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[해외논문] Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors 원문보기

Cell reports, v.34 no.8, 2021년, pp.108780 -   

Kweon, Hanseul (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Jung, Won Beom (Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS)) ,  Im, Geun Ho (Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS)) ,  Ryoo, Jia (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Lee, Joon-Hyuk (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Do, Hogyeong (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)) ,  Choi, Yeonsoo (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)) ,  Song, You-Hyang (Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)) ,  Jung, Hwajin (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) Korea<) ,  Park, Haram ,  Qiu, Lily R. ,  Ellegood, Jacob ,  Shim, Hyun-Ji ,  Yang, Esther ,  Kim, Hyun ,  Lerch, Jason P. ,  Lee, Seung-Hee ,  Chung, Won-Suk ,  Kim, Daesoo ,  Kim, Seong-Gi ,  Kim, Eunjoon

Abstract AI-Helper 아이콘AI-Helper

Summary CHD8 (chromodomain helicase DNA-binding protein 8) is a chromatin remodeler associated with autism spectrum disorders. Homozygous Chd8 deletion in mice leads to embryonic lethality, making it difficult to assess whether CHD8 regulates brain development and whether CHD8 haploinsufficiency-re...

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