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Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships

The Journal of nutritional biochemistry, v.13 no.10, 2002년, pp.572 - 584  

Heim, Kelly E (Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, NH 03824, USA) ,  Tagliaferro, Anthony R (Corresponding author. Tel.: +1-603-868-7244) ,  Bobilya, Dennis J (Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, NH 03824, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractFlavonoids are a class of secondary plant phenolics with significant antioxidant and chelating properties. In the human diet, they are most concentrated in fruits, vegetables, wines, teas and cocoa. Their cardioprotective effects stem from the ability to inhibit lipid peroxidation, chelate r...

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참고문헌 (129)

  1. Phytochemistry Harborne 55 481 2000 10.1016/S0031-9422(00)00235-1 Advances in flavonoid research since 1992 

  2. J Nutr Hammerstone 130 2086S 2000 10.1093/jn/130.8.2086S Procyanidin content and variation in some commonly consumed foods 

  3. J Agr Food Chem Carando 47 4161 1999 10.1021/jf9810564 Levels of flavan-3-ols in French wines 

  4. Proc Soc Exp Biol Med Prior 220 255 1999 10.3181/00379727-220-44376 Antioxidant capacity and polyphenolic components of teas 

  5. Food Rev Int Hara 11 371 1995 Special issue on tea 

  6. J Chromatogr Lopez 922 359 2001 10.1016/S0021-9673(01)00913-X Analysis of phenolic constituents of biological interest in red wines by high-performance liquid chromatography 

  7. J Agric Food Chem Kreft 47 4649 1999 10.1021/jf990186p Extraction of rutin from buckwheat (Fagopyrum esculentum Moench) seeds and determination by capillary electrophoresis 

  8. J Agric Food Chem Stewart 48 2663 2000 10.1021/jf000070p Occurrence of flavonols in tomatoes and tomato-based products 

  9. J Agric Food Chem Rousseff 35 1027 1987 10.1021/jf00078a040 Quantitative survey of narirutin, naringin, heperidin, and neohesperidin in citrus 

  10. Nutr Cancer Int J Reinli 26 123 1996 10.1080/01635589609514470 Phytoestrogen content of foods 

  11. J Agric Food Chem Hertog 40 2379 1992 10.1021/jf00024a011 Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands 

  12. Lancet Kondo 348 1514 1996 10.1016/S0140-6736(05)65927-2 Inhibition of LDL oxidation by cocoa 

  13. Atherosclerosis Mazur 145 421 1999 Inhibitory effect of procyanidin-rich extracts on LDL oxidation in vitro 

  14. Life Sci Facino 64 627 1999 10.1016/S0024-3205(98)00605-5 Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats 

  15. Lancet Hertog 342 1007 1993 10.1016/0140-6736(93)92876-U Dietary antioxidant flavonoids and risk of coronary heart disease 

  16. Am J Epidemiol Yochum 149 943 1999 10.1093/oxfordjournals.aje.a009738 Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women 

  17. Am J Clin Nutr Arts 74 227 2001 10.1093/ajcn/74.2.227 Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease 

  18. Adv Pharmacol Korkina 38 151 1997 10.1016/S1054-3589(08)60983-7 Antioxidant and chelating properties of flavonoids 

  19. IUBMB Life Sastre 49 427 2000 10.1080/152165400410281 Mitochondrial oxidative stress plays a key role in aging and apoptosis 

  20. Carcinogenesis Takabe 22 935 2001 10.1093/carcin/22.6.935 Oxidative stress promotes the development of transformation 

  21. Mutat Res Kawanishi 488 65 2001 10.1016/S1383-5742(00)00059-4 Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging 

  22. J Pak Med Assoc Khan 50 261 2000 Increased malondialdehyde levels in coronary heart disease 

  23. Biochem Pharmacol Mora 40 793 1990 10.1016/0006-2952(90)90317-E Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation 

  24. Circ Res Moore 77 335 1995 10.1161/01.RES.77.2.335 Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite 

  25. J Biol Chem Leeuwenburgh 272 1433 1997 10.1074/jbc.272.3.1433 Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima 

  26. Circ Res Ferdinandy 87 241 2000 10.1161/01.RES.87.3.241 Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure 

  27. Cardiovasc Res Wang 53 165 2002 10.1016/S0008-6363(01)00445-X Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2 

  28. Biol Chem Hoppe Seyler Beckmann 375 81 1994 10.1515/bchm3.1994.375.2.81 Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry 

  29. FEBS Lett Ferrali 416 123 1997 10.1016/S0014-5793(97)01182-4 Protection against oxidative damage of erythrocyte membranes by the flavonoid quercetin and its relation to iron chelating activity 

  30. Biochem Pharmacol Elliott 44 1603 1992 10.1016/0006-2952(92)90478-2 Inhibition of glutathione reductase by flavonoids 

  31. J Nutr Sci Vitaminol (Tokyo) Hirano 47 357 2001 10.3177/jnsv.47.357 Antioxidant ability of various flavonoids against DPPH radicals and LDL oxidation 

  32. J Nat Prod Cos 61 71 1998 10.1021/np970237h Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers 

  33. J Food Sci Agr Santos-Buelga 80 1094 2000 10.1002/(SICI)1097-0010(20000515)80:7<1094::AID-JSFA569>3.0.CO;2-1 Proanthocyanidins and tannin-like compounds in human nutrition 

  34. Crit Rev Food Sci Nutr Balantine 37 693 1997 10.1080/10408399709527797 The chemistry of tea flavonoids 

  35. J Agr Food Chem Yang 48 3990 2000 10.1021/jf000316q Characterization of grape procyanidins using high-performance liquid chromatography/mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry 

  36. Phytochemistry Guyot 44 351 1997 10.1016/S0031-9422(96)00480-3 Characterization of highly polymerized procyanidins in cider apple (Malus sylvestris var kermerrien) skin and pulp 

  37. J Agr Food Chem Adamson 47 4184 1999 10.1021/jf990317m HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity 

  38. J Nutr Biochem Cook 7 66 1996 10.1016/0955-2863(95)00168-9 Flavonoids 

  39. Free Radic Biol Med Rice-Evans 20 933 1996 10.1016/0891-5849(95)02227-9 Structure-antioxidant activity relationships of flavonoids and phenolic acids 

  40. J Biol Chem Leese 248 8170 1973 10.1016/S0021-9258(19)43209-2 On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase 

  41. FEBS Lett Day 468 166 2000 10.1016/S0014-5793(00)01211-4 Dietary flavonoid and isoflavone glycosides are hydrolyzed by lactase site of lactase phlorizin hydrolase 

  42. J Biol Chem Daniels 256 13004 1981 10.1016/S0021-9258(18)42997-3 Purification and characterization of a cytosolic broad specificity beta-glucosidase from human liver 

  43. J Biol Chem Gopalan 267 14027 1992 10.1016/S0021-9258(19)49673-7 Exolytic hydrolysis of toxic plant glucosides by guinea pig liver cytosolic beta-glucosidase 

  44. FEBS Lett Spencer 458 224 1999 10.1016/S0014-5793(99)01160-6 The small intestine can both absorb and glucuronidate luminal flavonoids 

  45. FEBS Lett Day 436 71 1998 10.1016/S0014-5793(98)01101-6 Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity 

  46. FEBS Lett Shimoi 438 220 1998 10.1016/S0014-5793(98)01304-0 Intestinal absorption of luteolin and luteolin 7-O-glucoside in rats and humans 

  47. Clin Chem Cao 45 574 1999 10.1093/clinchem/45.4.574 Anthocyanins are detected in human plasma after oral administration of an elderberry extract 

  48. J Nutr Crespy 131 3227 2001 10.1093/jn/131.12.3227 Bioavailability of phloretin and phloridzin in rats 

  49. FEBS Lett Manach 409 12 1997 10.1016/S0014-5793(97)00467-5 Bioavailability of rutin and quercitin in rats 

  50. Am J Clin Nutr Hollman 62 1276 1995 10.1093/ajcn/62.6.1276 Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers 

  51. Arch Pharm Res Kim 21 17 1998 10.1007/BF03216747 Intestinal bacterial metabolism of flavonoids and its relation to some biological activities 

  52. Free Radic Res Hollman 31 569 1999 10.1080/10715769900301141 The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man 

  53. Food Chem Toxicol Hollman 37 937 1999 10.1016/S0278-6915(99)00079-4 Dietary flavonoids 

  54. Arch Intern Med Erlund 161 1919 2001 10.1001/archinte.161.15.1919 Tea and coronary heart disease 

  55. J Nutr Olthof 130 1200 2000 10.1093/jn/130.5.1200 Bioavailabilities of quercetin-3-glucoside and quercetin-4′-glucoside do not differ in humans 

  56. Free Radic Biol Med Gee 25 19 1998 10.1016/S0891-5849(98)00020-3 Quercetin glucosides interact with the intestinal glucose transport pathway 

  57. J Agr Food Chem Deprez 47 4219 1999 10.1021/jf981380z Carbon-14 biolabeling of (+)-catechin and proanthocyanidin oligomers in willow tree cuttings 

  58. Xenobiotica Groenewoud 16 99 1986 10.3109/00498258609043512 The microbial metabolism of condensed (+)-catechin by rat caecal microflora 

  59. Biochem Biophys Res Commun Spencer 272 236 2000 10.1006/bbrc.2000.2749 Decomposition of cocoa procyanidins in the gastric milieu 

  60. Int J Syst Bacteriol Winter 41 355 1991 10.1099/00207713-41-3-355 Clostridium orbiscindens sp. Nov., a human intestinal bacterium capable of cleaving the flavonoid C-ring 

  61. J Pharm Sci Baba 72 1155 1983 10.1002/jps.2600721011 Studies on drug metabolism by use of isotopes XXVII 

  62. J Nutr Deprez 130 2733 2000 10.1093/jn/130.11.2733 Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids 

  63. Chem Pharm Bull Meselhy 45 888 1997 10.1248/cpb.45.888 Biotransformation of (?)-epicatechin 3-O-gallate by human intestinal bacteria 

  64. J Agr Food Chem Miyake 48 3217 2000 10.1021/jf990994g Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats 

  65. Chem Biol Interact Hodek 139 1 2002 10.1016/S0009-2797(01)00285-X Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 

  66. Xenobiotica Nielsen 28 389 1998 10.1080/004982598239498 In vitro biotransformation of flavonoids by rat liver microsomes 

  67. Mutat Res Rahden-Staron 498 57 2001 10.1016/S1383-5718(01)00267-4 Induction of rat liver cytochrome P450 isoenzymes by CYP1A and CYP2B by different fungicides, nitrofurans, and quercetin 

  68. Toxicology Dootsdar 144 31 2000 10.1016/S0300-483X(99)00215-2 Bioflavonoids 

  69. Life Sci Ng 66 709 2000 10.1016/S0024-3205(99)00642-6 Antioxidative activity of natural products from plants 

  70. J Biol Chem Zhu 269 292 1994 10.1016/S0021-9258(17)42348-9 Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids 

  71. J Nutr Walle 131 2648 2001 10.1093/jn/131.10.2648 Carbon dioxide is the major metabolite of quercetin in humans 

  72. J Nutr Warden 131 1731 2001 10.1093/jn/131.6.1731 Catechins are bioavailable in men and women drinking black tea throughout the day 

  73. J Nutr Piskula 128 1172 1998 10.1093/jn/128.7.1172 Accumulation of (?)-epicatechin metabolites in rat plasma after oral administration and distribution of conjugated enzymes in rat tissues 

  74. Free Radic Res Day 35 941 2001 10.1080/10715760100301441 Human metabolism of dietary flavonoids 

  75. Br J Clin Pharmacol Walle 51 143 2001 10.1111/j.1365-2125.2001.01317.x Disposition and metabolism of the flavonoid chrysin in normal volunteers 

  76. Free Radic Biol Med Spencer 31 1139 2001 10.1016/S0891-5849(01)00704-3 Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts 

  77. Eur J Clin Pharmacol Erlund 56 545 2000 10.1007/s002280000197 Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy human volunteers 

  78. Xenobiotica Sanz 24 689 1994 10.3109/00498259409043270 Influence of a series of natural flavonoids on free radical generating systems and oxidative stress 

  79. J Nutr Rein 130 2109S 2000 10.1093/jn/130.8.2109S Epicatechin in human plasma 

  80. J Nutr Wang 130 2115S 2000 10.1093/jn/130.8.2115S A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage 

  81. FEBS Lett Hollman 418 152 1997 10.1016/S0014-5793(97)01367-7 Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man 

  82. J Agric Food Chem Arts 50 1184 2002 10.1021/jf010855a Interactions between flavonoids and proteins 

  83. Free Radic Res Hollman 34 297 2001 10.1080/10715760100300261 Addition of milk does not affect the absorption of flavonols from tea in man 

  84. Free Radic Biol Med Cao 22 749 1997 10.1016/S0891-5849(96)00351-6 Antioxidant and prooxidant behavior of flavonoids 

  85. Biochem Biophys Res Commun Sekher Pannala 282 1161 2001 10.1006/bbrc.2001.4705 Flavonoid B-ring chemistry and antioxidant activity 

  86. Biochem Biophys Res Commun Haenen 236 591 1997 10.1006/bbrc.1997.7016 Peroxynitrite scavenging by flavonoids 

  87. J Agric Food Chem Burda 49 2774 2001 10.1021/jf001413m Antioxidant and antiradical activities of flavonoids 

  88. J Neurochem Kerry 73 247 1999 10.1046/j.1471-4159.1999.0730247.x Inhibition of peroxynitrite-mediated oxidation of dopamine by flavonoid and phenolic antioxidants and their structural relationships 

  89. Biochem Med Metab Biol Ratty 39 69 1988 10.1016/0885-4505(88)90060-6 Effects of flavonoids on nonenzymatic lipid peroxidation 

  90. J Nat Products Dugas 63 327 2000 10.1021/np990352n Evaluation of the total peroxyl radical-scavenging capacity of flavonoids 

  91. Biol Trace Elem Res Hu 47 327 1995 10.1007/BF02790134 Berghe, Structure-activity relationship of flavonoids with superoxide scavenging activity 

  92. Chem Res Toxicol Van Acker 9 1305 1996 10.1021/tx9600964 A quantum chemical explanation of the antioxidant activity of flavonoid 

  93. Free Radic Biol Med Arora 24 1355 1998 10.1016/S0891-5849(97)00458-9 Structure-activity relationships for antioxidant activities of a series of flavonoids in a liposomal system 

  94. Biochim Biophys Acta Gao 472 643 1999 10.1016/S0304-4165(99)00152-X Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi, 

  95. Experientia Cholbi 47 195 1990 10.1007/BF01945426 Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation 

  96. Biosci Biotechnol Biochem Lai 66 22 2002 10.1271/bbb.66.22 Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation 

  97. Free Radic Biol Med Matthiesen 2 307 1997 10.1016/S0891-5849(96)00277-8 Hydrogen bond formation as basis for radical scavenging activity 

  98. Methods Enzymol Bors 186 343 1990 10.1016/0076-6879(90)86128-I Flavonoids as antioxidants 

  99. FEBS Lett Arteel 462 167 1999 10.1016/S0014-5793(99)01498-2 Protection against peroxynitrite by cocoa polyphenol oligomers 

  100. Arch Biochem Biophys Ollila 399 103 2002 10.1006/abbi.2001.2759 Characterization of flavonoid-biomembrane interactions 

  101. Free Radic Biol Med Cao 14 303 1993 10.1016/0891-5849(93)90027-R Oxygen-radical absorbance capacity assay for antioxidants 

  102. Free Radic Biol Med Lien 26 285 1999 10.1016/S0891-5849(98)00190-7 Quantitative structure-activity relationship analysis of phenolic antioxidants 

  103. Redox Rep Plumb 4 13 1999 10.1179/135100099101534684 Antioxidant properties of flavonol glycosides from tea 

  104. Biochim Biophys Acta Ioku 1234 99 1995 10.1016/0005-2736(94)00262-N Antioxidant activity of quercitin monoglucosides in solution and phospholipid bilayers 

  105. Basic Life Sci Williamson 66 483 1999 Glycosylation, esterification and polymerization of flavonoids and hydroxycinnamates 

  106. Biochem Pharmacol Limasset 46 1257 1993 10.1016/0006-2952(93)90476-D Effects of flavonoids on the release of reactive oxygen species by stimulated human neutrophils 

  107. Biol Pharm Bull Vennat 17 1613 1994 10.1248/bpb.17.1613 Procyanidins from tormentil 

  108. J Agr Food Chem Castillo 48 1738 2000 10.1021/jf990665o Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (procyanidins) from grape seeds (Vitis vinifera) 

  109. J Clin Pharm Ther Nuttall 23 385 1998 10.1046/j.1365-2710.1998.00180.x An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect® 

  110. Clin Chem Whitehead 41 32 1995 10.1093/clinchem/41.1.32 Effect of red wine on the antioxidant capacity of serum 

  111. J Clin Pharm Ther Kendall 23 323 1998 10.1046/j.1365-2710.1998.00179.x Antioxidant therapy 

  112. Biochem Pharmacol Morel 45 13 1993 10.1016/0006-2952(93)90371-3 Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures 

  113. Arch Biochem Biophys Kostyuk 385 129 2001 10.1006/abbi.2000.2118 Influence of metal ions on flavonoid protection against asbestos-induced cell injury 

  114. Biochem Pharmacol Afanas’ev 50 627 1995 10.1016/0006-2952(95)00173-W Different antioxidant activities of bioflavonoid rutin in normal and iron-overloaded rats 

  115. Adv. Pharmacol. Galey 38 167 1997 10.1016/S1054-3589(08)60984-9 Potential use of iron chelators against oxidative damage 

  116. Free Radic Biol Med Sugihara 27 1313 1999 10.1016/S0891-5849(99)00167-7 Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid 

  117. Food Chem Toxicol Sahu 35 443 1997 10.1016/S0278-6915(97)00011-2 Lipid peroxidation and DNA damage induced by morin and naringenin in isolated rat liver nuclei 

  118. Cell Mol Biol Lett Soczynska-Kordala 6 277 2001 Metal ion-flavonoid associations in bilayer phospholipid membranes 

  119. Biometals Cheng 13 77 2000 10.1023/A:1009229429250 On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the Fenton reaction of the iron-ATP complex 

  120. Mol Genet Metab Yoshino 68 468 1999 10.1006/mgme.1999.2901 Prooxidant activity of flavonoids 

  121. Mutat Res Yamashita 425 107 1999 10.1016/S0027-5107(99)00029-9 Mechanism of oxidative DNA damage induced by quercetin in the presence of Cu(II) 

  122. Free Radic Biol Med Hanasaki 16 845 1994 10.1016/0891-5849(94)90202-X The correlation between active oxygen scavenging and antioxidative effects of flavonoids 

  123. Biochem Pharmacol Hodnick 35 2345 1986 10.1016/0006-2952(86)90461-2 Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids 

  124. Mol Immunol Ueda 38 781 2002 10.1016/S0161-5890(01)00115-8 Baicalin induces apoptosis via mitochondrial pathway as prooxidant 

  125. Fitoterapia Ismail 72 676 2001 10.1016/S0367-326X(01)00281-7 A novel cytotoxic flavonoid glycoside from Physalis angulata, 

  126. Free Radic Biol Med Ohshima 25 1057 1998 10.1016/S0891-5849(98)00141-5 Antioxidant and pro-oxidant actions of flavonoids 

  127. Free Radic Biol Med Bors 19 45 1995 10.1016/0891-5849(95)00011-L Interaction of flavonoids with ascorbate and determination of their univalent redox potentials 

  128. J Med Chem Borchardt 18 120 1975 10.1021/jm00235a030 Catechol-O-methyltransferase. 5. Structure-activity relationships for inhibition by flavonoids 

  129. Free Radic Res Rice-Evans 22 375 1995 10.3109/10715769509145649 The relative activities of plant-derived polyphenolic flavonoids 

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