$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Siraitia grosvenorii Residual Extract Attenuates Atopic Dermatitis by Regulating Immune Dysfunction and Skin Barrier Abnormality 원문보기

Nutrients, v.12 no.12, 2020년, pp.3638 -   

Sung, Yoon-Young (Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Korea) ,  Yuk, Heung-Joo (yysung@kiom.re.kr (Y.-Y.S.)) ,  Yang, Won-Kyung (yukhj@kiom.re.kr (H.-J.Y.)) ,  Kim, Seung-Hyung (Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Korea) ,  Kim, Dong-Seon (yysung@kiom.re.kr (Y.-Y.S.))

Abstract AI-Helper 아이콘AI-Helper

Atopic dermatitis is a persistent inflammatory skin disorder. Siraitia grosvenorii fruits (monk fruit or nahangwa in Korean, NHG) are used as a natural sweetener and as a traditional medicine for the treatment of asthma and bronchitis. We evaluated the activity of S. grosvenorii residual extract (NH...

주제어

참고문헌 (30)

  1. 1. Wallach D. Taieb A. Atopic dermatitis/atopic eczema Chem. Immunol. Allergy 2014 100 81 96 24925387 

  2. 2. Brunner P.M. Silverberg J.I. Guttman-Yassky E. Paller A.S. Kabashima K. Amagai M. Luger T.A. Deleuran M. Werfel T. Eyerich K. Councilors of the International Eczema Council. Increasing comorbidities suggest that atopic dermatitis is a systemic disorder J. Invest. Dermatol. 2017 137 18 25 10.1016/j.jid.2016.08.022 27771048 

  3. 3. Oliveira C. Torres T. More than skin deep: The systemic nature of atopic dermatitis Eur. J. Dermatol. 2019 29 250 258 31122909 

  4. 4. Weidinger S. Novak N. Atopic dermatitis Lancet 2016 387 1109 1122 10.1016/S0140-6736(15)00149-X 26377142 

  5. 5. Thyssen J.P. Kezic S. Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis J. Allergy Clin. Immunol. 2014 134 792 799 10.1016/j.jaci.2014.06.014 25065719 

  6. 6. Yamada K. Matsushita K. Wang J. Kanekura T. Topical glucose induces claudin-1 and filaggrin expression in a mouse model of atopic dermatitis and in keratinocyte culture, exerting anti-inflammatory effects by repairing skin barrier function Acta Derm. Venereol. 2018 98 19 25 10.2340/00015555-2807 28967978 

  7. 7. Gruber R. Bornchen C. Rose K. Daubmann A. Volksdorf T. Wladykowski E. Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis Am. J. Pathol. 2015 185 2777 2789 10.1016/j.ajpath.2015.06.021 26319240 

  8. 8. Howell M.D. Kim B.E. Gao P. Grant A.V. Boguniewicz M. DeBenedetto A. Schneider L. Beck L.A. Barnes K.C. Leung D.Y. Cytokine modulation of atopic dermatitis filaggrin skin expression Allergy Clin. Immunol. 2009 124 R7 R12 10.1016/j.jaci.2009.07.012 

  9. 9. Spergel J.M. Mizoguchi E. Oettgen H. Bhan A.K. Geha R.S. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis J. Clin. Invest. 1999 103 1103 1111 10.1172/JCI5669 10207161 

  10. 10. Werfel T. The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis J. Invest. Dermatol. 2009 129 1878 10.1038/jid.2009.71 19357709 

  11. 11. Thangam E.B. Jemima E.A. Singh H. Baig M.S. Khan M. Mathias C.B. Church M.K. Saluja R. The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: The hunt for new therapeutic targets Front. Immunol. 2018 9 1873 10.3389/fimmu.2018.01873 30150993 

  12. 12. Jutel M. Akdis C.A. Histamine as an immune modulator in chronic inflammatory responses Clin. Exp. Allergy 2007 37 308 310 10.1111/j.1365-2222.2007.02666.x 17359380 

  13. 13. Murata Y. Ogawa T. Suzuki Y.A. Yoshikawa S. Inui H. Sugiura M. Nakano Y. Digestion and absorption of Siraitia grosvenorii triterpenoids in the rat Biosci. Biotechnol. Biochem. 2010 74 673 676 10.1271/bbb.90832 20208371 

  14. 14. Gong X. Chen N. Ren K. Jia J. Wei K. Zhang L. Lv Y. Wang J. Li M. The fruits of Siraitia grosvenorii : A review of a Chinese food-medicine Front. Pharmacol. 2019 10 1400 10.3389/fphar.2019.01400 31849659 

  15. 15. Sung Y.Y. Kim H.K. Crocin ameliorates atopic dermatitis symptoms by down regulation of Th2 response via blocking of NF-κB/STAT6 signaling pathways in mice Nutrients 2018 10 1625 10.3390/nu10111625 

  16. 16. Yamamoto M. Haruna T. Yasui K. Takahashi H. Iduhara M. Takaki S. Deguchi M. Arimura A. A novel atopic dermatitis model induced by topical application with Dermatophagoides farinae extract in NC/Nga mice Allergol. Int. 2007 56 139 148 10.2332/allergolint.O-06-458 17460441 

  17. 17. Li C. Lin L.M. Sui F. Wang Z.M. Huo H.R. Dai L. Jiang T.L. Chemistry and pharmacology of Siraitia grosvenorii : A review Chin. J. Nat. Med. 2014 12 89 102 10.1016/S1875-5364(14)60015-7 24636058 

  18. 18. Lu Y. Zhu S. He Y. Mo C. Wu C. Zhang R. Zheng X. Tang Q. Systematic characterization of flavonoids from Siraitia grosvenorii leaf extract using an integrated strategy of high-speed counter-current chromatography combined with ultra high performance liquid chromatography and electrospray ionization quadrupole time-of-flight mass spectrometry J. Sep. Sci. 2020 43 852 864 31773887 

  19. 19. Simon D. Braathen L.R. Simon H.U. Eosinophils and atopic dermatitis Allergy 2004 59 561 570 10.1111/j.1398-9995.2004.00476.x 15147438 

  20. 20. Sung Y.Y. Kim Y.S. Kim H.K. Illicium verum extract inhibits TNF-α- and IFN-γ-induced expression of chemokines and cytokines in human keratinocytes J. Ethnopharmacol. 2012 144 182 189 10.1016/j.jep.2012.08.049 22974545 

  21. 21. Yang J.H. Lee E. Lee B. Cho W.K. Ma J.Y. Park K.I. Ethanolic extracts of Artemisia apiacea Hance improved atopic dermatitis-like skin lesions in vivo and suppressed TNF-alpha/IFN-gamma-induced proinflammatory chemokine production in vitro Nutrients 2018 10 806 10.3390/nu10070806 29932162 

  22. 22. Sung Y.Y. Kim S.H. Yuk H.J. Yang W.K. Lee Y.M. Son E. Kim D.S. Siraitia grosvenorii residual extract attenuates ovalbumin-induced lung inflammation by down-regulating IL-4, IL-5, IL-13, IL-17, and MUC5AC expression in mice Phytomedicine 2019 61 152835 10.1016/j.phymed.2019.152835 31035047 

  23. 23. Chen L. Martinez O. Overbergh L. Mathieu C. Prabhakar B.S. Chan L.S. Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model Clin. Exp. Immunol. 2004 138 375 387 10.1111/j.1365-2249.2004.02649.x 15544612 

  24. 24. Ming M. Zhao B. Shea C.R. Shah P. Qiang L. White S.R. Sims D.M. He Y.Y. Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge J. Allergy Clin. Immunol. 2015 135 936 945 10.1016/j.jaci.2014.09.035 25445829 

  25. 25. Saeki H. Tamaki K. Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases J. Dermatol. Sci. 2006 43 75 84 10.1016/j.jdermsci.2006.06.002 16859899 

  26. 26. Deckers J. Branco Madeira F. Hammad H. Innate immune cells in asthma Trends Immunol. 2013 34 540 547 10.1016/j.it.2013.08.004 24035576 

  27. 27. Vestergaard C. Yoneyama H. Murai M. Nakamura K. Tamaki K. Terashima Y. Imai T. Yoshie O. Irimura T. Mizutani H. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions J. Clin. Investig. 1999 104 1097 1105 10.1172/JCI7613 10525048 

  28. 28. Uysal P. Birtekocak F. Karul A.B. The relationship between serum TARC, TSLP and POSTN levels and childhood atopic dermatitis Clin. Lab. 2017 63 1071 1077 10.7754/Clin.Lab.2017.161107 28792717 

  29. 29. Park J.H. Ahn E.K. Ko H.J. Lee J.Y. Hwang S.M. Ko S. Oh J.S. Korean red ginseng water extract alleviates atopic dermatitis-like inflammatory responses by negative regulation of mitogen-activated protein kinase signaling pathway in vivo Biomed. Pharmacother. 2019 117 109066 10.1016/j.biopha.2019.109066 31226639 

  30. 30. Lim S.J. Kim M. Randy A. Nam E.J. Nho C.W. Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-α/IFN-γ-induced chemokines production in HaCaT cells J. Pharm. Pharmacol. 2016 68 1465 1479 10.1111/jphp.12640 27696405 

LOADING...
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로