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NTIS 바로가기KJFM : Korean journal of family medicine, v.43 no.5, 2022년, pp.277 - 289
Jung, Susie (Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea) , Choi, Beom-Hee (Greencross IMED Gangbuk Center, Seoul, Korea) , Joo, Nam-Seok (Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea)
Identifying and preventing modifiable risk factors for cardiovascular disease is very important. Vascular calcification has been studied clinically as an asymptomatic preclinical marker of atherosclerosis and a risk factor for cardio-cerebrovascular disease. It is known that higher homocysteine leve...
1 Roth GA Mensah GA Johnson CO Addolorato G Ammirati E Baddour LM Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 Study J Am Coll Cardiol 2020 76 2982 3021 33309175
2 Virani SS Alonso A Aparicio HJ Benjamin EJ Bittencourt MS Callaway CW Heart disease and stroke statistics-2021 update: a report from the American Heart Association Circulation 2021 143 e254 743 33501848
3 Global Burden of Disease Cancer Collaboration Fitzmaurice C Abate D Abbasi N Abbastabar H Abd-Allah F Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the Global Burden of Disease Study JAMA Oncol 2019 5 1749 68 31560378
4 GBD 2017 Causes of Death Collaborators Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017 Lancet 2018 392 1736 88 30496103
5 Norgren L Hiatt WR Dormandy JA Nehler MR Harris KA Fowkes FG Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II) J Vasc Surg 2007 45 Suppl S S5 67 17223489
6 McDermott MM Ankle-brachial index screening to improve health outcomes: where is the evidence? Ann Intern Med 2013 159 362 3 24026321
7 Vliegenthart R Oudkerk M Hofman A Oei HH van Dijck W van Rooij FJ Coronary calcification improves cardiovascular risk prediction in the elderly Circulation 2005 112 572 7 16009800
8 Rumberger JA Using noncontrast cardiac CT and coronary artery calcification measurements for cardiovascular risk assessment and management in asymptomatic adults Vasc Health Risk Manag 2010 6 579 91 20730074
9 Bos D Leening MJ Leveraging the coronary calcium scan beyond the coronary calcium score Eur Radiol 2018 28 3082 7 29383526
10 Stein JH Korcarz CE Hurst RT Lonn E Kendall CB Mohler ER Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine J Am Soc Echocardiogr 2008 21 93 111 18261694
11 Chambless LE Folsom AR Clegg LX Sharrett AR Shahar E Nieto FJ Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) Study Am J Epidemiol 2000 151 478 87 10707916
12 Van Campenhout A Moran CS Parr A Clancy P Rush C Jakubowski H Role of homocysteine in aortic calcification and osteogenic cell differentiation Atherosclerosis 2009 202 557 66 18602108
13 Moghadasian MH McManus BM Frohlich JJ Homocyst(e)ine and coronary artery disease: clinical evidence and genetic and metabolic background Arch Intern Med 1997 157 2299 308 9361570
14 Schalinske KL Smazal AL Homocysteine imbalance: a pathological metabolic marker Adv Nutr 2012 3 755 62 23153729
15 Skovierova H Vidomanova E Mahmood S Sopkova J Drgova A Cervenova T The molecular and cellular effect of homocysteine metabolism imbalance on human health Int J Mol Sci 2016 17 1733
16 Welch GN Loscalzo J Homocysteine and atherothrombosis N Engl J Med 1998 338 1042 50 9535670
17 Handy DE Loscalzo J Homocysteine and atherothrombosis: diagnosis and treatment Curr Atheroscler Rep 2003 5 276 83 12793968
18 Rennenberg RJ Kessels AG Schurgers LJ van Engelshoven JM de Leeuw PW Kroon AA Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis Vasc Health Risk Manag 2009 5 185 97 19436645
19 Detrano R Guerci AD Carr JJ Bild DE Burke G Folsom AR Coronary calcium as a predictor of coronary events in four racial or ethnic groups N Engl J Med 2008 358 1336 45 18367736
20 Shioi A Ikari Y Plaque calcification during atherosclerosis progression and regression J Atheroscler Thromb 2018 25 294 303 29238011
21 Karger AB Steffen BT Nomura SO Guan W Garg PK Szklo M Association between homocysteine and vascular calcification incidence, prevalence, and progression in the MESA cohort J Am Heart Assoc 2020 9 e013934 32013703
22 Roijers RB Debernardi N Cleutjens JP Schurgers LJ Mutsaers PH van der Vusse GJ Microcalcifications in early intimal lesions of atherosclerotic human coronary arteries Am J Pathol 2011 178 2879 87 21531376
23 Nadra I Mason JC Philippidis P Florey O Smythe CD McCarthy GM Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ Res 2005 96 1248 56 15905460
24 Otsuka F Sakakura K Yahagi K Joner M Virmani R Has our understanding of calcification in human coronary atherosclerosis progressed? Arterioscler Thromb Vasc Biol 2014 34 724 36 24558104
25 Wu B Pei X Li ZY How does calcification influence plaque vulnerability?: insights from fatigue analysis ScientificWorldJournal 2014 2014 417324 24955401
26 Kelly-Arnold A Maldonado N Laudier D Aikawa E Cardoso L Weinbaum S Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries Proc Natl Acad Sci U S A 2013 110 10741 6 23733926
27 Vancheri F Longo G Vancheri S Danial JS Henein MY Coronary artery microcalcification: imaging and clinical implications Diagnostics (Basel) 2019 9 125
28 Nissen SE Nicholls SJ Sipahi I Libby P Raichlen JS Ballantyne CM Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial JAMA 2006 295 1556 65 16533939
29 Banach M Serban C Sahebkar A Mikhailidis DP Ursoniu S Ray KK Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies BMC Med 2015 13 229 26385210
30 Knez A Becker A Leber A White C Becker CR Reiser MF Relation of coronary calcium scores by electron beam tomography to obstructive disease in 2,115 symptomatic patients Am J Cardiol 2004 93 1150 2 15110209
31 Sarwar A Shaw LJ Shapiro MD Blankstein R Hoffmann U Cury RC Diagnostic and prognostic value of absence of coronary artery calcification JACC Cardiovasc Imaging 2009 2 675 88 19520336
32 Budoff MJ Shaw LJ Liu ST Weinstein SR Mosler TP Tseng PH Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients J Am Coll Cardiol 2007 49 1860 70 17481445
33 Mitchell JD Paisley R Moon P Novak E Villines TC Coronary artery calcium and long-term risk of death, myocardial infarction, and stroke: the Walter Reed Cohort Study JACC Cardiovasc Imaging 2018 11 1799 806 29153576
34 Criqui MH Denenberg JO Ix JH McClelland RL Wassel CL Rifkin DE Calcium density of coronary artery plaque and risk of incident cardiovascular events JAMA 2014 311 271 8 24247483
35 Alfrey AC Ibels LS Role of phosphate and pyrophosphate in soft tissue calcification Adv Exp Med Biol 1978 103 187 93 213949
36 Bostrom K Watson KE Horn S Wortham C Herman IM Demer LL Bone morphogenetic protein expression in human atherosclerotic lesions J Clin Invest 1993 91 1800 9 8473518
37 McCullough PA Chinnaiyan KM Agrawal V Danielewicz E Abela GS Amplification of atherosclerotic calcification and Monckeberg’s sclerosis: a spectrum of the same disease process Adv Chronic Kidney Dis 2008 15 396 412 18805386
38 Schoppet M Al-Fakhri N Franke FE Katz N Barth PJ Maisch B Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Monckeberg’s sclerosis and atherosclerosis J Clin Endocrinol Metab 2004 89 4104 12 15292354
39 Tanimura A McGregor DH Anderson HC Calcification in atherosclerosis. I. Human studies J Exp Pathol 1986 2 261 73 2946818
40 Tanimura A McGregor DH Anderson HC Calcification in atherosclerosis. II. Animal studies J Exp Pathol 1986 2 275 97 3783282
41 Proudfoot D Skepper JN Hegyi L Bennett MR Shanahan CM Weissberg PL Apoptosis regulates human vascular calcification in vitro : evidence for initiation of vascular calcification by apoptotic bodies Circ Res 2000 87 1055 62 11090552
42 Kim KM Calcification of matrix vesicles in human aortic valve and aortic media Fed Proc 1976 35 156 62 1248649
43 Golub EE Role of matrix vesicles in biomineralization Biochim Biophys Acta 2009 1790 1592 8 19786074
44 New SE Aikawa E Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification Arterioscler Thromb Vasc Biol 2013 33 1753 8 23766262
45 Balcerzak M Hamade E Zhang L Pikula S Azzar G Radisson J The roles of annexins and alkaline phosphatase in mineralization process Acta Biochim Pol 2003 50 1019 38 14739992
46 Anderson HC Molecular biology of matrix vesicles Clin Orthop Relat Res 1995 314 266 80
47 Parhami F Morrow AD Balucan J Leitinger N Watson AD Tintut Y Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation: a possible explanation for the paradox of arterial calcification in osteoporotic patients Arterioscler Thromb Vasc Biol 1997 17 680 7 9108780
48 Raggi P Kleerekoper M Contribution of bone and mineral abnormalities to cardiovascular disease in patients with chronic kidney disease Clin J Am Soc Nephrol 2008 3 836 43 18322050
49 Escobar Guzman LF Escobar Guzman CA Lopes NH Pathophysiological and genetic aspects of vascular calcification Cardiol Res Pract 2020 2020 5169069 32411445
50 Reynolds JL Joannides AJ Skepper JN McNair R Schurgers LJ Proudfoot D Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD J Am Soc Nephrol 2004 15 2857 67 15504939
51 Proudfoot D Skepper JN Shanahan CM Weissberg PL Calcification of human vascular cells in vitro is correlated with high levels of matrix Gla protein and low levels of osteopontin expression Arterioscler Thromb Vasc Biol 1998 18 379 88 9514406
52 Shanahan CM Weissberg PL Metcalfe JC Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells Circ Res 1993 73 193 204 8508530
53 Giachelli CM Bae N Almeida M Denhardt DT Alpers CE Schwartz SM Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques J Clin Invest 1993 92 1686 96 8408622
54 Ikeda T Shirasawa T Esaki Y Yoshiki S Hirokawa K Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta J Clin Invest 1993 92 2814 20 8254036
55 Shanahan CM Cary NR Metcalfe JC Weissberg PL High expression of genes for calcification-regulating proteins in human atherosclerotic plaques J Clin Invest 1994 93 2393 402 8200973
56 Dhore CR Cleutjens JP Lutgens E Cleutjens KB Geusens PP Kitslaar PJ Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques Arterioscler Thromb Vasc Biol 2001 21 1998 2003 11742876
57 Byon CH Chen Y Molecular mechanisms of vascular calcification in chronic kidney disease: the link between bone and the vasculature Curr Osteoporos Rep 2015 13 206 15 25947259
58 Xiao G Jiang D Ge C Zhao Z Lai Y Boules H Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression J Biol Chem 2005 280 30689 96 16000305
59 Kim KM Apoptosis and calcification Scanning Microsc 1995 9 1137 78 8819895
60 Jakubowski H Metabolism of homocysteine thiolactone in human cell cultures: possible mechanism for pathological consequences of elevated homocysteine levels J Biol Chem 1997 272 1935 42 8999883
61 Mercie P Garnier O Lascoste L Renard M Closse C Durrieu F Homocysteine-thiolactone induces caspase-independent vascular endothelial cell death with apoptotic features Apoptosis 2000 5 403 11 11256881
62 Cheng Z Yang X Wang H Hyperhomocysteinemia and endothelial dysfunction Curr Hypertens Rev 2009 5 158 65 20495681
63 Naseem KM The role of nitric oxide in cardiovascular diseases Mol Aspects Med 2005 26 33 65 15722114
64 Leeuwenburgh C Hardy MM Hazen SL Wagner P Oh-ishi S Steinbrecher UP Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima J Biol Chem 1997 272 1433 6 8999808
65 Bian K Doursout MF Murad F Vascular system: role of nitric oxide in cardiovascular diseases J Clin Hypertens (Greenwich) 2008 10 304 10 18401228
66 Yang Q He GW Imbalance of homocysteine and H2S: significance, mechanisms, and therapeutic promise in vascular injury Oxid Med Cell Longev 2019 2019 7629673 31885816
67 Pushpakumar S Kundu S Sen U Endothelial dysfunction: the link between homocysteine and hydrogen sulfide Curr Med Chem 2014 21 3662 72 25005183
68 Kanagy NL Szabo C Papapetropoulos A Vascular biology of hydrogen sulfide Am J Physiol Cell Physiol 2017 312 C537 49 28148499
69 Li JJ Li Q Du HP Wang YL You SJ Wang F Homocysteine Triggers inflammatory responses in macrophages through inhibiting CSE-H2S signaling via DNA hypermethylation of CSE promoter Int J Mol Sci 2015 16 12560 77 26047341
70 Li MH Tang JP Zhang P Li X Wang CY Wei HJ Disturbance of endogenous hydrogen sulfide generation and endoplasmic reticulum stress in hippocampus are involved in homocysteine-induced defect in learning and memory of rats Behav Brain Res 2014 262 35 41 24423987
71 Tang XQ Shen XT Huang YE Chen RQ Ren YK Fang HR Inhibition of endogenous hydrogen sulfide generation is associated with homocysteine-induced neurotoxicity: role of ERK1/2 activation J Mol Neurosci 2011 45 60 7 21104457
72 Chen S Dong Z Zhao Y Sai N Wang X Liu H Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain Sci Rep 2017 7 6932 28761070
73 Li M Zhu Y Jaiswal SK Liu NF Mitochondria homeostasis and vascular medial calcification Calcif Tissue Int 2021 109 113 20 33660037
74 Zhang J Wang X Vikash V Ye Q Wu D Liu Y ROS and ROS-mediated cellular signaling Oxid Med Cell Longev 2016 2016 4350965 26998193
75 Fleury C Mignotte B Vayssiere JL Mitochondrial reactive oxygen species in cell death signaling Biochimie 2002 84 131 41 12022944
76 Yu EP Bennett MR The role of mitochondrial DNA damage in the development of atherosclerosis Free Radic Biol Med 2016 100 223 30 27320189
77 Slater AF Stefan C Nobel I van den Dobbelsteen DJ Orrenius S Signalling mechanisms and oxidative stress in apoptosis Toxicol Lett 1995 82-83 149 53 8597043
78 Austin RC Sood SK Dorward AM Singh G Shaughnessy SG Pamidi S Homocysteine-dependent alterations in mitochondrial gene expression, function and structure: homocysteine and H2O2 act synergistically to enhance mitochondrial damage J Biol Chem 1998 273 30808 17 9804859
79 Byon CH Javed A Dai Q Kappes JC Clemens TL Darley-Usmar VM Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling J Biol Chem 2008 283 15319 27 18378684
80 Kurozumi A Nakano K Yamagata K Okada Y Nakayamada S Tanaka Y IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2 Bone 2019 124 53 61 30981888
81 Henaut L Sanchez-Nino MD Aldamiz-Echevarria Castillo G Sanz AB Ortiz A Targeting local vascular and systemic consequences of inflammation on vascular and cardiac valve calcification Expert Opin Ther Targets 2016 20 89 105 26788590
82 Wen C Yang X Yan Z Zhao M Yue X Cheng X Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification Int J Cardiol 2013 168 2242 7 23453445
83 Moore KJ Sheedy FJ Fisher EA Macrophages in atherosclerosis: a dynamic balance Nat Rev Immunol 2013 13 709 21 23995626
84 Komohara Y Fujiwara Y Ohnishi K Shiraishi D Takeya M Contribution of macrophage polarization to metabolic diseases J Atheroscler Thromb 2016 23 10 7 26412584
85 Puri R Nicholls SJ Shao M Kataoka Y Uno K Kapadia SR Impact of statins on serial coronary calcification during atheroma progression and regression J Am Coll Cardiol 2015 65 1273 82 25835438
86 Raber L Taniwaki M Zaugg S Kelbaek H Roffi M Holmvang L Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study Eur Heart J 2015 36 490 500 25182248
87 Sun Y Byon CH Yuan K Chen J Mao X Heath JM Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification Circ Res 2012 111 543 52 22773442
88 Savinov AY Salehi M Yadav MC Radichev I Millan JL Savinova OV Transgenic overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in vascular endothelium results in generalized arterial calcification J Am Heart Assoc 2015 4 e002499 26675253
89 Bouletreau PJ Warren SM Spector JA Peled ZM Gerrets RP Greenwald JA Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells: implications for fracture healing Plast Reconstr Surg 2002 109 2384 97 12045566
90 Mody N Parhami F Sarafian TA Demer LL Oxidative stress modulates osteoblastic differentiation of vascular and bone cells Free Radic Biol Med 2001 31 509 19 11498284
91 Henze LA Luong TT Boehme B Masyout J Schneider MP Brachs S Impact of C-reactive protein on osteo-/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells Aging (Albany NY) 2019 11 5445 62 31377747
92 Cola C Almeida M Li D Romeo F Mehta JL Regulatory role of endothelium in the expression of genes affecting arterial calcification Biochem Biophys Res Commun 2004 320 424 7 15219845
93 Sakamoto M Minamino T Toko H Kayama Y Zou Y Sano M Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy Circ Res 2006 99 1411 8 17095722
94 Dong Y Zhang M Wang S Liang B Zhao Z Liu C Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo Diabetes 2010 59 1386 96 20299472
95 Tabas I The role of endoplasmic reticulum stress in the progression of atherosclerosis Circ Res 2010 107 839 50 20884885
96 Olas B Kontek B Hydrogen sulfide decreases the plasma lipid peroxidation induced by homocysteine and its thiolactone Mol Cell Biochem 2015 404 39 43 25701360
97 Hofmann MA Lalla E Lu Y Gleason MR Wolf BM Tanji N Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model J Clin Invest 2001 107 675 83 11254667
98 Papatheodorou L Weiss N Vascular oxidant stress and inflammation in hyperhomocysteinemia Antioxid Redox Signal 2007 9 1941 58 17822365
99 Fu Y Wang X Kong W Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets Br J Pharmacol 2018 175 1173 89 28836260
100 Lee SJ Lee IK Jeon JH Vascular calcification-new insights into its mechanism Int J Mol Sci 2020 21 2685
101 Iyemere VP Proudfoot D Weissberg PL Shanahan CM Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification J Intern Med 2006 260 192 210 16918817
102 Wu JT Circulating homocysteine is an inflammation marker and a risk factor of life-threatening inflammatory diseases J Biomed Lab Sci 2007 19 107 11
103 Graham IM Daly LE Refsum HM Robinson K Brattstrom LE Ueland PM Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project JAMA 1997 277 1775 81 9178790
104 Stampfer MJ Malinow MR Willett WC Newcomer LM Upson B Ullmann D A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians JAMA 1992 268 877 81 1640615
105 Nygard O Nordrehaug JE Refsum H Ueland PM Farstad M Vollset SE Plasma homocysteine levels and mortality in patients with coronary artery disease N Engl J Med 1997 337 230 6 9227928
106 Ubbink JB Vermaak WJ van der Merwe A Becker PJ Delport R Potgieter HC Vitamin requirements for the treatment of hyperhomocysteinemia in humans J Nutr 1994 124 1927 33 7931701
107 Landgren F Israelsson B Lindgren A Hultberg B Andersson A Brattstrom L Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid J Intern Med 1995 237 381 8 7714461
108 Homocysteine Lowering Trialists’ Collaboration Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists’ Collaboration BMJ 1998 316 894 8 9569395
109 Malinow MR Duell PB Hess DL Anderson PH Kruger WD Phillipson BE Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease N Engl J Med 1998 338 1009 15 9535664
110 Quinlivan EP McPartlin J McNulty H Ward M Strain JJ Weir DG Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease Lancet 2002 359 227 8 11812560
111 Lee BJ Huang MC Chung LJ Cheng CH Lin KL Su KH Folic acid and vitamin B12 are more effective than vitamin B6 in lowering fasting plasma homocysteine concentration in patients with coronary artery disease Eur J Clin Nutr 2004 58 481 7 14985687
112 Homocysteine Lowering Trialists’ Collaboration Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials Am J Clin Nutr 2005 82 806 12 16210710
113 Hodis HN Mack WJ Dustin L Mahrer PR Azen SP Detrano R High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial Stroke 2009 40 730 6 19118243
114 Kim BJ Kim BS Kang JH Plasma homocysteine and coronary artery calcification in Korean men Eur J Prev Cardiol 2015 22 478 85 24480877
115 Joo NS Jung S Kim YN Choi BH Cut-off value of serum homocysteine in relation to increase of coronary artery calcification J Investig Med 2021 69 345 50
116 Held C Sumner G Sheridan P McQueen M Smith S Dagenais G Correlations between plasma homocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals: baseline data from the Homocysteine and Atherosclerosis Reduction Trial (HART) Vasc Med 2008 13 245 53 18940900
117 Jacques PF Kalmbach R Bagley PJ Russo GT Rogers G Wilson PW The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene J Nutr 2002 132 283 8 11823591
118 Heese P Linnebank M Semmler A Muschler MA Heberlein A Frieling H Alterations of homocysteine serum levels during alcohol withdrawal are influenced by folate and riboflavin: results from the German Investigation on Neurobiology in Alcoholism (GINA) Alcohol Alcohol 2012 47 497 500 22645037
119 Wilcken DE Wilcken B B vitamins and homocysteine in cardiovascular disease and aging Ann N Y Acad Sci 1998 854 361 70 9928444
120 Olthof MR van Vliet T Boelsma E Verhoef P Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women J Nutr 2003 133 4135 8 14652361
121 Steenge GR Verhoef P Katan MB Betaine supplementation lowers plasma homocysteine in healthy men and women J Nutr 2003 133 1291 5 12730412
122 Bidulescu A Chambless LE Siega-Riz AM Zeisel SH Heiss G Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study BMC Cardiovasc Disord 2007 7 20 17629908
123 Dalmeijer GW Olthof MR Verhoef P Bots ML van der Schouw YT Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women Eur J Clin Nutr 2008 62 386 94 17375117
124 Lever M George PM Elmslie JL Atkinson W Slow S Molyneux SL Betaine and secondary events in an acute coronary syndrome cohort PLoS One 2012 7 e37883 22649561
125 Amer M Qayyum R The relationship between 25-hydroxyvitamin D and homocysteine in asymptomatic adults J Clin Endocrinol Metab 2014 99 633 8 24276459
126 Al-Bayyari N Al-Zeidaneen S Hailat R Hamadneh J Vitamin D3 prevents cardiovascular diseases by lowering serum total homocysteine concentrations in overweight reproductive women: a randomized, placebo-controlled clinical trial Nutr Res 2018 59 65 71 30442234
127 Young KA Snell-Bergeon JK Naik RG Hokanson JE Tarullo D Gottlieb PA Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes Diabetes Care 2011 34 454 8 20978098
128 Thiele I Linseisen J Meisinger C Schwab S Huth C Peters A Associations between calcium and vitamin D supplement use as well as their serum concentrations and subclinical cardiovascular disease phenotypes Atherosclerosis 2015 241 743 51 26141019
129 Mao PJ Zhang C Tang L Xian YQ Li YS Wang WD Effect of calcium or vitamin D supplementation on vascular outcomes: a meta-analysis of randomized controlled trials Int J Cardiol 2013 169 106 11 24035175
130 Kheiri B Abdalla A Osman M Ahmed S Hassan M Bachuwa G Vitamin D deficiency and risk of cardiovascular diseases: a narrative review Clin Hypertens 2018 24 9 29977597
131 Barbarawi M Kheiri B Zayed Y Barbarawi O Dhillon H Swaid B Vitamin D supplementation and cardiovascular disease risks in more than 83 000 individuals in 21 randomized clinical trials: a meta-analysis JAMA Cardiol 2019 4 765 76 31215980
132 Park KY Chung PW Kim YB Moon HS Suh BC Won YS Serum vitamin D status as a predictor of prognosis in patients with acute ischemic stroke Cerebrovasc Dis 2015 40 73 80 26184826
133 Kriebitzsch C Verlinden L Eelen G van Schoor NM Swart K Lips P 1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase J Bone Miner Res 2011 26 2991 3000 21898591
134 Luo G Ducy P McKee MD Pinero GJ Loyer E Behringer RR Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein Nature 1997 386 78 81 9052783
135 Booth SL Al Rajabi A Determinants of vitamin K status in humans Vitam Horm 2008 78 1 22 18374187
136 Berkner KL Runge KW The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis J Thromb Haemost 2004 2 2118 32 15613016
137 Vermeer C Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase Biochem J 1990 266 625 36 2183788
138 Lanham-New SA Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment Proc Nutr Soc 2008 67 163 76 18412990
139 van Ballegooijen AJ Beulens JW The role of vitamin K status in cardiovascular health: evidence from observational and clinical studies Curr Nutr Rep 2017 6 197 205 28944098
140 Geleijnse JM Vermeer C Grobbee DE Schurgers LJ Knapen MH van der Meer IM Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study J Nutr 2004 134 3100 5 15514282
141 Shea MK O’Donnell CJ Hoffmann U Dallal GE Dawson-Hughes B Ordovas JM Vitamin K supplementation and progression of coronary artery calcium in older men and women Am J Clin Nutr 2009 89 1799 807 19386744
142 Beulens JW Bots ML Atsma F Bartelink ML Prokop M Geleijnse JM High dietary menaquinone intake is associated with reduced coronary calcification Atherosclerosis 2009 203 489 93 18722618
143 Gast GC de Roos NM Sluijs I Bots ML Beulens JW Geleijnse JM A high menaquinone intake reduces the incidence of coronary heart disease Nutr Metab Cardiovasc Dis 2009 19 504 10 19179058
144 Vossen LM Schurgers LJ van Varik BJ Kietselaer BL Vermeer C Meeder JG Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: rationale and study protocol (VitaK-CAC Trial) Nutrients 2015 7 8905 15 26516910
145 Schurgers LJ Joosen IA Laufer EM Chatrou ML Herfs M Winkens MH Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype PLoS One 2012 7 e43229 22952653
146 Westenfeld R Krueger T Schlieper G Cranenburg EC Magdeleyns EJ Heidenreich S Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial Am J Kidney Dis 2012 59 186 95 22169620
147 Bjorklund G Svanberg E Dadar M Card DJ Chirumbolo S Harrington DJ The role of matrix Gla protein (MGP) in vascular calcification Curr Med Chem 2020 27 1647 60 30009696
148 Schurgers LJ Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease Kidney Int 2013 83 782 4 23633049
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