[논문]Cyclophilin Inhibition Protects Against Experimental Acute Kidney Injury and Renal Interstitial Fibrosis

Leong, Khai Gene; Ozols, Elyce; Kanellis, John; Badal, Shawn S.; Liles, John T.; Nikolic-Paterson, David J.; Ma, Frank Y.

doi:10.3390/ijms22010271

Cyclophilin Inhibition Protects Against Experimental Acute Kidney Injury and Renal Interstitial Fibrosis 원문보기

International journal of molecular sciences, v.22 no.1, 2021년, pp.271 -

Leong, Khai Gene (Monash Medical Centre, Department of Nephrology, Clayton, VIC 3168, Australia) , Ozols, Elyce (khaigeneleong@gmail.com (K.G.L.)) , Kanellis, John (elyce.ozols@monash.edu (E.O.)) , Badal, Shawn S. (john.kanellis@monash.edu (J.K.)) , Liles, John T. (frank.ma@monash.edu (F.Y.M.)) , Nikolic-Paterson, David J. (Monash Medical Centre, Department of Nephrology, Clayton, VIC 3168, Australia) , Ma, Frank Y. (khaigeneleong@gmail.com (K.G.L.))

Abstract ▼ AI-Helper

Cyclophilins have important homeostatic roles, but following tissue injury, cyclophilin A (CypA) can promote leukocyte recruitment and inflammation, while CypD can facilitate mitochondrial-dependent cell death. This study investigated the therapeutic potential of a selective cyclophilin inhibitor (GS-642362), which does not block calcineurin function, in mouse models of tubular cell necrosis and renal fibrosis. Mice underwent bilateral renal ischemia/reperfusion injury (IRI) and were killed 24 h later: treatment with 10 or 30 mg/kg/BID GS-642362 (or vehicle) began 1 h before surgery. In the second model, mice underwent unilateral ureteric obstruction (UUO) surgery and were killed 7 days later; treatment with 10 or 30 mg/kg/BID GS-642362 (or vehicle) began 1 h before surgery. GS-642362 treatment gave a profound and dose-dependent protection from acute renal failure in the IRI model. This protection was associated with reduced tubular cell death, including a dramatic reduction in neutrophil infiltration. In the UUO model, GS-642362 treatment significantly reduced tubular cell death, macrophage infiltration, and renal fibrosis. This protective effect was independent of the upregulation of IL-2 and activation of the stress-activated protein kinases (p38 and JNK). In conclusion, GS-642362 was effective in suppressing both acute kidney injury and renal fibrosis. These findings support further investigation of cyclophilin blockade in other types of acute and chronic kidney disease.

주제어

참고문헌 (46)

1. Qu X. Wang C. Zhang J. Qie G. Zhou J. The Roles of CD147 and/or Cyclophilin A in Kidney Diseases Mediat. Inflamm. 2014 2014 1 10 10.1155/2014/728673 25580061

상세보기
2. Nigro P. Pompilio G. Capogrossi M.C. Cyclophilin A: A key player for human disease Cell Death Dis. 2013 4 e888 10.1038/cddis.2013.410 24176846

상세보기
3. Bukrinsky M. Extracellular cyclophilins in health and disease Biochim. Biophys. Acta Gen. Subj. 2015 1850 2087 2095 10.1016/j.bbagen.2014.11.013

상세보기
4. Wang P. Heitman J. The cyclophilins Genome Biol. 2005 6 226 10.1186/gb-2005-6-7-226 15998457

상세보기
5. Dear J.W. Simpson K.J. Nicolai M.P.J. Catterson J.H. Street J. Huizinga T. Craig D.G. Dhaliwal K. Webb S. Bateman D.N. Cyclophilin A is a Damage-Associated Molecular Pattern Molecule That Mediates Acetamino-phen-Induced Liver Injury J. Immunol. 2011 187 3347 10.4049/jimmunol.1100165 21824865

상세보기
6. Seizer P. Gawaz M. May A.E. Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases Cardiovasc. Res. 2014 102 17 23 10.1093/cvr/cvu035 24518139

상세보기
7. Yuan W. Ge H. He B. Pro-inflammatory activities induced by CyPA-EMMPRIN interaction in monocytes Atherosclerosis 2010 213 415 421 10.1016/j.atherosclerosis.2010.09.033 21035802

상세보기
8. Argaud L. Gateau-Roesch O. Muntean D. Chalabreysse L. Loufouat J. Robert D. Ovize M. Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury J. Mol. Cell. Cardiol. 2005 38 367 374 10.1016/j.yjmcc.2004.12.001 15698843

상세보기
9. Heinzmann D. Bangert A. Muller A.M. von Ungern-Sternberg S.N. Emschermann F. Schonberger T. Chatterjee M. Mack A.F. Klingel K. Kandolf R. The Novel Extracellular Cyclophilin A (CyPA)—Inhibitor MM284 Reduces Myocardial Inflammation and Re-modeling in a Mouse Model of Troponin I—Induced Myocarditis PLoS ONE 2015 10 e0124606 10.1371/journal.pone.0124606 25894208

상세보기
10. Javadov S. Kuznetsov A.V. Mitochondrial Permeability Transition and Cell Death: The Role of Cyclophilin, D Front. Physiol. 2013 4 76 10.3389/fphys.2013.00076 23596421

상세보기
11. Rieusset J. Fauconnier J. Paillard M. Belaidi E. Tubbs E. Chauvin M.-A. Durand A. Bravard A. Teixeira G. Bartosch B. Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance Diabetologia 2015 59 614 623 10.1007/s00125-015-3829-8 26660890

상세보기
12. Matouschek A. Rospert S. Schmid K. Glick B.S. Schatz G. Cyclophilin catalyzes protein folding in yeast mitochondria Proc. Natl. Acad. Sci. USA 1995 92 6319 6323 10.1073/pnas.92.14.6319 7603990

상세보기
13. Baines C.P. Kaiser R.A. Purcell N.H. Blair N.S. Osinska H. Hambleton M.A. Brunskill E.W. Sayen M.R. Gottlieb R.A. Dorn G.W. Loss of cyclophilin D reveals a critical role for mitochondrial permeability tran-sition in cell death Nature 2005 434 658 662 10.1038/nature03434 15800627

상세보기
14. Nakagawa T. Shimizu S. Watanabe T. Yamaguchi O. Otsu K. Yamagata H. Inohara H. Kubo T. Tsujimoto Y. Cy-clophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death Nature 2005 434 652 658 10.1038/nature03317 15800626

상세보기
15. Devalaraja-Narashimha K. Diener A.M. Padanilam B.J. Cyclophilin D gene ablation protects mice from ischemic renal injury Am. J. Physiol. Physiol. 2009 297 F749 F759 10.1152/ajprenal.00239.2009 19553348

상세보기
16. Harding M.W. Handschumacher R.E. Cyclophilin, a Primary Molecular Target for Cyclosporine Transplant 1988 46 29S 35S 10.1097/00007890-198808001-00006

상세보기
17. Fliri H. Baumann G. Enz A. Kallen J. Luyten M. Mikol V. Movva R. Quesniaux V. Schreier M. Walkinshaw M. Cyclosporins. Structure-activity relationships Ann. N. Y. Acad. Sci. 1993 696 47 53 10.1111/j.1749-6632.1993.tb17141.x 8109856

상세보기
18. Borel J.F. Feurer C. Magnée C. Stähelin H. Effects of the new anti-lymphocytic peptide cyclosporin A in animals Immunology 1977 32 1017 1025 328380
19. Bennett W.M. Norman D.J. Action and toxicity of cyclosporine Ann. Rev. Med. 1986 37 215 224 10.1146/annurev.me.37.020186.001243 2939791

상세보기
20. Yang H. Li R. Zhang L. Zhang S. Dong W. Chen Y. Wang W. Li C. Ye Z. Zhao X. p53-cyclophilin D mediates renal tubular cell apoptosis in ischemia-reperfusion-induced acute kidney in-jury Am. J. Physiol. Renal. Physiol. 2019 317 F1311 F1317 10.1152/ajprenal.00072.2019 31339772

상세보기
21. Ar’Rajab A. Dawidson I.J. Harris R.B. Mileski W.J. Sentementes J.T. Deleterious effect of cyclosporins on the ischemic kidney in the rat and the protection by the calcium antagonist verapamil J. Am. Soc. Nephrol. 1994 5 93 101 7948788

상세보기
22. Johnson D.W. Saunders H.J. Johnson F.J. Huq S.O. Field M.J. Pollock C.A. Fibrogenic Effects of Cyclosporin A on the Tubulointerstitium: Role of Cytokines and Growth Factors Nephron Exp. Nephrol. 1999 7 470 478 10.1159/000020626 10559645

상세보기
23. O’Neal J.B. Shaw A.D. Iv F.T.B. Acute kidney injury following cardiac surgery: Current understanding and future directions Crit. Care 2016 20 1 9 10.1186/s13054-016-1352-z 26728475

상세보기
24. Parr S.K. Matheny M.E. Abdel-Kader K. Greevy R.A. Bian A. Fly J. Chen G. Speroff T. Hung A.M. Ikizler T.A. Acute kidney injury is a risk factor for subsequent proteinuria Kidney Int. 2018 93 460 469 10.1016/j.kint.2017.07.007 28927644

상세보기
25. Triverio P.-A. Martin P.-Y. Romand J. Pugin J. Perneger T. Saudan P. Long-term prognosis after acute kidney injury requiring renal replacement therapy Nephrol. Dial. Transplant. 2009 24 2186 2189 10.1093/ndt/gfp072 19228754

상세보기
26. Mackman R.L. Steadman V.A. Dean D.K. Jansa P. Poullennec K.G. Appleby T. Austin C. Blakemore C.A. Cai R. Cannizzaro C. Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle J. Med. Chem. 2018 61 9473 9499 10.1021/acs.jmedchem.8b00802 30074795

상세보기
27. Hou W. Leong K.G. Ozols E. Tesch G.H. Nikolic-Paterson D.J. Ma F.Y. Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney Clin. Exp. Pharmacol. Physiol. 2018 45 250 260 10.1111/1440-1681.12881 29230844

상세보기
28. Linkermann A. Brasen J.H. Darding M. Jin M.K. Sanz A.B. Heller J.O. De Zen F. Weinlich R. Ortiz A. Walczak H. Two independent pathways of regulated necrosis mediate is-chemia-reperfusion injury Proc. Natl. Acad. Sci. USA 2013 110 12024 12029 10.1073/pnas.1305538110 23818611

상세보기
29. Park J.S. Pasupulati R. Feldkamp T. Roeser N.F. Weinberg J.M. Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury Am. J. Physiol. Physiol. 2011 301 F134 F150 10.1152/ajprenal.00033.2011

상세보기
30. Klausner J.M. Paterson I.S. Goldman G. Kobzik L. Rodzen C. Lawrence R. Valeri C.R. Shepro D. Hechtman H.B. Postischemic renal injury is mediated by neutrophils and leukotrienes Am. J. Physiol. Content 1989 256 794 802 10.1152/ajprenal.1989.256.5.F794

상세보기
31. Ryan J. Kanellis J. Blease K. Ma F.Y. Nikolic-Paterson D.J. Spleen Tyrosine Kinase Signaling Promotes Myeloid Cell Recruitment and Kidney Damage after Renal Ischemia/Reperfusion Injury Am. J. Pathol. 2016 186 2032 2042 10.1016/j.ajpath.2016.04.007 27322771

상세보기
32. Singbartl K. Ley K. Protection from ischemia-reperfusion induced severe acute renal failure by blocking E-selectin Crit. Care Med. 2000 28 2507 2514 10.1097/00003246-200007000-00053 10921586

상세보기
33. Perrucci G. Gowran A. Zanobini M. Capogrossi M.C. Pompilio G. Nigro P. Peptidyl-prolyl isomerases: A full cast of critical actors in cardiovascular diseases Cardiovasc. Res. 2015 106 353 364 10.1093/cvr/cvv096 25750190

상세보기
34. Christofferson D.E. Yuan J. Cyclophilin A release as a biomarker of necrotic cell death Cell Death Differ. 2010 17 1942 1943 10.1038/cdd.2010.123 20930851

상세보기
35. Constant S.L. Heine S.J. Olive D. Murphy P.M. Bukrinsky M.I. Gao J.-L. Cyclophilin A cooperates with MIP-2 to augment neutrophil migration J. Inflamm. Res. 2011 4 93 104 10.2147/JIR.S20733 22096373

상세보기
36. Leong K.G. Ozols E. Kanellis J. Nikolic-Paterson D.J. Ma F.Y. Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis Int. J. Mol. Sci. 2020 21 3667 10.3390/ijms21103667

상세보기
37. Ma F.Y. Han Y. Ozols E. Chew P. Vesey D.A. Gobe G.C. Morais C. Lohman R.J. Suen J.Y. Johnson D.W. Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the ob-structed kidney Nephrology 2019 24 983 991 31314137

상세보기
38. Ma F.Y. Tesch G.H. Nikolic-Paterson D.J. ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney Am. J. Physiol. Physiol. 2014 307 F1263 F1273 10.1152/ajprenal.00211.2014

상세보기
39. Ma F.Y. Flanc R.S. Tesch G.H. Han Y. Atkins R.C. Bennett B.L. Friedman G.C. Fan J.-H. Nikolic-Paterson D.J. A Pathogenic Role for c-Jun Amino-Terminal Kinase Signaling in Renal Fibrosis and Tubular Cell Apoptosis J. Am. Soc. Nephrol. 2007 18 472 484 10.1681/ASN.2006060604 17202416

상세보기
40. Stambe C. Atkins R.C. Tesch G.H. Masaki T. Schreiner G.F. Nikolic-Paterson D.J. The role of p38alpha mito-gen-activated protein kinase activation in renal fibrosis J. Am. Soc. Nephrol. 2004 15 370 379 10.1097/01.ASN.0000109669.23650.56 14747383

상세보기
41. Sarró E. Durán M. Rico A. Bou-Teen D. Fernández-Majada V. Croatt A.J. Nath K.A. Salcedo M.T. Gundelach J.H. Batlle D. Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype J. Mol. Cell Biol. 2020 12 499 514 10.1093/jmcb/mjaa005 32162654

상세보기
42. Seizer P. Klingel K. Sauter M. Westermann D. Ochmann C. Schönberger T. Schleicher R. Stellos K. Schmidt E.-M. Borst O. Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis J. Mol. Cell. Cardiol. 2012 53 6 14 10.1016/j.yjmcc.2012.03.004 22446162

상세보기
43. Kuo J. Bobardt M. Chatterji U. Mayo P.R. Trepanier D.J. Foster R.T. Gallay P.A. Ure D.R. A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models J. Pharmacol. Exp. Ther. 2019 371 231 241 10.1124/jpet.119.261099 31406003

상세보기
44. Lindblom R.S. Higgins G.C. Nguyen T.-V. Arnstein M. Henstridge D.C. Granata C. Snelson M. Thallas-Bonke V. Cooper M.E. Forbes J.M. Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D Clin. Sci. 2020 134 239 259 10.1042/CS20190787 31943002

상세보기
45. Lan H.Y. Mu W. Nikolic-Paterson D.J. Atkins R.C. A novel, simple, reliable, and sensitive method for multiple immu-noenzyme staining: Use of microwave oven heating to block antibody crossreactivity and retrieve antigens J. Histochem. Cyto-chem. 1995 43 97 102 10.1177/43.1.7822770 7822770

상세보기
46. Ma F.Y. Tesch G.H. Ozols E. Xie M. Schneider M.D. Nikolic-Paterson D.J. TGF-beta1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney Am. J. Physiol. Renal. Physiol. 2011 300 F1410 F1421 10.1152/ajprenal.00018.2011 21367917

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Cyclophilin Inhibition Protects Against Experimental Acute Kidney Injury and Renal Interstitial Fibrosis 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (46)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트