[논문]Extract of Boehmeria nivea Suppresses Mast Cell-Mediated Allergic Inflammation by Inhibiting Mitogen-Activated Protein Kinase and Nuclear Factor-κB

Lim, Ji-Ye; Lee, Ji-Hyun; Lee, Bo-Ri; Kim, Mi Ae; Lee, Young-Mi; Kim, Dae-Ki; Choi, Jin Kyeong

doi:10.3390/molecules25184178

[해외논문] Extract of Boehmeria nivea Suppresses Mast Cell-Mediated Allergic Inflammation by Inhibiting Mitogen-Activated Protein Kinase and Nuclear Factor-κB 원문보기

Molecules a journal of synthetic chemistry and natural product chemistry, v.25 no.18, 2020년, pp.4178 -

Lim, Ji-Ye (Department of Immunology and Institute of Medical Sciences, Medical School, Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea) , Lee, Ji-Hyun (84juce@naver.com (J.-Y.L.)) , Lee, Bo-Ri (jihyunsh1211@naver.com (J.-H.L.)) , Kim, Mi Ae (Department of Immunology and Institute of Medical Sciences, Medical School, Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea) , Lee, Young-Mi (84juce@naver.com (J.-Y.L.)) , Kim, Dae-Ki (jihyunsh1211@naver.com (J.-H.L.)) , Choi, Jin Kyeong (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk 54538, Korea)

Abstract ▼ AI-Helper

Mast cells are effector cells that initiate allergic inflammatory immune responses by inducing inflammatory mediators. Boehmeria nivea (Linn.) Gaudich is a natural herb in the nettle family Urticaceae that possesses numerous pharmacological properties. Despite the various pharmacological benefits of Boehmeria nivea, its effects on allergic inflammation have not yet been determined. Here, we investigated the effect of the ethanol extract of Boehmeria nivea (BNE) on degranulation rat basophilic leukemia (RBL)-2H3 mast cells stimulated with anti-dinitrophenyl (anti-DNP) and bovine serum albumin (BSA) during immunoglobulin E (IgE)-mediated allergic immune response. The results showed inhibition of the release of β-hexosaminidase and histamine from the cells. BNE suppressed pro-inflammatory cytokines (Tumor necrosis factor (TNF)-α, Interleukin (IL)-1β, and IL-6) and reduced T helper (Th)2 cytokine IL-4 expression and/or secretion correlated with the downregulation of p38, extracellular signal-regulated kinases (ERK) mitogen-activated protein kinase (MAPK), and nuclear factor-κB (NF-κB) signaling pathways in treated RBL-2H3 mast cells. In passive cutaneous anaphylaxis, treatment with BNE during IgE-mediated local allergic reaction triggered a reduction in mouse ear pigmentation and thickness. Taken together, these results indicated that BNE suppressed mast cell-mediated inflammation, suggesting that BNE might be a candidate for the treatment of various allergic disorders.

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참고문헌 (40)

1. Bischoff S.C. Role of mast cells in allergic and non-allergic immune responses: Comparison of human and murine data Nat. Rev. Immunol. 2007 7 93 104 10.1038/nri2018 17259966

상세보기
2. Akin C. Mast cell activation disorders J. Allergy Clin. Immunol. Pract. 2014 2 252 258 10.1016/j.jaip.2014.03.007 24811013

상세보기
3. Mukai K. Tsai M. Saito H. Galli S.J. Mast cells as sources of cytokines, chemokines, and growth factors Immunol. Rev. 2018 282 121 150 10.1111/imr.12634 29431212

상세보기
4. Metcalfe D.D. Peavy R.D. Gilfillan A.M. Mechanisms of mast cell signaling in anaphylaxis J. Allergy Clin. Immunol. 2009 124 639 646 10.1016/j.jaci.2009.08.035 19815110

상세보기
5. Wei J. Lin L. Su X. Qin S. Xu Q. Tang Z. Deng Y. Zhou Y. He S. Anti-hepatitis B virus activity of Boehmeria nivea leaf extracts in human HepG2.2.15 cells Biomed. Rep. 2014 2 147 151 10.3892/br.2013.205 24649087

상세보기
6. Sung M.J. Davaatseren M. Kim S.H. Kim M.J. Hwang J.T. Boehmeria nivea attenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages Pharm. Biol. 2013 51 1131 1136 10.3109/13880209.2013.781196 23750815

상세보기
7. Shin E.J. Sung M.J. Yang H.J. Kim M.S. Hwang J.T. Boehmeria nivea attenuates the development of dextran sulfate sodium-induced experimental colitis Mediat. Inflamm. 2014 2014 231942 10.1155/2014/231942 25045208

상세보기
8. Semwal D.K. Rawat U. Semwal R. Singh R. Krishan P. Singh M. Singh G.J. Chemical constituents from the leaves of Boehmeria rugulosa with antidiabetic and antimicrobial activities J. Asian Nat. Prod. Res. 2009 11 1045 1055 10.1080/10286020903352526 20183275

상세보기
9. Cai X.F. Jin X. Lee D. Yang Y.T. Lee K. Hong Y.S. Lee J.H. Lee J.J. Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells J. Nat. Prod. 2006 69 1095 1097 10.1021/np060081y 16872154

상세보기
10. Sancheti S. Sancheti S. Bafna M. Kim H.R. You Y.H. Seo S.Y. Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea root extract in streptozotocin-induced diabetic rats Rev. Bras. Farmacogn. 2011 21 146 154 10.1590/S0102-695X2011005000021

상세보기
11. Lee T.T. Chen C.L. Shieh Z.H. Lin J.C. Yu B. Study on antioxidant activity of Echinacea purpurea L. extracts and its impact on cell viability Afr. J. Biotechnol. 2009 8 5097 5105
12. Chirumbolo S. Dietary assumption of plant polyphenols and prevention of allergy Curr. Pharm. Des. 2014 20 811 839 10.2174/13816128113199990042 23701556

상세보기
13. Thangam E.B. Jemima E.A. Singh H. Baig M.S. Khan M. Mathias C.B. Church M.K. Saluja R. The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: The hunt for new therapeutic targets Front. Immunol. 2018 9 1873 10.3389/fimmu.2018.01873 30150993

상세보기
14. Theoharides T.C. Alysandratos K.D. Angelidou A. Delivanis D.A. Sismanopoulos N. Zhang B. Asadi S. Vasiadi M. Weng Z. Miniati A. Mast cells and inflammation Biochim. Biophys. Acta 2012 1822 21 33 10.1016/j.bbadis.2010.12.014 21185371

상세보기
15. Chen Y. Wang G. Wang H. Cheng C. Zang G. Guo X. Liu R.H. Phytochemical profiles and antioxidant activities in six species of ramie leaves PLoS ONE 2014 9 e108140 10.1371/journal.pone.0108140 25243741

상세보기
16. Wang H. Qiu C. Chen L. Abbasi A.M. Guo X. Liu R.H. Comparative study of phenolic profiles, antioxidant and antiproliferative activities in different vegetative parts of ramie ( Boehmeria nivea L.) Molecules 2019 24 1551 10.3390/molecules24081551 31010162

상세보기
17. Jung C.H. Lee J.Y. Cho C.H. Kim C.J. Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin Arch. Pharm. Res. 2007 30 1599 1607 10.1007/BF02977330 18254248

원문보기 상세보기
18. Choi J.K. Kim S.H. Rutin suppresses atopic dermatitis and allergic contact dermatitis Exp. Biol. Med. (Maywood) 2013 238 410 417 10.1177/1535370213477975 23760007

상세보기
19. Kilic K. Sakat M.S. Yildirim S. Kandemir F.M. Gozeler M.S. Dortbudak M.B. Kucukler S. The amendatory effect of hesperidin and thymol in allergic rhinitis: An ovalbumin-induced rat model Eur. Arch. Otorhinolaryngol. 2019 276 407 415 10.1007/s00405-018-5222-y 30488351

상세보기
20. Lee J. Kim A.R. Lee J.J. Ramie leaf extracts suppresses adipogenic differentiation in 3T3-L1 cells and pig preadipocytes Asian Australas. J. Anim. Sci. 2016 29 1338 1344 10.5713/ajas.15.0384 26954122

원문보기 상세보기
21. Kim S.H. Sung M.J. Park J.H. Yang H.J. Hwang J.T. Boehmeria nivea stimulates glucose uptake by activating peroxisome proliferator-activated receptor gamma in C2C12 cells and improves glucose intolerance in mice fed a high-fat diet Evid. Based. Complement. Alternat. Med. 2013 10.1155/2013/867893

상세보기
22. Abbas A.K. Lichtman A.H. Pillai S. Baker D.L. Baker A. Cellular and Molecular Immunology 9th ed. Elsevier Philadelphia, PA, USA 2018 565
23. Choi Y.A. Lee S. Choi J.K. Kang B.C. Kim M.J. Dhakal H. Kwon T.K. Khang D. Kim S.H. The suppressive effect of dabrafenib, a therapeutic agent for metastatic melanoma, in IgE-mediated allergic inflammation Int. Immunopharmacol. 2020 83 106398 10.1016/j.intimp.2020.106398 32197228

상세보기
24. Roitt I.M. Brostoff J. Male D.K. Immunology 9th ed. Elsevier Philadelphia, PA, USA 2020 416
25. Azzolina A. Guarneri P. Lampiasi N. Involvement of p38 and JNK MAPKs pathways in substance P-induced production of TNF-alpha by peritoneal mast cells Cytokine 2002 18 72 80 10.1006/cyto.2002.0879 12096921

상세보기
26. Guma M. Kashiwakura J. Crain B. Kawakami Y. Beutler B. Firestein G.S. Kawakami T. Karin M. Corr M. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis Proc. Natl. Acad. Sci. USA 2010 107 22122 22127 10.1073/pnas.1016401107 21135226

상세보기
27. Rao A. NF-ATp: A transcription factor required for the co-ordinate induction of several cytokine genes Immunol. Today 1994 15 274 281 10.1016/0167-5699(94)90007-8 8068174

상세보기
28. Lin A. Minden A. Martinetto H. Claret F.X. Lange-Carter C. Mercurio F. Johnson G.L. Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2 Science 1995 268 286 290 10.1126/science.7716521 7716521

상세보기
29. Potaczek D.P. Harb H. Michel S. Alhamwe B.A. Renz H. Tost J. Epigenetics and allergy: From basic mechanisms to clinical applications Epigenomics 2017 9 539 571 10.2217/epi-2016-0162 28322581

상세보기
30. Alaskhar Alhamwe B. Khalaila R. Wolf J. von Bulow V. Harb H. Alhamdan F. Hii C.S. Prescott S.L. Ferrante A. Renz H. {Alaskhar Alhamwe, 2018 #201}and their role in epigenetics of atopy and allergic diseases Allergy Asthma Clin. Immunol. 2018 14 39 29796022
31. Marwick J.A. Tudor C. Khorasani N. Michaeloudes C. Bhavsar P.K. Chung K.F. Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes PLoS ONE 2015 10 e0124961 10.1371/journal.pone.0124961 25905622

상세보기
32. Choi J.K. Jang Y.H. Lee S. Lee S.R. Choi Y.A. Jin M. Choi J.H. Park J.H. Park P.H. Choi H. Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes Food Chem. Toxicol. 2017 110 142 150 10.1016/j.fct.2017.10.025 29050978

상세보기
33. Kim M.J. Kim Y.Y. Choi Y.A. Baek M.C. Lee B. Park P.H. Shin T.Y. Kwon T.K. Khang D. Kim S.H. Elaeocarpusin inhibits mast cell-mediated allergic inflammation Front. Pharmacol. 2018 9 591 10.3389/fphar.2018.00591 29930511

상세보기
34. Kim Y.Y. Lee S. Jang H.J. Hur G. Lee S.W. Jung K. Lee S.J. Kim S.H. Rho M.C. Cynanchum atratum ameliorates airway inflammation via maintaining alveolar barrier and regulating mast cell-mediated inflammatory responses Am. J. Chin. Med. 2019 47 1795 1814 10.1142/S0192415X19500915 31795744

상세보기
35. Marquardt D.L. Walker L.L. Dependence of mast cell IgE-mediated cytokine production on nuclear factor-kappaB activity J. Allergy Clin. Immunol. 2000 105 500 505 10.1067/mai.2000.104942 10719300

상세보기
36. Conti P. Kempuraj D. Di Gioacchino M. Boucher W. Letourneau R. Kandere K. Barbacane R.C. Reale M. Felaco M. Frydas S. Interleukin-6 and mast cells Allergy Asthma Proc. 2002 23 331 335 12476543
37. Nam S.T. Kim H.W. Kim H.S. Park Y.H. Lee D. Lee M.B. Min K.Y. Kim Y.M. Choi W.S. Furaltadone suppresses IgE-mediated allergic response through the inhibition of Lyn/Syk pathway in mast cells Eur. J. Pharmacol. 2018 828 119 125 10.1016/j.ejphar.2018.03.035 29588153

상세보기
38. Park H.H. Lee S. Son H.Y. Park S.B. Kim M.S. Choi E.J. Singh T.S. Ha J.H. Lee M.G. Kim J.E. {Park, 2008 #136}and expression of proinflammatory cytokines in mast cells Arch. Pharm. Res. 2008 31 1303 1311 18958421
39. Park S.H. Park E.K. Kim D.H. Citrus unshiu and Poncirus trifoliata Planta Med. 2005 71 24 27 10.1055/s-2005-837746 15678369

상세보기
40. Murata K. Takano S. Masuda M. Iinuma M. Matsuda H. Anti-degranulating activity in rat basophil leukemia RBL-2H3 cells of flavanone glycosides and their aglycones in citrus fruits J. Nat. Med. 2013 67 643 646 10.1007/s11418-012-0699-y 22903244

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