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Analytical chemistry, v.93 no.7, 2021년, pp.3576 - 3585
Skottvoll, Frøydis Sved (Department of Chemistry , University of Oslo , P.O. Box 1033, Blindern, NO-0315 Oslo , Norway) , Hansen, Frederik André (Department of Pharmacy , University of Oslo , P.O. Box 1068, Blindern, NO-0316 Oslo , Norway) , Harrison, Sean (Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine , University of Oslo , P.O. Box 1112, Blindern, NO-0317 Oslo , Norway) , Boger, Ida Sneis (Department of Chemistry , University of Oslo , P.O. Box 1033, Blindern, NO-0315 Oslo , Norway) , Mrsa, Ago (Department of Chemistry , University of Oslo , P.O. Box 1033, Blindern, NO-0315 Oslo , Norway) , Restan, Magnus Saed (Department of Pharmacy , University of Oslo , P.O. Box 1068, Blindern, NO-0316 Oslo , Norway) , Stein, Matthias (Institute of Medicinal and Pharmaceutical Chemistry , TU Braunschweig , Beethovenstr. 55 , DE-38106 Braunschweig , Germany) , Lundanes, Elsa (Department of Chemistry , Universi) , Pedersen-Bjergaard, Stig , Aizenshtadt, Aleksandra , Krauss, Stefan , Sullivan, Gareth , Bogen, Inger Lise , Wilson, Steven Ray
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Liver organoids are emerging tools for precision drug development and toxicity screening. We demonstrate that electromembrane extraction (EME) based on electrophoresis across an oil membrane is suited for segregating selected organoid-derived drug metabolites prior to mass spectrometry (MS)-based me...
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