$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Jujube ( Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation 원문보기

Evidence-based Complementary and Alternative Medicine : eCAM, v.2020, 2020년, pp.6684331 -   

Hong, Sungwha (Department of Food Science and Biotechnology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea) ,  Kim, Younghwa (School of Food Biotechnology and Nutrition, Kyungsung University, Busan 48434, Republic of Korea) ,  Sung, Jeehye (Food Science and Biotechnology, Andong National University, Andong, Gyeongbuk 36729, Republic of Korea) ,  Lee, Hana (Department of Food Science and Biotechnology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea) ,  Heo, Huijin (Department of Food Science and Biotechnology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea) ,  Jeong, Heon Sang (Department of Food Science and Biotechnology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea) ,  Lee, Junsoo (Department of Food Science and Biotechnology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea)

Abstract AI-Helper 아이콘AI-Helper

This study aimed at evaluating the cytoprotective activity of jujube water extract (JWE) against alcohol-induced oxidative stress via the activation of the Nrf2 pathway in HepG2 cells. JWE had various phenolic compounds, and the vanillic acid content was the highest in the extract. To determine the ...

참고문헌 (44)

  1. 1 Gao B. Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets Gastroenterology 2011 141 5 1572 1585 10.1053/j.gastro.2011.09.002 2-s2.0-80054872790 21920463 

  2. 2 Park S. H. Kim C. H. Kim D. J. Prevalence of alcoholic liver disease among Korean adults: results from the fourth korea national health and nutrition examination survey, 2009 Substance Use & Misuse 2011 46 14 1755 1762 10.3109/10826084.2011.620053 2-s2.0-80055071482 21999409 

  3. 3 Cederbaum A. I. Alcohol metabolism Clinics in Liver Disease 2012 16 4 667 685 10.1016/j.cld.2012.08.002 2-s2.0-84867921274 23101976 

  4. 4 Caro A. A. Cederbaum A. I. Oxidativestress, toxicology, andpharmacology Ofcyp2E1 Annual Review of Pharmacology and Toxicology 2004 44 1 27 42 10.1146/annurev.pharmtox.44.101802.121704 2-s2.0-1342323673 

  5. 5 Lu Y. Cederbaum A. I. CYP2E1 and oxidative liver injury by alcohol Free Radical Biology and Medicine 2008 44 5 723 738 10.1016/j.freeradbiomed.2007.11.004 2-s2.0-39149123560 18078827 

  6. 6 Yan S.-L. Yang H.-T. Lee H.-L. Yin M.-C. Protective effects of maslinic acid against alcohol-induced acute liver injury in mice Food and Chemical Toxicology 2014 74 149 155 10.1016/j.fct.2014.09.018 2-s2.0-84908335983 25301236 

  7. 7 Han Y. Xu Q. Hu J.-N. Han X.-Y. Li W. Zhao L.-C. Maltol, a food flavoring agent, attenuates acute alcohol-induced oxidative damage in mice Nutrients 2015 7 1 682 696 10.3390/nu7010682 2-s2.0-84921763596 25608939 

  8. 8 Li S. Hong M. Tan H.-Y. Wang N. Feng Y. Insights into the role and interdependence of oxidative stress and inflammation in liver diseases Oxidative Medicine and Cellular Longevity 2016 2016 21 10.1155/2016/4234061 2-s2.0-85008873207 4234061 

  9. 9 Lee J. Yang J. Jeon J. Sang Jeong H. Lee J. Sung J. Hepatoprotective effect of esculetin on ethanol-induced liver injury in human HepG2 cells and C57BL/6J mice Journal of Functional Foods 2018 40 536 543 10.1016/j.jff.2017.11.024 2-s2.0-85036563865 

  10. 10 Shu G. Qiu Y. Hao J. Fu Q. Deng X. Nuciferine alleviates acute alcohol-induced liver injury in mice: roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf 2 /HO-1 cascade Journal of Functional Foods 2019 58 105 113 10.1016/j.jff.2019.04.055 2-s2.0-85064910191 

  11. 11 Lu C. Xu W. Zhang F. Shao J. Zheng S. Nrf2 knockdown disrupts the protective effect of curcumin on alcohol-induced hepatocyte necroptosis Molecular Pharmaceutics 2016 13 12 4043 4053 10.1021/acs.molpharmaceut.6b00562 2-s2.0-85002879717 27764939 

  12. 12 Huang X. Kojima-Yuasa A. Norikura T. Kennedy D. O. Hasuma T. Matsui-Yuasa I. Mechanism of the anti-cancer activity of Zizyphus jujuba in HepG2 cells The American Journal of Chinese Medicine 2007 35 3 517 532 10.1142/s0192415x0700503x 2-s2.0-34347378466 17597510 

  13. 13 Li J.-W. Fan L.-P. Ding S.-D. Ding X.-L. Nutritional composition of five cultivars of chinese jujube Food Chemistry 2007 103 2 454 460 10.1016/j.foodchem.2006.08.016 2-s2.0-33846912685 

  14. 14 Gao Q.-H. Wu P.-T. Liu J.-R. Wu C.-S. Parry J. W. Wang M. Physico-chemical properties and antioxidant capacity of different jujube ( Ziziphus jujuba mill.) cultivars grown in loess plateau of China Scientia Horticulturae 2011 130 1 67 72 10.1016/j.scienta.2011.06.005 2-s2.0-79961171290 

  15. 15 Pawlowska A. M. Camangi F. Bader A. Braca A. Flavonoids of Zizyphus jujuba L. and Zizyphus spina -christi (L.) willd (rhamnaceae) fruits Food Chemistry 2009 112 4 858 862 10.1016/j.foodchem.2008.06.053 2-s2.0-50049130680 

  16. 16 Fard M. Beydokhti H. Tahergorabi Z. Abedini M. Mitra M. Ziziphus jujuba : a red fruit with promising anticancer activities Pharmacognosy Reviews 2015 9 18 99 106 10.4103/0973-7847.162108 2-s2.0-84938872222 26392706 

  17. 17 Kamiloglu O. Ercisli S. Sengul M. Toplu C. Serce S. Total phenolics and antioxidant activity of jujube ( Zizyphus jujube mill.) genotypes selected from Turkey African Journal of Biotechnology 2009 8 2 303 307 

  18. 18 Chen J. Du C. Y. Q. Lam K. Y. C. The standardized extract of Ziziphus jujuba fruit (jujube) regulates pro-inflammatory cytokine expression in cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF- κ B activity Phytotherapy Research 2014 28 10 1527 1532 10.1002/ptr.5160 2-s2.0-84908419880 24806434 

  19. 19 Liu N. Yang M. Huang W. Composition, antioxidant activities and hepatoprotective effects of the water extract of Ziziphus jujuba cv. jinsixiaozao RSC Advances 2017 7 11 6511 6522 10.1039/c6ra27516h 2-s2.0-85010378944 

  20. 20 Sung J. Suh J. H. Wang Y. Effects of heat treatment of mandarin peel on flavonoid profiles and lipid accumulation in 3T3-L1 adipocytes Journal of Food and Drug Analysis 2019 27 3 729 735 10.1016/j.jfda.2019.05.002 2-s2.0-85066311290 31324288 

  21. 21 Wang H. Joseph J. A. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States department of agriculture and does not imply its approval to the exclusion of other products that may be suitable Free Radical Biology and Medicine 1999 27 5 612 616 10.1016/s0891-5849(99)00107-0 2-s2.0-0032820452 10490282 

  22. 22 Baker M. A. Cerniglia G. J. Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples Analytical Biochemistry 1990 190 2 360 365 10.1016/0003-2697(90)90208-q 2-s2.0-0025043947 2291479 

  23. 23 Buege J. A. Aust S. D. Microsomal lipid peroxidation Methods in Enzymology 1978 52 302 310 10.1016/s0076-6879(78)52032-6 2-s2.0-0017872475 672633 

  24. 24 Gao Q.-H. Wu C.-S. Wang M. The jujube ( Ziziphus jujuba mill.) fruit: a review of current knowledge of fruit composition and health benefits Journal of Agricultural and Food Chemistry 2013 61 14 3351 3363 10.1021/jf4007032 2-s2.0-84876157286 23480594 

  25. 25 Huang W. Wang Y. Jiang X. Protective effect of flavonoids from Ziziphus jujuba cv. jinsixiaozao against acetaminophen-induced liver injury by inhibiting oxidative stress and inflammation in mice Molecules 2017 22 10 1 18 10.3390/molecules22101781 2-s2.0-85032916425 

  26. 26 Ramaiah S. K. A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters Food and Chemical Toxicology 2007 45 9 1551 1557 10.1016/j.fct.2007.06.007 2-s2.0-34547118377 17658209 

  27. 27 Saravanan N. Rajasankar S. Nalini N. Antioxidant effect of 2-hydroxy-4-methoxy benzoic acid on ethanol-induced hepatotoxicity in rats Journal of Pharmacy and Pharmacology 2007 59 3 445 453 10.1211/jpp.59.3.0015 2-s2.0-34247633081 17331349 

  28. 28 Pan P.-H. Lin S.-Y. Wang Y.-Y. Protective effects of rutin on liver injury induced by biliary obstruction in rats Free Radical Biology and Medicine 2014 73 106 116 10.1016/j.freeradbiomed.2014.05.001 2-s2.0-84901979303 24815012 

  29. 29 Altamirano J. Bataller R. Alcoholic liver disease: pathogenesis and new targets for therapy Nature Reviews Gastroenterology & Hepatology 2011 8 9 491 501 10.1038/nrgastro.2011.134 2-s2.0-80052433519 21826088 

  30. 30 Ramirez A. Vazquez-Sanchez A. Y. Carrion-Robalino N. Camacho J. Ion channels and oxidative stress as a potential link for the diagnosis or treatment of liver diseases Oxidative Medicine and Cellular Longevity 2016 2016 1 17 10.1155/2016/3928714 2-s2.0-84961339911 

  31. 31 Tang A. Tan J. Sun M. Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis Radiology 2013 267 2 422 431 10.1148/radiol.12120896 2-s2.0-84876907610 23382291 

  32. 32 Madushani Herath K. H. I. N. Cho J. Kim A. Phenolic acid and flavonoid-rich fraction of sasa quelpaertensis Nakai leaves prevent alcohol induced fatty liver through AMPK activation Journal of Ethnopharmacology 2018 224 335 348 10.1016/j.jep.2018.06.008 2-s2.0-85048706421 29906537 

  33. 33 Hinson J. A. Reid A. B. McCullough S. S. James L. P. Acetaminophen­induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition Drug Metabolism Reviews 2004 36 3-4 805 822 10.1081/dmr-200033494 2-s2.0-7544222053 15554248 

  34. 34 Li B. Lee D.-S. Kang Y. Yao N.-Q. An R.-B. Kim Y.-C. Protective effect of ganodermanondiol isolated from the lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf 2 -mediated antioxidant enzymes Food and Chemical Toxicology 2013 53 317 324 10.1016/j.fct.2012.12.016 2-s2.0-84872372918 23266269 

  35. 35 Nioi P. Hayes J. D. Contribution of NAD (P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf 2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2004 555 1 149 171 10.1016/j.mrfmmm.2004.05.023 2-s2.0-5444240961 15476858 

  36. 36 Horie M. Warabi E. Komine S. Oh S. Shoda J. Cytoprotective role of Nrf 2 in electrical pulse stimulated C2C12 myotube PLoS One 2015 10 12 e0144835 10.1371/journal.pone.0144835 2-s2.0-84957110335 

  37. 37 Tanigawa S. Fujii M. Hou D. Action of Nrf 2 and Keap1 in ARE-mediated NQO1 expression by quercetin Free Radical Biology and Medicine 2007 42 11 1690 1703 10.1016/j.freeradbiomed.2007.02.017 2-s2.0-34247282872 17462537 

  38. 38 Myhrstad M. C. W. Carlsen H. Nordstrom O. Blomhoff R. Moskaug J. Ø. Flavonoids increase the intracellular glutathione level by transactivation of the γ -glutamylcysteine synthetase catalytical subunit promoter Free Radical Biology and Medicine 2002 32 5 386 393 10.1016/s0891-5849(01)00812-7 2-s2.0-0036489186 11864778 

  39. 39 Lee J.-S. Surh Y.-J. Nrf 2 as a novel molecular target for chemoprevention Cancer Letters 2005 224 2 171 184 10.1016/j.canlet.2004.09.042 2-s2.0-19444379739 15914268 

  40. 40 Surh Y.-J. Cancer chemoprevention with dietary phytochemicals Nature Reviews Cancer 2003 3 10 768 780 10.1038/nrc1189 2-s2.0-0142166328 14570043 

  41. 41 Itoh K. Tong K. I. Yamamoto M. Molecular mechanism activating Nrf 2 -keap1 pathway in regulation of adaptive response to electrophiles Free Radical Biology and Medicine 2004 36 10 1208 1213 10.1016/j.freeradbiomed.2004.02.075 2-s2.0-1942455887 15110385 

  42. 42 Jadeja R. N. Upadhyay K. K. Devkar R. V. Khurana S. Naturally occurring Nrf 2 activators: potential in treatment of Liver injury Oxidative Medicine and Cellular Longevity 2016 2016 13 10.1155/2016/3453926 2-s2.0-85008883748 3453926 

  43. 43 Liu S. Hou W. Yao P. Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage Toxicology in Vitro 2012 26 1 74 80 10.1016/j.tiv.2011.10.013 2-s2.0-84855343368 22056766 

  44. 44 Yang S. Y. Pyo M. C. Nam M. H. Lee K. W. ERK/Nrf 2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress BMC Complementary and Alternative Medicine 2019 19 139 1 13 10.1186/s12906-019-2551-3 2-s2.0-85067560029 30606178 

LOADING...

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로