[논문]당뇨병성 망막병증에 대한 보양환오탕(補陽還五湯)의 효과: 체계적 문헌 고찰 및 메타분석

오정화; 김혜나; 윤화정

doi:10.6114/jkood.2023.36.4.051

[국내논문] 당뇨병성 망막병증에 대한 보양환오탕(補陽還五湯)의 효과: 체계적 문헌 고찰 및 메타분석
The Effect of Boyanghwano-tang for Diabetic Retinopathy: A Systematic Review and Meta-Analysis 원문보기

韓方眼耳鼻咽喉皮膚科學會誌 = The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, v.36 no.4, 2023년, pp.51 - 69

오정화 (동의대학교 한의과대학 안이비인후피부과학 교실) , 김혜나 (동의대학교 한의과대학 안이비인후피부과학 교실) , 윤화정 (동의대학교 한의과대학 안이비인후피부과학 교실)

Abstract ▼ AI-Helper

Objectives : The purpose of this study is to assess the effect of using Boyanghwano-tang(BYHWT) for diabetic retinopathy. Methods : We searched randomized controlled trials(RCTs) that used BYHWT for diabetic retinopathy in 10 databases(RISS, KISS, ScienceON, KCI, OASIS, DBpia, CNKI, Wanfang Database, PubMed, Cochrane Library) on August 12, 2023. Outcome measurements included total effective rate(TER) and visual acuity as the primary outcome measurements, and the secondary outcome measurements included fasting blood glucose(FBG), 2hPG, HbA1c, ET-1, NO, etc. The indicator of stability included adverse reactions. A meta-analysis was conducted according to TER, visual acuity, FBG. Results : A total of 8 randomized control trials were selected. The treatment group which used BYHWT showed significant improvement effects in TER and visual acuity compared to the control group which used western medicine or chinese patent medicine alone. TER: (RR: 1.22, CI 1.14 to 1.31, P=<0.00001), visual acuity: (RR: 2.06, CI 1.40 to 3.03, P=0.0002). Secondary outcome measurements including FBG also showed improvement in the treatment group compared to the control group. FBG: (MD: -0.15, CI -0.43 to 0.31, P=0.28). Adverse reactions were only mentioned in one study, which showed that no adverse reactions occurred in both the treatment and control groups. Conclusions : This study suggests that BYHWT is effective for diabetic retinopathy. However these findings should be interpreted cautiously due to the insufficient number of studies and unknown or high risk of bias in the included trials.

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표/그림 (10)

그림 Fig. 1. PRISMA Flow Chart
표 Table 1. Summary of Included Studies
표 Table 2. Herbal Materials which Composed of Boyanghwano-tang Gagam
표 Table 3. Efficacy Evaluation
그림 Fig. 2. Forest Plot : Comparison of TER. BYHWT(ALL), BYHWT(ALL)+WM+CM VS WM+CM BYHWT : Boyanghwano-tang, BYHWT(ALL) : BYHWT, Modified BYHWT, BYHWT combined with other decotion, WM : Western medicine, CM : Chinese patent medicine
그림 Fig. 3. Forest Plot : Comparison of TER. BYHWT(ALL)+WM VS WM
그림 Fig. 4. Forest Plot : Comparison of Visucal Improvement. BYHWT+Modified BYHWT+WM+CM VS WM+CM
그림 Fig. 5. Forest Plot : Comparison of FBG. BYHWT+Modified BYHWT+WM VS WM
그림 Fig. 6. Risk of Bias Summary
그림 Fig. 7. Risk of Bias Graph

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