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A Personalized Cancer Vaccine that Induces Synergistic Innate and Adaptive Immune Responses

Advanced materials, v.35 no.36, 2023년, pp.2303080 -   

Kuen, Da‐Sol (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul National University 08826 Seoul Republic of Korea) ,  Hong, Jihye (Interdisciplinary Program for Bioengineering Seoul National University 08826 Seoul Republic of Korea) ,  Lee, Suyoung (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul National University 08826 Seoul Republic of Korea) ,  Koh, Choong‐Hyun (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul National University 08826 Seoul Republic of Korea) ,  Kwak, Minkyeong (Laboratory of Immune Regulation Institute of Pharmaceutical Sciences College of Pharmacy Seoul National University 08826 Seoul Republic of Korea) ,  Kim, Byung‐Seok (Division of Life Sciences College of Life Science and Bioengineering Incheon National University 22012 Incheon Republic of Korea) ,  Jung, Mungyo (School of Chemical and Biological Engineering Seoul National University 08826 Seoul Republic of Korea) ,  Kim, Yoon‐Joo (Department of Hematology Catholic Hematology Hospital and Leukemia<) ,  Cho, Byung‐Sik (?brk) ,  Kim, Byung‐Soo ,  Chung, Yeonseok

Abstract AI-Helper 아이콘AI-Helper

AbstractTo demonstrate potent efficacy, a cancer vaccine needs to activate both innate and adaptive immune cells. Personalized cancer vaccine strategies often require the identification of patient‐specific neoantigens; however, the clonal and mutational heterogeneity of cancer cells presents ...

참고문헌 (53)

  1. Longo, Dan L., Döhner, Hartmut, Weisdorf, Daniel J., Bloomfield, Clara D.. Acute Myeloid Leukemia. The New England journal of medicine, vol.373, no.12, 1136-1152.

  2. 10.1136/bmj.n2026 

  3. Dohner, Hartmut, Estey, Elihu, Grimwade, David, Amadori, Sergio, Appelbaum, Frederick R., Buchner, Thomas, Dombret, Hervé, Ebert, Benjamin L., Fenaux, Pierre, Larson, Richard A., Levine, Ross L., Lo-Coco, Francesco, Naoe, Tomoki, Niederwieser, Dietger, Ossenkoppele, Gert J., Sanz, Miguel, Sierra, Jorge, Tallman, Martin S., Tien, Hwei-Fang, Wei, Andrew H., Lowenberg, Bob, Bloomfield, Clara D.. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood, vol.129, no.4, 424-447.

  4. Yilmaz, Musa, Wang, Feng, Loghavi, Sanam, Bueso-Ramos, Carlos, Gumbs, Curtis, Little, Latasha, Song, Xingzhi, Zhang, Jianhua, Kadia, Tapan, Borthakur, Gautam, Jabbour, Elias, Pemmaraju, Naveen, Short, Nicholas, Garcia-Manero, Guillermo, Estrov, Zeev, Kantarjian, Hagop, Futreal, Andrew, Takahashi, Koichi, Ravandi, Farhad. Late relapse in acute myeloid leukemia (AML): clonal evolution or therapy-related leukemia?. Blood cancer journal, vol.9, no.2, 7-.

  5. Thol, Felicitas, Ganser, Arnold. Treatment of Relapsed Acute Myeloid Leukemia. Current treatment options in oncology, vol.21, no.8, 66-.

  6. Linenberger, M L. CD33-directed therapy with gemtuzumab ozogamicin in acute myeloid leukemia: progress in understanding cytotoxicity and potential mechanisms of drug resistance. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, vol.19, no.2, 176-182.

  7. Gill, Saar, Tasian, Sarah K., Ruella, Marco, Shestova, Olga, Li, Yong, Porter, David L., Carroll, Martin, Danet-Desnoyers, Gwenn, Scholler, John, Grupp, Stephan A., June, Carl H., Kalos, Michael. Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells. Blood, vol.123, no.15, 2343-2354.

  8. Lynn, Rachel C., Poussin, Mathilde, Kalota, Anna, Feng, Yang, Low, Philip S., Dimitrov, Dimiter S., Powell Jr, Daniel J.. Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells. Blood, vol.125, no.22, 3466-3476.

  9. Koedam, Jan, Wermke, Martin, Ehninger, Armin, Cartellieri, Marc, Ehninger, Gerhard. Chimeric antigen receptor T-cell therapy in acute myeloid leukemia. Current opinion in hematology, vol.29, no.2, 74-83.

  10. Cummins, Katherine D., Gill, Saar. Chimeric antigen receptor T-cell therapy for acute myeloid leukemia: how close to reality?. Haematologica, vol.104, no.7, 1302-1308.

  11. J.Byrne Deaths trigger pause in Celyad's allogeneic CAR‐T trial https://www.biopharma‐reporter.com/Article/2022/03/01/deaths‐trigger‐pause‐in‐celyad‐s‐allogeneic‐car‐t‐trial (accessed: August 2022). 

  12. Ribas, Antoni, Wolchok, Jedd D.. Cancer immunotherapy using checkpoint blockade. Science, vol.359, no.6382, 1350-1355.

  13. Daver, Naval, Basu, Sreyashi, Garcia-Manero, Guillermo, Cortes, Jorge E., Ravandi, Farhad, Jabbour, Elias J., Hendrickson, Stephany, Pierce, Sherry, Ning, Jing, Konopleva, Marina, Andreeff, Michael, Kornblau, Steven M., Pemmaraju, Naveen, Bueso-Ramos, Carlos E, Blando, Jorge, Hidalgo Lopez, Juliana Elisa, Allison, James, Kantarjian, Hagop M., Sharma, Padmanee. Phase IB/II Study of Nivolumab in Combination with Azacytidine (AZA) in Patients (pts) with Relapsed Acute Myeloid Leukemia (AML). Blood, vol.128, no.22, 763-763.

  14. Zeidan, Amer M., Knaus, Hanna A., Robinson, Tara M., Towlerton, Andrea M.H., Warren, Edus H., Zeidner, Joshua F., Blackford, Amanda L., Duffield, Amy S., Rizzieri, David, Frattini, Mark G., Levy, Yair M., Schroeder, Mark A., Ferguson, Anna, Sheldon, Katherine E., DeZern, Amy E., Gojo, Ivana, Gore, Steven D., Streicher, Howard, Luznik, Leo, Smith, B. Douglas. A Multi-center Phase I Trial of Ipilimumab in Patients with Myelodysplastic Syndromes following Hypomethylating Agent Failure. Clinical Cancer research : an official journal of the American Association for Cancer Research, vol.24, no.15, 3519-3527.

  15. Marofi, Faroogh, Rahman, Heshu Sulaiman, Al-Obaidi, Zaid Mahdi Jaber, Jalil, Abduladheem Turki, Abdelbasset, Walid Kamal, Suksatan, Wanich, Dorofeev, Aleksei Evgenievich, Shomali, Navid, Chartrand, Max Stanley, Pathak, Yashwant, Hassanzadeh, Ali, Baradaran, Behzad, Ahmadi, Majid, Saeedi, Hossein, Tahmasebi, Safa, Jarahian, Mostafa. Novel CAR T therapy is a ray of hope in the treatment of seriously ill AML patients. Stem cell research & therapy, vol.12, no.1, 465-.

  16. Saxena, Mansi, van der Burg, Sjoerd H., Melief, Cornelis J. M., Bhardwaj, Nina. Therapeutic cancer vaccines. Nature reviews. Cancer, vol.21, no.6, 360-378.

  17. Bandyopadhyay, Keya, Marrero, Idania, Kumar, Vipin. NKT cell subsets as key participants in liver physiology and pathology. Cellular & molecular immunology. = 中國免疫學雜誌. 英文版, vol.13, no.3, 337-346.

  18. Schuringa, Jan Jacob, Bonifer, Constanze. Dissecting Clonal Heterogeneity in AML. Cancer cell, vol.38, no.6, 782-784.

  19. Smits, Evelien L. J., Lee, Cindy, Hardwick, Nicola, Brooks, Suzanne, Van Tendeloo, Viggo F. I., Orchard, Kim, Guinn, Barbara-ann. Clinical evaluation of cellular immunotherapy in acute myeloid leukaemia. Cancer immunology, immunotherapy : CII, vol.60, no.6, 757-769.

  20. Gibbins, John D., Ancelet, Lindsay R., Weinkove, Robert, Compton, Benjamin J., Painter, Gavin F., Petersen, Troels R., Hermans, Ian F.. An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment. Blood, vol.124, no.19, 2953-2963.

  21. Ghosh, Arnab, Wolenski, Matthias, Klein, Christoph, Welte, Karl, Blazar, Bruce R., Sauer, Martin G.. Cytotoxic T Cells Reactive to an Immunodominant Leukemia-associated Antigen can be Specifically Primed and Expanded by Combining a Specific Priming Step With Nonspecific Large-scale Expansion. Journal of immunotherapy, vol.31, no.2, 121-131.

  22. Exley, M., Garcia, J., Wilson, S. B., Spada, F., Gerdes, D., Tahir, S. M. A., Patton, K. T., Blumberg¶, R. S., Porcelli, S., Chott**, A., Balk, S. P.. CD1d structure and regulation on human thymocytes, peripheral blood T cells,B cells and monocytes. Immunology, vol.100, no.1, 37-47.

  23. Fujii, Shin-ichiro, Shimizu, Kanako, Kronenberg, Mitchell, Steinman, Ralph M.. Prolonged IFN-γ–producing NKT response induced with α-galactosylceramide–loaded DCs. Nature immunology, vol.3, no.9, 867-874.

  24. Hewitt, Eric W.. The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology, vol.110, no.2, 163-169.

  25. Chung, Yeonseok, Kim, Byung-Seok, Kim, Yeon-Jeong, Ko, Hyun-Jeong, Ko, Sung-Youl, Kim, Dong-Hyeon, Kang, Chang-Yuil. CD1d-Restricted T Cells License B Cells to Generate Long-Lasting Cytotoxic Antitumor ImmunityIn vivo. Cancer research : the official organ of the American Association for Cancer Research, Inc, vol.66, no.13, 6843-6850.

  26. Jung, Mungyo, Kang, Mikyung, Kim, Byung‐Seok, Hong, Jihye, Kim, Cheesue, Koh, Choong‐Hyun, Choi, Garam, Chung, Yeonseok, Kim, Byung‐Soo. Nanovesicle‐Mediated Targeted Delivery of Immune Checkpoint Blockades to Potentiate Therapeutic Efficacy and Prevent Side Effects. Advanced materials, vol.34, no.9, 2106516-.

  27. Hood, J.L., Scott, M.J., Wickline, S.A.. Maximizing exosome colloidal stability following electroporation. Analytical biochemistry, vol.448, 41-49.

  28. LaBelle, James L., Truitt, Robert L.. Characterization of a Murine NKT Cell Tumor Previously Described as an Acute Myelogenous Leukemia. Leukemia & lymphoma, vol.43, no.8, 1637-1644.

  29. Longmire, Michelle, Choyke, Peter L, Kobayashi, Hisataka. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. Nanomedicine, vol.3, no.5, 703-717.

  30. J. Vis. Exp. Mopin A. 54270 116 2016 

  31. Meredith, Matthew M., Liu, Kang, Darrasse-Jeze, Guillaume, Kamphorst, Alice O., Schreiber, Heidi A., Guermonprez, Pierre, Idoyaga, Juliana, Cheong, Cheolho, Yao, Kai-Hui, Niec, Rachel E., Nussenzweig, Michel C.. Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. The Journal of experimental medicine, vol.209, no.6, 1153-1165.

  32. Liao, Dan, Wang, Mengyao, Liao, Yi, Li, Jun, Niu, Ting. A Review of Efficacy and Safety of Checkpoint Inhibitor for the Treatment of Acute Myeloid Leukemia. Frontiers in pharmacology, vol.10, 609-.

  33. Isidori, Alessandro, Cerchione, Claudio, Daver, Naval, DiNardo, Courtney, Garcia-Manero, Guillermo, Konopleva, Marina, Jabbour, Elias, Ravandi, Farhad, Kadia, Tapan, Burguera, Adolfo de la Fuente, Romano, Alessandra, Loscocco, Federica, Visani, Giuseppe, Martinelli, Giovanni, Kantarjian, Hagop, Curti, Antonio. Immunotherapy in Acute Myeloid Leukemia: Where We Stand. Frontiers in oncology, vol.11, 656218-.

  34. Miles, Linde A., Bowman, Robert L., Merlinsky, Tiffany R., Csete, Isabelle S., Ooi, Aik T., Durruthy-Durruthy, Robert, Bowman, Michael, Famulare, Christopher, Patel, Minal A., Mendez, Pedro, Ainali, Chrysanthi, Demaree, Benjamin, Delley, Cyrille L., Abate, Adam R., Manivannan, Manimozhi, Sahu, Sombeet, Goldberg, Aaron D., Bolton, Kelly L., Zehir, Ahmet, Rampal, Raajit, Carroll, Martin P., Meyer, Sara E., Viny, Aaron D., Levine, Ross L.. Single cell mutation analysis of clonal evolution in myeloid malignancies. Nature, vol.587, no.7834, 477-482.

  35. Dai, Shengming, Wei, Dong, Wu, Zhen, Zhou, Xiangyang, Wei, Xiaomou, Huang, Haixin, Li, Guisheng. Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer. Molecular therapy : the journal of the American Society of Gene Therapy, vol.16, no.4, 782-790.

  36. Ji, Young Sok, Park, Seong Kyu, Ryu, Seongho. Whole leukemia cell vaccines: Past progress and future directions. Vaccine, vol.38, no.22, 3811-3820.

  37. Johnson, Daniel T., Zhou, Jiarong, Kroll, Ashley V., Fang, Ronnie H., Yan, Ming, Xiao, Crystal, Chen, Xiufen, Kline, Justin, Zhang, Liangfang, Zhang, Dong-Er. Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, vol.36, no.4, 994-1005.

  38. Nam, Gi‐Hoon, Choi, Yoonjeong, Kim, Gi Beom, Kim, Seohyun, Kim, Seong A, Kim, In‐San. Emerging Prospects of Exosomes for Cancer Treatment: From Conventional Therapy to Immunotherapy. Advanced materials, vol.32, no.51, 2002440-.

  39. Herrmann, Inge Katrin, Wood, Matthew John Andrew, Fuhrmann, Gregor. Extracellular vesicles as a next-generation drug delivery platform. Nature nanotechnology, vol.16, no.7, 748-759.

  40. Goh, Wei Jiang, Zou, Shui, Ong, Wei Yi, Torta, Federico, Alexandra, Alvarez Fernandez, Schiffelers, Raymond M., Storm, Gert, Wang, Jiong-Wei, Czarny, Bertrand, Pastorin, Giorgia. Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative. Scientific reports, vol.7, 14322-.

  41. Clin. Cancer Res. Giaccone G. 3702 8 2002 

  42. Saka, Hideo, Kitagawa, Chiyoe, Ichinose, Yukito, Takenoyama, Mitsuhiro, Ibata, Hidenori, Kato, Tatsuo, Takami, Koji, Yamashita, Motohiro, Maeda, Tadashi, Takeo, Sadanori, Ueda, Hitoshi, Okabayashi, Kan, Nagashima, Seiji, Oka, Tadayuki, Kouso, Hidenori, Fukuyama, Seiichi, Yoshimoto, Kentaro, Shimokawa, Mototsugu, Saito, Akiko M., Ito, Suminobu. A randomized phase II study to assess the effect of adjuvant immunotherapy using α-GalCer-pulsed dendritic cells in the patients with completely resected stage II–IIIA non-small cell lung cancer: study protocol for a randomized controlled trial. Trials, vol.18, no.1, 429-.

  43. Toyoda, Takahide, Kamata, Toshiko, Tanaka, Kazuhisa, Ihara, Fumie, Takami, Mariko, Suzuki, Hidemi, Nakajima, Takahiro, Ikeuchi, Takayuki, Kawasaki, Yohei, Hanaoka, Hideki, Nakayama, Toshinori, Yoshino, Ichiro, Motohashi, Shinichiro. Phase II study of α-galactosylceramide-pulsed antigen-presenting cells in patients with advanced or recurrent non-small cell lung cancer. Journal for immunotherapy of cancer, vol.8, no.1, e000316-.

  44. Di Francia, Raffaele, Crisci, Stefania, De Monaco, Angela, Cafiero, Concetta, Re, Agnese, Iaccarino, Giancarla, De Filippi, Rosaria, Frigeri, Ferdinando, Corazzelli, Gaetano, Micera, Alessandra, Pinto, Antonio. Response and Toxicity to Cytarabine Therapy in Leukemia and Lymphoma: From Dose Puzzle to Pharmacogenomic Biomarkers. Cancers, vol.13, no.5, 966-.

  45. Lin, J.M., Li, B., Rimmer, E., VanRoey, M., Jooss, K.. Enhancement of the anti-tumor efficacy of a GM-CSF-secreting tumor cell immunotherapy in preclinical models by cytosine arabinoside. Experimental hematology, vol.36, no.3, 319-328.

  46. Spanoudakis, Emmanouil, Hu, Ming, Naresh, Kikkeri, Terpos, Evangelos, Melo, Valeria, Reid, Alistair, Kotsianidis, Ioannis, Abdalla, Saad, Rahemtulla, Amin, Karadimitris, Anastasios. Regulation of multiple myeloma survival and progression by CD1d. Blood, vol.113, no.11, 2498-2507.

  47. Spizzo, Gilbert, Fong, Dominic, Wurm, Martin, Ensinger, Christian, Obrist, Peter, Hofer, Carina, Mazzoleni, Guido, Gastl, Guenther, Went, Philip. EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis. Journal of clinical pathology, vol.64, no.5, 415-420.

  48. Dhodapkar, Kavita M., Barbuto, Scott, Matthews, Phillip, Kukreja, Anjli, Mazumder, Amitabha, Vesole, David, Jagannath, Sundar, Dhodapkar, Madhav V.. Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood, vol.112, no.7, 2878-2885.

  49. Liu, D., Song, L., Brawley, V.S., Robison, N., Wei, J., Gao, X., Tian, G., Margol, A., Ahmed, N., Asgharzadeh, S., Metelitsa, L.S.. Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells. Clinical immunology : the official journal of the Clinical Immunology Society, vol.149, no.1, 55-64.

  50. Metelitsa, Leonid S., Wu, Hong-Wei, Wang, Hong, Yang, Yujun, Warsi, Zamir, Asgharzadeh, Shahab, Groshen, Susan, Wilson, S. Brian, Seeger, Robert C.. Natural Killer T Cells Infiltrate Neuroblastomas Expressing the Chemokine CCL2. The Journal of experimental medicine, vol.199, no.9, 1213-1221.

  51. Tarbell, Kristin V., Yamazaki, Sayuri, Olson, Kara, Toy, Priscilla, Steinman, Ralph M.. CD25 + CD4 + T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes. The Journal of experimental medicine, vol.199, no.11, 1467-1477.

  52. Liu, Daofeng, Song, Liping, Wei, Jie, Courtney, Amy N., Gao, Xiuhua, Marinova, Ekaterina, Guo, Linjie, Heczey, Andras, Asgharzadeh, Shahab, Kim, Eugene, Dotti, Gianpietro, Metelitsa, Leonid S.. IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity. The Journal of clinical investigation, vol.122, no.6, 2221-2233.

  53. Brennan, Patrick J., Cheng, Tan-Yun, Pellicci, Daniel G., Watts, Gerald F. M., Veerapen, Natacha, Young, David C., Rossjohn, Jamie, Besra, Gurdyal S., Godfrey, Dale I., Brenner, Michael B., Moody, D. Branch. Structural determination of lipid antigens captured at the CD1d–T-cell receptor interface. Proceedings of the National Academy of Sciences of the United States of America, vol.114, no.31, 8348-8353.

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