Dall’Oglio, Federica
(Dermatology Clinic, University of Catania, Catania, Italy)
,
Musumeci, Maria Letizia
(Dermatology Clinic, University of Catania, Catania, Italy)
,
Puglisi, Davide Francesco
(Dermatology Clinic, University of Catania, Catania, Italy)
,
Micali, Giuseppe
(Dermatology Clinic, University of Catania, Catania, Italy)
AbstractBackgroundDiaper dermatitis (DD) is an acute inflammatory reaction, regardless of the cause, of the diaper‐covered area. Topical skin barrier repair cosmetic products are the mainstay treatment to cure and/or prevent DD.AimsTo assess the efficacy/tolerability of a zinc gluconate‐...
AbstractBackgroundDiaper dermatitis (DD) is an acute inflammatory reaction, regardless of the cause, of the diaper‐covered area. Topical skin barrier repair cosmetic products are the mainstay treatment to cure and/or prevent DD.AimsTo assess the efficacy/tolerability of a zinc gluconate‐taurine/zinc oxide and panthenol/ glycerin/ Butyrospermum parkii butter barrier cream using clinical evaluation.MethodsIn this prospective, open‐label trial, 20 patients (10 infants/10 adults), with mild/moderate DD enrolled at the Dermatology University Clinic of Catania (Italy) were instructed to apply the cream twice daily for 30 days. Degree of erythema was performed clinically by a 5‐point severity scale (from 0 = no erythema to 4 = severe erythema), at baseline, at 15 and 30 days. An Investigator Global Assessment (IGA) using a 6‐point scale (from −1 = worsening to 4 = complete response/clear) along with product tolerability was also performed at 15 and 30 days. Statistical analysis was performed using SAS version 9.ResultsAt 15 days, a reduction of clinical erythema assessment (CEA) from baseline was observed (mean from 3.2 ± 0.8 to 2.5 ± 0.3; p < 0.06), that although nonsignificant, showed a significant progressive improvement at 30 days (mean from 3.2 ± 0.8 to 1.1 ± 0.9; p < 0.0001) without any age differences.ConclusionsOur preliminary results indicate that the tested barrier cream may represent a promising approach in DD rash. It may be used in mild‐to‐moderate forms in monotherapy without significant side effects or, where required, in association with pharmacological agents. Its long‐term use is likely safe.
AbstractBackgroundDiaper dermatitis (DD) is an acute inflammatory reaction, regardless of the cause, of the diaper‐covered area. Topical skin barrier repair cosmetic products are the mainstay treatment to cure and/or prevent DD.AimsTo assess the efficacy/tolerability of a zinc gluconate‐taurine/zinc oxide and panthenol/ glycerin/ Butyrospermum parkii butter barrier cream using clinical evaluation.MethodsIn this prospective, open‐label trial, 20 patients (10 infants/10 adults), with mild/moderate DD enrolled at the Dermatology University Clinic of Catania (Italy) were instructed to apply the cream twice daily for 30 days. Degree of erythema was performed clinically by a 5‐point severity scale (from 0 = no erythema to 4 = severe erythema), at baseline, at 15 and 30 days. An Investigator Global Assessment (IGA) using a 6‐point scale (from −1 = worsening to 4 = complete response/clear) along with product tolerability was also performed at 15 and 30 days. Statistical analysis was performed using SAS version 9.ResultsAt 15 days, a reduction of clinical erythema assessment (CEA) from baseline was observed (mean from 3.2 ± 0.8 to 2.5 ± 0.3; p < 0.06), that although nonsignificant, showed a significant progressive improvement at 30 days (mean from 3.2 ± 0.8 to 1.1 ± 0.9; p < 0.0001) without any age differences.ConclusionsOur preliminary results indicate that the tested barrier cream may represent a promising approach in DD rash. It may be used in mild‐to‐moderate forms in monotherapy without significant side effects or, where required, in association with pharmacological agents. Its long‐term use is likely safe.
1 Šikić Pogačar M , Maver U , Marčun Varda N , Mičetić‐Turk D . Diagnosis and management of diaper dermatitis in infants with emphasis on skin microbiota in the diaper area . Int J Dermatol . 2018 ; 57 ( 3 ): 265 ‐ 275 . 28986935
2 Tüzün Y , Wolf R , Bağlam S , Engin B . Diaper (napkin) dermatitis: A fold (intertriginous) dermatosis . Clin Dermatol . 2015 ; 33 ( 4 ): 477 ‐ 482 . 26051065
3 Bonifazi A , Saldaña M , Escandón‐Pérez S , Tirado‐Sánchez A . Diaper dermatitis in elderly . J Dermatitis . 2017 ; 2 ( 1 ): 106 ‐ 108 .
4 Blume‐Peytavi U , Kanti V . Prevention and treatment of diaper dermatitis . Pediatr Dermatol . 2018 ; 35 ( Suppl 1 ): s19 ‐ s23 . 29596731
5 Gupta M , Mahajan VK , Mehta KS , Chauhan PS . Zinc therapy in dermatology: a review . Dermatol Res Pract . 2014 ; 2014 : 709152 . 25120566
6 Zinc‐gluconate . [Access date 2021 Jan 25]. https://thedermreview.com/zinc‐gluconate
11 Verma N , Chakrabarti R , Das RH , Gautam HK . Anti‐inflammatory effects of shea butter through inhibition of iNOS, COX‐2, and cytokines via the Nf‐κB pathway in LPS‐activated J774 macrophage cells . J Complement Integr Med . 2012 ; 9 : Article 4 . 22499721
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