[논문]Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals

Lee, Sullim; Jegal, Hyun; Bong, Sim-Kyu; Yoon, Kyeong-No; Park, No-June; Shin, Myoung-Sook; Yang, Min Hye; Kim, Yong Kee; Kim, Su-Nam

doi:10.3390/biom10010057

Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals 원문보기

Biomolecules, v.10 no.1, 2020년, pp.57 -

Lee, Sullim (Department of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam 13120, Korea) , Jegal, Hyun (sullimlee@gachon.ac.kr) , Bong, Sim-Kyu (Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea) , Yoon, Kyeong-No (wprkfgus3@gmail.com (H.J.)) , Park, No-June (115044@kist.re.kr (S.-K.B.)) , Shin, Myoung-Sook (kyeongnoyoon@naver.com (K.-N.Y.)) , Yang, Min Hye (parknojune@kist.re.kr (N.-J.P.)) , Kim, Yong Kee (Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea) , Kim, Su-Nam (wprkfgus3@gmail.com (H.J.))

Abstract ▼ AI-Helper

To investigate the potential effects of acorn shells on atopic dermatitis (AD), we utilized oxazolone (OX)- or 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesion mouse models. Our research demonstrates that Acorn shell extract (ASE) improved the progression of AD-like lesions, including swelling, which were induced by oxazolone on Balb/c mouse ears. Additionally, ASE significantly decreased the ear thickness (OX: 0.42 ± 0.01 mm, OX-ASE: 0.32 ± 0.02 mm) and epidermal thickness (OX: 75.3 ± 32.6 µm, OX-ASE: 46.1 ± 13.4 µm). The continuous DNCB-induced AD mouse model in SKH-1 hairless mice demonstrated that ASE improved AD-like symptoms, including the recovery of skin barrier dysfunction, Immunoglobulin E hyperproduction (DNCB: 340.1 ± 66.8 ng/mL, DNCB-ASE: 234.8 ± 32.9 ng/mL) and an increase in epidermal thickness (DNCB: 96.4 ± 21.9 µm, DNCB-ASE: 52.4 ± 16.3 µm). In addition, we found that ASE suppressed the levels of AD-involved cytokines, such as Tumor Necrosis Factor α, IL-1β, IL-25 and IL-33 in both animal models. Furthermore, gallic acid and ellagic acid isolated from ASE suppressed β-hexosaminidase release and IL-4 expression in RBL-2H3 cells. The acorn shell and its active phytochemicals have potential as a new remedy for the improvement of atopic dermatitis and other inflammatory diseases.

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참고문헌 (55)

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Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals 원문보기

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Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals 원문보기

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