$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Rapid determination of rosmarinic acid and its two bioactive metabolites in the plasma of rats by LC–MS/MS and application to a pharmacokinetics study

Biomedical chromatography : BMC, v.35 no.2, 2021년, pp.e4984 -   

Wang, Xiangyang (State Key Laboratory of Component‐) ,  Qian, Yuexin (based Chinese Medicine and Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China) ,  Li, Xue (State Key Laboratory of Component‐) ,  Jia, Xue (based Chinese Medicine and Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China) ,  Yan, Zhexuan (State Key Laboratory of Component‐) ,  Han, Min (based Chinese Medicine and Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China) ,  Qiao, Miao (Tasly Academy, Tasly Holding Group Co., Ltd., Tianjin, China) ,  Ma, Xiaohui (Skate Key Laboratory of Core Technology in Innovation Chinese Medicine, Tasly Pharmaceutical Group Co., Ltd., Tianjin, China) ,  Chu, Yang (Tasly Academy, Tasly Holding Group Co., Ltd., T) ,  Zhou, Shuiping ,  Yang, Wenzhi

Abstract AI-Helper 아이콘AI-Helper

AbstractRosmarinic acid (RA), an ester compound of caffeic acid (CA) and 3,4‐dihydroxyphenyllacic acid, is widely distributed in the herbs of the Lamiaceae family and has shown a wide spectrum of pharmacological properties. CA and FA (ferulic acid) are two bioactive metabolites in vivo after o...

주제어

참고문헌 (36)

  1. Anwar , J. , Spanevello , R. M. , Pimentel , V. C. , Gutierres , J. , Thome , G. , Cardoso , A. , … Schetinger , M. R. ( 2013 ). Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats . Food and Chemical Toxicology , 56 , 459 – 466 . https://doi.org/10.1016/j.fct.2013.02.030 

  2. Baba , S. , Osakabe , N. , Natsume , M. , & Terao , J. ( 2004 ). Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m ‐coumaric acid . Life Sciences , 75 , 165 – 178 . https://doi.org/10.1016/j.lfs.2003.11.028 

  3. Fikry , E. M. , Gad , A. M. , Eid , A. H. , & Arab , H. H. ( 2019 ). Caffeic acid and ellagic acid ameliorate adjuvant‐induced arthritis in rats via targeting inflammatory signals, chitinase‐3‐like protein‐1 and angiogenesis . Biomedicine & Pharmacotherapy , 110 , 878 – 886 . https://doi.org/10.1016/j.biopha.2018.12.041 

  4. Furtado , R. A. , Oliveira , B. R. , Silva , L. R. , Cleto , S. S. , Munari , C. C. , Cunha , W. R. , & Tavares , D. C. ( 2015 ). Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis . European Journal of Cancer Prevention , 24 , 106 – 112 . https://doi.org/10.1097/CEJ.0000000000000055 

  5. Ghasemzadeh Rahbardar , M. , Amin , B. , Mehri , S. , Mirnajafi‐Zadeh , S. J. , & Hosseinzadeh , H. ( 2017 ). Anti‐inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain . Biomedicine & Pharmacotherapy , 86 , 441 – 449 . https://doi.org/10.1016/j.biopha.2016.12.049 

  6. Guo , Z. , Li , B. , Gu , J. , Zhu , P. , Su , F. , Bai , R. , … Xie , Y. ( 2019 ). Simultaneous quantification and pharmacokinetic study of nine bioactive components of Orthosiphon stamineus Benth. Extract in rat plasma by UHPLC−MS/MS . Molecules , 24 , 3057 . https://doi.org/10.3390/molecules24173057 

  7. Kabala‐Dzik , A. , Rzepecka‐Stojko , A. , Kubina , R. , Wojtyczka , R. D. , Buszman , E. , & Stojko , J. ( 2018 ). Caffeic acid versus caffeic acid phenethyl ester in the treatment of breast cancer MCF‐7 cells: Migration rate inhibition . Integrative Cancer Therapies , 17 , 1247 – 1259 . https://doi.org/10.1177/1534735418801521 

  8. Khalil , N. , Fekry , M. , Bishr , M. , El‐Zalabani , S. , & Salama , O. ( 2018 ). Foliar spraying of salicylic acid induced accumulation of phenolics, increased radical scavenging activity and modified the composition of the essential oil of water stressed Thymus vulgaris L . Plant Physiology and Biochemistry , 123 , 65 – 74 . https://doi.org/10.1016/j.plaphy.2017.12.007 

  9. Kim , G. D. , Park , Y. S. , Jin , Y. H. , & Park , C. S. ( 2015 ). Production and applications of rosmarinic acid and structurally related compounds . Applied Microbiology and Biotechnology , 99 , 2083 – 2092 . https://doi.org/10.1007/s00253-015-6395-6 

  10. Konishi , Y. , Hitomi , Y. , Yoshida , M. , & Yoshioka , E. ( 2005 ). Pharmacokinetic study of caffeic and rosmarinic acids in rats after oral administration . Journal of Agricultural and Food Chemistry , 53 , 4740 – 4746 . https://doi.org/10.1021/jf0478307 

  11. Liu , Y. , Shen , J. , Xu , L. , Li , H. , Li , Y. , & Yi , L. ( 2017 ). Ferulic acid inhibits neuro‐inflammation in mice exposed to chronic unpredictable mild stress . International Immunopharmacology , 45 , 128 – 134 . https://doi.org/10.1016/j.intimp.2017.02.007 

  12. Lu , P. , Xing , Y. , Xue , Z. , Ma , Z. , Zhang , B. , Peng , H. , … Li , J. ( 2019 ). Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution . Biomedical Chromatography , 33 , e4561 . https://doi.org/10.1002/bmc.4561 

  13. Lucarini , R. , Bernardes , W. A. , Ferreira , D. S. , Tozatti , M. G. , Furtado , R. , Bastos , J. K. , … Cunha , W. R. ( 2013 ). In vivo analgesic and anti‐inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative . Pharmaceutical Biology , 51 , 1087 – 1090 . https://doi.org/10.3109/13880209.2013.776613 

  14. Ma , Z. , Yang , J. , Yang , Y. , Wang , X. , Chen , G. , Shi , A. , … Lu , L. ( 2020 ). Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ‐1 via regulation of the PTEN‐PI3K‐Akt signaling pathway . Phytomedicine , 68 , 153186 . https://doi.org/10.1016/j.phymed.2020.153186 

  15. Makino , T. , Ito , M. , Kiuchiu , F. , Ono , T. , Muso , E. , & Honda , G. ( 2001 ). Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents . Planta Medica , 67 , 24 – 28 . https://doi.org/10.1055/s-2001-10878 

  16. Min , J. , Chen , H. , Gong , Z. , Liu , X. , Wu , T. , Li , W. , … Wang , N. ( 2018 ). Pharmacokinetic and pharmacodynamic properties of rosmarinic acid in rat cholestatic liver injury . Molecules , 23 , 2287 . https://doi.org/10.3390/molecules23092287 

  17. Mori , T. , Koyama , N. , Guillot‐Sestier , M. V. , Tan , J. , & Town , T. ( 2013 ). Ferulic acid is a nutraceutical β ‐secretase modulator that improves behavioral impairment and Alzheimer‐like pathology in transgenic mice . PLoS ONE , 8 , e55774 . https://doi.org/10.1371/journal.pone.0055774 

  18. Ngo , Y. L. , Lau , C. H. , & Chua , L. S. ( 2018 ). Review on rosmarinic acid extraction, fractionation and its anti‐diabetic potential . Food and Chemical Toxicology , 121 , 687 – 700 . https://doi.org/10.1016/j.fct.2018.09.064 

  19. Perez‐Mendoza , M. B. , Llorens‐Escobar , L. , Vanegas‐Espinoza , P. E. , Cifuentes , A. , Ibanez , E. , & Villar‐Martinez , A. A. D. ( 2019 ). Chemical characterization of leaves and calli extracts of Rosmarinus officinalis by UHPLC−MS . Electrophoresis , 2 , 1 – 8 . https://doi.org/10.1002/elps.201900152 

  20. Petersen , M. , & Simmonds , M. S. ( 2003 ). Rosmarinic acid . Phytochemistry , 62 , 121 – 125 . https://doi.org/10.1016/S0031-9422(02)00513-7 

  21. Qiang , Z. , Ye , Z. , Hauck , C. , Murphy , P. A. , McCoy , J. A. , Widrlechner , M. P. , … Hendrich , S. ( 2011 ). Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco‐2 cell monolayers . Journal of Ethnopharmacology , 137 , 1107 – 1112 . https://doi.org/10.1016/j.jep.2011.07.037 

  22. Qiao , S. , Li , W. , Tsubouchi , R. , Haneda , M. , Murakami , K. , Takeuchi , F. , … Yoshino , M. ( 2005 ). Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages . Free Radical Research , 39 , 995 – 1003 . https://doi.org/10.1080/10715760500231836 

  23. Qu , C. , Xu , D. D. , Yue , S. J. , Shen , L. F. , Zhou , G. S. , Chen , Y. Y. , … Duan , J. A. ( 2020 ). Pharmacodynamics and pharmacokinetics of Danshen in isoproterenol‐induced acute myocardial ischemic injury combined with Honghua . Journal of Ethnopharmacology , 247 , 112284 . https://doi.org/10.1016/j.jep.2019.112284 

  24. Sanbongi , C. , Takano , H. , Osakabe , N. , Sasa , N. , Natsume , M. , Yanagisawa , R. , … Yoshikawa , T. ( 2004 ). Rosmarinic acid in Perilla extract inhibits allergic inflammation induced by mite allergen, In a Mouse Model . Clinical and Experimental Allergy , 34 , 971 – 977 . https://doi.org/10.1111/j.1365-2222.2004.01979.x 

  25. Shi , B. , Li , Q. , Feng , Y. , Dai , X. , Zhao , R. , Zhao , Y. , … Zheng , X. ( 2020 ). Pharmacokinetics of 13 active components in a rat model of middle cerebral artery occlusion after intravenous injection of Radix Salviae miltiorrhizae–Lignum Dalbergiae Odoriferae prescription . Journal of Separation Science , 43 , 531 – 546 . https://doi.org/10.1002/jssc.201900748 

  26. Su , C. H. , Pham , T. T. T. , & Chen , H. H. ( 2020 ). Aqueous enzymatic extraction of rosmarinic acid from Salvia officinalis: Optimization using response surface methodology . Phytochemical Analysis , 29 , 1 – 8 . https://doi.org/10.1002/pca.2922 

  27. Su , J. , Jia , F. , Lu , J. , Chen , W. , Sun , H. , Liu , T. , & Wu , X. ( 2020 ). Characterization of the metabolites of rosmarinic acid in human liver microsomes using liquid chromatography combined with electrospray ionization tandem mass spectrometry . Biomedical Chromatography , 34 , e4806 . https://doi.org/10.1002/bmc.4806 

  28. Sudhagar , S. , Sathya , S. , Anuradha , R. , Gokulapriya , G. , Geetharani , Y. , & Lakshmi , B. S. ( 2018 ). Inhibition of epidermal growth factor receptor by ferulic acid and 4‐vinylguaiacol in human breast cancer cells . Biotechnology Letters , 40 , 257 – 262 . https://doi.org/10.1017/s10529-017-2475-2 

  29. Swamy , M. K. , Sinniah , U. R. , & Ghasemzadeh , A. ( 2018 ). Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics . Applied Microbiology Biotechnology , 102 , 7775 – 7793 . https://doi.org/10.1007/s00253-018-9223-y 

  30. US FDA . ( 2008 ). Guidance for industry: Safety testing of drug metabolites , US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research and Center for Veterinary Medicine. 

  31. US FDA . ( 2018 ). Guidance for industry: Bioanalytical method validation . US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research and Center for Veterinary Medicine. 

  32. Wang , J. X. , Li , G. Y. , Rui , T. Q. , Kang , A. , Li , G. C. , Fu , T. M. , … Cai , B. C. ( 2017 ). Pharmacokinetics of rosmarinic acid in rats by LC−MS/MS: Absolute bioavailability and dose proportionality . RSC Advances , 7 , 9057 – 9063 . https://doi.org/10.1039/C6RA28237G 

  33. Wang , X. Y. , Li , W. , Ma , X. H. , Chu , Y. , Li , S. M. , Guo , J. H. , … Zhu , Y. H. ( 2015 ). Simultaneous determination of caffeic acid and its major pharmacologically active metabolites in rat plasma by LC−MS/MS and its application in pharmacokinetic study . Biomedical Chromatography , 29 , 552 – 559 . https://doi.org/10.1002/bmc.3313 

  34. Yang , Y. , Ying , S. , Li , T. , Zhe , J. , Chen , D. , & Wang , J. ( 2018 ). A sensitive LC−MS/MS‐based bioanalytical method for quantification of salviaflaside and rosmarinic acid in rat plasma and its application in a pharmacokinetic study . Biomedical Chromatography , 32 , e4259 . https://doi.org/10.1002/bmc.4259 

  35. Zhang , L. , Xu , H. , & Zhan , L. ( 2018 ). Pharmacokinetic assessments of liquiritin, protocatechuic aldehyde and rosmarinic acid in rat plasma by UPLC−MS–MS after administration of ZibuPiyin Recipe . Journal of Chromatographic Science , 56 , 139 – 146 . https://doi.org/10.1093/chromsci/bmx093 

  36. Zhu , F. , Asada , T. , Sato , A. , Koi , Y. , Nishiwaki , H. , & Tamura , H. ( 2014 ). Rosmarinic acid extract for antioxidant, antiallergic, and α ‐glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from Perilla leaves . Journal of Agricultural and Food Chemistry , 62 , 885 – 892 . https://doi.org/10.1021/jf404318j 

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로