$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[국내논문] Genistein alleviates pulmonary fibrosis by inactivating lung fibroblasts

BMB reports, v.57 no.3, 2024년, pp.143 - 148  

Seung-hyun Kwon (Veterans Medical Research Institute, Veterans Health Service Medical Center) ,  Hyunju Chung (Core Research Laboratory, Medical Science Research Institute, Kyung Hee University Hospital at Gangdong) ,  Jung-Woo Seo (Core Research Laboratory, Medical Science Research Institute, Kyung Hee University Hospital at Gangdong) ,  Hak Su Kim (Veterans Medical Research Institute, Veterans Health Service Medical Center)

Abstract AI-Helper 아이콘AI-Helper

Pulmonary fibrosis is a serious lung disease that occurs predominantly in men. Genistein is an important natural soybean-derived phytoestrogen that affects various biological functions, such as cell migration and fibrosis. However, the antifibrotic effects of genistein on pulmonary fibrosis are larg...

Keyword

참고문헌 (38)

  1. Lederer DJ and Martinez FJ (2018) Idiopathic pulmonary?fibrosis. N Engl J Med 378, 1811-1823 

  2. Richeldi L, Collard HR and Jones MG (2017) Idiopathic?pulmonary fibrosis. Lancet 389, 1941-1952 

  3. Raghu G, Chen SY, Hou Q, Yeh WS and Collard HR?(2016) Incidence and prevalence of idiopathic pulmonary?fibrosis in US adults 18-64 years old. Eur Respir J 48, 179-186 

  4. Sathish V, Martin YN and Prakash YS (2015) Sex steroid?signaling: implications for lung diseases. Pharmacol Ther?150, 94-108 

  5. Smith LC, Moreno S, Robertson L et al (2018) Transforming growth factor beta1 targets estrogen receptor signaling?in bronchial epithelial cells. Respir Res 19, 160 

  6. Avouac J, Pezet S, Gonzalez V et al (2020) Estrogens?Counteract the profibrotic effects of TGF-beta and their?inhibition exacerbates experimental dermal fibrosis. J?Invest Dermatol 140, 593-601 e597 

  7. Pedram A, Razandi M, Narayanan R and Levin ER (2016)?Estrogen receptor beta signals to inhibition of cardiac?fibrosis. Mol Cell Endocrinol 434, 57-68 

  8. Mankhey RW, Wells CC, Bhatti F and Maric C (2007)?17beta-Estradiol supplementation reduces tubulointerstitial?fibrosis by increasing MMP activity in the diabetic kidney.?Am J Physiol Regul Integr Comp Physiol 292, R769-777 

  9. Voltz JW, Card JW, Carey MA et al (2008) Male sex?hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol?Biol 39, 45-52 

  10. Morani A, Barros RP, Imamov O et al (2006) Lung dysfunction causes systemic hypoxia in estrogen receptor?beta knockout (ERbeta-/-) mice. Proc Natl Acad Sci U S?A 103, 7165-7169 

  11. Tissier R, Waintraub X, Couvreur N et al (2007) Pharmacological postconditioning with the phytoestrogen genistein. J Mol Cell Cardiol 42, 79-87 

  12. Lee GS, Choi KC, Kim HJ and Jeung EB (2004) Effect of?genistein as a selective estrogen receptor beta agonist on?the expression of Calbindin-D9k in the uterus of immature?rats. Toxicol Sci 82, 451-457 

  13. Hillman GG, Singh-Gupta V, Lonardo F et al (2013)?Radioprotection of lung tissue by soy isoflavones. J Thorac?Oncol 8, 1356-1364 

  14. Day RM, Barshishat-Kupper M, Mog SR et al (2008) Genistein protects against biomarkers of delayed lung sequelae?in mice surviving high-dose total body irradiation. J Radiat?Res 49, 361-372 

  15. Ning Y, Chen J, Shi Y et al (2020) Genistein ameliorates?renal fibrosis through regulation snail via m6A RNA?Demethylase ALKBH5. Front Pharmacol 11, 579265 

  16. Salas AL, Montezuma TD, Farina GG, Reyes-Esparza J and?Rodriguez-Fragoso L (2008) Genistein modifies liver fibrosis and improves liver function by inducing uPA expression and proteolytic activity in CCl4-treated rats. Pharmacology 81, 41-49 

  17. Yang R, Jia Q, Liu XF and Ma SF (2018) Effect of genistein?on myocardial fibrosis in diabetic rats and its mechanism.?Mol Med Rep 17, 2929-2936 

  18. Sharifi-Rad J, Quispe C, Imran M et al (2021) Genistein:?an integrative overview of its mode of action, pharmacological properties, and health benefits. Oxid Med Cell?Longev 2021, 3268136 

  19. Ganai AA and Farooqi H (2015) Bioactivity of genistein: a?review of in vitro and in vivo studies. Biomed Pharmacother 76, 30-38 

  20. Todd NW, Luzina IG and Atamas SP (2012) Molecular?and cellular mechanisms of pulmonary fibrosis. Fibrogenesis Tissue Repair 5, 11 

  21. Yanai H, Shteinberg A, Porat Z et al (2015) Cellular?senescence-like features of lung fibroblasts derived from?idiopathic pulmonary fibrosis patients. Aging (Albany NY)?7, 664-672 

  22. Kolosova I, Nethery D and Kern JA (2011) Role of?Smad2/3 and p38 MAP kinase in TGF-beta1-induced?epithelial-mesenchymal transition of pulmonary epithelial?cells. J Cell Physiol 226, 1248-1254 

  23. Finnson KW, Almadani Y and Philip A (2020) Non-canonical (non-SMAD2/3) TGF-beta signaling in fibrosis: mechanisms and targets. Semin Cell Dev Biol 101, 115-122 

  24. Ravanti L, Heino J, Lopez-Otin C and Kahari VM (1999)?Induction of collagenase-3 (MMP-13) expression in human?skin fibroblasts by three-dimensional collagen is mediated?by p38 mitogen-activated protein kinase. J Biol Chem?274, 2446-2455 

  25. Huang X, Chen S, Xu L et al (2005) Genistein inhibits p38?map kinase activation, matrix metalloproteinase type 2,?and cell invasion in human prostate epithelial cells. Cancer?Res 65, 3470-3478 

  26. Varone F, Mastrobattista A, Franchi P et al (2018) Pulmonary fibrolysis in a patient with idiopathic pulmonary?fibrosis: improvement of clinical and radiological pattern?after treatment with pirfenidone. Clin Respir J 12, 347-351 

  27. Sakai N and Tager AM (2013) Fibrosis of two: epithelial?cell-fibroblast interactions in pulmonary fibrosis. Biochim?Biophys Acta 1832, 911-921 

  28. Stewart AG, Thomas B and Koff J (2018) TGF-beta: master?regulator of inflammation and fibrosis. Respirology 23,?1096-1097 

  29. Chitra P, Saiprasad G, Manikandan R and Sudhandiran G?(2015) Berberine inhibits Smad and non-Smad signaling?cascades and enhances autophagy against pulmonary?fibrosis. J Mol Med (Berl) 93, 1015-1031 

  30. Camara J and Jarai G (2010) Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha.?Fibrogenesis Tissue Repair 3, 2 

  31. Itoigawa Y, Harada N, Harada S et al (2015) TWEAK enhances TGF-beta-induced epithelial-mesenchymal transition?in human bronchial epithelial cells. Respir Res 16, 48 

  32. Kim HS, Yoo HJ, Lee KM et al (2021) Stearic acid attenuates profibrotic signalling in idiopathic pulmonary fibrosis. Respirology 26, 255-263 

  33. Kim HS, Moon SJ, Lee SE, Hwang GW, Yoo HJ and Song?JW (2021) The arachidonic acid metabolite 11,12-epoxyeicosatrienoic acid alleviates pulmonary fibrosis. Exp Mol?Med 53, 864-874 

  34. Zhao YD, Yin L, Archer S et al (2017) Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic?study. BMJ Open Respir Res 4, e000183 

  35. Ung CY, Onoufriadis A, Parsons M, McGrath JA and Shaw?TJ (2021) Metabolic perturbations in fibrosis disease. Int J?Biochem Cell Biol 139, 106073 

  36. Kendall RT and Feghali-Bostwick CA (2014) Fibroblasts in?fibrosis: novel roles and mediators. Front Pharmacol 5,?123 

  37. Kim S, Nam Y, Kim MJ et al (2023) Proteomic analysis for?the effects of non-saponin fraction with rich polysaccharide from Korean Red Ginseng on Alzheimer's disease in?a mouse model. J Ginseng Res 47, 302-310 

  38. Tyanova S and Cox J (2018) Perseus: a bioinformatics?platform for integrative analysis of proteomics data in?cancer research. Methods Mol Biol 1711, 133-148 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로