$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Telomeres: history, health, and hallmarks of aging 원문보기

Cell, v.184 no.2, 2021년, pp.306 - 322  

Chakravarti, Deepavali (Department of Cancer Biology, The University of Texas MD Anderson Cancer Center) ,  LaBella, Kyle A. (Department of Cancer Biology, The University of Texas MD Anderson Cancer Center) ,  DePinho, Ronald A. (Department of Cancer Biology, The University of Texas MD Anderson Cancer Center)

Abstract AI-Helper 아이콘AI-Helper

Summary The escalating social and economic burden of an aging world population has placed aging research at center stage. The hallmarks of aging comprise diverse molecular mechanisms and cellular systems that are interrelated and act in concert to drive the aging process. Here, through the lens of ...

참고문헌 (149)

  1. Nat. Med. Allsopp 9 369 2003 10.1038/nm0403-369 Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells 

  2. Mol. Cell. Oncol. Amano 6 e1632613 2019 10.1080/23723556.2019.1632613 Telomeres and sirtuins: at the end we meet again 

  3. Cell Metab. Amano 29 1274 2019 10.1016/j.cmet.2019.03.001 Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease 

  4. EMBO J. Anderson 38 e100492 2019 10.15252/embj.2018100492 Length-independent telomere damage drives post-mitotic cardiomyocyte senescence 

  5. Nat. Rev. Genet. Armanios 13 693 2012 10.1038/nrg3246 The telomere syndromes 

  6. Carcinogenesis Artandi 31 9 2010 10.1093/carcin/bgp268 Telomeres and telomerase in cancer 

  7. Nature Artandi 406 641 2000 10.1038/35020592 Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice 

  8. Science Auluck 295 865 2002 10.1126/science.1067389 Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson’s disease 

  9. Cell Metab. Bai 13 461 2011 10.1016/j.cmet.2011.03.004 PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation 

  10. Nature Baker 479 232 2011 10.1038/nature10600 Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders 

  11. Mech. Ageing Dev. Barnes 177 37 2019 10.1016/j.mad.2018.03.013 The impact of oxidative DNA damage and stress on telomere homeostasis 

  12. J. Clin. Invest. Begus-Nahrmann 122 2283 2012 10.1172/JCI61745 Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis 

  13. Science Bell 348 1036 2015 10.1126/science.aab0015 Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer 

  14. Am. J. Respir. Crit. Care Med. Birch 193 929 2016 10.1164/rccm.201510-2035LE Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis 

  15. Cardiovasc. Res. Birks 79 472 2008 10.1093/cvr/cvn083 Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy 

  16. J. Mol. Biol. Blackburn 120 33 1978 10.1016/0022-2836(78)90294-2 A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena 

  17. Cell Blasco 91 25 1997 10.1016/S0092-8674(01)80006-4 Telomere shortening and tumor formation by mouse cells lacking telomerase RNA 

  18. Science Bodnar 279 349 1998 10.1126/science.279.5349.349 Extension of life-span by introduction of telomerase into normal human cells 

  19. Vet. Pathol. Brayton 49 85 2012 10.1177/0300985811430696 Pathobiology of aging mice and GEM: background strains and experimental design 

  20. Nat. Rev. Cancer Brosh 9 701 2009 10.1038/nrc2693 When mutants gain new powers: news from the mutant p53 field 

  21. Science Brunet 303 2011 2004 10.1126/science.1094637 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase 

  22. Nature Bussian 562 578 2018 10.1038/s41586-018-0543-y Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline 

  23. N. Engl. J. Med. Calado 361 2353 2009 10.1056/NEJMra0903373 Telomere diseases 

  24. Blood Calado 114 2236 2009 10.1182/blood-2008-09-178871 Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells 

  25. Leukemia Calado 26 700 2012 10.1038/leu.2011.272 Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia 

  26. Dis. Model. Mech. Carneiro 9 737 2016 10.1242/dmm.025130 Telomeres in aging and disease: lessons from zebrafish 

  27. Nat. Rev. Genet. Cesare 11 319 2010 10.1038/nrg2763 Alternative lengthening of telomeres: models, mechanisms and implications 

  28. Nat. Commun. Chakravarti 11 4766 2020 10.1038/s41467-020-18420-w Telomere dysfunction activates YAP1 to drive tissue inflammation 

  29. Nat. Genet. Chang 45 473 2013 10.1038/ng.2617 Cancer chromosomes going to POT1 

  30. Genes Dev. Chang 17 88 2003 10.1101/gad.1029903 Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression 

  31. Nat. Genet. Chang 36 877 2004 10.1038/ng1389 Essential role of limiting telomeres in the pathogenesis of Werner syndrome 

  32. Nat. Commun. Chen 8 14929 2017 10.1038/ncomms14929 Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer 

  33. Cell Chin 97 527 1999 10.1016/S0092-8674(00)80762-X p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis 

  34. PLoS Genet. Choi 4 e10 2008 10.1371/journal.pgen.0040010 TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program 

  35. Nat. Genet. Choudhury 39 99 2007 10.1038/ng1937 Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation 

  36. Cancer Cell Colla 27 644 2015 10.1016/j.ccell.2015.04.007 Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome 

  37. Annu. Rev. Pathol. Coppe 5 99 2010 10.1146/annurev-pathol-121808-102144 The senescence-associated secretory phenotype: the dark side of tumor suppression 

  38. Proc. Natl. Acad. Sci. USA Creighton 17 492 1931 10.1073/pnas.17.8.492 A Correlation of Cytological and Genetical Crossing-Over in Zea Mays 

  39. Nature d’Adda di Fagagna 426 194 2003 10.1038/nature02118 A DNA damage checkpoint response in telomere-initiated senescence 

  40. Cell Dang 149 22 2012 10.1016/j.cell.2012.03.003 MYC on the path to cancer 

  41. Annu. Rev. Genet. de Lange 52 223 2018 10.1146/annurev-genet-032918-021921 Shelterin-Mediated Telomere Protection 

  42. Hum. Mol. Genet. Dillon 21 2288 2012 10.1093/hmg/dds049 Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse 

  43. Cell Ding 148 896 2012 10.1016/j.cell.2012.01.039 Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases 

  44. Clin. Ophthalmol. Dow 10 243 2016 10.2147/OPTH.S100042 Evaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study 

  45. Mol. Cell. Biol. Du 24 8437 2004 10.1128/MCB.24.19.8437-8446.2004 Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes 

  46. EBioMedicine Ellison-Hughes 56 102473 2020 10.1016/j.ebiom.2019.09.053 First evidence that senolytics are effective at decreasing senescent cells in humans 

  47. Cancer Res. Farazi 63 5021 2003 Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma 

  48. Cell Fearon 61 759 1990 10.1016/0092-8674(90)90186-I A genetic model for colorectal tumorigenesis 

  49. Science Feng 269 1236 1995 10.1126/science.7544491 The RNA component of human telomerase 

  50. Cancers (Basel) Fernandes 12 1901 2020 10.3390/cancers12071901 Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential 

  51. Curr. Pharm. Des. Fernandez 24 1905 2018 10.2174/1381612824666180316114832 TA-65, A Telomerase Activator improves Cardiovascular Markers in Patients with Metabolic Syndrome 

  52. Science Flores 309 1253 2005 10.1126/science.1115025 Effects of telomerase and telomere length on epidermal stem cell behavior 

  53. Science Flynn 347 273 2015 10.1126/science.1257216 Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors 

  54. Nat. Genet. Fredriksson 46 1258 2014 10.1038/ng.3141 Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types 

  55. Nat. Genet. Gao 48 1119 2016 10.1038/ng.3641 Punctuated copy number evolution and clonal stasis in triple-negative breast cancer 

  56. Nat. Cell Biol. Ghosh 14 1270 2012 10.1038/ncb2621 Telomerase directly regulates NF-κB-dependent transcription 

  57. Age (Dordr.) Gonzalez-Guardia 36 9681 2014 10.1007/s11357-014-9681-9 Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study 

  58. Cell Greenberg 97 515 1999 10.1016/S0092-8674(00)80761-8 Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse 

  59. Cell Greider 43 405 1985 10.1016/0092-8674(85)90170-9 Identification of a specific telomere terminal transferase activity in Tetrahymena extracts 

  60. Nature Greider 337 331 1989 10.1038/337331a0 A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis 

  61. Cell Griffith 97 503 1999 10.1016/S0092-8674(00)80760-6 Mammalian telomeres end in a large duplex loop 

  62. Nature Hahn 400 464 1999 10.1038/22780 Creation of human tumour cells with defined genetic elements 

  63. Cell Harel 160 1013 2015 10.1016/j.cell.2015.01.038 A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate 

  64. Nature Harley 345 458 1990 10.1038/345458a0 Telomeres shorten during ageing of human fibroblasts 

  65. Rejuvenation Res. Harley 14 45 2011 10.1089/rej.2010.1085 A natural product telomerase activator as part of a health maintenance program 

  66. Science Harrington 275 973 1997 10.1126/science.275.5302.973 A mammalian telomerase-associated protein 

  67. Nature Hastie 346 866 1990 10.1038/346866a0 Telomere reduction in human colorectal carcinoma and with ageing 

  68. Exp. Cell Res. Hayflick 37 614 1965 10.1016/0014-4827(65)90211-9 The Limited in Vitro Lifetime of Human Diploid Cell Strains 

  69. Exp. Cell Res. Hayflick 25 585 1961 10.1016/0014-4827(61)90192-6 The serial cultivation of human diploid cell strains 

  70. Science Heaphy 333 425 2011 10.1126/science.1207313 Altered telomeres in tumors with ATRX and DAXX mutations 

  71. Oncogene Henson 21 598 2002 10.1038/sj.onc.1205058 Alternative lengthening of telomeres in mammalian cells 

  72. Science Hoffmeyer 336 1549 2012 10.1126/science.1218370 Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells 

  73. Cells Hong 8 392 2019 10.3390/cells8050392 Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases 

  74. Science Horn 339 959 2013 10.1126/science.1230062 TERT promoter mutations in familial and sporadic melanoma 

  75. Nat. Rev. Mol. Cell Biol. Houtkooper 13 225 2012 10.1038/nrm3293 Sirtuins as regulators of metabolism and healthspan 

  76. Aging Cell Hsieh 12 269 2013 10.1111/acel.12053 Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts 

  77. Cell Hu 148 651 2012 10.1016/j.cell.2011.12.028 Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer 

  78. Nature 578 82 2020 10.1038/s41586-020-1969-6 Pan-cancer analysis of whole genomes 

  79. Nature Jaskelioff 469 102 2011 10.1038/nature09603 Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice 

  80. Aging Cell Jonassaint 12 319 2013 10.1111/acel.12041 The gastrointestinal manifestations of telomere-mediated disease 

  81. FASEB J. Kakimura 16 601 2002 10.1096/fj.01-0530fje Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins 

  82. Cell Kamijo 91 649 1997 10.1016/S0092-8674(00)80452-3 Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF 

  83. Mutat. Res. Kaneko 316 277 1996 10.1016/S0921-8734(96)90010-7 Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging 

  84. Proc. Natl. Acad. Sci. USA Killela 110 6021 2013 10.1073/pnas.1303607110 TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal 

  85. Eur. J. Cancer Kipling 33 792 1997 10.1016/S0959-8049(97)00060-9 Telomere structure and telomerase expression during mouse development and tumorigenesis 

  86. Nature Kipling 347 400 1990 10.1038/347400a0 Hypervariable ultra-long telomeres in mice 

  87. J. Biol. Chem. Klucken 279 25497 2004 10.1074/jbc.M400255200 Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity 

  88. Genes Dev. Lai 22 1948 2008 10.1101/gad.1661708 Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart 

  89. Cytogenet. Genome Res. Laish 150 93 2016 10.1159/000454654 Telomere Dysfunction in Nonalcoholic Fatty Liver Disease and Cryptogenic Cirrhosis 

  90. Nature Lee 392 569 1998 10.1038/33345 Essential role of mouse telomerase in highly proliferative organs 

  91. EMBO J. Leri 22 131 2003 10.1093/emboj/cdg013 Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation 

  92. Nat. Cell Biol. Li 22 282 2020 10.1038/s41556-020-0471-6 Programmable base editing of mutated TERT promoter inhibits brain tumour growth 

  93. Science Lingner 276 561 1997 10.1126/science.276.5312.561 Reverse transcriptase motifs in the catalytic subunit of telomerase 

  94. Nature Loayza 423 1013 2003 10.1038/nature01688 POT1 as a terminal transducer of TRF1 telomere length control 

  95. Cell Lopez-Otin 153 1194 2013 10.1016/j.cell.2013.05.039 The hallmarks of aging 

  96. J. Gerontol. A Biol. Sci. Med. Sci. Ludlow 69 821 2014 10.1093/gerona/glt211 Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers 

  97. Nat. Rev. Mol. Cell Biol. Maciejowski 18 175 2017 10.1038/nrm.2016.171 Telomeres in cancer: tumour suppression and genome instability 

  98. Nat. Rev. Genet. Melzer 21 88 2020 10.1038/s41576-019-0183-6 The genetics of human ageing 

  99. Cancer Cell Mender 38 400 2020 10.1016/j.ccell.2020.05.020 Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity 

  100. Cell Meyerson 90 785 1997 10.1016/S0092-8674(00)80538-3 hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization 

  101. Nat. Commun. Missios 5 4924 2014 10.1038/ncomms5924 Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice 

  102. Nat. Rev. Neurosci. Muchowski 6 11 2005 10.1038/nrn1587 Modulation of neurodegeneration by molecular chaperones 

  103. Collecting Net Muller 8 182 1938 The remaking of chromosomes 

  104. Cell Stem Cell Nagpal 26 896 2020 10.1016/j.stem.2020.03.016 Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells 

  105. Nature Nassour 565 659 2019 10.1038/s41586-019-0885-0 Autophagic cell death restricts chromosomal instability during replicative crisis 

  106. Nature Navin 472 90 2011 10.1038/nature09807 Tumour evolution inferred by single-cell sequencing 

  107. Cancer Cell O’Hagan 2 149 2002 10.1016/S1535-6108(02)00094-6 Telomere dysfunction provokes regional amplification and deletion in cancer genomes 

  108. J. Theor. Biol. Olovnikov 41 181 1973 10.1016/0022-5193(73)90198-7 A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon 

  109. Ageing Res. Rev. Opresko 33 52 2017 10.1016/j.arr.2016.05.009 Telomere-associated aging disorders 

  110. Nature Park 460 66 2009 10.1038/nature08137 Telomerase modulates Wnt signalling by association with target gene chromatin 

  111. Genes Dev. Pech 29 2420 2015 10.1101/gad.271783.115 High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells 

  112. Aging Cell Pignolo 7 23 2008 10.1111/j.1474-9726.2007.00350.x Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis 

  113. Cell Puente 157 565 2014 10.1016/j.cell.2014.03.032 The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response 

  114. Nature Reya 434 843 2005 10.1038/nature03319 Wnt signalling in stem cells and cancer 

  115. Nature Rheinbay 578 102 2020 10.1038/s41586-020-1965-x Analyses of non-coding somatic drivers in 2,658 cancer whole genomes 

  116. Gastroenterology Risques 135 410 2008 10.1053/j.gastro.2008.04.008 Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage 

  117. Cancer Res. Risques 71 1669 2011 10.1158/0008-5472.CAN-10-1966 Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation 

  118. Nat. Rev. Mol. Cell Biol. Roake 21 384 2020 10.1038/s41580-020-0234-z Regulation of human telomerase in homeostasis and disease 

  119. Nature Rodgers 434 113 2005 10.1038/nature03354 Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 

  120. Cancer Treat. Rev. Ruden 39 444 2013 10.1016/j.ctrv.2012.06.007 Novel anticancer therapeutics targeting telomerase 

  121. Cell Rudolph 96 701 1999 10.1016/S0092-8674(00)80580-2 Longevity, stress response, and cancer in aging telomerase-deficient mice 

  122. Science Rudolph 287 1253 2000 10.1126/science.287.5456.1253 Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery 

  123. Nat. Genet. Rudolph 28 155 2001 10.1038/88871 Telomere dysfunction and evolution of intestinal carcinoma in mice and humans 

  124. Cell Sacco 143 1059 2010 10.1016/j.cell.2010.11.039 Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice 

  125. Nature Sahin 470 359 2011 10.1038/nature09787 Telomere dysfunction induces metabolic and mitochondrial compromise 

  126. Nature Sarin 436 1048 2005 10.1038/nature03836 Conditional telomerase induction causes proliferation of hair follicle stem cells 

  127. Cell Saxton 169 361 2017 10.1016/j.cell.2017.03.035 mTOR Signaling in Growth, Metabolism, and Disease 

  128. Cell Schaetzlein 130 863 2007 10.1016/j.cell.2007.08.029 Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice 

  129. EMBO J. Schepers 30 1104 2011 10.1038/emboj.2011.26 Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes 

  130. Exp. Cell Res. Shay 196 33 1991 10.1016/0014-4827(91)90453-2 A role for both RB and p53 in the regulation of human cellular senescence 

  131. Mol. Cell. Biol. Smogorzewska 20 1659 2000 10.1128/MCB.20.5.1659-1668.2000 Control of human telomere length by TRF1 and TRF2 

  132. Nat. Genet. Sottoriva 47 209 2015 10.1038/ng.3214 A Big Bang model of human colorectal tumor growth 

  133. Nat. Cell Biol. Sperka 14 73 2011 10.1038/ncb2388 Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction 

  134. Cell Tomas-Loba 135 609 2008 10.1016/j.cell.2008.09.034 Telomerase reverse transcriptase delays aging in cancer-resistant mice 

  135. Nat. Genet. Totoki 46 1267 2014 10.1038/ng.3126 Trans-ancestry mutational landscape of hepatocellular carcinoma genomes 

  136. N. Engl. J. Med. Townsley 374 1922 2016 10.1056/NEJMoa1515319 Danazol Treatment for Telomere Diseases 

  137. Nature Trifunovic 429 417 2004 10.1038/nature02517 Premature ageing in mice expressing defective mitochondrial DNA polymerase 

  138. Nature Tyner 415 45 2002 10.1038/415045a p53 mutant mice that display early ageing-associated phenotypes 

  139. Am. J. Pathol. van Heek 161 1541 2002 10.1016/S0002-9440(10)64432-X Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia 

  140. Cell van Steensel 92 401 1998 10.1016/S0092-8674(00)80932-0 TRF2 protects human telomeres from end-to-end fusions 

  141. Am. J. Hum. Genet. Vaziri 52 661 1993 Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes 

  142. Genes Dev. Wang 12 1769 1998 10.1101/gad.12.12.1769 Myc activates telomerase 

  143. Nat. New Biol. Watson 239 197 1972 10.1038/newbio239197a0 Origin of concatemeric T7 DNA 

  144. Science Westerheide 323 1063 2009 10.1126/science.1165946 Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1 

  145. FASEB J. Wiemann 16 935 2002 10.1096/fj.01-0977com Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis 

  146. Proc. Natl. Acad. Sci. USA Won 101 11328 2004 10.1073/pnas.0401801101 Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells 

  147. Nature Wong 421 643 2003 10.1038/nature01385 Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing 

  148. Dev. Genet. Wright 18 173 1996 10.1002/(SICI)1520-6408(1996)18:2<173::AID-DVG10>3.0.CO;2-3 Telomerase activity in human germline and embryonic tissues and cells 

  149. Genes Dev. Yang 34 1392 2020 10.1101/gad.328575.119 Break-induced replication promotes fragile telomere formation 

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로