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Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss 원문보기

International journal of molecular sciences, v.22 no.5, 2021년, pp.2510 -   

Rim, John Hoon (Department of Pharmacology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea) ,  Choi, Jae Young (JOHNHOON1@yuhs.ac) ,  Jung, Jinsei (Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Korea) ,  Gee, Heon Yung (JYCHOI@yuhs.ac)

Abstract AI-Helper 아이콘AI-Helper

Potassium voltage-gated channel subfamily q member 4 (KCNQ4) is a voltage-gated potassium channel that plays essential roles in maintaining ion homeostasis and regulating hair cell membrane potential. Reduction of the activity of the KCNQ4 channel owing to genetic mutations is responsible for nonsyn...

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참고문헌 (90)

  1. 1. Petit C. El-Amraoui A. Avan P. Audition: Hearing and Deafness Neuroscience in the 21st Century 2nd ed. Springer New York, NY, USA 2016 

  2. 2. Cunningham L.L. Tucci D.L. Hearing Loss in Adults N. Engl. J. Med. 2017 377 2465 2473 10.1056/NEJMra1616601 29262274 

  3. 3. Petit C. Levilliers J. Hardelin J.P. Molecular genetics of hearing loss Annu. Rev. Genet. 2001 35 589 646 10.1146/annurev.genet.35.102401.091224 11700295 

  4. 4. Raviv D. Dror A.A. Avraham K.B. Hearing loss: A common disorder caused by many rare alleles Ann. N. Y. Acad. Sci. 2010 1214 168 179 10.1111/j.1749-6632.2010.05868.x 21175685 

  5. 5. Chadha S. Cieza A. World Health Organization and Its Initiative for Ear and Hearing Care Otolaryngol. Clin. N. Am. 2018 51 535 542 10.1016/j.otc.2018.01.002 29486926 

  6. 6. Kubisch C. Schroeder B.C. Friedrich T. Lutjohann B. El-Amraoui A. Marlin S. Petit C. Jentsch T.J. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness Cell 1999 96 437 446 10.1016/S0092-8674(00)80556-5 10025409 

  7. 7. van Laer L. Carlsson P.I. Ottschytsch N. Bondeson M.L. Konings A. Vandevelde A. Dieltjens N. Fransen E. Snyders D. Borg E. The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss Hum. Mutat. 2006 27 786 795 10.1002/humu.20360 16823764 

  8. 8. Peixoto Pinheiro B. Vona B. Lowenheim H. Ruttiger L. Knipper M. Adel Y. Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway Pflug. Arch. Eur. J. Physiol. 2020 10.1007/s00424-020-02496-w 

  9. 9. Wulff H. Castle N.A. Pardo L.A. Voltage-gated potassium channels as therapeutic targets Nat. Rev. Drug Discov. 2009 8 982 1001 10.1038/nrd2983 19949402 

  10. 10. Maljevic S. Wuttke T.V. Seebohm G. Lerche H. KV7 channelopathies Pflug. Arch. Eur. J. Physiol. 2010 460 277 288 10.1007/s00424-010-0831-3 

  11. 11. Schroeder B.C. Hechenberger M. Weinreich F. Kubisch C. Jentsch T.J. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents J. Biol. Chem. 2000 275 24089 24095 10.1074/jbc.M003245200 10816588 

  12. 12. Lerche C. Scherer C.R. Seebohm G. Derst C. Wei A.D. Busch A.E. Steinmeyer K. Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity J. Biol. Chem. 2000 275 22395 22400 10.1074/jbc.M002378200 10787416 

  13. 13. Wang Q. Curran M.E. Splawski I. Burn T.C. Millholland J.M. VanRaay T.J. Shen J. Timothy K.W. Vincent G.M. de Jager T. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias Nat. Genet. 1996 12 17 23 10.1038/ng0196-17 8528244 

  14. 14. Splawski I. Timothy K.W. Vincent G.M. Atkinson D.L. Keating M.T. Molecular basis of the long-QT syndrome associated with deafness N. Engl. J. Med. 1997 336 1562 1567 10.1056/NEJM199705293362204 9164812 

  15. 15. Neyroud N. Tesson F. Denjoy I. Leibovici M. Donger C. Barhanin J. Faure S. Gary F. Coumel P. Petit C. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome Nat. Genet. 1997 15 186 189 10.1038/ng0297-186 9020846 

  16. 16. Singh N.A. Charlier C. Stauffer D. DuPont B.R. Leach R.J. Melis R. Ronen G.M. Bjerre I. Quattlebaum T. Murphy J.V. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns Nat. Genet. 1998 18 25 29 10.1038/ng0198-25 9425895 

  17. 17. Biervert C. Schroeder B.C. Kubisch C. Berkovic S.F. Propping P. Jentsch T.J. Steinlein O.K. A potassium channel mutation in neonatal human epilepsy Science 1998 279 403 406 10.1126/science.279.5349.403 9430594 

  18. 18. Charlier C. Singh N.A. Ryan S.G. Lewis T.B. Reus B.E. Leach R.J. Leppert M. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family Nat. Genet. 1998 18 53 55 10.1038/ng0198-53 9425900 

  19. 19. Lehman A. Thouta S. Mancini G.M.S. Naidu S. van Slegtenhorst M. McWalter K. Person R. Mwenifumbo J. Salvarinova R. Guella I. Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy Am. J. Hum. Genet. 2017 101 65 74 10.1016/j.ajhg.2017.05.016 28669405 

  20. 20. Naito T. Nishio S.-Y. Iwasa Y.-I. Yano T. Kumakawa K. Abe S. Ishikawa K. Kojima H. Namba A. Oshikawa C. Comprehensive Genetic Screening of KCNQ4 in a Large Autosomal Dominant Nonsyndromic Hearing Loss Cohort: Genotype-Phenotype Correlations and a Founder Mutation PLoS ONE 2013 8 e63231 23717403 

  21. 21. Jung J. Lin H. Koh Y.I. Ryu K. Lee J.S. Rim J.H. Choi H.J. Lee H.J. Kim H.Y. Yu S. Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment Exp. Mol. Med. 2019 51 99 10.1038/s12276-019-0300-9 

  22. 22. Gao Y. Yechikov S. Vazquez A.E. Chen D. Nie L. Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss J. Cell. Mol. Med. 2013 17 889 900 10.1111/jcmm.12080 23750663 

  23. 23. Leitner M.G. Feuer A. Ebers O. Schreiber D.N. Halaszovich C.R. Oliver D. Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers Br. J. Pharmacol. 2012 165 2244 2259 10.1111/j.1476-5381.2011.01697.x 21951272 

  24. 24. Jung J. Choi H.B. Koh Y.I. Rim J.H. Choi H.J. Kim S.H. Lee J.H. An J. Kim A. Lee J.S. Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss Sci. Rep. 2018 8 16659 10.1038/s41598-018-34876-9 30413759 

  25. 25. Shin D.H. Jung J. Koh Y.I. Rim J.H. Lee J.S. Choi H.J. Joo S.Y. Yu S. Cha D.H. Lee S.Y. A recurrent mutation in KCNQ4 in Korean families with nonsyndromic hearing loss and rescue of the channel activity by KCNQ activators Hum. Mutat. 2019 40 335 346 10.1002/humu.23698 30556268 

  26. 26. Wangemann P. K + cycling and the endocochlear potential Hear. Res. 2002 165 1 9 10.1016/S0378-5955(02)00279-4 12031509 

  27. 27. Delmaghani S. El-Amraoui A. Inner Ear Gene Therapies Take Off: Current Promises and Future Challenges J. Clin. Med. 2020 9 2309 10.3390/jcm9072309 

  28. 28. Pan B. Akyuz N. Liu X.-P. Asai Y. Nist-Lund C. Kurima K. Derfler B.H. Gyorgy B. Limapichat W. Walujkar S. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells Neuron 2018 99 736 753.e6 10.1016/j.neuron.2018.07.033 30138589 

  29. 29. Delpire E. Lu J. England R. Dull C. Thorne T. Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter Nat. Genet. 1999 22 192 195 10.1038/9713 10369265 

  30. 30. Marcus D.C. Wu T. Wangemann P. Kofuji P. KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential Am. J. Physiol. Cell Physiol. 2002 282 C403 C407 10.1152/ajpcell.00312.2001 11788352 

  31. 31. Dallos P. Cochlear amplification, outer hair cells and prestin Curr. Opin. Neurobiol. 2008 18 370 376 10.1016/j.conb.2008.08.016 18809494 

  32. 32. Housley G.D. Ashmore J.F. Ionic currents of outer hair cells isolated from the guinea-pig cochlea J. Physiol. 1992 448 73 98 10.1113/jphysiol.1992.sp019030 1593487 

  33. 33. Dallos P. Zheng J. Cheatham M.A. Prestin and the cochlear amplifier J. Physiol. 2006 576 37 42 10.1113/jphysiol.2006.114652 16873410 

  34. 34. Marcotti W. Kros C.J. Developmental expression of the potassium current I K,n contributes to maturation of mouse outer hair cells J. Physiol. 1999 520 653 660 10.1111/j.1469-7793.1999.00653.x 10545133 

  35. 35. Winter H. Braig C. Zimmermann U. Geisler H.-S. Franzer J.-T. Weber T. Ley M. Engel J. Knirsch M. Bauer K. Thyroid hormone receptors TRα1 and TRβ differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells J. Cell Sci. 2006 119 2975 2984 10.1242/jcs.03013 16803873 

  36. 36. Boettger T. Hubner C.A. Maier H. Rust M.B. Beck F.X. Jentsch T.J. Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4 Nature 2002 416 874 878 10.1038/416874a 11976689 

  37. 37. Kharkovets T. Hardelin J.P. Safieddine S. Schweizer M. El-Amraoui A. Petit C. Jentsch T.J. KCNQ4, a K + channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway Proc. Natl. Acad. Sci. USA 2000 97 4333 4338 10.1073/pnas.97.8.4333 10760300 

  38. 38. Mammano F. Ashmore J.F. Differential expression of outer hair cell potassium currents in the isolated cochlea of the guinea-pig J. Physiol. 1996 496 639 646 10.1113/jphysiol.1996.sp021715 8930832 

  39. 39. Beisel K.W. Nelson N.C. Delimont D.C. Fritzsch B. Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA211Published on the World Wide Web on 13 September 2000 Mol. Brain Res. 2000 82 137 149 10.1016/S0169-328X(00)00204-7 11042367 

  40. 40. Oliver D. Knipper M. Derst C. Fakler B. Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels J. Neurosci. Off. J. Soc. Neurosci. 2003 23 2141 2149 10.1523/JNEUROSCI.23-06-02141.2003 

  41. 41. Beisel K.W. Rocha-Sanchez S.M. Morris K.A. Nie L. Feng F. Kachar B. Yamoah E.N. Fritzsch B. Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss J. Neurosci. Off. J. Soc. Neurosci. 2005 25 9285 9293 10.1523/JNEUROSCI.2110-05.2005 

  42. 42. Kharkovets T. Dedek K. Maier H. Schweizer M. Khimich D. Nouvian R. Vardanyan V. Leuwer R. Moser T. Jentsch T.J. Mice with altered KCNQ4 K + channels implicate sensory outer hair cells in human progressive deafness EMBO J. 2006 25 642 652 10.1038/sj.emboj.7600951 16437162 

  43. 43. Carignano C. Barila E.P. Rias E.I. Dionisio L. Aztiria E. Spitzmaul G. Inner Hair Cell and Neuron Degeneration Contribute to Hearing Loss in a DFNA2-Like Mouse Model Neuroscience 2019 410 202 216 10.1016/j.neuroscience.2019.05.012 31102762 

  44. 44. Ruttiger L. Sausbier M. Zimmermann U. Winter H. Braig C. Engel J. Knirsch M. Arntz C. Langer P. Hirt B. Deletion of the Ca 2+ -activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss Proc. Natl. Acad. Sci. USA 2004 101 12922 12927 10.1073/pnas.0402660101 15328414 

  45. 45. Selyanko A.A. Hadley J.K. Wood I.C. Abogadie F.C. Jentsch T.J. Brown D.A. Inhibition of KCNQ1?4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors J. Physiol. 2000 522 Pt 3 349 355 10.1111/j.1469-7793.2000.t01-2-00349.x 10713961 

  46. 46. Alberti P.W. Symons F. Hyde M.L. Occupational hearing loss. The significance of asymmetrical hearing thresholds Acta Otolaryngol. 1979 87 255 263 10.3109/00016487909126417 443006 

  47. 47. World Health Organization Hearing Loss Due to Recreational Exposure to Loud Sounds: A Review World Health Organization Geneva, Switzerland 2015 

  48. 48. Konings A. Laer L.V. Camp G.V. Genetic Studies on Noise-Induced Hearing Loss: A Review Ear Hear. 2009 30 151 159 10.1097/AUD.0b013e3181987080 19194285 

  49. 49. Pawelczyk M. van Laer L. Fransen E. Rajkowska E. Konings A. Carlsson P.I. Borg E. van Camp G. Sliwinska-Kowalska M. Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss Ann. Hum. Genet. 2009 73 Pt 4 411 421 10.1111/j.1469-1809.2009.00521.x 19523148 

  50. 50. Sliwinska-Kowalska M. Pawelczyk M. Contribution of genetic factors to noise-induced hearing loss: A human studies review Mutat. Res. 2013 752 61 65 10.1016/j.mrrev.2012.11.001 23207014 

  51. 51. Guo H. Ding E. Sheng R. Cheng J. Cai W. Guo J. Wang N. Zhang H. Zhu B. Genetic variation in KCNQ4 gene is associated with susceptibility to noise-induced hearing loss in a Chinese population Environ. Toxicol. Pharm. 2018 63 55 59 10.1016/j.etap.2018.08.009 30153627 

  52. 52. Marchetta P. Mohrle D. Eckert P. Reimann K. Wolter S. Tolone A. Lang I. Wolters M. Feil R. Engel J. Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss Front. Aging Neurosci. 2020 12 83 10.3389/fnagi.2020.00083 32327991 

  53. 53. Engel J. Braig C. Ruttiger L. Kuhn S. Zimmermann U. Blin N. Sausbier M. Kalbacher H. Munkner S. Rohbock K. Two classes of outer hair cells along the tonotopic axis of the cochlea Neuroscience 2006 143 837 849 10.1016/j.neuroscience.2006.08.060 17074442 

  54. 54. Xiong Q. Gao Z. Wang W. Li M. Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds Trends Pharmacol. Sci. 2008 29 99 107 10.1016/j.tips.2007.11.010 18206251 

  55. 55. Rostock A. Tober C. Rundfeldt C. Bartsch R. Engel J. Polymeropoulos E.E. Kutscher B. Loscher W. Honack D. White H.S. D-23129: A new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures Epilepsy Res. 1996 23 211 223 10.1016/0920-1211(95)00101-8 8739124 

  56. 56. Rundfeldt C. The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells Eur. J. Pharmacol. 1997 336 243 249 10.1016/S0014-2999(97)01249-1 9384239 

  57. 57. Tober C. Rostock A. Rundfeldt C. Bartsch R. D-23129: A potent anticonvulsant in the amygdala kindling model of complex partial seizures Eur. J. Pharmacol. 1996 303 163 169 10.1016/0014-2999(96)00073-8 8813562 

  58. 58. French J.A. Abou-Khalil B.W. Leroy R.F. Yacubian E.M.T. Shin P. Hall S. Mansbach H. Nohria V. Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy Neurology 2011 76 1555 1563 10.1212/WNL.0b013e3182194bd3 21451152 

  59. 59. Gunthorpe M.J. Large C.H. Sankar R. The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy Epilepsia 2012 53 412 424 10.1111/j.1528-1167.2011.03365.x 22220513 

  60. 60. Tatulian L. Delmas P. Abogadie F.C. Brown D.A. Activation of Expressed KCNQ Potassium Currents and Native Neuronal M-Type Potassium Currents by the Anti-Convulsant Drug Retigabine J. Neurosci. 2001 21 5535 5545 10.1523/JNEUROSCI.21-15-05535.2001 11466425 

  61. 61. Schenzer A. Friedrich T. Pusch M. Saftig P. Jentsch T.J. Grotzinger J. Schwake M. Molecular Determinants of KCNQ (K v 7) K + Channel Sensitivity to the Anticonvulsant Retigabine J. Neurosci. 2005 25 5051 5060 10.1523/JNEUROSCI.0128-05.2005 15901787 

  62. 62. Friedman A.K. Juarez B. Ku S.M. Zhang H. Calizo R.C. Walsh J.J. Chaudhury D. Zhang S. Hawkins A. Dietz D.M. KCNQ channel openers reverse depressive symptoms via an active resilience mechanism Nat. Commun. 2016 7 11671 10.1038/ncomms11671 27216573 

  63. 63. Fretwell L.V. Woolard J. Cardiovascular responses to retigabine in conscious rats―Under normotensive and hypertensive conditions Br. J. Pharm. 2013 169 1279 1289 10.1111/bph.12203 23581476 

  64. 64. Hayashi H. Iwata M. Tsuchimori N. Matsumoto T. Activation of peripheral KCNQ channels attenuates inflammatory pain Mol. Pain 2014 10 15 10.1186/1744-8069-10-15 24555569 

  65. 65. Korsgaard M.P.G. Hartz B.P. Brown W.D. Ahring P.K. Strøbæk D. Mirza N.R. Anxiolytic Effects of Maxipost (BMS-204352) and Retigabine via Activation of Neuronal K v 7 Channels J. Pharmacol. Exp. Ther. 2005 314 282 292 10.1124/jpet.105.083923 15814569 

  66. 66. Redrobe J.P. Nielsen A.N. Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania Behav. Brain Res. 2009 198 481 485 10.1016/j.bbr.2008.12.027 19162078 

  67. 67. Brickel N. Gandhi P. VanLandingham K. Hammond J. DeRossett S. The urinary safety profile and secondary renal effects of retigabine (ezogabine): A first-in-class antiepileptic drug that targets KCNQ (Kv7) potassium channels Epilepsia 2012 53 606 612 10.1111/j.1528-1167.2012.03441.x 22428574 

  68. 68. Wainger B.J. Macklin E.A. Vucic S. McIlduff C.E. Paganoni S. Maragakis N.J. Bedlack R. Goyal N.A. Rutkove S.B. Lange D.J. Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial JAMA Neurol. 2021 78 186 196 10.1001/jamaneurol.2020.4300 33226425 

  69. 69. van Rijn C.M. van Bree E.W. Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex Eur. J. Pharm. 2003 464 95 100 10.1016/S0014-2999(03)01426-2 

  70. 70. Schroder R.L. Jespersen T. Christophersen P. Strobaek D. Jensen B.S. Olesen S.P. KCNQ4 channel activation by BMS-204352 and retigabine Neuropharmacology 2001 40 888 898 10.1016/S0028-3908(01)00029-6 11378159 

  71. 71. Li T. Wu K. Yue Z. Wang Y. Zhang F. Shen H. Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs Mol. Cell 2020 81 25 37 10.1016/j.molcel.2020.10.037 33238160 

  72. 72. Wuttke T.V. Seebohm G. Bail S. Maljevic S. Lerche H. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate Mol. Pharm. 2005 67 1009 1017 10.1124/mol.104.010793 15662042 

  73. 73. Zhang H. Craciun L.C. Mirshahi T. Rohacs T. Lopes C.M.B. Jin T. Logothetis D.E. PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents Neuron 2003 37 963 975 10.1016/S0896-6273(03)00125-9 12670425 

  74. 74. Zaydman M.A. Silva J.R. Delaloye K. Li Y. Liang H. Larsson H.P. Shi J. Cui J. Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening Proc. Natl. Acad. Sci. USA 2013 110 13180 13185 10.1073/pnas.1305167110 23861489 

  75. 75. Sheppard A.M. Chen G.-D. Salvi R. Potassium ion channel openers, Maxipost and Retigabine, protect against peripheral salicylate ototoxicity in rats Hear. Res. 2015 327 1 8 10.1016/j.heares.2015.04.007 25937133 

  76. 76. Wang L. Qiao G.-H. Hu H.-N. Gao Z.-B. Nan F.-J. Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity ACS Med. Chem. Lett. 2019 10 27 33 10.1021/acsmedchemlett.8b00315 30655942 

  77. 77. Liu R. Tzounopoulos T. Wipf P. Synthesis and Optimization of Kv7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity ACS Med. Chem. Lett. 2019 10 929 935 10.1021/acsmedchemlett.9b00097 31223450 

  78. 78. Dalby-Brown W. Jessen C. Hougaard C. Jensen M.L. Jacobsen T.A. Nielsen K.S. Erichsen H.K. Grunnet M. Ahring P.K. Christophersen P. Characterization of a novel high-potency positive modulator of Kv7 channels Eur. J. Pharmacol. 2013 709 52 63 10.1016/j.ejphar.2013.03.039 23562623 

  79. 79. Jepps T.A. Bentzen B.H. Stott J.B. Povstyan O.V. Sivaloganathan K. Dalby-Brown W. Greenwood I.A. Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370 Br. J. Pharmacol. 2014 171 4413 4424 10.1111/bph.12805 24909207 

  80. 80. Marks R. Pearse A.D. Walker A.P. The effects of a shampoo containing zinc pyrithione on the control of dandruff Br. J. Derm. 1985 112 415 422 10.1111/j.1365-2133.1985.tb02314.x 

  81. 81. Xiong Q. Sun H. Li M. Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants Nat. Chem. Biol. 2007 3 287 296 10.1038/nchembio874 17435769 

  82. 82. Xiong Q. Sun H. Zhang Y. Nan F. Li M. Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers Proc. Natl. Acad. Sci. USA 2008 105 3128 3133 10.1073/pnas.0712256105 18272489 

  83. 83. Hewawasam P. Gribkoff V.K. Pendri Y. Dworetzky S.I. Meanwell N.A. Martinez E. Boissard C.G. Post-Munson D.J. Trojnacki J.T. Yeleswaram K. The synthesis and characterization of BMS-204352 (MaxiPost™) and related 3-fluorooxindoles as openers of maxi-K potassium channels Bioorg. Med. Chem. Lett. 2002 12 1023 1026 10.1016/S0960-894X(02)00101-4 11909708 

  84. 84. Lobarinas E. Dalby-Brown W. Stolzberg D. Mirza N.R. Allman B.L. Salvi R. Effects of the potassium ion channel modulators BMS-204352 Maxipost and its R-enantiomer on salicylate-induced tinnitus in rats Physiol. Behav. 2011 104 873 879 10.1016/j.physbeh.2011.05.022 21640740 

  85. 85. Bentzen B.H. Schmitt N. Calloe K. Dalby Brown W. Grunnet M. Olesen S.P. The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels Neuropharmacology 2006 51 1068 1077 10.1016/j.neuropharm.2006.07.001 16904708 

  86. 86. Wu Y.J. Boissard C.G. Greco C. Gribkoff V.K. Harden D.G. He H. L’Heureux A. Kang S.H. Kinney G.G. Knox R.J. (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine J. Med. Chem. 2003 46 3197 3200 10.1021/jm034073f 12852750 

  87. 87. Blom S.M. Rottlander M. Kehler J. Bundgaard C. Schmitt N. Jensen H.S. From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group PLoS ONE 2014 9 e100209 10.1371/journal.pone.0100209 24956197 

  88. 88. Landoulsi Z. Miceli F. Palmese A. Amoresano A. Marino G. El Ayeb M. Taglialatela M. Benkhalifa R. Subtype-Selective Activation of K v 7 Channels by AaTXK β (2?64) , a Novel Toxin Variant from the Androctonus australis Scorpion Venom Mol. Pharmacol. 2013 84 763 773 10.1124/mol.113.088971 24019223 

  89. 89. Zhang X. An H. Li J. Zhang Y. Liu Y. Jia Z. Zhang W. Chu L. Zhang H. Selective activation of vascular Kv 7.4/Kv 7.5 K + channels by fasudil contributes to its vasorelaxant effect Br. J. Pharmacol. 2016 173 3480 3491 10.1111/bph.13639 27677924 

  90. 90. Yu H. Wu M. Townsend S.D. Zou B. Long S. Daniels J.S. McManus O.B. Li M. Lindsley C.W. Hopkins C.R. Discovery, Synthesis, and Structure?Activity Relationship of a Series of N-Aryl-bicyclo [2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener ACS Chem. Neurosci. 2011 2 572 577 10.1021/cn200065b 22125664 

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