[논문]Selective seratonin 1F (5-HT1F) receptor agonist LY334370 for acute migraine: a randomised controlled trial

doi:10.1016/S0140-6736(01)06347-4

[해외논문] Selective seratonin 1F (5-HT1F) receptor agonist LY334370 for acute migraine: a randomised controlled trial

The Lancet, v.358 no.9289 = no.9289, 2001년, pp.1230 - 1234

Goldstein, DJ (Neuroscience Division, Lilly Research Laboratories, Indianapolis, IN, USA) , Roon, KI (Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands) , Offen, WW (Neuroscience Division, Lilly Research Laboratories, Indianapolis, IN, USA) , Ramadan, NM (Neuroscience Division, Lilly Research Laboratories, Indianapolis, IN, USA) , Phebus, LA (Neuroscience Division, Lilly Research Laboratories, Indianapolis, IN, USA) , Johnson, KW (Neuroscience Division, Lilly Research Laboratories, Indianapolis, IN, USA) , Schaus, JM (Discovery Chemistry Research, Lilly Research Laboratories, Indianapolis, IN) , Ferrari, MD (Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands)

Abstract ▼ AI-Helper

Summary Background Triptans (5-HT1B/1D receptor agonists) are effective drugs for acute migraine, but the side-effect of coronary vasoconstriction restricts their use in patients who are at risk of coronary artery disease. We have studied the efficacy of LY334370, a selective serotonin 1F (5-HT1F) receptor agonist with preclinical efficacy and no vasoconstriction, for migraine relief. Methods We gave LY334370 (20, 60, or 200 mg) or placebo to 99 outpatients with moderate or severe migraine headaches in a double blind, parallel group study. We measured efficacy by sustained response, response at 2 h, pain free at 2 h, and sustained pain free. Findings The proportions of patients with defined endpoints for placebo and LY334370 20, 60, and 200 mg, respectively, were: sustained response, two of 26 (8%), three of 22 (14%), 11 of 30 (37%), and 11 of 21 (52%) (dose response p<0·001); response, five of 26 (19%), four of 22 (18%), 15 of 30 (50%), and 15 of 21 (71%) (p<0·001); pain free, one of 26 (4%), none of 22, eight of 30 (27%), and eight of 21 (38%) (p=0·001); sustained pain free, one of 26 (4%), none of 22, seven of 30 (23%), and seven of 21 (33%) (p=0·002); recurrence rates, one of five (20%), none of four, four of 15 (27%), and three of 15 (20%). More patients given LY334370 than placebo reported asthenia, somnolence, and dizziness. Interpretation Our findings show that LY334370 is effective in treatment of acute migraine through selective trigeminovascular neuronal inhibition.

참고문헌 (18)

Eur J Pharmacol Wainscott 352 117 1998 10.1016/S0014-2999(98)00336-7 Human 5-HT1F receptor-stimulated [35S]GTPgS binding: correlation with inhibition of guinea pig dural plasma protein extravasation

상세보기
Proc Natl Acad Sci USA Adham 90 408 1993 10.1073/pnas.90.2.408 Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase

상세보기
Neuroreport Johnson 8 2237 1997 10.1097/00001756-199707070-00029 5-HT1F receptor agonists inhibit neurogenic inflammation in guinea pigs

상세보기
Life Sci Phebus 61 2117 1997 10.1016/S0024-3205(97)00885-0 Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine

상세보기
Br J Pharmacol Bouchelet 129 501 2000 10.1038/sj.bjp.0703081 No contractile effect for 5-HT1D and 5-HT1F receptor agonists in human and bovine cerebral arteries: similarity with human coronary

상세보기
Cephalalgia Shepheard 19 851 1999 10.1046/j.1468-2982.1999.1910851.x Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370

상세보기
J Pharmacol Exp Ther Cohen 290 935 1999 5 hydroxytryptamine (1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin (1F) receptor agonist in rabbit saphenous vein

상세보기
Br J Pharmacol Cohen 131 562 2000 10.1038/sj.bjp.0703587 Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT1F receptor agonists and PGF2α

상세보기
Cephalalgia Goldstein 17 785 1997 10.1046/j.1468-2982.1997.1707785.x Ineffectiveness of neurokinin-1 antagonist in acute migraine: a crossover study

상세보기
Cephalalgia 8 suppl 7 1 1988 Classification and diagnosis criteria for headache disorders, cranial neuralgias, and facial pain
Cephalalgia Goldstein 19 248 1999 10.1046/j.1468-2982.1999.019004248.x Efficacy definitions for migraine studies

상세보기
Lancet Ferrari 351 1043 1998 10.1016/S0140-6736(97)11370-8 Migraine

상세보기
Cephalalgia Ferrari 19 (suppl 23) 2 1999 10.1177/0333102499019S2302 How to assess and compare drugs in the management of migraine: success rate in terms of response and recurrence
Cephalalgia 11 1 1991 10.1046/j.1468-2982.1991.1101001.x Guidelines for controlled trials of drugs in migraine (first edition)

상세보기
Br J Pharmacol Cumberbatch 126 1478 1999 10.1038/sj.bjp.0702444 Dural vasodilation causes a sensitization of rat trigeminal neurones in vivo that is blocked by a 5HT 1B/1D agonist

상세보기
Ann Neurol Goadsby 43 711 1998 10.1002/ana.410430605 Serotonin inhibits trigeminal nucleus activity evoked by craniovascular stimulation trough a 5HT1B/1D receptor: a central action in migraine?

상세보기
Neuropharmacol Adham 36 569 1997 10.1016/S0028-3908(97)00020-8 Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homologue

상세보기
Cephalalgia Davies 20 554 2000 10.1046/j.1468-2982.2000.00082.x Determinants of patient satisfaction with migraine therapy

상세보기

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[해외논문] Selective seratonin 1F (5-HT1F) receptor agonist LY334370 for acute migraine: a randomised controlled trial

Abstract ▼ AI-Helper

참고문헌 (18)

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