[논문]Emerging functions of circular RNA in aging

Kim, Eunah; Kim, Yoon Ki; Lee, Seung-Jae V.

doi:10.1016/j.tig.2021.04.014

[해외논문] Emerging functions of circular RNA in aging

Trends in genetics, v.37 no.9, 2021년, pp.819 - 829

Kim, Eunah (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) , Kim, Yoon Ki (Creative Research Initiatives Center for Molecular Biology of Translation, Korea University) , Lee, Seung-Jae V. (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)

Abstract ▼ AI-Helper

Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes. Recent studies indicate that the levels of circRNAs change with age in various tissues in multiple species, ranging from nematodes to mammals. Here we discuss the functional roles of circRNAs in animal aging and longevity. We review studies regarding the differential expression of circRNAs that contributes to cellular senescence and the pathogenesis of aging-associated diseases. We explore the features of aging-associated circRNAs by discussing their potential as biomarkers of aging, tissue specificity, physiological roles, action mechanisms, and evolutionarily conserved characteristics. Our review provides insights into current progress in circRNA research and their significant functions in the aging process. Highlights Circular RNAs (circRNAs) are closed and cyclic RNAs that are widely expressed in eukaryotes and have multiple functions, including interacting with proteins, sponging miRNAs, encoding proteins, and regulating gene expression via binding promoters. The expression patterns and stability of circRNAs have emerged as promising candidate biomarkers of aging and age-associated diseases. The levels of circRNAs generally increase with age in various species and may play roles in aging and cellular senescence. Specifically, ciRS-7/circCDR1as and circSfl are associated with Alzheimer’s disease and fruit fly longevity, respectively. It will be important to identify functional circRNAs to elucidate the underlying mechanisms regarding their roles in aging and/or age-related diseases.

Keyword

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