[논문]A Systematic Review of the Effect of Centella asiatica on Wound Healing

Arribas-Ló; pez, Elena; Zand, Nazanin; Ojo, Omorogieva; Snowden, Martin John; Kochhar, Tony

doi:10.3390/ijerph19063266

[해외논문] A Systematic Review of the Effect of Centella asiatica on Wound Healing 원문보기

International journal of environmental research and public health, v.19 no.6, 2022년, pp.3266 -

Arribas-López, Elena (School of Science, Medway Campus, University of Greenwich, Central Ave, Gillingham, Chatham Maritime, Kent ME4 4TB, UK) , Zand, Nazanin (e.arribaslopez@greenwich.ac.uk (E.A.-L.)) , Ojo, Omorogieva (n.zandfard@greenwich.ac.uk (N.Z.)) , Snowden, Martin John (m.j.snowden@greenwich.ac.uk (M.J.S.)) , Kochhar, Tony (School of Science, Medway Campus, University of Greenwich, Central Ave, Gillingham, Chatham Maritime, Kent ME4 4TB, UK)

Abstract ▼ AI-Helper

Background: Under metabolic stress conditions, there is a higher demand for nutrients which needs to be met. This is to reduce the risk of delay in wound healing which could lead to chronic wound. Aim: This is a systematic review of the effect of Centella asiatica on wound healing. C. asiatica is a traditional medicinal plant used due to its antimicrobial, antioxidant, anti-inflammatory, neuroprotective, and wound healing properties. Methods: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed for the systematic review and four electronic databases were used. Results: Four clinical trials met the inclusion criteria. The following distinct areas were identified under C. asiatica: wound contraction and granulation; healing/bleeding time and re-epithelialization; VAS (visual analogue scale) scores; skin erythema and wound appearance. Conclusions: C. asiatica might enhance wound healing resulting from improved angiogenesis. This might occur due to its stimulating effect on collagen I, Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) production. Besides, C. asiatica has shown an anti-inflammatory effect observed by the reduction in Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumour Necrosis Factor α (TNFα), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and lipoxygenase (LOX) activity. Delivery systems such as nanoencapsulation could be used to increase C. asiatica bioavailability. Nevertheless, more studies are needed in order to perform a meta-analysis and ascertain the effects of C. asiatica on wound healing and its different parameters.

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표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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[해외논문] A Systematic Review of the Effect of Centella asiatica on Wound Healing 원문보기

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