$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer’s disease

Brain research. Molecular brain research, v.84 no.1/2, 2000년, pp.135 - 140  

Szot, Patricia (Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA) ,  Leverenz, James B (Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA) ,  Peskind, Elaine R (Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA) ,  Kiyasu, Elizabeth (Department of Medicine, University of Washington, Seattle, WA 98195, USA) ,  Rohde, Kirsten (Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA) ,  Miller, Margaret A (Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA 98195, USA) ,  Raskind, Murray A (Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractDespite the loss of locus coeruleus (LC) noradrenergic neurons in Alzheimer’s disease (AD), cerebrospinal fluid norepinephrine (NE) levels are normal or increased in AD. This paradox suggests compensatory upregulation of NE synthetic capacity or downregulation of the NE transporter (N...

주제어

참고문헌 (32)

  1. 1987 

  2. Neurology Bondareff 32 164 1982 10.1212/WNL.32.2.164 Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus coeruleus) in senile dementia 

  3. J. Comp. Neurol. Chan-Palay 287 373 1989 10.1002/cne.902870308 Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer’s type and in Parkinson’s disease with and without dementia and depression 

  4. Br. Med. J. Cross 282 93 1981 10.1136/bmj.282.6258.93 Reduced dopamine-β-hydroxylase activity in Alzheimer’s disease 

  5. J. Neurochem. Cubells 65 502 1995 10.1046/j.1471-4159.1995.65020502.x Differential in vivo regulation of mRNA encoding the norepinephrine transporter and tyrosine hydroxylase in rat adrenal medulla and locus ceruleus 

  6. Exp. Brain Res. Dyon-Laurent 96 203 1993 10.1007/BF00227100 Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study 

  7. Am. J. Psychiatry Elrod 154 25 1997 10.1176/ajp.154.1.25 Effects of Alzheimer’s disease severity on cerebrospinal fluid norepinephrine concentration 

  8. Brain Res. Bull. Fallon 9 295 1982 10.1016/0361-9230(82)90143-5 Monoamine innervation of the forebrain: collateralization 

  9. J. Psychiatr. Res. Folstein 12 189 1975 10.1016/0022-3956(75)90026-6 Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician 

  10. J. Comp. Neurol. Fritschy 321 421 1992 10.1002/cne.903210309 Restoration of ascending noradrenergic projections by residual locus coeruleus neurons: compensatory response to neurotoxin-induced cell death in the adult rat brain 

  11. Ann. Neurol. German 32 667 1992 10.1002/ana.410320510 Disease-specific patterns of locus coeruleus cell loss 

  12. Neurobiol. Aging Gottfries 4 261 1983 10.1016/0197-4580(83)90002-7 Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT) 

  13. Neurosci. Lett. Harrison 200 151 1995 10.1016/0304-3940(95)12102-A The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins 

  14. Mol. Brain Res. Harrison 9 161 1991 10.1016/0169-328X(91)90143-L Terminal coma affects messenger RNA detection in postmortem human temporal cortex 

  15. Ann. Neurol. Hoogendijk 45 82 1999 10.1002/1531-8249(199901)45:1<82::AID-ART14>3.0.CO;2-T Increased activity of surviving locus ceruleus neurons in Alzheimer’s disease 

  16. Brain Res. Bull. Loughlin 9 287 1982 10.1016/0361-9230(82)90142-3 Locus coeruleus projections to cortex: topography, morphology and collateralizations 

  17. Br. J. Psychiatry Mann 136 533 1980 10.1192/bjp.136.6.533 Changes in the monoamine containing neurons of the human CNS in senile dementia 

  18. Neurobiol. Aging Mann 2 57 1981 10.1016/0197-4580(81)90060-9 Central amine metabolism in Alzheimer’s disease: in vivo relationship to cognitive deficit 

  19. Neurosci. Lett. Marcyniuk 64 247 1986 10.1016/0304-3940(86)90336-8 Loss of nerve cells from locus coeruleus in Alzheimer’s disease is topographically arranged 

  20. Neurology McKhann 34 939 1984 10.1212/WNL.34.7.939 Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer’s disease 

  21. Neurology Morris 48 1508 1997 10.1212/WNL.48.6.1508 Clinical dementia rating training and reliability in multicenter studies: the Alzheimer’s Disease Cooperative Study experience 

  22. Biochemistry O’Malley 26 6910 1987 10.1021/bi00396a007 Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5′ alternative splice sites responsible for multiple mRNAs 

  23. Brain Res. Palmer 401 231 1987 10.1016/0006-8993(87)91408-9 Monoaminergic innervation of the frontal and temporal lobes in Alzheimer’s disease 

  24. J. Neurol. Sci. Perry 51 279 1981 10.1016/0022-510X(81)90106-4 Neuropathological and biochemical observations on the noradrenergic system in Alzheimer’s disease 

  25. Arch. Gen. Psychiatry Raskind 41 343 1984 10.1001/archpsyc.1984.01790150033006 Norepinephrine and MHPG levels in CSF and plasma in Alzheimer’s disease 

  26. J. Neurol. Sci. Reinikainen 84 101 1988 10.1016/0022-510X(88)90179-7 A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer’s disease 

  27. Exp. Brain Res. Sara 89 125 1992 10.1007/BF00229009 Noradrenergic hyperactivity after partial fornix section: role in cholinergic dependent memory performance 

  28. Mol. Brain Res. Szot 44 46 1997 10.1016/S0169-328X(96)00217-3 Effect of pentylenetetrazol on the expression of tyrosine hydroxylase mRNA and norepinephrine and dopamine transporter mRNA 

  29. Brain Res. Tejani-Butt 631 147 1993 10.1016/0006-8993(93)91201-3 Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer’s disease 

  30. J. Neurol. Transm. Park. Dis. Dement. Sect. Tohgi 4 69 1992 10.1007/BF02257623 Concentrations of monoamines and their metabolites in the cerebrospinal fluid from patients with senile dementia of the Alzheimer type and vascular dementia of the Binswanger’s type 

  31. J. Neurol. Sci. Tomlinson 49 419 1981 10.1016/0022-510X(81)90031-9 Cell loss in the locus coeruleus in senile dementia of the Alzheimer type 

  32. J. Neurochem. Zhu 68 134 1997 10.1046/j.1471-4159.1997.68010134.x Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors 

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로