다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Frontiers in pharmacology, v.12, 2021년, pp.702487 -
Sampaio, Laeza Alves (Graduate Program of Applied Sciences to Health, Federal University of Sergipe, Lagarto , Brazil) , Pina, Lícia Tairiny Santos (Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju , Brazil) , Serafini, Mairim Russo (Department of Pharmacy, Federal University of Sergipe, Sã) , Tavares, Débora dos Santos (o Cristó) , Guimarães, Adriana Gibara (vã)
AI-Helper
Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural compounds that act against several diseases, including cancer. Thus, this systematic review aimed to examine and synthesize the...
Abbas A. Al-Fatlawi A. ( 2018 ). Anti-proliferative and Pro-apoptotic Activity of Carvacrol on Human Cancer Cells . Int. J. Pharm. Res. 10 ( 2 ), 174 – 180 . 10.3892/or.2012.1877
Abdel-Aleem H. Ahmed A. Sabra A. M. Zakhari M. Soliman M. Hamed H. ( 1996 ). Serum Alphal-Fucosidase Enzyme Activity in Ovarian and Other Female Genital Tract Tumors . Int. J. Gynecol. Obstet. 55 ( 3 ), 273 – 279 . 10.1016/s0020-7292(96)02770-1
Abed R. ( 2011 ). Cytotoxic, Cytogenetics and Immunomodulatory Effects of Thymol from Thymus Vulgaris on Cancer and Normal Cell Lines In Vitro and In Vivo . Al-mustansiriyah J. Sci. 22 ( 5 ), 41 – 53 . 10.3403/30303631
Agodi A. Barchitta M. Quattrocchi A. Maugeri A. Vinciguerra M. ( 2015 ). DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis . PLoS ONE 10 ( 8 ), e0135078 . 10.1371/journal.pone.0135078 26267895
Ahmed H. Shousha W. El-Mezayen H. Ismaiel N. Mahmoud N. ( 2013 ). In Vivo antitumor Potential of Carvacrol against Hepatocellular Carcinoma in Rat Model . World J. Pharm. Pharm. Sci. 2 ( 5 ), 2367 – 2396 . 10.3748/wjg.v8.i3.464
Akalin G. Incesu Z. ( 2011 ). The Effect of Carvacrol on Apoptosis of H-RAS and N-RAS Transformed Cell Lines . Turk J. Pharm. Sci. 8 ( 2 ), 105 – 116 . 10.1007/978-1-4757-1235-3_13
Al-Fatlawi A. Ahmad A. ( 2014 ). Cytotoxicity and Pro-apoptotic Activity of Carvacrol on Human Breast Cancer Cell Line MCF-7 . World J. Pharm. Sci. 2 ( 10 ), 1218 – 1223 . 10.3923/pjbs.2021.646.655
Allawzi A. Elajaili H. Redente E. F. Nozik-Grayck E. ( 2019 ). Oxidative Toxicology of Bleomycin: Role of the Extracellular Redox Environment . Curr. Opin. Toxicol. 13 ( 13 ), 68 – 73 . 10.1016/j.cotox.2018.08.001 31289762
Alrehaili A. A. Gharib A. F. Karam R. A. Alhakami R. A. El Sawy W. H. Abd Elrahman T. M. ( 2020 ). Clinical Significance of Plasma MMP‐2 and MMP‐9 Levels as Biomarkers for Tumor Expression in Breast Cancer Patients in Egypt . Mol. Biol. Rep. 47 ( 2 ), 1153 – 1160 . 10.1007/s11033-019-05216-5 31820313
Alzahrani A. S. ( 2019 ). PI3K/Akt/mTOR Inhibitors in Cancer: At the Bench and Bedside . Semin. Cancer Biol. 59 , 125 – 132 . 10.1016/j.semcancer.2019.07.009 31323288
Arigesavan K. Sudhandiran G. ( 2015 ). Carvacrol Exhibits Anti-oxidant and Anti-inflammatory Effects against 1, 2-dimethyl Hydrazine Plus Dextran Sodium Sulfate Induced Inflammation Associated Carcinogenicity in the colon of Fischer 344 Rats . Biochem. Biophysical Res. Commun. 461 ( 2 ), 314 – 320 . 10.1016/j.bbrc.2015.04.030
Arunasree K. M. ( 2010 ). Anti-proliferative Effects of Carvacrol on a Human Metastatic Breast Cancer Cell Line, MDA-MB 231 . Phytomedicine 17 ( 8–9 ), 581 – 588 . 10.1016/j.phymed.2009.12.008 20096548
Arya R. Saldanha S. N. ( 2019 ). “ Dietary Phytochemicals, Epigenetics, and Colon Cancer Chemoprevention ,” in Epigenetics of Cancer Prevention . Editors Bishayee A. Bhatia D. ( Cambridge : Academic Press ), 205 – 229 . 10.1016/B978-0-12-812494-9.00010-X
Ashraf M. A. ( 2020 ). Phytochemicals as Potential Anticancer Drugs: Time to Ponder Nature's Bounty . Biomed. Res. Int. 2020 , e8602879 . 10.1155/2020/8602879
Asif M. ( 2015 ). Role of Fruit and Vegetable in the Treatment of Cancer . Curr. Sci. Perspect. 1 ( 1 ), 33 – 40 . 10.1533/9781845694296.4.272
Aydın E. Türkez H. Keleş M. S. ( 2014 ). The Effect of Carvacrol on Healthy Neurons and N2a Cancer Cells: Some Biochemical, Anticancerogenicity and Genotoxicity Studies . Cytotechnology 66 ( 1 ), 149 – 157 . 10.1007/s10616-013-9547-5 23553016
Ayude D. Fernández-Rodríguez J. Rodríguez-Berrocal F. J. Martínez-Zorzano V. S. De Carlos A. Gil E. ( 2000 ). Value of the Serum Alpha-L-Fucosidase Activity in the Diagnosis of Colorectal Cancer . Oncology 59 ( 4 ), 310 – 316 . 10.1159/000012188 11096343
Backus H. H. J. Van Groeningen C. J. Vos W. Dukers D. F. Bloemena E. Wouters D. ( 2002 ). Differential Expression of Cell Cycle and Apoptosis Related Proteins in Colorectal Mucosa, Primary colon Tumours, and Liver Metastases . J. Clin. Pathol. 55 ( 3 ), 206 – 211 . 10.1136/jcp.55.3.206 11896073
Bailon-Moscoso N. Cevallos-Solorzano G. Romero-Benavides J. Ramirez Orellana M. ( 2017 ). Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies . Curr. Genomics 18 ( 2 ), 106 – 131 . 10.2174/1389202917666160808125645 28367072
Baj T. Biernasiuk A. Wróbel R. Malm A. ( 2020 ). Chemical Composition and In Vitro Activity of Origanum Vulgare L., Satureja Hortensis L., Thymus Serpyllum L. And Thymus Vulgaris L. Essential Oils towards Oral Isolates of Candida Albicans and Candida Glabrata . Open Chem. 18 ( 1 ), 108 – 118 . 10.1515/chem-2020-0011
Balan D. J. Rajavel T. Das M. Sathya S. Jeyakumar M. Devi K. P. ( 2021 ). Thymol Induces Mitochondrial Pathway-Mediated Apoptosis via ROS Generation, Macromolecular Damage and SOD Diminution in A549 Cells . Pharmacol. Rep. 73 ( 1 ), 240 – 254 . 10.1007/s43440-020-00171-6 33095436
Baranauskaite J. Kubiliene A. Marksa M. Petrikaite V. Vitkevičius K. Baranauskas A. ( 2017 ). The Influence of Different Oregano Species on the Antioxidant Activity Determined Using HPLC Postcolumn DPPH Method and Anticancer Activity of Carvacrol and Rosmarinic Acid . Biomed. Res. Int. 2017 , 1681392 . 10.1155/2017/1681392 29181386
Basu A. Haldar S. ( 1998 ). The Relationship between BcI2, Bax and P53: Consequences for Cell Cycle Progression and Cell Death . Mol. Hum. Reprod. 4 ( 12 ), 1099 – 1109 . 10.1093/molehr/4.12.1099 9872359
Bei R. Mizejewski G. J. ( 2011 ). Alpha Fetoprotein Is More Than a Hepatocellular Cancer Biomarker: from Spontaneous Immune Response in Cancer Patients to the Development of an AFP-Based Cancer Vaccine . Curr. Mol. Med. 11 ( 7 ), 564 – 581 . 10.2174/156652411800615162 21707514
Belyi V. A. Ak P. Markert E. Wang H. Hu W. Puzio-Kuter A. ( 2010 ). The Origins and Evolution of the P53 Family of Genes . Cold Spring Harbor Perspect. Biol. 2 ( 6 ), a001198 . 10.1101/cshperspect.a001198
Bhakkiyalakshmi E. Suganya N. Sireesh D. Krishnamurthi K. Saravana Devi S. Rajaguru P. ( 2016 ). Carvacrol Induces Mitochondria-Mediated Apoptosis in HL-60 Promyelocytic and Jurkat T Lymphoma Cells . Eur. J. Pharmacol. 772 , 92 – 98 . 10.1016/j.ejphar.2015.12.046 26724845
Binétruy B. Heasley L. Bost F. Caron L. Aouadi M. ( 2007 ). Concise Review: Regulation of Embryonic Stem Cell Lineage Commitment by Mitogen-Activated Protein Kinases . Stem Cells 25 ( 5 ), 1090 – 1095 . 10.1634/stemcells.2006-0612 17218395
Bou-Hanna C. Jarry A. Lode L. Schmitz I. Schulze-Osthoff K. Kury S. ( 2015 ). Acute Cytotoxicity of MIRA-1/NSC19630, a Mutant P53-Reactivating Small Molecule, against Human normal and Cancer Cells via a Caspase-9-dependent Apoptosis . Cancer Lett. 359 ( 2 ), 211 – 217 . 10.1016/j.canlet.2015.01.014 25617798
Bouhtit F. Najar M. Moussa Agha D. Melki R. Najimi M. Sadki K. ( 2021 ). New Anti-leukemic Effect of Carvacrol and Thymol Combination through Synergistic Induction of Different Cell Death Pathways . Molecules 26 ( 2 ), 410 . 10.3390/molecules26020410
Carqueijeiro I. Langley C. Grzech D. Koudounas K. Papon N. O’Connor S. E. ( 2020 ). Beyond the Semi-synthetic Artemisinin: Metabolic Engineering of Plant-Derived Anti-cancer Drugs . Curr. Opin. Biotechnol. 65 , 17 – 24 . 10.1016/j.copbio.2019.11.017 31841858
Chamanara M. Abdollahi A. Rezayat S. M. Ghazi-Khansari M. Dehpour A. Nassireslami E. ( 2019 ). Thymol Reduces Acetic Acid-Induced Inflammatory Response through Inhibition of NF-kB Signaling Pathway in Rat colon Tissue . Inflammopharmacol 27 ( 6 ), 1275 – 1283 . 10.1007/s10787-019-00583-8
Chan H. Ho J. Liu X. Zhang L. Wong S. H. Chan M. ( 2017 ). Potential and Use of Bacterial Small RNAs to Combat Drug Resistance: a Systematic Review . Infect. Drug Resist. 10 , 521 – 532 . 10.2147/IDR.S148444 29290689
Chang H.-T. Hsu S.-S. Chou C.-T. Cheng J.-S. Wang J.-L. Lin K.-L. ( 2011 ). Effect of Thymol on Ca2+ Homeostasis and Viability in MG63 Human Osteosarcoma Cells . Pharmacology 88 ( 3–4 ), 201 – 212 . 10.1159/000331864 21986213
Chauhan A. K. Bahuguna A. Paul S. Kang S. C. ( 2018 ). Thymol Elicits HCT-116 Colorectal Carcinoma Cell Death through Induction of Oxidative Stress . Acamc 17 ( 14 ), 1942 – 1950 . 10.2174/1871520617666170327121228
Chen W.-L. Barszczyk A. Turlova E. Deurloo M. Liu B. Yang B. B. ( 2015 ). Inhibition of TRPM7 by Carvacrol Suppresses Glioblastoma Cell Proliferation, Migration and Invasion . Oncotarget 6 ( 18 ), 16321 – 16340 . 10.18632/oncotarget.3872 25965832
Coccimiglio J. Alipour M. Jiang Z.-H. Gottardo C. Suntres Z. ( 2016 ). Antioxidant, Antibacterial, and Cytotoxic Activities of the Ethanolic Origanum vulgare Extract and its Major Constituents . Oxidative Med. Cell. longevity 2016 , 1404505 . 10.1155/2016/1404505
Collins T. S. Hurwitz H. I. ( 2005 ). Targeting Vascular Endothelial Growth Factor and Angiogenesis for the Treatment of Colorectal Cancer . Semin. Oncol. 32 ( 1 ), 61 – 68 . 10.1053/j.seminoncol.2004.09.026 15726507
Conklin K. A. ( 2004 ). Chemotherapy-associated Oxidative Stress: Impact on Chemotherapeutic Effectiveness . Integr. Cancer Ther. 3 ( 4 ), 294 – 300 . 10.1177/1534735404270335 15523100
Dabrowska C. Li M. Fan Y. ( 2016 ). Apoptotic Caspases in Promoting Cancer: Implications from Their Roles in Development and Tissue Homeostasis . Adv. Exp. Med. Biol. 930 , 89 – 112 . 10.1007/978-3-319-39406-0_4 27558818
Dai W. Sun C. Huang S. Zhou Q. ( 2016 ). Carvacrol Suppresses Proliferation and Invasion in Human Oral Squamous Cell Carcinoma . Onco Targets Ther. 9 , 2297 – 2304 . 10.2147/OTT.S98875 27143925
De Boer H. J. Cotingting C. ( 2014 ). Medicinal Plants for Women's Healthcare in Southeast Asia: A Meta-Analysis of Their Traditional Use, Chemical Constituents, and Pharmacology . J. Ethnopharmacology 151 ( 2 ), 747 – 767 . 10.1016/j.jep.2013.11.030
De La Chapa J. J. Singha P. K. Lee D. R. Gonzales C. B. ( 2018 ). Thymol Inhibits Oral Squamous Cell Carcinoma Growth via Mitochondria-Mediated Apoptosis . J. Oral Pathol. Med. 47 ( 7 ), 674 – 682 . 10.1111/jop.12735 29777637
de Sá Junior P. L. Câmara D. A. D. Porcacchia A. S. Fonseca P. M. M. Jorge S. D. Araldi R. P. ( 2017 ). The Roles of ROS in Cancer Heterogeneity and Therapy . Oxidative Med. Cell. longevity 2017 , 2467940 . 10.1155/2017/2467940
Deb D. D. Parimala G. Saravana Devi S. Chakraborty T. ( 2011 ). Effect of Thymol on Peripheral Blood Mononuclear Cell PBMC and Acute Promyelotic Cancer Cell Line HL-60 . Chemico-Biological Interactions 193 ( 1 ), 97 – 106 . 10.1016/j.cbi.2011.05.009 21640085
Elbe H. Yigitturk G. Cavusoglu T. Baygar T. Ozgul Onal M. Ozturk F. ( 2020 ). Comparison of Ultrastructural Changes and the Anticarcinogenic Effects of Thymol and Carvacrol on Ovarian Cancer Cells: Which Is More Effective? Ultrastructural Pathol. 44 ( 2 ), 193 – 202 . 10.1080/01913123.2020.1740366
Elbe H. Yigitturk G. Cavusoglu T. Uyanikgil Y. Ozturk F. ( 2020 ). Apoptotic Effects of Thymol, a Novel Monoterpene Phenol, on Different Types of Cancer . Bratisl Lek Listy 121 ( 2 ), 122 – 128 . 10.4149/BLL_2020_016 32115964
Elshafie H. Armentano M. Carmosino M. Bufo S. De Feo V. Camele I. ( 2017 ). Cytotoxic Activity of Origanum Vulgare L. On Hepatocellular Carcinoma Cell Line HepG2 and Evaluation of its Biological Activity . Molecules 22 ( 9 ), 1435 . 10.3390/molecules22091435
Fan K. Li X. Cao Y. Qi H. Li L. Zhang Q. ( 2015 ). Carvacrol Inhibits Proliferation and Induces Apoptosis in Human colon Cancer Cells . Anticancer Drugs 26 ( 8 ), 813 – 823 . 10.1097/CAD.0000000000000263 26214321
Ferraz R. P. C. Bomfim D. S. Carvalho N. C. Soares M. B. P. da Silva T. B. Machado W. J. ( 2013 ). Cytotoxic Effect of Leaf Essential Oil of Lippia Gracilis Schauer (Verbenaceae) . Phytomedicine 20 ( 7 ), 615 – 621 . 10.1016/j.phymed.2013.01.015 23453306
Fiandalo M. V. Kyprianou N. ( 2012 ). Caspase Control: Protagonists of Cancer Cell Apoptosis . Exp. Oncol. 34 ( 3 ), 165 – 175 . 23070001
Fitsiou E. Anestopoulos I. Chlichlia K. Galanis A. Kourkoutas I. Panayiotidis M. I. ( 2016 ). Antioxidant and Antiproliferative Properties of the Essential Oils of Satureja Thymbra and Satureja Parnassica and Their Major Constituents . Anticancer Res. 36 ( 11 ), 5757 – 5764 . 10.21873/anticanres.11159 27793897
Fouad H. Salem H. Ellakwa D. E. S. Abdel‐Hamid M. ( 2019 ). MMP‐2 and MMP‐9 as Prognostic Markers for the Early Detection of Urinary Bladder Cancer . J. Biochem. Mol. Toxicol. 33 ( 4 ), e22275 . 10.1002/jbt.22275 30548095
Fundyler O. Khanna M. Smoller B. R. ( 2004 ). Metalloproteinase-2 Expression Correlates with Aggressiveness of Cutaneous Squamous Cell Carcinomas . Mod. Pathol. 17 ( 5 ), 496 – 502 . 10.1038/modpathol.3800066 14990972
Georgakilas A. G. Martin O. A. Bonner W. M. ( 2017 ). p21: A Two-Faced Genome Guardian . Trends Mol. Med. 23 ( 4 ), 310 – 319 . 10.1016/j.molmed.2017.02.001 28279624
Ghavami S. Hashemi M. Ande S. R. Yeganeh B. Xiao W. Eshraghi M. ( 2009 ). Apoptosis and Cancer: Mutations within Caspase Genes . J. Med. Genet. 46 ( 8 ), 497 – 510 . 10.1136/jmg.2009.066944 19505876
Ghorani V. Alavinezhad A. Rajabi O. Mohammadpour A. H. Boskabady M. H. ( 2021 ). Safety and Tolerability of Carvacrol in Healthy Subjects: a Phase I Clinical Study . Drug Chem. Toxicol. 44 ( 2 ), 177 – 189 . 10.1080/01480545.2018.1538233 30486682
Giardina M. G. Matarazzo M. Varriale A. Morante R. Napoli A. Martino R. ( 1992 ). Serum Alpha-L-Fucosidase. A Useful Marker in the Diagnosis of Hepatocellular Carcinoma . Cancer 70 ( 5 ), 1044 – 1048 . 10.1002/1097-0142(19920901)70:5<1044::aid-cncr2820700506>3.0.co;2-u 1381268
Gordaliza M. ( 2007 ). Natural Products as Leads to Anticancer Drugs . Clin. Transl Oncol. 9 ( 12 ), 767 – 776 . 10.1007/s12094-007-0138-9 18158980
Gottlieb T. M. Oren M. ( 1998 ). p53 and Apoptosis . Semin. Cancer Biol. 8 ( 5 ), 359 – 368 . 10.1006/scbi.1998.0098 10101801
Gouveia D. N. Costa J. S. Oliveira M. A. Rabelo T. K. Silva A. M. d. O. e. Carvalho A. A. ( 2018 ). α-Terpineol Reduces Cancer Pain via Modulation of Oxidative Stress and Inhibition of iNOS . Biomed. Pharmacother. 105 , 652 – 661 . 10.1016/j.biopha.2018.06.027 29902764
Govindaraju S. Arulselvi P. I. ( 2018 ). Characterization ofColeus Aromaticusessential Oil and its Major Constituent Carvacrol Forin Vitroantidiabetic and Antiproliferative Activities . J. Herbs, Spices Med. Plants 24 ( 1 ), 37 – 51 . 10.1080/10496475.2017.1369483
Günes-Bayir A. Kocyigit A. Güler E. M. Bilgin M. G. Ergün İ. S. Dadak A. ( 2018 ). Effects of Carvacrol on Human Fibroblast (WS-1) and Gastric Adenocarcinoma (AGS) Cells In Vitro and on Wistar Rats In Vivo . Mol. Cel Biochem. 448 ( 5 ), 237 – 249 . 10.1007/s11010-018-3329-5
Günes-Bayir A. Kocyigit A. Guler E. M. Dadak A. ( 2020 ). In Vitro Hormetic Effect Investigation of Thymol on Human Fibroblast and Gastric Adenocarcinoma Cells . Molecules 25 ( 14 ), 3270 . 10.3390/molecules25143270
Günes-Bayir A. Kocyigit A. Güler E. M. ( 2018 ). In Vitro effects of Two Major Phenolic Compounds from the Family Lamiaceae Plants on the Human Gastric Carcinoma Cells . Toxicol. Ind. Health 34 ( 8 ), 525 – 539 . 10.1177/0748233718761698 29848188
Hamilton E. Infante J. R. ( 2016 ). Targeting CDK4/6 in Patients with Cancer . Cancer Treat. Rev. 45 , 129 – 138 . 10.1016/j.ctrv.2016.03.002 27017286
Harris S. L. Levine A. J. ( 2005 ). The P53 Pathway: Positive and Negative Feedback Loops . Oncogene 24 ( 17 ), 2899 – 2908 . 10.1038/sj.onc.1208615 15838523
Hassan H. F. H. Mansour A. M. Salama S. A. El-Sayed E.-S. M. ( 2021 ). The Chemopreventive Effect of Thymol against Dimethylhydrazine And/or High Fat Diet-Induced colon Cancer in Rats: Relevance to NF-Κb . Life Sci. 274 , 119335 . 10.1016/j.lfs.2021.119335 33713663
Hassen A. M. Taye G. Gizaw M. Hussien F. M. ( 2019 ). Quality of Life and Associated Factors Among Patients with Breast Cancer under Chemotherapy at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia . PLoS ONE 14 ( 9 ), e0222629 . 10.1371/journal.pone.0222629 31539399
Heidarian E. Keloushadi M. ( 2019 ). Antiproliferative and Anti-invasion Effects of Carvacrol on PC3 Human Prostate Cancer Cells through Reducing pSTAT3, pAKT, and pERK1/2 Signaling Proteins . Int. J. Prev. Med. 10 , 156 . 10.4103/ijpvm.IJPVM_292_17 32133074
Hensley P. Mishra M. Kyprianou N. ( 2013 ). Targeting Caspases in Cancer Therapeutics . Biol. Chem. 394 ( 7 ), 831 – 843 . 10.1515/hsz-2013-0128 23509217
Hooijmans C. R. Rovers M. M. De Vries R. B. Leenaars M. Ritskes-Hoitinga M. Langendam M. W. ( 2014 ). SYRCLE's Risk of Bias Tool for Animal Studies . BMC Med. Res. Methodol. 14 , 43 . 10.1186/1471-2288-14-43 24667063
Horng C.-T. Chou C. Sun T. Liang W. Kuo C. Wang J. ( 2017 ). Effect of Carvacrol on Ca^(2+) Movement and Viability in PC3 Human Prostate Cancer Cells . Chin. J. Physiol. 60 ( 5 ), 275 – 283 . 10.4077/cjp.2017.bag506 28950692
Horvathova E. Turcaniova V. Slamenova D. ( 2007 ). Comparative Study of DNA-Damaging and DNA-Protective Effects of Selected Components of Essential Plant Oils in Human Leukemic Cells K562 . Neoplasma 54 ( 6 ), 478 – 483 . 17949230
Horváthová E. Sramková M. Lábaj J. Slamenová D. ( 2006 ). Study of Cytotoxic, Genotoxic and DNA-Protective Effects of Selected Plant Essential Oils on Human Cells Cultured In Vitro . Neuro Endocrinol. Lett. 27 ( Suppl. 2 ), 44 – 47 . 10.4172/2167-0412.1000170 17159777
Hsu S.-S. Lin K.-L. Chou C.-T. Chiang A.-J. Liang W.-Z. Chang H.-T. ( 2011 ). Effect of Thymol on Ca2+ Homeostasis and Viability in Human Glioblastoma Cells . Eur. J. Pharmacol. 670 ( 1 ), 85 – 91 . 10.1016/j.ejphar.2011.08.017 21914442
Huang H. Zhang X.-F. Zhou H.-J. Xue Y.-H. Dong Q.-Z. Ye Q.-H. ( 2010 ). Expression and Prognostic Significance of Osteopontin and Caspase-3 in Hepatocellular Carcinoma Patients after Curative Resection . Cancer Sci. 101 ( 5 ), 1314 – 1319 . 10.1111/j.1349-7006.2010.01524.x 20345480
Ingham M. Schwartz G. K. ( 2017 ). Cell-Cycle Therapeutics Come of Age . J. Clin. Oncol. 35 ( 25 ), 2949 – 2959 . 10.1200/JCO.2016.69.0032 28580868
Jaafari A. Mouse H. A. Rakib E. M. M’barek L. A. Tilaoui M. Benbakhta C. ( 2007 ). Chemical Composition and Antitumor Activity of Different Wild Varieties of Moroccan Thyme . Rev. Bras. Farmacogn. 17 ( 4 ), 477 – 491 . 10.1590/S0102-695X2007000400002
Jaafari A. Tilaoui M. Mouse H. A. M'bark L. A. Aboufatima R. Chait A. ( 2012 ). Comparative Study of the Antitumor Effect of Natural Monoterpenes: Relationship to Cell Cycle Analysis . Rev. Bras. Farmacogn. 22 ( 3 ), 534 – 540 . 10.1590/S0102-695X2012005000021
Jabłońska-Trypuć A. Matejczyk M. Rosochacki S. ( 2016 ). Matrix Metalloproteinases (MMPs), the Main Extracellular Matrix (ECM) Enzymes in Collagen Degradation, as a Target for Anticancer Drugs . J. Enzyme Inhib. Med. Chem. 31 ( Suppl. 1 ), 177 – 183 . 10.3109/14756366.2016.1161620 27028474
Jamali T. Kavoosi G. Safavi M. Ardestani S. ( 2018 ). In-vitro Evaluation of Apoptotic Effect of OEO and Thymol in 2D and 3D Cell Cultures and the Study of Their Interaction Mode with DNA . Sci. Rep. 8 ( 1 ), 15787 . 10.1038/s41598-018-34055-w 30361692
Jayakumar S. Madankumar A. Asokkumar S. Raghunandhakumar S. Gokula dhas K. Kamaraj S. ( 2012 ). Potential Preventive Effect of Carvacrol against Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats . Mol. Cel Biochem. 360 ( 1–2 ), 51 – 60 . 10.1007/s11010-011-1043-7
Jung C. Y. Kim S. Y. Lee C. ( 2018 ). Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells . Anticancer Res. 38 ( 1 ), 279 – 286 . 10.21873/anticanres.12219 29277784
Karkabounas S. Kostoula O. K. Daskalou T. Veltsistas P. Karamouzis M. Zelovitis I. ( 2006 ). Anticarcinogenic and Antiplatelet Effects of Carvacrol . Exp. Oncol. 28 ( 2 ), 121 – 125 . 10.1080/01913123.2020.1740366 16837902
Kelly K. ( 2009 ). The History of Medicine. The Middle Ages . Medicine : Stonehenge , 500 – 1450 .
Khan F. Khan I. Farooqui A. Ansari I. A. ( 2017 ). Carvacrol Induces Reactive Oxygen Species (ROS)-mediated Apoptosis along with Cell Cycle Arrest at G0/G1 in Human Prostate Cancer Cells . Nutr. Cancer 69 ( 7 ), 1075 – 1087 . 10.1080/01635581.2017.1359321 28872904
Khan F. Singh V. K. Saeed M. Kausar M. A. Ansari I. A. ( 2019 ). Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-independent Human Prostate Cancer Cells via Inhibition of Notch Signaling . Anticancer Agents Med. Chem. 19 ( 13 ), 1588 – 1608 . 10.2174/1871520619666190731152942 31364516
Kim B. Srivastava S. K. Kim S.-H. ( 2015 ). Caspase-9 as a Therapeutic Target for Treating Cancer . Expert Opin. Ther. Targets 19 ( 1 ), 113 – 127 . 10.1517/14728222.2014.961425 25256701
Kim C. Kim B. ( 2018 ). Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review . Nutrients 10 ( 8 ), 1021 . 10.3390/nu10081021
Kim E. K. Choi E.-J. ( 2015 ). Compromised MAPK Signaling in Human Diseases: an Update . Arch. Toxicol. 89 ( 6 ), 867 – 882 . 10.1007/s00204-015-1472-2 25690731
Kocal G. Pakdemirli A. ( 2020 ). Antiproliferative Effects of Carvacrol on Neuroblastoma Cells . J. Dr Behcet Uz Child. Hosp. 10 ( 1 ), 61 – 64 . 10.5222/buchd.2020.59251
Koparal A. T. Zeytinoglu M. ( 2003 ). Effects of Carvacrol on a Human Non-small Cell Lung Cancer (NSCLC) Cell Line, A549 . Cytotechnology 43 ( 1–3 ), 149 – 154 . 10.1023/b:cyto.0000039917.60348.45 19003220
Koss B. Greengard O. ( 1982 ). Effect of Neoplasms on the Content and Activity of Alkaline Phosphatase and Gamma-Glutamyl Transpeptidase in Uninvolved Host Tissues . Cancer Res. 42 ( 6 ), 2146 – 2158 . 6122501
Koyama H. Iwata H. Kuwabara Y. Iwase H. Kobayashi S. Fujii Y. ( 1990 ). Gelatinolytic Activity of Matrix Metalloproteinase-2 and -9 in Oesophageal Carcinoma; a Study Using In Situ Zymography . Eur. J. Cancer 36 ( 16 ), 2164 – 2170 . 10.1016/s0959-8049(00)00297-5
Krelin Y. Zhang L. Kang T.-B. Appel E. Kovalenko A. Wallach D. ( 2008 ). Caspase-8 Deficiency Facilitates Cellular Transformation In Vitro . Cell Death Differ. 15 ( 9 ), 1350 – 1355 . 10.1038/cdd.2008.88 18566604
Krens S. F. G. Spaink H. P. Snaar-Jagalska B. E. ( 2006 ). Functions of the MAPK Family in Vertebrate-Development . FEBS Lett. 580 ( 21 ), 4984 – 4990 . 10.1016/j.febslet.2006.08.025 16949582
Kroemer G. Dallaporta B. Resche-Rigon M. ( 1998 ). The Mitochondrial Death/life Regulator in Apoptosis and Necrosis . Annu. Rev. Physiol. 60 , 619 – 642 . 10.1146/annurev.physiol.60.1.619 9558479
Landis J. R. Koch G. G. ( 1977 ). The Measurement of Observer Agreement for Categorical Data . Biometrics 33 ( 1 ), 159 – 174 . 10.2307/2529310 843571
Lee D. J. Zeidner J. F. ( 2019 ). Cyclin-dependent Kinase (CDK) 9 and 4/6 Inhibitors in Acute Myeloid Leukemia (AML): a Promising Therapeutic Approach . Expert Opin. Investig. Drugs 28 ( 11 ), 989 – 1001 . 10.1080/13543784.2019.1678583
Lee H. S. Park S. W. ( 2016 ). Systemic Chemotherapy in Advanced Pancreatic Cancer . Gut Liver 10 ( 3 ), 340 – 347 . 10.5009/gnl15465 27114434
Lee K. P. Kim J.-E. Park W.-H. Hong H. ( 2016 ). Regulation of C6 Glioma Cell Migration by Thymol . Oncol. Lett. 11 ( 4 ), 2619 – 2624 . 10.3892/ol.2016.4237 27073528
Li D. Yang M. Liao A. Zeng B. Liu D. Yao Y. ( 2018 ). Linc00483 as ceRNA Regulates Proliferation and Apoptosis through Activating MAPKs in Gastric Cancer . J. Cel Mol Med. 22 ( 8 ), 3875 – 3886 . 10.1111/jcmm.13661
Li H. Hu J. Wu S. Wang L. Cao X. Zhang X. ( 2016 ). Auranofin-mediated Inhibition of PI3K/AKT/mTOR axis and Anticancer Activity in Non-small Cell Lung Cancer Cells . Oncotarget 7 ( 3 ), 3548 – 3558 . 10.18632/oncotarget.6516 26657290
Li L. He L. Wu Y. Zhang Y. ( 2021 ). Carvacrol Affects Breast Cancer Cells through TRPM7 Mediated Cell Cycle Regulation . Life Sci. 266 , 118894 . 10.1016/j.lfs.2020.118894 33310045
Li S. Zhao H. Bao L. ( 2019 ). Preliminary Study on the Mechanism of Carvacrol Regulating Hepatocellular Carcinoma Based on Network Pharmacology . Lett. Drug Des. Discov. 16 ( 11 ), 1286 – 1295 . 10.2174/1570180816666190516105906
Li Y. Wen J.-m. Du C.-j. Hu S.-m. Chen J.-x. Zhang S.-g. ( 2017 ). Thymol Inhibits Bladder Cancer Cell Proliferation via Inducing Cell Cycle Arrest and Apoptosis . Biochem. Biophysical Res. Commun. 491 ( 2 ), 530 – 536 . 10.1016/j.bbrc.2017.04.009
Li Y. Xu J. z. Gu C. x. Liu G. l. Tian K. ( 2018 ). Carvacrol Suppresses Inflammatory Responses in Rheumatoid Arthritis Fibroblast‐like Synoviocytes . J. Cel Biochem. 120 ( 5 ), 8169 – 8176 . 10.1002/jcb.28098
Liang W.-Z. Chou C.-T. Lu T. Chi C.-C. Tseng L.-L. Pan C.-C. ( 2013 ). The Mechanism of Carvacrol-Evoked [Ca2+]i Rises and Non-ca2+-triggered Cell Death in OC2 Human Oral Cancer Cells . Toxicology 303 , 152 – 161 . 10.1016/j.tox.2012.10.026 23146755
Liang W. Z. Lu C. H. ( 2012 ). Carvacrol-induced [Ca2+]i Rise and Apoptosis in Human Glioblastoma Cells . Life Sci. 90 ( 17–18 ), 703 – 711 . 10.1016/j.lfs.2012.03.027 22480511
Lim W. Ham J. Bazer F. W. Song G. ( 2019 ). Carvacrol Induces Mitochondria-Mediated Apoptosis via Disruption of Calcium Homeostasis in Human Choriocarcinoma Cells . J. Cel Physiol. 234 ( 2 ), 1803 – 1815 . 10.1002/jcp.27054
Lin S.-C. Lo S.-S. Liu C.-J. Chung M.-Y. Huang J.-W. Chang K.-W. ( 2004 ). Functional Genotype in Matrix Metalloproteinases-2 Promoter Is a Risk Factor for Oral Carcinogenesis . J. Oral Pathol. Med. 33 ( 7 ), 405 – 409 . 10.1111/j.1600-0714.2004.00231.x 15250832
Liu W.-W. Zeng Z.-Y. Wu Q.-L. Hou J.-H. Chen Y.-Y. ( 2005 ). Overexpression of MMP-2 in Laryngeal Squamous Cell Carcinoma: a Potential Indicator for Poor Prognosis . Otolaryngol. Head Neck Surg. 132 ( 3 ), 395 – 400 . 10.1016/j.otohns.2004.09.050 15746850
Llana-Ruiz-Cabello M. Gutiérrez-Praena D. Pichardo S. Moreno F. J. Bermúdez J. M. Aucejo S. ( 2014 ). Cytotoxicity and Morphological Effects Induced by Carvacrol and Thymol on the Human Cell Line Caco-2 . Food Chem. Toxicol. 64 , 281 – 290 . 10.1016/j.fct.2013.12.005 24326232
Llana-Ruiz-Cabello M. Gutiérrez-Praena D. Puerto M. Pichardo S. Jos Á. Cameán A. M. ( 2015 ). In Vitro pro-oxidant/antioxidant Role of Carvacrol, Thymol and Their Mixture in the Intestinal Caco-2 Cell Line . Toxicol. Vitro 29 ( 4 ), 647 – 656 . 10.1016/j.tiv.2015.02.006
Lu L. C. Tsay S. L. Chang S. Y. Chen C. M. Liu C. Y. ( 2019 ). Daily Activity, Mood, and Quality of Life in Colorectal Cancer Patients with Chemotherapy‐induced Peripheral Neuropathy: A Mediation Effect Analysis . Cancer Med. 8 ( 3 ), 963 – 971 . 10.1002/cam4.1976 30741481
Luo Y. Wu J.-Y. Lu M.-H. Shi Z. Na N. Di J.-M. ( 2016 ). Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways . Oxidative Med. Cell Longevity 2016 , 1 – 11 . 10.1155/2016/1469693
Mari A. Mani G. Nagabhishek S. N. Balaraman G. Subramanian N. Mirza F. B. ( 2020 ). Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells . Chin. J. Integr. Med. 12 , 133 . 10.1007/s11655-020-3193-5
Martino E. Casamassima G. Castiglione S. Cellupica E. Pantalone S. Papagni F. ( 2018 ). Vinca Alkaloids and Analogues as Anti-cancer Agents: Looking Back, Peering Ahead . Bioorg. Med. Chem. Lett. 28 ( 17 ), 2816 – 2826 . 10.1016/j.bmcl.2018.06.044 30122223
Marullo R. Werner E. Degtyareva N. Moore B. Altavilla G. Ramalingam S. S. ( 2013 ). Cisplatin Induces a Mitochondrial-ROS Response that Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions . PloS one 8 ( 11 ), e81162 . 10.1371/journal.pone.0081162 24260552
Maryam K. Shakeri S. Kiani K. ( 2015 ). Preparation and In Vitro Investigation of Antigastric Cancer Activities of Carvacrol‐loaded Human Serum Albumin Nanoparticles . IET nanobiotechnol. 9 ( 5 ), 294 – 299 . 10.1049/iet-nbt.2014.0040 26435283
Mehdi S. Ahmad A. Irshad M. Manzoor N. Rizvi M. ( 2011 ). Cytotoxic Effect of Carvacrol on Human Cervical Cancer Cells . Biol. Med. 3 ( 2 ), 307 – 312 . 10.26226/morressier.5770e29ad462b80290b4ba57
Melušová M. Jantová S. Horváthová E. ( 2014 ). Carvacrol and Rosemary Oil at Higher Concentrations Induce Apoptosis in Human Hepatoma HepG2 Cells . Interdiscip. Toxicol. 7 ( 4 ), 189 – 194 . 10.2478/intox-2014-0027 26109899
Melusova M. Slamenova D. Kozics K. Jantova S. Horvathova E. ( 2014 ). Carvacrol and Rosemary Essential Oil Manifest Cytotoxic, DNA-Protective and Pro-apoptotic Effect Having No Effect on DNA Repair . Neoplasma 61 ( 6 ), 690 – 699 . 10.4149/neo_2014_084 25341996
Mishra B. B. Tiwari V. K. ( 2011 ). Natural Products: an Evolving Role in Future Drug Discovery . Eur. J. Med. Chem. 46 ( 10 ), 4769 – 4807 . 10.1016/j.ejmech.2011.07.057 21889825
Nagase H. Visse R. Murphy G. ( 2006 ). Structure and Function of Matrix Metalloproteinases and TIMPs . Cardiovasc. Res. 69 ( 3 ), 562 – 573 . 10.1016/j.cardiores.2005.12.002 16405877
National Cancer Institute ( 2019 ). National Cancer Institute . Available at: https://www.inca.gov.br/estimativa/introducao ( Acesseced November 13, 2020 ).
Nelson R. L. ( 1982 ). The Comparative Clinical Pharmacology and Pharmacokinetics of Vindesine, Vincristine, and Vinblastine in Human Patients with Cancer . Med. Pediatr. Oncol. 10 ( 2 ), 115 – 127 . 10.1002/mpo.2950100202 7070351
Neville B. ( 2011 ). Patologia Oral e Maxilofacial . Amsterdam : Elsevier Brasil , 3475 .
O'Donnell J. S. Massi D. Teng M. W. L. Mandala M. ( 2018 ). PI3K-AKT-mTOR Inhibition in Cancer Immunotherapy, Redux . Semin. Cancer Biol. 48 , 91 – 103 . 10.1016/j.semcancer.2017.04.015 28467889
Olsson M. Zhivotovsky B. ( 2011 ). Caspases and Cancer . Cel Death Differ 18 ( 9 ), 1441 – 1449 . 10.1038/cdd.2011.30
Ouzzani M. Hammady H. Fedorowicz Z. Elmagarmid A. ( 2016 ). Rayyan-a Web and mobile App for Systematic Reviews . Syst. Rev. 5 ( 1 ), 1 – 10 . 10.1186/s13643-016-0384-4 26729230
Ozawa S. Shankar R. Leopold C. Orubu S. ( 2019 ). Access to Medicines through Health Systems in Low- and Middle-Income Countries . Health Policy Plan 34 , iii1 – iii3 . 10.1093/heapol/czz119 31816069
Özkan A. Erdogan A. ( 2011 ). A Comparative Evaluation of Antioxidant and Anticancer Activity of Essential Oil from Origanum Onites (Lamiaceae) and its Two Major Phenolic Components . Turk J. Biol. 35 ( 2011 ), 735 – 742 . 10.1016/j.toxlet.2010.03.459
Ozkan A. Erdogan A. ( 2012 ). A Comparative Study of the Antioxidant/prooxidant Effects of Carvacrol and Thymol at Various Concentrations on Membrane and DNA of Parental and Drug Resistant H1299 Cells . Nat. Prod. Commun. 7 ( 12 ), 1557 – 1560 . 10.1177/1934578x1200701201 23413548
Page M. J. McKenzie J. E. Bossuyt P. M. Boutron I. Hoffmann T. C. Mulrow C. D. ( 2021 ). The PRISMA 2020 Statement: an Updated Guideline for Reporting Systematic Reviews . Plos Med. 18 ( 3 ), e1003583 . 10.1371/journal.pmed.1003583 33780438
Pakdemirli A. Karaca C. Sever T. Daşkin E. Leblebici A. Yiğitbaşi T. ( 2020 ). Carvacrol Alters Soluble Factors in HCT-116 and HT-29 Cell Lines . Turk J. Med. Sci. 50 ( 1 ), 271 – 276 . 10.3906/sag-1907-173 31742371
Paolicchi A. Pompella A. Tonarelli P. Gadducci A. Genazzani A. R. Zunino F. ( 1996 ). Gamma-glutamyltranspeptidase Activity in Human Ovarian Carcinoma . Anticancer Res. 16 ( 5B ), 3053 – 3058 . 8920766
Pathania A. S. Guru S. K. Verma M. K. Sharma C. Abdullah S. T. Malik F. ( 2013 ). Disruption of the PI3K/AKT/mTOR Signaling cascade and Induction of Apoptosis in HL-60 Cells by an Essential Oil from Monarda Citriodora . Food Chem. Toxicol. 62 , 246 – 254 . 10.1016/j.fct.2013.08.037 23994707
Pernas S. Tolaney S. M. Winer E. P. Goel S. ( 2018 ). CDK4/6 Inhibition in Breast Cancer: Current Practice and Future Directions . Ther. Adv. Med. Oncol. 10 , 175883591878645 . 10.1177/1758835918786451
Pompella A. De Tata V. Paolicchi A. Zunino F. ( 2006 ). Expression of γ-glutamyltransferase in Cancer Cells and its Significance in Drug Resistance . Biochem. Pharmacol. 71 ( 3 ), 231 – 238 . 10.1016/j.bcp.2005.10.005 16303117
Potočnjak I. Gobin I. Domitrović R. ( 2018 ). Carvacrol Induces Cytotoxicity in Human Cervical Cancer Cells but Causes Cisplatin Resistance: Involvement of MEK-ERK Activation . Phytother Res. 32 ( 6 ), 1090 – 1097 . 10.1002/ptr.6048 29417642
Powell H. A. Tata L. J. Baldwin D. R. Potter V. A. Stanley R. A. Khakwani A. ( 2014 ). Treatment Decisions and Survival for People with Small-Cell Lung Cancer . Br. J. Cancer 110 ( 4 ), 908 – 915 . 10.1038/bjc.2013.812 24398511
Prasad S. Gupta S. C. Tyagi A. K. ( 2017 ). Reactive Oxygen Species (ROS) and Cancer: Role of Antioxidative Nutraceuticals . Cancer Lett. 387 , 95 – 105 . 10.1016/j.canlet.2016.03.042 27037062
Rojas-Armas J. P. Arroyo-Acevedo J. L. Palomino-Pacheco M. Herrera-Calderón O. Ortiz-Sánchez J. M. Rojas-Armas A. ( 2020 ). The Essential Oil of Cymbopogon Citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-Anthracene (DMBA)-Induced Breast Cancer in Female Rats . Molecules 25 ( 14 ), 3284 . 10.3390/molecules25143284
Salehi B. Mishra A. P. Shukla I. Sharifi-Rad M. Contreras M. d. M. Segura-Carretero A. ( 2018 ). Thymol, Thyme, and Other Plant Sources: Health and Potential Uses . Phytotherapy Res. 32 ( 9 ), 1688 – 1706 . 10.1002/ptr.6109
Santos C. P. d. Pinto J. A. O. Santos C. A. d. Cruz E. M. O. Arrigoni-Blank M. d. F. Andrade T. M. ( 2016 ). Harvest Time and Geographical Origin Affect the Essential Oil of Lippia Gracilis Schauer . Ind. Crops Prod. 79 , 205 – 210 . 10.1016/j.indcrop.2015.11.015
Satooka H. Kubo I. ( 2012 ). Effects of Thymol on B16-F10 Melanoma Cells . J. Agric. Food Chem. 60 ( 10 ), 2746 – 2752 . 10.1021/jf204525b 22352891
Semenza G. L. ( 2003 ). Targeting HIF-1 for Cancer Therapy . Nat. Rev. Cancer 3 ( 10 ), 721 – 732 . 10.1038/nrc1187 13130303
Seresht H. R. Albadry B. J. Al-mosawi A. K. M. Gholami O. Cheshomi H. ( 2019 ). The Cytotoxic Effects of Thymol as the Major Component of Trachyspermum Ammi on Breast Cancer (MCF-7) Cells . Pharm. Chem. J. 53 ( 2 ), 101 – 107 . 10.1007/s11094-019-01961-w
Shalini S. Dorstyn L. Dawar S. Kumar S. ( 2015 ). Old, New and Emerging Functions of Caspases . Cel Death Differ 22 ( 4 ), 526 – 539 . 10.1038/cdd.2014.216
Sharifi-Rad M. Varoni E. M. Iriti M. Martorell M. Setzer W. N. Del Mar Contreras M. ( 2018 ). Carvacrol and Human Health: A Comprehensive Review . Phytotherapy Res. 32 ( 9 ), 1675 – 1687 . 10.1002/ptr.6103
Sheorain J. Mehra M. Thakur R. Grewal S. Kumari S. ( 2019 ). In Vitro anti-inflammatory and Antioxidant Potential of Thymol Loaded Bipolymeric (Tragacanth Gum/chitosan) Nanocarrier . Int. J. Biol. Macromolecules 125 , 1069 – 1074 . 10.1016/j.ijbiomac.2018.12.095
Shojaei S. Kiumarsi A. Moghadam A. R. Alizadeh J. Marzban H. Ghavami S. ( 2014 ). “ Perillyl Alcohol (Monoterpene Alcohol), Limonene ,” in The Enzymes Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids . Editors Zahra Bathaie S. Tamanoi F. ( Cambridge : Academic Press ), 1 – 258 . 10.1016/B978-0-12-802215-3.00002-1
Shuman Moss L. A. Jensen-Taubman S. Stetler-Stevenson W. G. ( 2012 ). Matrix Metalloproteinases . Am. J. Pathol. 181 ( 6 ), 1895 – 1899 . 10.1016/j.ajpath.2012.08.044 23063657
Silva E. R. de Carvalho F. O. Teixeira L. G. B. Santos N. G. L. Felipe F. A. Santana H. S. R. ( 2018 ). Pharmacological Effects of Carvacrol in In Vitro Studies: A Review . Curr. Pharm. Des. 24 ( 29 ), 3454 – 3465 . 10.2174/1381612824666181003123400 30280662
Sisto F. Carradori S. Guglielmi P. Spano M. Secci D. Granese A. ( 2021 ). Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains of H. pylori and AGS Cell Line . Molecules 26 ( 7 ), 1829 . 10.3390/molecules26071829 33805064
Sisto F. Carradori S. Guglielmi P. Traversi C. B. Spano M. Sobolev A. P. ( 2020 ). Synthesis and Biological Evaluation of Carvacrol-Based Derivatives as Dual Inhibitors of H. pylori Strains and AGS Cell Proliferation . Pharmaceuticals 13 ( 11 ), 405 . 10.3390/ph13110405
Sivaranjani A. Sivagami G. Nalini N. ( 2016 ). Chemopreventive Effect of Carvacrol on 1,2-dimethylhydrazine Induced Experimental colon Carcinogenesis . J. Cancer Res. Ther. 12 ( 2 ), 755 – 762 . 10.4103/0973-1482.154925 27461646
Siveen K. S. Prabhu K. Krishnankutty R. Kuttikrishnan S. Tsakou M. Alali F. Q. ( 2017 ). Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges . Curr. Vasc. Pharmacol. 15 ( 4 ), 339 – 351 . 10.2174/1570161115666170105124038 28056756
Slamenová D. Horváthová E. Sramková M. Marsálková L. ( 2007 ). DNA-protective Effects of Two Components of Essential Plant Oils Carvacrol and Thymol on Mammalian Cells Cultured In Vitro . Neoplasma 54 ( 2 ), 108 – 112 . 10.7287/peerj.9626v0.1/reviews/1 17319782
Soković M. Glamoclija J. Ciric A. ( 2013 ). Natural Products from Plants and Fungi as Fungicides. Fungicides—Showcases of Integrated Plant Disease. Management from Around the World. Chapter: Natural Products from Plants and Fungi as Fungicides . Berlin : Springer , 185 – 232 . 10.5772/50277
Song M. Bode A. M. Dong Z. Lee M.-H. ( 2019 ). AKT as a Therapeutic Target for Cancer . Cancer Res. 79 ( 6 ), 1019 – 1031 . 10.1158/0008-5472.CAN-18-2738 30808672
Soung Y. H. Lee J. W. Kim S. Y. Jang J. Park Y. G. Park W. S. ( 2005 ). CASPASE-8 Gene Is Inactivated by Somatic Mutations in Gastric Carcinomas . Cancer Res. 65 ( 3 ), 815 – 821 . 10.1038/sj.onc.1208244 15705878
Srinivas U. S. Tan B. W. Q. Vellayappan B. A. Jeyasekharan A. D. ( 2019 ). ROS and the DNA Damage Response in Cancer . Redox Biol. 25 , 101084 . 10.1016/j.redox.2018.101084 30612957
Srivastav V. K. Egbuna C. Tiwari M. ( 2020 ). Plant Secondary Metabolites as lead Compounds for the Production of Potent Drugs . Phytochemicals as Lead Comp. New Drug 14 , 3 – 14 . 10.1016/B978-0-12-817890-4.00001-9
Subramaniyan J. Krishnan G. Balan R. Mgj D. Ramasamy E. Ramalingam S. ( 2014 ). Carvacrol Modulates Instability of Xenobiotic Metabolizing Enzymes and Downregulates the Expressions of PCNA, MMP-2, and MMP-9 during Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats . Mol. Cel Biochem. 395 ( 1 ), 65 – 76 . 10.1007/s11010-014-2112-5
Suntres Z. E. Coccimiglio J. Alipour M. ( 2015 ). The Bioactivity and Toxicological Actions of Carvacrol . Crit. Rev. Food Sci. Nutr. 55 ( 3 ), 304 – 318 . 10.1080/10408398.2011.653458 24915411
Swanton E. Savory P. Cosulich S. Clarke P. Woodman P. ( 1999 ). Bcl-2 Regulates a Caspase-3/caspase-2 Apoptotic cascade in Cytosolic Extracts . Oncogene 18 ( 10 ), 1781 – 1787 . 10.1038/sj.onc.1202490 10086332
Tayarani-Najaran Z. Akaberi M. Hassanzadeh B. Shirazi N. Asili J. Al-Najjar H. ( 2019 ). Analysis of the Essential Oils of Five Artemisia Species and Evaluation of Their Cytotoxic and Proapoptotic Effects . Mini Rev. Med. Chem. 19 ( 11 ), 902 – 912 . 10.2174/1389557519666190311155021 30864526
Thakor P. Subramanian R. B. Thakkar S. S. Ray A. Thakkar V. R. ( 2017 ). Phytol Induces ROS Mediated Apoptosis by Induction of Caspase 9 and 3 through Activation of TRAIL, FAS and TNF Receptors and Inhibits Tumor Progression Factor Glucose 6 Phosphate Dehydrogenase in Lung Carcinoma Cell Line (A549) . Biomed. Pharmacother. 92 , 491 – 500 . 10.1016/j.biopha.2017.05.066 28575806
Thapa D. Richardson A. J. Zweifel B. Wallace R. J. Gratz S. W. ( 2019 ). Genoprotective Effects of Essential Oil Compounds against Oxidative and Methylated DNA Damage in Human Colon Cancer Cells . J. Food Sci. 84 ( 7 ), 1979 – 1985 . 10.1111/1750-3841.14665 31206673
Trindade G. G. G. Thrivikraman G. Menezes P. P. França C. M. Lima B. S. Carvalho Y. M. B. G. ( 2019 ). Carvacrol/β-cyclodextrin Inclusion Complex Inhibits Cell Proliferation and Migration of Prostate Cancer Cells . Food Chem. Toxicol. 125 , 198 – 209 . 10.1016/j.fct.2019.01.003 30615955
Van Wyk B. Wink M. ( 2018 ). Medicinal Plants of the World . Germany : CABI. University of Johannesburg, South Africa, Heidelberg University .
Wagner E. F. Nebreda Á. R. ( 2009 ). Signal Integration by JNK and P38 MAPK Pathways in Cancer Development . Nat. Rev. Cancer 9 ( 8 ), 537 – 549 . 10.1038/nrc2694 19629069
Wang C. Jin H. Gao D. Lieftink C. Evers B. Jin G. ( 2018 ). Phospho-ERK Is a Biomarker of Response to a Synthetic Lethal Drug Combination of Sorafenib and MEK Inhibition in Liver Cancer . J. Hepatol. 69 ( 5 ), 1057 – 1065 . 10.1016/j.jhep.2018.07.004 30030148
Wang J. Su B. Zhu H. Chen C. Zhao G. ( 2016 ). Protective Effect of Geraniol Inhibits Inflammatory Response, Oxidative Stress and Apoptosis in Traumatic Injury of the Spinal Cord through Modulation of NF-Κb and P38 MAPK . Exp. Ther. Med. 12 ( 6 ), 3607 – 3613 . 10.3892/etm.2016.385010.3892/etm.2016.3850 28105094
Wang X. Wang Q. ( 2018 ). Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity . Can. J. Gastroenterol. Hepatol. 2018 , e9049252 . 10.1155/2018/9049252
Wang Y. He Q.-Y. Chiu J.-F. ( 2014 ). Dioscin Induced Activation of P38 MAPK and JNK via Mitochondrial Pathway in HL-60 Cell Line . Eur. J. Pharmacol. 735 , 52 – 58 . 10.1016/j.ejphar.2014.04.018 24755146
Weingart S. Zhang L. Sweeney M. Hassett M. ( 2018 ). Chemotherapy Medication Errors . Lancet Oncol. 19 ( 4 ), 191 – 199 . 10.1016/S1470-2045(18)30094-9
Whitfield J. B. ( 2001 ). Gamma Glutamyl Transferase . Crit. Rev. Clin. Lab. Sci. 38 ( 4 ), 263 – 355 . 10.1080/20014091084227 11563810
WHO ( 2007-2017 ). Ten Years in Public Health 2007-2017. World Health Organization; Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All . Available at: http://www.who.int/publications/10-year-review/en/ ( Acesseced November 20, 2020 ).
Wiart C. ( 2007 ). Ethnopharmacology of Medicinal Plants—Asia and the Pacific | Christophe Wiart | Springer . Available at: https://www.springer.com/gp/book/9781588297488 ( Acesseced December 21, 2020 ).
Wong R. J. Ahmed A. Gish R. G. ( 2015 ). Elevated Alpha-Fetoprotein . Clin. Liver Dis. 19 ( 2 ), 309 – 323 . 10.1016/j.cld.2015.01.005 25921665
World Health Organization ( 2020 ). Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All . Available at: https://www.who.int/publications/i/item/who-report-on-cancer-setting-priorities-investing-wisely-and-providing-care-for-all ( Acesseced November 13, 2020 ).
Wu Q. Wu W. Fu B. Shi L. Wang X. Kuca K. ( 2019 ). JNK Signaling in Cancer Cell Survival . Med. Res. Rev. 39 ( 6 ), 2082 – 2104 . 10.1002/med.21574 30912203
Wullschleger S. Loewith R. Hall M. N. ( 2006 ). TOR Signaling in Growth and Metabolism . Cell 124 ( 3 ), 471 – 484 . 10.1016/j.cell.2006.01.016 16469695
Yeh J.-H. Chou C-T. Chen I-S. Lu T. Lin K-L. Yu C-C. ( 2017 ). Effect of Thymol on Ca^(2+) Homeostasis and Viability in PC3 Human Prostate Cancer Cells . Chin. J. Physiol. 60 ( 1 ), 32 – 40 . 10.4077/CJP.2017.BAF447 28052644
Yin Q.-h. Yan F.-x. Zu X.-Y. Wu Y.-h. Wu X.-p. Liao M.-c. ( 2012 ). Anti-proliferative and Pro-apoptotic Effect of Carvacrol on Human Hepatocellular Carcinoma Cell Line HepG-2 . Cytotechnology 64 ( 1 ), 43 – 51 . 10.1007/s10616-011-9389-y 21938469
Yoo J. y. Kim C. H. Song S. H. Shim B. Y. Jeong Y. J. Ahn M. I. ( 2004 ). Expression of Caspase-3 and C-Myc in Non-small Cell Lung Cancer . Cancer Res. Treat. 36 ( 5 ), 303 – 307 . 10.4143/crt.2004.36.5.303 20368820
Yu X. Zhang R. Yang T. Zhang M. Xi K. Lin Y. ( 2019 ). Alpha-l-fucosidase: a Novel Serum Biomarker to Predict Prognosis in Early Stage Esophageal Squamous Cell Carcinoma . J. Thorac. Dis. 11 ( 9 ), 3980 – 3990 . 10.21037/jtd.2019.08.92 31656672
Zarubin T. Han J. ( 2005 ). Activation and Signaling of the P38 MAP Kinase Pathway . Cell Res. 15 ( 1 ), 11 – 18 . 10.1038/sj.cr.7290257 15686620
Zeng L. P. Hu Z. M. Li K. Xia K. ( 2016 ). miR‐222 Attenuates Cisplatin‐induced Cell Death by Targeting the PPP 2R2A/Akt/mTOR Axis in Bladder Cancer Cells . J. Cel. Mol. Med. 20 ( 3 ), 559 – 567 . 10.1111/jcmm.12760
Zeng Q. Che Y. Zhang Y. Chen M. Guo Q. Zhang W. ( 2020 ). Thymol Isolated from Thymus Vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway . Drug Des. Devel Ther. 14 , 2535 – 2547 . 10.2147/DDDT.S25421810.2147/dddt.s254218
Zeytinoglu H. Incesu Z. Baser K. H. C. ( 2003 ). Inhibition of DNA Synthesis by Carvacrol in Mouse Myoblast Cells Bearing a Human N-RAS Oncogene . Phytomedicine 10 ( 4 ), 292 – 299 . 10.1078/094471103322004785 12809359
Zhai C.-L. Tang G.-M. Qian G. Hu H.-L. Wang S.-J. Yin D. ( 2019 ). MicroRNA-98 Attenuates Cardiac Ischemia-Reperfusion Injury through Inhibiting DAPK1 Expression . IUBMB Life 71 ( 2 ), 166 – 176 . 10.1002/iub.1879 30419147
Zhang H. Liu H. Iles K. E. Liu R.-M. Postlethwait E. M. Laperche Y. ( 2006 ). 4-Hydroxynonenal Induces Rat γ-Glutamyl Transpeptidase through Mitogen-Activated Protein Kinase-Mediated Electrophile Response Element/Nuclear Factor Erythroid 2-Related Factor 2 Signaling . Am. J. Respir. Cel Mol Biol 34 ( 2 ), 174 – 181 . 10.1165/rcmb.2005-0280OC
Zhang L. Yu J. Park B. Kinzler K. Vogelstein B. ( 2000 ). Role of BAX in the Apoptotic Response to Anticancer Agents . Science 290 ( 5493 ), 989 – 992 . 10.1126/science.290.5493.989 11062132
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.