[논문]Effects of L -Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study

Baba, Yoshitake; Inagaki, Shun; Nakagawa, Sae; Kaneko, Toshiyuki; Kobayashi, Makoto; Takihara, Takanobu

doi:10.1089/jmf.2020.4803

Effects of L -Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study

Journal of medicinal food, v.24 no.4, 2021년, pp.333 - 341

Baba, Yoshitake (Central Research Institute, ITO EN, LTD., Shizuoka, Japan.) , Inagaki, Shun (Central Research Institute, ITO EN, LTD., Shizuoka, Japan.) , Nakagawa, Sae (Central Research Institute, ITO EN, LTD., Shizuoka, Japan.) , Kaneko, Toshiyuki (Tokyo Skytree Station Medical Clinic, Tokyo, Japan.) , Kobayashi, Makoto (Central Research Institute, ITO EN, LTD., Shizuoka, Japan.) , Takihara, Takanobu (Central Research Institute, ITO EN, LTD., Shizuoka, Japan.)

Abstract ▼ AI-Helper

L-theanine (γ-glutamylethylamide), an amino acid in green tea, has been shown to affect brain functions by relieving stress disorders, improving mood, and maintaining normal sleep. However, the cognitive functions for which theanine is effective are unclear. This study aimed to clarify which cognitive functions are positively affected by intake of L-theanine. A double-blind, randomized, placebo-controlled study was conducted. The subjects were Japanese men and women aged 50-69 years. Mini Mental State Examination-Japanese version score was 24 or higher. Cognitrax was used as a test battery for cognitive function. Evaluations were performed before the intervention, after a single dose of L-theanine, and after 12 weeks of regular intake. The single dose of L-theanine reduced the reaction time to attention tasks (Stroop test, Part 1), and it increased the number of correct answers and decreased the number of omission errors in working memory tasks (4-Part continuous performance test, Part 4). In conclusion, our study indicated that L-theanine may contribute to improving attention, thus enhancing working memory and executive functions. Clinical Trial No.: UMIN000033812.

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참고문헌 (36)

1. Sakato Y : Studies on the chemical constituents of tea; III. A new amide theanine . Nippon Nogeikagaku Kaishi (Japanese) 1949 ; 23 : 262 ？ 267
2. Casimir J , Jadot J , Renard M : Separation and characterization of N-ethyl-gamma-glutamine from Xerocomus badius . Biochim Biophys Acta 1960 ; 39 : 462 ？ 468 13808157
3. Goto T , Yoshida Y , Amano I , Horie H : Chemical composition of commercially available Japanese green tea . Foods Food Ingredients J Jpn 1996 ; 170 : 46 ？ 51
4. Yoneda Y , Kuramoto N , Kawada K : The role of glutamine in neurogenesis promoted by the green tea amino acid theanine in neural progenitor cells for brain health . Neurochem Int 2019 ; 129 : 104505 31310779

상세보기
5. Tamano H , Fukura K , Suzuki M , Sakamoto K , Yokogoshi H , Takeda A : Preventive effect of theanine intake on stress-induced impairments of hippocamapal long-term potentiation and recognition memory . Brain Res Bull 2013 ; 95 : 1 ？ 6 23458739

상세보기
6. Unno K , Fujitani K , Takamori N , et al. : Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice . Free Radic Res 2011 ; 45 : 966 ？ 974 21425911

상세보기
7. Nguyen BT , Sharma N , Shin EJ , et al. : Theanine attenuates memory impairments induced by klotho gene depletion in mice . Food Funct 2019 ; 10 : 325 ？ 332 30574980

상세보기
8. Noguchi-Shinohara M , Sohshi Y , Dohmoto C , et al. : Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline . PLoS One 2014 ; 9 : e96013 24828424

상세보기
9. Kuriyama S , Hozawa A , Ohmori K , et al. : Green tea consumption and cognitive function: A cross-sectional study from the Tsurugaya Project . Am J Clin Nutr 2006 ; 83 : 355 ？ 361 16469995

상세보기
10. Sekita A , Ninomiya T , Tanizaki Y , et al. : Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: The Hisayama Study . Acta Psychiatr Scand 2010 ; 122 : 319 ？ 325 20626720

상세보기
11. Ninomiya T : Japanese legacy cohort studies: The Hisayama Study . J Epidemiol 2018 ; 28 : 444 ？ 451 30298863
12. Lieberman HR , Wurtman RJ , Emde GG , Roberts C , Coviella ILG : The effects of low doses of caffeine on human performance and mood . Psychopharmacology (Berl) 1987 ; 92 : 308 ？ 312 3114783
13. Smit HJ , Rogers PJ : Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers . Psychopharmacology (Berl) 2000 ; 152 : 167 ？ 173 11057520
14. Takeda A , Sakamoto K , Tamano H , et al. : Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory . Cell Mol Neurobiol 2011 ; 31 : 1079 ？ 1088 21604187

상세보기
15. Chang X , Rong C , Chen Y , et al. : (-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression . Exp Cell Res 2015 ; 334 : 136 ？ 145 25882496

상세보기
16. Gundimeda U , McNeil TH , Fan TK , et al. : Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: Role of 67-kDa laminin receptor and hydrogen peroxide . Biochem Biophys Res Commun 2014 ; 445 : 218 ？ 224 24508265

상세보기
17. Addicot MA , Laurienti PJ : A comparison of the effects of caffeine following abstinence and normal caffeine use . Psychopharmacology (Berl) 2009 ; 207 : 423 ？ 431 19777214
18. Baba Y , Takihara T , Sagesaka Y , Kaneko T : Effects of a daily intake of matcha on cognitive function in middle-aged and older subjects―A placebo-controlled, randomized, double-blind, parallel-group study . Jpn Pharmacol Ther 2019 ; 47 : 1689 ？ 1702
19. Kakuda T , Yanase H , Utsunomiya K , Nozawa A , Unno T , Kataoka K : Protective effect of γ -glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils . Neurosci Lett 2000 ; 289 : 189 ？ 192 10961661
20. Kakuda T , Nozawa A , Sugimoto A , Niino H : Inhibition by theanine of binding of [3H]AMPA, [3H]Kainate, and [3H]MDL 105,519 to glutamate receptors . Biosci Biotechnol Biochem 2002 ; 66 : 2683 ？ 2686 12596867

상세보기
21. Ogura M , Kakuda T , Takarada T , et al. : Promotion of both proliferation and neuronal differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter slc38a1 . PLoS One 2012 ; 7 : e48270 23110224

상세보기
22. Folstein MF , Folstein SE , McHugh PR : ‘Mini-mental state’: A practical method for grading the cognitive state of patients for the clinician . J Psychiatr Res 1975 ; 12 : 189 ？ 198 1202204

상세보기
23. Sugishita M , Hemmi I , Tomoko T : Reexamination of the validity and reliability of the Japanese version of the Mini-Mental State Examination (MMSE-J) . Jpn J Cogn Neurosci 2016 ; 18 : 168 ？ 183
24. Gualtieri CT , Johnson LG : Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs . Arch Clin Neuropsychol 2006 ; 21 : 623 ？ 643 17014981

상세보기
25. Keenan EK , Finnie MDA , Jones PS , Rogers PJ , Priestley CM : How much theanine in a cup of tea? Effects of tea type and method of preparation . Food Chem 2011 ; 125 : 588 ？ 594

상세보기
26. Huang ZL , Qu WM , Eguchi N , et al. : Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine . Nat Neurosci 2005 ; 8 : 858 ？ 859 15965471

상세보기
27. Kakuda T , Nozawa A , Unno T , Okamura N , Okai O : Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat . Biosci Biotechnol Biochem 2000 ; 64 : 287 ？ 293 10737183

상세보기
28. Haskell CF , Kennedy DO , Milne AL , Wesnes KA , Scholey AB : The effects of L-theanine, caffeine and their combination on cognition and mood . Biol Psychol 2008 ; 77 : 113 ？ 122 18006208

상세보기
29. Kobayashi K , Nagato Y , Aoi N , et al. : Effects of L-Theanine on the release of alpha-brain waves in human volunteers . J Agric Chem Soc Jpn 1998 ; 72 : 153 ？ 157
30. Nobre AC , Rao A , Owen GN : L-theanine, a natural constituent in tea, and its effect on mental state . Asia Pac J Clin Nutr 2008 ; 17 : 167 ？ 168 18296328

상세보기
31. Gomez-Ramirez M , Higgins BA , Rycroft JA , et al. : The deployment of intersensory selective attention: A high-density electrical mapping study of the effects of theanine . Clin Neuropharmacol 2007 ; 30 : 25 ？ 38 17272967

상세보기
32. Gomez-Ramirez M , Kelly SP , Montesi JL , Foxe JJ : The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task . Brain Topogr 2009 ; 22 : 44 ？ 51 18841456

상세보기
33. Baddeley A : The episodic buffer: A new component of working memory? Trends Cogn Sci 2000 ; 4 : 417 ？ 423 11058819
34. Hideya K : Neuroscience of working memory . Jpn J Geriatr Psychiatry 2014 ; 25 : 504 ？ 508
35. Ide K , Yamada H , Takuma N , et al. : Green tea consumption affects cognitive dysfunction in the elderly: A pilot study . Nutrients 2014 ; 6 : 4032 ？ 4042 25268837

상세보기
36. Kataoka Y , Utsunomiya K , Kimbara N , Fukushima K , Mori T , Shiba J : Preventive effect of green tea containing theanine at a high concentration on dementia in aged volunteers . J Jpn Mibyou Syst Assoc [In Japanese] 2009 ; 15 : 17 ？ 23

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Effects of L -Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study

Abstract ▼ AI-Helper

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