑식; 조일주

doi:10.6116/kjh.2023.38.6.73

네트워크 약리학 기반 대황목단피탕(大黃牧丹皮湯)의 건선 조절 효능 및 작용 기전 예측
Prediction the efficacy and mechanism of action of Daehwangmokdanpitang to treat psoriasis based on network pharmacology 원문보기

大韓本草學會誌 = The Korea journal of herbology, v.38 no.6, 2023년, pp.73 - 91

권빛나 (원광대학교 한의과대학 약리학교실) , 김동욱 (원광대학교 한의과대학 약리학교실) , 양갑식 (우석대학교 한의과대학 임상약리연구실) , 조일주 (원광대학교 한의과대학 뇌졸중한의중점연구센터)

Abstract ▼ AI-Helper

Objectives : This study used a network pharmacology approach to elucidate the efficacy and molecular mechanisms of Daehwangmokdanpitang (DHMDPT) on Psoriasis. Methods : Using OASIS databases and PubChem database, compounds of DHMDPT and their target genes were collected. The putative target genes of DHMDPT and known target genes of psoriasis were compared and found the correlation. Then, the network was constructed using Cytoscape 3.10.1. The key target genes were screened by Analyzer network and their functional enrichment analysis was conducted based on the Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms. Results : The result showed that total 30 compounds and 439 related genes were gathered from DHMDPT. 264 genes were interacted with psoriasis gene set, suggesting that the effects of DHMDPT are closely related to psoriasis. Based on GO enrichment analysis and KEGG pathways, 'Binding', 'Cytokine Activity', 'Receptor Ligand Activity' 'HIF-1 signaling pathway', 'IL-17 signaling pathway', 'Toll-like receptor signaling pathway', and 'TNF signaling pathway' were predicted as functional pathways of 16 key target genes of DHMDPT on psoriasis. Among the target genes, IL6, IL1B, TNF, AKT1 showed high correlation with the results of KEGG pathways. Additionally, Emodin, Acetovanillone, Gallic acid, and Ferulic acid showed a high relevance with key genes and their mechanisms. Conclusion : Through a network pharmacological method, DHMDPT was predicted to have high relevance with psoriasis. This study could be used as a basis for studying therapeutic effects of DHMDPT on psoriasis.

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표/그림 (8)

표 Table 1. Physicochmical properties of the compounds from DHMDPT for good oral bioavailability.
표 Table 2. List of the active compounds from DHMDPT with the Pubchem ID.
그림 Fig. 1. Veen diagram of intersection targets between DHMDPT network and gene sets of psoriasis
그림 Fig. 2. Process of topological screening for the PPI network. (A) Network of intersection targets between DHMDPT and gene sets of psoriasis. (B) Network of primary screening of key targets. (C) Network of final key targets.
표 Table 3 Detailed information of the 16 key targets.
그림 Fig. 3. Biological processes related to targets of DHMDPT using GO enrichment analysis database. The blue bars represent molecular function, the green bars represent cellular components, and the red bars represent biological process. GO terms in each category were listed in valid order based on p-value.
그림 Fig. 4. Biological processes related to targets of DHMDPT using KEGG Pathways database.
그림 Fig. 5. The herb, compound, target and pathway network of DHMDPT in the treatment of psoriasis. The pink represents tang, the greens represent herb, the purples represents component, the yellows represent target, and the oranges represent pathway. *Abbreviations: PS, Persicae Semen; MRC, Moutan Radicis Cortex; TS, Trichosanthis Semen; RR, Rhei Radix.

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