[논문]E-cadherin gene mutations in human intrahepatic cholangiocarcinoma

Endo, Kanenori; Ashida, Keigo; Miyake, Noriko; Terada, Tadashi

doi:10.1002/1096-9896(2000)9999:9999<::AID-PATH816>3.0.CO;2-K

[해외논문] E-cadherin gene mutations in human intrahepatic cholangiocarcinoma

The Journal of pathology : a journal of the Pathological Society of Great Britain and Ireland, v.193 no.3, 2001년, pp.310 - 317

Endo, Kanenori (Second Department of Pathology, Tottori University, Faculty of Medicine, 86 Nishi-cho, Yonago 683-8503, Tottori, Japan) , Ashida, Keigo (Second Department of Pathology, Tottori University, Faculty of Medicine, 86 Nishi-cho, Yonago 683-8503, Tottori, Japan) , Miyake, Noriko (Second Department of Pathology, Tottori University, Faculty of Medicine, 86 Nishi-cho, Yonago 683-8503, Tottori, Japan) , Terada, Tadashi (Second Department of Pathology, Tottori University, Faculty of Medicine, 86 Nishi-cho, Yonago 683-8503, Tottori, Japan)

Abstract ▼ AI-Helper

Deletions or mutations of the E-cadherin gene may result in reduced cell adhesiveness. In particular, conservative point mutations within the N-terminal calcium-binding pocket (including exons 7, 8, and 9) are frequently detected in several cancers and are enough to abolish cell–cell adhesion. There have been no studies on E-cadherin gene mutations in human intrahepatic cholangiocarcinoma (ICC). Human ICCs were therefore investigated for E-cadherin gene mutations within exons 7, 8, and 9. In addition, the relationships were analysed between their mutations and the immunohistochemical expression of E-cadherin, histological grade, and clinicopathological parameters. The E-cadherin gene was analysed in 34 tumours by nested polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP) followed by DNA sequencing. In four of the 34 cases (11.8%), tumour-restricted mobility shifts were observed; two cases harboured a single shift, one case presented two different mobility shifts, and one case presented three different mobility shifts within exons 7 and 8, encoding extracellular domains of E-cadherin. Polymorphism as previously reported was not identified and all seven new DNA alterations were not present in genomic DNA of non-tumour origin. The E-cadherin gene mutations correlated significantly with down-regulated E-cadherin protein expression and high ICC histological grade. These data suggest that E-cadherin gene mutations in ICC are associated with reduced cell adhesiveness and high histological grade. Copyright © 2000 John Wiley & Sons, Ltd.

Keyword

참고문헌 (46)

J Cell Biol Gumbiner 107 1575 1988 10.1083/jcb.107.4.1575

상세보기
Science Takeichi 251 1451 1991 10.1126/science.2006419

상세보기
Trends Genet Kemler 9 317 1993 10.1016/0168-9525(93)90250-L

상세보기
Proc Natl Acad Sci U S A Cowin 91 10759 1994 10.1073/pnas.91.23.10759

상세보기
Curr Opin Cell Biol Takeichi 5 806 1993 10.1016/0955-0674(93)90029-P

상세보기
Biochim Biophys Acta-Rev Cancer Birchmeier 1198 11 1994 10.1016/0304-419X(94)90003-5

상세보기
Mol Biol Rep Mareel 19 45 1994 10.1007/BF00987321

상세보기
Cancer Res Oka 53 1696 1993

상세보기
Differentiation Mansouri 38 67 1998 10.1111/j.1432-0436.1988.tb00593.x

상세보기
Cytogenet Cell Genet Natt 50 145 1989 10.1159/000132745

상세보기
Proc Natl Acad Sci U S A Ozawa 87 4246 1990 10.1073/pnas.87.11.4246

상세보기
Cell Ozawa 63 1033 1990 10.1016/0092-8674(90)90506-A

상세보기
Proc Natl Acad Sci U S A Oda 91 1858 1994 10.1073/pnas.91.5.1858

상세보기
Jpn J Cancer Res Mura 87 843 1996 10.1111/j.1349-7006.1996.tb02109.x

상세보기
EMBO J Berx 14 6107 1995 10.1002/j.1460-2075.1995.tb00301.x

상세보기
Cancer Res Becker 54 3845 1994

상세보기
Nature Guiford 392 402 1998 10.1038/32918

상세보기
Lab Invest Machado 79 459 1999

상세보기
Int J Cancer Soares 70 32 1997 10.1002/(SICI)1097-0215(19970106)70:1<32::AID-IJC5>3.0.CO;2-7

상세보기
Hepatology Ashida 27 974 1998 10.1002/hep.510270412

상세보기
Jpn J Cancer Res Tamura 87 1153 1996 10.1111/j.1349-7006.1996.tb03125.x

상세보기
Jpn J Cancer Res Kanai 85 1035 1994 10.1111/j.1349-7006.1994.tb02902.x

상세보기
Histological Typing of Tumours of the Liver Ishak 1994 10.1007/978-3-642-85156-8 Histological Typing of Tumours of the Liver. (2nd edn), WHO Series. Springer-Verlag: Berlin, 1994.
TNM Classification of Malignant Tumours Hermanek 1992 TNM Classification of Malignant Tumours. (4th edn). International Union Against Cancer. Springer-Verlag: Berlin, 1992.
Lab Invest Sugano 68 361 1993

상세보기
Am J Pathol Williams 155 1467 1999 10.1016/S0002-9440(10)65461-2

상세보기
J Pathol Krishnadath 182 331 1997 10.1002/(SICI)1096-9896(199707)182:3<331::AID-PATH860>3.0.CO;2-D

상세보기
Int J Cancer Gabbert 69 184 1996 10.1002/(SICI)1097-0215(19960621)69:3<184::AID-IJC6>3.0.CO;2-W

상세보기
Science Fearon 247 49 1990 10.1126/science.2294591

상세보기
Cancer Res Hohne 52 2616 1992

상세보기
Am J Respir Crit Care Med Sulzer 157 1319 1998 10.1164/ajrccm.157.4.9703099

상세보기
Cancer Res Gao 53 2723 1993

상세보기
Br J Urol Kuczyk 81 406 1998 10.1046/j.1464-410x.1998.00539.x

상세보기
J Cell Biol Frixen 113 173 1991 10.1083/jcb.113.1.173

상세보기
Cell Vleminckx 66 107 1991 10.1016/0092-8674(91)90143-M

상세보기
Am J Pathol Keller 155 337 1999 10.1016/S0002-9440(10)65129-2

상세보기
Cancer Res Shimoyama 49 2128 1989

상세보기
Oncogene Berx 13 1919 1996

상세보기
Gut Ilyas 40 654 1997 10.1136/gut.40.5.654

상세보기
Cancer Res Graff 58 2063 1998

상세보기
Cancer Res Hiraguri 58 1972 1998

상세보기
Int J Oncol Saito 12 293 1998

상세보기
Br J Cancer Wijnhoven 80 1652 1999 10.1038/sj.bjc.6690577

상세보기
Cancer Res Shimoyama 52 5770 1992

상세보기
Mol Cell Biol Kawanishi 15 1175 1995 10.1128/MCB.15.3.1175

상세보기
Cancer Res Mayer 53 1690 1993

상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증