참고문헌 (161)

1. 1. Jung H. Kim D.O. Byun J.E. Kim W.S. Kim M.J. Song H.Y. Kim Y.K. Kang D.K. Park Y.J. Kim T.D. Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity Nat. Commun. 2016 7 13674 10.1038/ncomms13674 27929088 

   상세보기

2. 2. Morrison S.J. Weissman I.L. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype Immunity 1994 1 661 673 10.1016/1074-7613(94)90037-X 7541305 

   상세보기

3. 3. Buitenhuis M. Verhagen L.P. van Deutekom H.W. Castor A. Verploegen S. Koenderman L. Jacobsen S.E. Coffer P.J. Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis Blood 2008 111 112 121 10.1182/blood-2006-07-037572 17890457 

   상세보기

4. 4. Janzen V. Forkert R. Fleming H.E. Saito Y. Waring M.T. Dombkowski D.M. Cheng T. DePinho R.A. Sharpless N.E. Scadden D.T. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a Nature 2006 443 421 426 10.1038/nature05159 16957735 

   상세보기

5. 5. Rigaud S. Sauer K. IP3 3-kinase B prevents bone marrow failure Oncotarget 2015 6 15706 15707 10.18632/oncotarget.4480 26202960 

   상세보기

6. 6. Lee D.H. Kim T.S. Lee D. Lim D.S. Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition Sci. Rep. 2018 8 942 10.1038/s41598-018-19637-y 29343826 

   상세보기

7. 7. Rossi D.J. Seita J. Czechowicz A. Bhattacharya D. Bryder D. Weissman I.L. Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging Cell Cycle 2007 6 2371 2376 10.4161/cc.6.19.4759 17700071 

   상세보기

8. 8. Kirschner K. Chandra T. Kiselev V. Flores-Santa Cruz D. Macaulay I.C. Park H.J. Li J. Kent D.G. Kumar R. Pask D.C. Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment Cell Rep. 2017 19 1503 1511 10.1016/j.celrep.2017.04.074 28538171 

   상세보기

9. 9. De Haan G. Lazare S.S. Aging of hematopoietic stem cells Blood 2018 131 479 487 10.1182/blood-2017-06-746412 29141947 

   상세보기

10. 10. Beerman I. Seita J. Inlay M.A. Weissman I.L. Rossi D.J. Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle Cell Stem Cell 2014 15 37 50 10.1016/j.stem.2014.04.016 24813857 

    상세보기

11. 11. Lee J. Yoon S.R. Choi I. Jung H. Causes and mechanisms of hematopoietic stem cell aging Int. J. Mol. Sci. 2019 20 1272 10.3390/ijms20061272 

    상세보기

12. 12. Rossi D.J. Bryder D. Zahn J.M. Ahlenius H. Sonu R. Wagers A.J. Weissman I.L. Cell intrinsic alterations underlie hematopoietic stem cell aging Proc. Natl. Acad. Sci. USA 2005 102 9194 9199 10.1073/pnas.0503280102 15967997 

    상세보기

13. 13. Kuranda K. Vargaftig J. de la Rochere P. Dosquet C. Charron D. Bardin F. Tonnelle C. Bonnet D. Goodhardt M. Age-related changes in human hematopoietic stem/progenitor cells Aging Cell 2011 10 542 546 10.1111/j.1474-9726.2011.00675.x 21418508 

    상세보기

14. 14. Dykstra B. Olthof S. Schreuder J. Ritsema M. de Haan G. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells J. Exp. Med. 2011 208 2691 2703 10.1084/jem.20111490 22110168 

    상세보기

15. 15. Li X. Zeng X. Xu Y. Wang B. Zhao Y. Lai X. Qian P. Huang H. Mechanisms and rejuvenation strategies for aged hematopoietic stem cells J. Hematol. Oncol. 2020 13 31 10.1186/s13045-020-00864-8 32252797 

    상세보기

16. 16. Kim M. Moon H.B. Spangrude G.J. Major age-related changes of mouse hematopoietic stem/progenitor cells Ann. N. Y. Acad. Sci. 2003 996 195 208 10.1111/j.1749-6632.2003.tb03247.x 12799297 

    상세보기

17. 17. Snoeck H.W. Aging of the hematopoietic system Curr. Opin. Hematol. 2013 20 355 361 10.1097/MOH.0b013e3283623c77 23739721 

    상세보기

18. 18. Beerman I. Bhattacharya D. Zandi S. Sigvardsson M. Weissman I.L. Bryder D. Rossi D.J. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion Proc. Natl. Acad. Sci. USA 2010 107 5465 5470 10.1073/pnas.1000834107 20304793 

    상세보기

19. 19. Cho R.H. Sieburg H.B. Muller-Sieburg C.E. A new mechanism for the aging of hematopoietic stem cells: Aging changes the clonal composition of the stem cell compartment but not individual stem cells Blood 2008 111 5553 5561 10.1182/blood-2007-11-123547 18413859 

    상세보기

20. 20. Yamamoto R. Wilkinson A.C. Ooehara J. Lan X. Lai C.Y. Nakauchi Y. Pritchard J.K. Nakauchi H. Large-scale clonal analysis resolves aging of the mouse hematopoietic stem cell compartment Cell Stem Cell 2018 22 600 607 e4 10.1016/j.stem.2018.03.013 29625072 

    상세보기

21. 21. Rube C.E. Fricke A. Widmann T.A. Furst T. Madry H. Pfreundschuh M. Rube C. Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging PLoS ONE 2011 6 e17487 10.1371/journal.pone.0017487 21408175 

    상세보기

22. 22. Bernitz J.M. Kim H.S. MacArthur B. Sieburg H. Moore K. Hematopoietic stem cells count and remember self-renewal divisions Cell 2016 167 1296 1309 10.1016/j.cell.2016.10.022 27839867 

    상세보기

23. 23. Cho I.J. Lui P.P. Obajdin J. Riccio F. Stroukov W. Willis T.L. Spagnoli F. Watt F.M. Mechanisms, hallmarks, and implications of stem cell quiescence Stem Cell Rep. 2019 12 1190 1200 10.1016/j.stemcr.2019.05.012 31189093 

    상세보기

24. 24. Tumpel S. Rudolph K.L. Quiescence: Good and bad of stem cell aging Trends Cell Biol. 2019 29 672 685 10.1016/j.tcb.2019.05.002 31248787 

    상세보기

25. 25. Li J. Quiescence regulators for hematopoietic stem cell Exp. Hematol. 2011 39 511 520 10.1016/j.exphem.2011.01.008 21288477 

    상세보기

26. 26. Venezia T.A. Merchant A.A. Ramos C.A. Whitehouse N.L. Young A.S. Shaw C.A. Goodell M.A. Molecular signatures of proliferation and quiescence in hematopoietic stem cells PLoS Biol. 2004 2 e301 10.1371/journal.pbio.0020301 15459755 

    상세보기

27. 27. Nakamura-Ishizu A. Takizawa H. Suda T. The analysis, roles and regulation of quiescence in hematopoietic stem cells Development 2014 141 4656 4666 10.1242/dev.106575 25468935 

    상세보기

28. 28. Walter D. Lier A. Geiselhart A. Thalheimer F.B. Huntscha S. Sobotta M.C. Moehrle B. Brocks D. Bayindir I. Kaschutnig P. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells Nature 2015 520 549 552 10.1038/nature14131 25707806 

    상세보기

29. 29. Visnjic D. Kalajzic Z. Rowe D.W. Katavic V. Lorenzo J. Aguila H.L. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency Blood 2004 103 3258 3264 10.1182/blood-2003-11-4011 14726388 

    상세보기

30. 30. Arai F. Hirao A. Ohmura M. Sato H. Matsuoka S. Takubo K. Ito K. Koh G.Y. Suda T. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche Cell 2004 118 149 161 10.1016/j.cell.2004.07.004 15260986 

    상세보기

31. 31. Yoshihara H. Arai F. Hosokawa K. Hagiwara T. Takubo K. Nakamura Y. Gomei Y. Iwasaki H. Matsuoka S. Miyamoto K. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche Cell Stem Cell 2007 1 685 697 10.1016/j.stem.2007.10.020 18371409 

    상세보기

32. 32. Greenbaum A. Hsu Y.M. Day R.B. Schuettpelz L.G. Christopher M.J. Borgerding J.N. Nagasawa T. Link D.C. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance Nature 2013 495 227 230 10.1038/nature11926 23434756 

    상세보기

33. 33. Ding L. Morrison S.J. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches Nature 2013 495 231 235 10.1038/nature11885 23434755 

    상세보기

34. 34. Wang Z. Ema H. Mechanisms of self-renewal in hematopoietic stem cells Int. J. Hematol. 2016 103 498 509 10.1007/s12185-015-1919-5 26662558 

    상세보기

35. 35. Bowers M. Zhang B. Ho Y. Agarwal P. Chen C.C. Bhatia R. Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development Blood 2015 125 2678 2688 10.1182/blood-2014-06-582924 25742698 

    상세보기

36. 36. Parmar K. Mauch P. Vergilio J.A. Sackstein R. Down J.D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia Proc. Natl. Acad. Sci. USA 2007 104 5431 5436 10.1073/pnas.0701152104 17374716 

    상세보기

37. 37. Trimarchi J.M. Lees J.A. Sibling rivalry in the E2F family Nat. Rev. Mol. Cell Biol. 2002 3 11 20 10.1038/nrm714 11823794 

    상세보기

38. 38. Viatour P. Somervaille T.C. Venkatasubrahmanyam S. Kogan S. McLaughlin M.E. Weissman I.L. Butte A.J. Passegue E. Sage J. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family Cell Stem Cell 2008 3 416 428 10.1016/j.stem.2008.07.009 18940733 

    상세보기

39. 39. Spencer S.L. Cappell S.D. Tsai F.C. Overton K.W. Wang C.L. Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit Cell 2013 155 369 383 10.1016/j.cell.2013.08.062 24075009 

    상세보기

40. 40. Takubo K. Goda N. Yamada W. Iriuchishima H. Ikeda E. Kubota Y. Shima H. Johnson R.S. Hirao A. Suematsu M. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells Cell Stem Cell 2010 7 391 402 10.1016/j.stem.2010.06.020 20804974 

    상세보기

41. 41. Takubo K. Nagamatsu G. Kobayashi C.I. Nakamura-Ishizu A. Kobayashi H. Ikeda E. Goda N. Rahimi Y. Johnson R.S. Soga T. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells Cell Stem Cell 2013 12 49 61 10.1016/j.stem.2012.10.011 23290136 

    상세보기

42. 42. Lu Z. Hong C.C. Kong G. Assumpcao A. Ong I.M. Bresnick E.H. Zhang J. Pan X. Polycomb group protein YY1 is an essential regulator of hematopoietic stem cell quiescence Cell Rep. 2018 22 1545 1559 10.1016/j.celrep.2018.01.026 29425509 

    상세보기

43. 43. Ho T.T. Warr M.R. Adelman E.R. Lansinger O.M. Flach J. Verovskaya E.V. Figueroa M.E. Passegue E. Autophagy maintains the metabolism and function of young and old stem cells Nature 2017 543 205 210 10.1038/nature21388 28241143 

    상세보기

44. 44. Dykstra B. de Haan G. Hematopoietic stem cell aging and self-renewal Cell Tissue Res. 2008 331 91 101 10.1007/s00441-007-0529-9 18008087 

    상세보기

45. 45. Seita J. Weissman I.L. Hematopoietic stem cell: Self-renewal versus differentiation Wiley Interdiscip. Rev. Syst. Biol. Med. 2010 2 640 653 10.1002/wsbm.86 20890962 

    상세보기

46. 46. Morrison S.J. Wandycz A.M. Akashi K. Globerson A. Weissman I.L. The aging of hematopoietic stem cells Nat. Med. 1996 2 1011 1016 10.1038/nm0996-1011 8782459 

    상세보기

47. 47. Nygren J.M. Bryder D. Jacobsen S.E. Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property J. Immunol. 2006 177 201 208 10.4049/jimmunol.177.1.201 16785515 

    상세보기

48. 48. Bowie M.B. McKnight K.D. Kent D.G. McCaffrey L. Hoodless P.A. Eaves C.J. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect J. Clin. Investig. 2006 116 2808 2816 10.1172/JCI28310 17016561 

    

49. 49. Nygren J.M. Bryder D. A novel assay to trace proliferation history in vivo reveals that enhanced divisional kinetics accompany loss of hematopoietic stem cell self-renewal PLoS ONE 2008 3 e3710 10.1371/journal.pone.0003710 19002266 

    상세보기

50. 50. Omatsu Y. Seike M. Sugiyama T. Kume T. Nagasawa T. Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation Nature 2014 508 536 540 10.1038/nature13071 24590069 

    상세보기

51. 51. Zhou B.O. Yue R. Murphy M.M. Peyer J.G. Morrison S.J. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow Cell Stem Cell 2014 15 154 168 10.1016/j.stem.2014.06.008 24953181 

    상세보기

52. 52. Nie Y. Han Y.C. Zou Y.R. CXCR4 is required for the quiescence of primitive hematopoietic cells J. Exp. Med. 2008 205 777 783 10.1084/jem.20072513 18378795 

    상세보기

53. 53. Thoren L.A. Liuba K. Bryder D. Nygren J.M. Jensen C.T. Qian H. Antonchuk J. Jacobsen S.E. Kit regulates maintenance of quiescent hematopoietic stem cells J. Immunol. 2008 180 2045 2053 10.4049/jimmunol.180.4.2045 18250409 

    상세보기

54. 54. Larsson J. Blank U. Helgadottir H. Bjornsson J.M. Ehinger M. Goumans M.J. Fan X. Leveen P. Karlsson S. TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro Blood 2003 102 3129 3135 10.1182/blood-2003-04-1300 12842983 

    상세보기

55. 55. Yamazaki S. Ema H. Karlsson G. Yamaguchi T. Miyoshi H. Shioda S. Taketo M.M. Karlsson S. Iwama A. Nakauchi H. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche Cell 2011 147 1146 1158 10.1016/j.cell.2011.09.053 22118468 

    상세보기

56. 56. Karlsson G. Blank U. Moody J.L. Ehinger M. Singbrant S. Deng C.X. Karlsson S. Smad4 is critical for self-renewal of hematopoietic stem cells J. Exp. Med. 2007 204 467 474 10.1084/jem.20060465 17353364 

    상세보기

57. 57. Essers M.A. Offner S. Blanco-Bose W.E. Waibler Z. Kalinke U. Duchosal M.A. Trumpp A. IFNalpha activates dormant haematopoietic stem cells in vivo Nature 2009 458 904 908 10.1038/nature07815 19212321 

    상세보기

58. 58. Franceschi C. Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases J. Gerontol. A Biol. Sci. Med. Sci. 2014 69 Suppl. 1 S4 S9 10.1093/gerona/glu057 24833586 

    상세보기

59. 59. Baldridge M.T. King K.Y. Goodell M.A. Inflammatory signals regulate hematopoietic stem cells Trends Immunol. 2011 32 57 65 10.1016/j.it.2010.12.003 21233016 

    상세보기

60. 60. Pronk C.J. Veiby O.P. Bryder D. Jacobsen S.E. Tumor necrosis factor restricts hematopoietic stem cell activity in mice: Involvement of two distinct receptors J. Exp. Med. 2011 208 1563 1570 10.1084/jem.20110752 21768269 

    상세보기

61. 61. Lee J. Cho Y.S. Jung H. Choi I. Pharmacological regulation of oxidative stress in stem cells Oxid. Med. Cell Longev. 2018 2018 4081890 10.1155/2018/4081890 30363995 

    상세보기

62. 62. Jang Y.Y. Sharkis S.J. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche Blood 2007 110 3056 3063 10.1182/blood-2007-05-087759 17595331 

    상세보기

63. 63. Staber P.B. Zhang P. Ye M. Welner R.S. Nombela-Arrieta C. Bach C. Kerenyi M. Bartholdy B.A. Zhang H. Alberich-Jorda M. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells Mol. Cell 2013 49 934 946 10.1016/j.molcel.2013.01.007 23395001 

    상세보기

64. 64. Miyamoto K. Araki K.Y. Naka K. Arai F. Takubo K. Yamazaki S. Matsuoka S. Miyamoto T. Ito K. Ohmura M. Foxo3a is essential for maintenance of the hematopoietic stem cell pool Cell Stem Cell 2007 1 101 112 10.1016/j.stem.2007.02.001 18371339 

    상세보기

65. 65. Jung H. Kim M.J. Kim D.O. Kim W.S. Yoon S.J. Park Y.J. Yoon S.R. Kim T.D. Suh H.W. Yun S. TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress Cell Metab. 2013 18 75 85 10.1016/j.cmet.2013.06.002 23823478 

    상세보기

66. 66. Chen Z. Amro E.M. Becker F. Holzer M. Rasa S.M.M. Njeru S.N. Han B. Di Sanzo S. Chen Y. Tang D. Cohesin-mediated NF-kappaB signaling limits hematopoietic stem cell self-renewal in aging and inflammation J. Exp. Med. 2019 216 152 175 10.1084/jem.20181505 30530755 

    상세보기

67. 67. Yu W.M. Liu X. Shen J. Jovanovic O. Pohl E.E. Gerson S.L. Finkel T. Broxmeyer H.E. Qu C.K. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation Cell Stem Cell 2013 12 62 74 10.1016/j.stem.2012.11.022 23290137 

    상세보기

68. 68. Sun D. Luo M. Jeong M. Rodriguez B. Xia Z. Hannah R. Wang H. Le T. Faull K.F. Chen R. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal Cell Stem Cell 2014 14 673 688 10.1016/j.stem.2014.03.002 24792119 

    상세보기

69. 69. Florian M.C. Dorr K. Niebel A. Daria D. Schrezenmeier H. Rojewski M. Filippi M.D. Hasenberg A. Gunzer M. Scharffetter-Kochanek K. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation Cell Stem Cell 2012 10 520 530 10.1016/j.stem.2012.04.007 22560076 

    상세보기

70. 70. Manning G. Whyte D.B. Martinez R. Hunter T. Sudarsanam S. The protein kinase complement of the human genome Science 2002 298 1912 1934 10.1126/science.1075762 12471243 

    상세보기

71. 71. Endicott J.A. Noble M.E. Johnson L.N. The structural basis for control of eukaryotic protein kinases Annu. Rev. Biochem. 2012 81 587 613 10.1146/annurev-biochem-052410-090317 22482904 

    상세보기

72. 72. Hu T. Li C. Wang L. Zhang Y. Peng L. Cheng H. Chu Y. Wang W. Ema H. Gao Y. PDK1 plays a vital role on hematopoietic stem cell function Sci. Rep. 2017 7 4943 10.1038/s41598-017-05213-3 28694518 

    상세보기

73. 73. Huang J. Zhang Y. Bersenev A. O’Brien W.T. Tong W. Emerson S.G. Klein P.S. Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice J. Clin. Investig. 2009 119 3519 3529 10.1172/JCI40572 19959876 

    

74. 74. Kleppe M. Spitzer M.H. Li S. Hill C.E. Dong L. Papalexi E. De Groote S. Bowman R.L. Keller M. Koppikar P. Jak1 integrates cytokine sensing to regulate hematopoietic stem cell function and stress hematopoiesis Cell Stem Cell 2017 21 489 501 10.1016/j.stem.2017.08.011 28965767 

    상세보기

75. 75. Guo F. Zhang S. Grogg M. Cancelas J.A. Varney M.E. Starczynowski D.T. Du W. Yang J.Q. Liu W. Thomas G. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis Haematologica 2013 98 1353 1358 10.3324/haematol.2012.080424 23716557 

    상세보기

76. 76. Polak R. Buitenhuis M. The PI3K/PKB signaling module as key regulator of hematopoiesis: Implications for therapeutic strategies in leukemia Blood 2012 119 911 923 10.1182/blood-2011-07-366203 22065598 

    상세보기

77. 77. Vanhaesebroeck B. Guillermet-Guibert J. Graupera M. Bilanges B. The emerging mechanisms of isoform-specific PI3K signalling Nat. Rev. Mol. Cell Biol. 2010 11 329 341 10.1038/nrm2882 20379207 

    상세보기

78. 78. Gopal A.K. Kahl B.S. de Vos S. Wagner-Johnston N.D. Schuster S.J. Jurczak W.J. Flinn I.W. Flowers C.R. Martin P. Viardot A. PI3Kdelta inhibition by idelalisib in patients with relapsed indolent lymphoma N. Engl. J. Med. 2014 370 1008 1018 10.1056/NEJMoa1314583 24450858 

    상세보기

79. 79. Elich M. Sauer K. Regulation of hematopoietic cell development and function through phosphoinositides Front. Immunol. 2018 9 931 10.3389/fimmu.2018.00931 29780388 

    상세보기

80. 80. Siegemund S. Rigaud S. Conche C. Broaten B. Schaffer L. Westernberg L. Head S.R. Sauer K. IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice Blood 2015 125 2786 2797 10.1182/blood-2014-06-583187 25788703 

    상세보기

81. 81. Haneline L.S. White H. Yang F.C. Chen S. Orschell C. Kapur R. Ingram D.A. Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo Blood 2006 107 1375 1382 10.1182/blood-2005-05-1985 16239435 

    상세보기

82. 82. Buitenhuis M. Coffer P.J. The role of the PI3K-PKB signaling module in regulation of hematopoiesis Cell Cycle 2009 8 560 566 10.4161/cc.8.4.7654 19197152 

    상세보기

83. 83. Okkenhaug K. Fruman D.A. PI3Ks in lymphocyte signaling and development Curr. Top. Microbiol. Immunol. 2010 346 57 85 20563708 

    상세보기

84. 84. Fruman D.A. Mauvais-Jarvis F. Pollard D.A. Yballe C.M. Brazil D. Bronson R.T. Kahn C.R. Cantley L.C. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha Nat. Genet. 2000 26 379 382 10.1038/81715 11062485 

    상세보기

85. 85. Okkenhaug K. Bilancio A. Farjot G. Priddle H. Sancho S. Peskett E. Pearce W. Meek S.E. Salpekar A. Waterfield M.D. Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice Science 2002 297 1031 1034 10.1126/science.1073560 12130661 

    상세보기

86. 86. Liu L. Zhu S. Gong Z. Low B.C. K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis PLoS ONE 2008 3 e2850 10.1371/journal.pone.0002850 18682746 

    상세보기

87. 87. Maira S.M. Stauffer F. Brueggen J. Furet P. Schnell C. Fritsch C. Brachmann S. Chene P. De Pover A. Schoemaker K. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity Mol. Cancer Ther. 2008 7 1851 1863 10.1158/1535-7163.MCT-08-0017 18606717 

    상세보기

88. 88. Perry J.M. He X.C. Sugimura R. Grindley J.C. Haug J.S. Ding S. Li L. Cooperation between both Wnt/{beta}ccc-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion Genes Dev. 2011 25 1928 1942 10.1101/gad.17421911 21890648 

    상세보기

89. 89. Burgering B.M. Coffer P.J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction Nature 1995 376 599 602 10.1038/376599a0 7637810 

    상세보기

90. 90. Manning B.D. Cantley L.C. AKT/PKB signaling: Navigating downstream Cell 2007 129 1261 1274 10.1016/j.cell.2007.06.009 17604717 

    상세보기

91. 91. Chen W.S. Xu P.Z. Gottlob K. Chen M.L. Sokol K. Shiyanova T. Roninson I. Weng W. Suzuki R. Tobe K. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene Genes Dev. 2001 15 2203 2208 10.1101/gad.913901 11544177 

    상세보기

92. 92. Cho H. Mu J. Kim J.K. Thorvaldsen J.L. Chu Q. Crenshaw E.B. 3rd Kaestner K.H. Bartolomei M.S. Shulman G.I. Birnbaum M.J. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) Science 2001 292 1728 1731 10.1126/science.292.5522.1728 11387480 

    상세보기

93. 93. Cho H. Thorvaldsen J.L. Chu Q. Feng F. Birnbaum M.J. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice J. Biol. Chem. 2001 276 38349 38352 10.1074/jbc.C100462200 11533044 

    상세보기

94. 94. Juntilla M.M. Wofford J.A. Birnbaum M.J. Rathmell J.C. Koretzky G.A. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation Proc. Natl. Acad. Sci. USA 2007 104 12105 12110 10.1073/pnas.0705285104 17609365 

    상세보기

95. 95. Tschopp O. Yang Z.Z. Brodbeck D. Dummler B.A. Hemmings-Mieszczak M. Watanabe T. Michaelis T. Frahm J. Hemmings B.A. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis Development 2005 132 2943 2954 10.1242/dev.01864 15930105 

    상세보기

96. 96. Juntilla M.M. Patil V.D. Calamito M. Joshi R.P. Birnbaum M.J. Koretzky G.A. AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species Blood 2010 115 4030 4038 10.1182/blood-2009-09-241000 20354168 

    상세보기

97. 97. Garofalo R.S. Orena S.J. Rafidi K. Torchia A.J. Stock J.L. Hildebrandt A.L. Coskran T. Black S.C. Brees D.J. Wicks J.R. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta J. Clin. Investig. 2003 112 197 208 10.1172/JCI16885 12843127 

    상세보기

98. 98. Kharas M.G. Okabe R. Ganis J.J. Gozo M. Khandan T. Paktinat M. Gilliland D.G. Gritsman K. Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice Blood 2010 115 1406 1415 10.1182/blood-2009-06-229443 20008787 

    상세보기

99. 99. Lin K.K. Rossi L. Boles N.C. Hall B.E. George T.C. Goodell M.A. CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway PLoS Biol. 2011 9 e1001148 10.1371/journal.pbio.1001148 21931533 

    상세보기

100. 100. Chiarini F. Del Sole M. Mongiorgi S. Gaboardi G.C. Cappellini A. Mantovani I. Follo M.Y. McCubrey J.A. Martelli A.M. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism Leukemia 2008 22 1106 1116 10.1038/leu.2008.79 18385752 

     상세보기

101. 101. Papa V. Tazzari P.L. Chiarini F. Cappellini A. Ricci F. Billi A.M. Evangelisti C. Ottaviani E. Martinelli G. Testoni N. Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells Leukemia 2008 22 147 160 10.1038/sj.leu.2404980 17928881 

     상세보기

102. 102. She Q.B. Chandarlapaty S. Ye Q. Lobo J. Haskell K.M. Leander K.R. DeFeo-Jones D. Huber H.E. Rosen N. Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling PLoS ONE 2008 3 e3065 10.1371/journal.pone.0003065 18725974 

     상세보기

103. 103. Chen S. Gao R. Kobayashi M. Yu H. Yao C. Kapur R. Yoder M.C. Liu Y. Pharmacological inhibition of AKT activity in human CD34(+) cells enhances their ability to engraft immunodeficient mice Exp. Hematol. 2017 45 74 84 10.1016/j.exphem.2016.09.003 27645691 

     상세보기

104. 104. Tabellini G. Tazzari P.L. Bortul R. Billi A.M. Conte R. Manzoli L. Cocco L. Martelli A.M. Novel 2′-substituted, 3′-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway Br. J. Haematol. 2004 126 574 582 10.1111/j.1365-2141.2004.05073.x 15287952 

     상세보기

105. 105. Knapp D.J. Hammond C.A. Aghaeepour N. Miller P.H. Pellacani D. Beer P.A. Sachs K. Qiao W. Wang W. Humphries R.K. Distinct signaling programs control human hematopoietic stem cell survival and proliferation Blood 2017 129 307 318 10.1182/blood-2016-09-740654 27827829 

     상세보기

106. 106. Evangelisti C. Ricci F. Tazzari P. Chiarini F. Battistelli M. Falcieri E. Ognibene A. Pagliaro P. Cocco L. McCubrey J.A. Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia J. Cell. Physiol. 2011 226 822 831 10.1002/jcp.22407 20857426 

     상세보기

107. 107. Gan B. DePinho R.A. mTORC1 signaling governs hematopoietic stem cell quiescence Cell Cycle 2009 8 1003 1006 10.4161/cc.8.7.8045 19270523 

     상세보기

108. 108. Foster K.G. Fingar D.C. Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony J. Biol. Chem. 2010 285 14071 14077 10.1074/jbc.R109.094003 20231296 

     상세보기

109. 109. Wullschleger S. Loewith R. Hall M.N. TOR signaling in growth and metabolism Cell 2006 124 471 484 10.1016/j.cell.2006.01.016 16469695 

     상세보기

110. 110. Proud C.G. The multifaceted role of mTOR in cellular stress responses DNA Repair 2004 3 927 934 10.1016/j.dnarep.2004.03.012 15279778 

     상세보기

111. 111. Martelli A.M. Evangelisti C. Chiarini F. Grimaldi C. Cappellini A. Ognibene A. McCubrey J.A. The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis Biochim. Biophys. Acta 2010 1803 991 1002 10.1016/j.bbamcr.2010.04.005 20399811 

     상세보기

112. 112. Zhang J. Grindley J.C. Yin T. Jayasinghe S. He X.C. Ross J.T. Haug J.S. Rupp D. Porter-Westpfahl K.S. Wiedemann L.M. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention Nature 2006 441 518 522 10.1038/nature04747 16633340 

     상세보기

113. 113. Chen C. Liu Y. Liu R. Ikenoue T. Guan K.L. Liu Y. Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species J. Exp. Med. 2008 205 2397 2408 10.1084/jem.20081297 18809716 

     상세보기

114. 114. Gangloff Y.G. Mueller M. Dann S.G. Svoboda P. Sticker M. Spetz J.F. Um S.H. Brown E.J. Cereghini S. Thomas G. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development Mol. Cell. Biol. 2004 24 9508 9516 10.1128/MCB.24.21.9508-9516.2004 15485918 

     상세보기

115. 115. Delgoffe G.M. Kole T.P. Zheng Y. Zarek P.E. Matthews K.L. Xiao B. Worley P.F. Kozma S.C. Powell J.D. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment Immunity 2009 30 832 844 10.1016/j.immuni.2009.04.014 19538929 

     상세보기

116. 116. Yilmaz O.H. Valdez R. Theisen B.K. Guo W. Ferguson D.O. Wu H. Morrison S.J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells Nature 2006 441 475 482 10.1038/nature04703 16598206 

     상세보기

117. 117. Yee K.W. Zeng Z. Konopleva M. Verstovsek S. Ravandi F. Ferrajoli A. Thomas D. Wierda W. Apostolidou E. Albitar M. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies Clin. Cancer Res. 2006 12 5165 5173 10.1158/1078-0432.CCR-06-0764 16951235 

     상세보기

118. 118. Decker T. Sandherr M. Goetze K. Oelsner M. Ringshausen I. Peschel C. A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL Ann. Hematol. 2009 88 221 227 10.1007/s00277-008-0582-9 18704419 

     상세보기

119. 119. Choi J. Chen J. Schreiber S.L. Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP Science 1996 273 239 242 10.1126/science.273.5272.239 8662507 

     상세보기

120. 120. Janes M.R. Limon J.J. So L. Chen J. Lim R.J. Chavez M.A. Vu C. Lilly M.B. Mallya S. Ong S.T. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor Nature Med. 2010 16 205 213 10.1038/nm.2091 20072130 

     상세보기

121. 121. Evangelisti C. Ricci F. Tazzari P. Tabellini G. Battistelli M. Falcieri E. Chiarini F. Bortul R. Melchionda F. Pagliaro P. Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia Leukemia 2011 25 781 791 10.1038/leu.2011.20 21331075 

     상세보기

122. 122. Yang A. Xiao X. Zhao M. LaRue A.C. Schulte B.A. Wang G.Y. Differential reponses of hematopoietic stem and progenitor cells to mTOR inhibition Stem Cells Int. 2015 2015 561404 10.1155/2015/561404 26221145 

     상세보기

123. 123. Frame S. Cohen P. GSK3 takes centre stage more than 20 years after its discovery Biochem. J. 2001 359 Pt 1 1 16 10.1042/bj3590001 11563964 

     상세보기

124. 124. Cohen P. The hormonal control of glycogen metabolism in mammalian muscle by multivalent phosphorylation Biochem. Soc. Trans. 1979 7 459 480 10.1042/bst0070459 221283 

     상세보기

125. 125. Patel S. Woodgett J. Glycogen synthase kinase-3 and cancer: Good cop, bad cop? Cancer Cell 2008 14 351 353 10.1016/j.ccr.2008.10.013 18977324 

     상세보기

126. 126. Banerji V. Frumm S.M. Ross K.N. Li L.S. Schinzel A.C. Hahn C.K. Kakoza R.M. Chow K.T. Ross L. Alexe G. The intersection of genetic and chemical genomic screens identifies GSK-3alpha as a target in human acute myeloid leukemia J. Clin. Investig. 2012 122 935 947 10.1172/JCI46465 22326953 

     상세보기

127. 127. McCubrey J.A. Steelman L.S. Bertrand F.E. Davis N.M. Abrams S.L. Montalto G. D’Assoro A.B. Libra M. Nicoletti F. Maestro R. Multifaceted roles of GSK-3 and Wnt/beta-catenin in hematopoiesis and leukemogenesis: Opportunities for therapeutic intervention Leukemia 2014 28 15 33 10.1038/leu.2013.184 23778311 

     상세보기

128. 128. Trowbridge J.J. Xenocostas A. Moon R.T. Bhatia M. Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation Nat. Med. 2006 12 89 98 10.1038/nm1339 16341242 

     상세보기

129. 129. Purton L.E. Scadden D.T. Limiting factors in murine hematopoietic stem cell assays Cell Stem Cell 2007 1 263 270 10.1016/j.stem.2007.08.016 18371361 

     상세보기

130. 130. Kiel M.J. Yilmaz O.H. Iwashita T. Yilmaz O.H. Terhorst C. Morrison S.J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells Cell 2005 121 1109 1121 10.1016/j.cell.2005.05.026 15989959 

     상세보기

131. 131. Goessling W. North T.E. Loewer S. Lord A.M. Lee S. Stoick-Cooper C.L. Weidinger G. Puder M. Daley G.Q. Moon R.T. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration Cell 2009 136 1136 1147 10.1016/j.cell.2009.01.015 19303855 

     상세보기

132. 132. Bhat R. Xue Y. Berg S. Hellberg S. Ormo M. Nilsson Y. Radesater A.C. Jerning E. Markgren P.O. Borgegard T. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418 J. Biol. Chem. 2003 278 45937 45945 10.1074/jbc.M306268200 12928438 

     상세보기

133. 133. Kyriakis J.M. Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation Physiol. Rev. 2001 81 807 869 10.1152/physrev.2001.81.2.807 11274345 

     상세보기

134. 134. Geest C.R. Coffer P.J. MAPK signaling pathways in the regulation of hematopoiesis J. Leukoc. Biol. 2009 86 237 250 10.1189/jlb.0209097 19498045 

     상세보기

135. 135. Wang Y. Kellner J. Liu L. Zhou D. Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion Stem Cells Dev. 2011 20 1143 1152 10.1089/scd.2010.0413 21198398 

     상세보기

136. 136. Kirito K. Fox N. Kaushansky K. Thrombopoietin stimulates Hoxb4 expression: An explanation for the favorable effects of TPO on hematopoietic stem cells Blood 2003 102 3172 3178 10.1182/blood-2003-03-0944 12855555 

     상세보기

137. 137. Nagata Y. Moriguchi T. Nishida E. Todokoro K. Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3 Blood 1997 90 929 934 10.1182/blood.V90.3.929 9242520 

     상세보기

138. 138. Rausch O. Marshall C.J. Cooperation of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways during granulocyte colony-stimulating factor-induced hemopoietic cell proliferation J. Biol. Chem. 1999 274 4096 4105 10.1074/jbc.274.7.4096 9933603 

     상세보기

139. 139. Ito K. Hirao A. Arai F. Takubo K. Matsuoka S. Miyamoto K. Ohmura M. Naka K. Hosokawa K. Ikeda Y. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells Nat. Med. 2006 12 446 451 10.1038/nm1388 16565722 

     상세보기

140. 140. Zhou L. Opalinska J. Verma A. p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure Cell Cycle 2007 6 534 537 10.4161/cc.6.5.3921 17351344 

     상세보기

141. 141. Pargellis C. Tong L. Churchill L. Cirillo P.F. Gilmore T. Graham A.G. Grob P.M. Hickey E.R. Moss N. Pav S. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site Nat. Struct. Biol. 2002 9 268 272 10.1038/nsb770 11896401 

     상세보기

142. 142. Campbell R.M. Anderson B.D. Brooks N.A. Brooks H.B. Chan E.M. De Dios A. Gilmour R. Graff J.R. Jambrina E. Mader M. Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity Mol. Cancer Ther. 2014 13 364 374 10.1158/1535-7163.MCT-13-0513 24356814 

     상세보기

143. 143. Thalheimer F.B. Wingert S. De Giacomo P. Haetscher N. Rehage M. Brill B. Theis F.J. Hennighausen L. Schroeder T. Rieger M.A. Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells Stem Cell Rep. 2014 3 34 43 10.1016/j.stemcr.2014.05.010 

     상세보기

144. 144. Tesio M. Tang Y. Mudder K. Saini M. von Paleske L. Macintyre E. Pasparakis M. Waisman A. Trumpp A. Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway J. Exp. Med. 2015 212 525 538 10.1084/jem.20141438 25824820 

     상세보기

145. 145. Hu T. Li C. Zhang Y. Wang L. Peng L. Cheng H. Wang W. Chu Y. Xu M. Cheng T. Phosphoinositide-dependent kinase 1 regulates leukemia stem cell maintenance in MLL-AF9-induced murine acute myeloid leukemia Biochem. Biophys. Res. Commun. 2015 459 692 698 10.1016/j.bbrc.2015.03.007 25769952 

     상세보기

146. 146. Mora A. Komander D. van Aalten D.M. Alessi D.R. PDK1, the master regulator of AGC kinase signal transduction Semin. Cell Dev. Biol. 2004 15 161 170 10.1016/j.semcdb.2003.12.022 15209375 

     상세보기

147. 147. Cantrell D.A. Phosphoinositide 3-kinase signalling pathways J. Cell Sci. 2001 114 Pt 8 1439 1445 11282020 

     상세보기

148. 148. Brader S. Eccles S.A. Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis Tumori 2004 90 2 8 10.1177/030089160409000102 15143962 

     상세보기

149. 149. Janus J.M. O’Shaughnessy R.F.L. Harwood C.A. Maffucci T. Phosphoinositide 3-kinase-dependent signalling pathways in cutaneous squamous cell carcinomas Cancers 2017 9 86 10.3390/cancers9070086 

     상세보기

150. 150. Wang W. Sun X. Hu T. Wang L. Dong S. Gu J. Chu Y. Wang X. Li Y. Ru Y. PDK1 regulates definitive HSCs via the FOXO pathway during murine fetal liver hematopoiesis Stem Cell Res. 2018 30 192 200 10.1016/j.scr.2018.05.020 29960148 

     상세보기

151. 151. Alessi D.R. Sakamoto K. Bayascas J.R. LKB1-dependent signaling pathways Annu. Rev. Biochem. 2006 75 137 163 10.1146/annurev.biochem.75.103004.142702 16756488 

     상세보기

152. 152. Inoki K. Zhu T. Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival Cell 2003 115 577 590 10.1016/S0092-8674(03)00929-2 14651849 

     상세보기

153. 153. Corradetti M.N. Inoki K. Bardeesy N. DePinho R.A. Guan K.L. Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome Genes Dev. 2004 18 1533 1538 10.1101/gad.1199104 15231735 

     상세보기

154. 154. Gwinn D.M. Shackelford D.B. Egan D.F. Mihaylova M.M. Mery A. Vasquez D.S. Turk B.E. Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol. Cell 2008 30 214 226 10.1016/j.molcel.2008.03.003 18439900 

     상세보기

155. 155. Nakada D. Saunders T.L. Morrison S.J. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells Nature 2010 468 653 658 10.1038/nature09571 21124450 

     상세보기

156. 156. Gan B. Hu J. Jiang S. Liu Y. Sahin E. Zhuang L. Fletcher-Sananikone E. Colla S. Wang Y.A. Chin L. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells Nature 2010 468 701 704 10.1038/nature09595 21124456 

     상세보기

157. 157. Brault L. Gasser C. Bracher F. Huber K. Knapp S. Schwaller J. PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers Haematologica 2010 95 1004 1015 10.3324/haematol.2009.017079 20145274 

     

158. 158. Breuer M.L. Cuypers H.T. Berns A. Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas EMBO J. 1989 8 743 748 10.1002/j.1460-2075.1989.tb03434.x 2721500 

     상세보기

159. 159. Mikkers H. Allen J. Knipscheer P. Romeijn L. Hart A. Vink E. Berns A. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer Nat. Genet. 2002 32 153 159 10.1038/ng950 12185366 

     상세보기

160. 160. Allen J.D. Verhoeven E. Domen J. van der Valk M. Berns A. Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc Oncogene 1997 15 1133 1141 10.1038/sj.onc.1201288 9294606 

     상세보기

161. 161. An N. Lin Y.W. Mahajan S. Kellner J.N. Wang Y. Li Z. Kraft A.S. Kang Y. Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells Stem Cells 2013 31 1202 1212 10.1002/stem.1369 23495171 

     상세보기

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