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Mutagenic activity of halogenated propanes and propenes: effect of bromine and chlorine positioning

Chemico-biological interactions, v.93 no.1, 1994년, pp.73 - 84  

Lag, M. (Department of Environmental Medicine, National Institute of Public Health, Geitmyrsveien 75, 0462 ,, Oslo, Norway) ,  Omichinski, J.G. ,  Dybing, E. ,  Nelson, S.D. ,  Soderlund, E.J.

Abstract AI-Helper 아이콘AI-Helper

A series of halogenated propanes and propenes were studied for mutagenic effects in Salmonella typhimurium TA100 in the absence or presence of NADPH plus liver microsomes from phenobarbital-induced rats as an exogenous metabolism system. The cytotoxic and mutagenic effects of the halogenated propane...

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참고문헌 (36)

  1. Experientia Jones 35 1432 1979 10.1007/BF01962767 The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane in the rat 

  2. Xenobiotica Jones 11 541 1981 10.3109/00498258109045865 The metabolism of 1,3-dibromopropane by the rat 

  3. Toxicol. Lett. James 8 7 1981 10.1016/0378-4274(81)90130-2 Metabolism of 1,3-dibromopropane 

  4. Mol. Pharmacol. Tachizawa 22 745 1982 Rat liver microsomal metabolism of propyl halides 

  5. Toxicol. Appl. Pharmacol. Volp 75 8 1984 10.1016/0041-008X(84)90070-X Disposition of 1,2,3-trichloropropane in the Fischer 344 rat: conventional and physiological pharmacokinetics 

  6. Dybing Vol. 10 139 1989 Mutagenicity and organ damage of 1,2-dibromo-3-chloropropane (DBCP) and tris(2,3-dibromopropyl)phosphate (Tris-BP): role of metabolic activation 

  7. Chem. Res. Toxicol. Pearson 3 458 1990 10.1021/tx00017a012 Metabolic activation of 1,2-dibromo-3-chloropropane to mutagenic metabolites. Detection and mechanism of formation of (Z)- and (E)-2 chloro-3-(bromomethyl)oxirane 

  8. Biochemistry Pearson 29 4971 1990 10.1021/bi00472a030 Metabolic activation of 1,2-dibromo-3-chloropropane. Evidence for the formation of reactive episulfonium ion intermediates 

  9. Cancer Res. Cmarik 50 2747 1990 Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes 

  10. J. Toxicol. Environ. Health Fisher 23 171 1988 10.1080/15287398809531104 Tissue levels of glutathione following acute inhalation of 1,3-dichloropropene 

  11. Food Chem. Toxicol. Eder 24 667 1986 10.1016/0278-6915(86)90155-9 Genotoxicity of allyl compounds - a quick screening strategy based on structure-activity relationships and a battery of prescreening tests 

  12. Chem. Res. Toxicol. Lag 4 528 1991 10.1021/tx00023a007 Effect of bromine and chlorine positioning in the induction of renal and testicular toxicity by halogenated propanes 

  13. J. Toxicol. Environ. Health. Miller 19 503 1986 10.1080/15287398609530948 Mutagen activation of 1,2-dibromo-3-chloropropane by cytosolic glutathione S-transferases and microsomal enzymes 

  14. Toxicol. Appl. Pharmacol. Omichinski 91 358 1987 10.1016/0041-008X(87)90058-5 Renal necrosis and DNA damage caused by selectively deuterated and methylated analogues of 1,2-dibromo-3-chloropropane in the rat 

  15. Mol. Pharmacol. Omichinski 34 74 1988 The role of oxidative and conjugative pathways in the activation of 1,2-dibromo-3-chloropropane to DNA-damaging products in rat testicular cells 

  16. Toxicol. Appl. Pharmacol. Søderlund 94 437 1988 10.1016/0041-008X(88)90284-0 Testicular necrosis and DNA damage caused by selectively deuterated and methylated analogues of 1,2-dibromo-3-chloropropane in the rat 

  17. Carcinogenesis Holme 10 49 1989 10.1093/carcin/10.1.49 Different mechanisms are involved in DNA damage, bacterial mutagenicity and cytotoxicity induced by 1,2-dibromo-3-chloropropane (DBCP) in suspensions of rat liver cells 

  18. Chem.-Biol. Interact. Lag 69 33 1989 10.1016/0009-2797(89)90097-5 Metabolism of selectively methylated and deuterated analogues of 1,2-dibromo-3-chloropropane: role in organ toxicity and mutagenicity 

  19. Toxicology Lag 58 133 1989 10.1016/0300-483X(89)90003-6 Species differences in testicular necrosis and DNA damage, distribution and metabolism of 1,2-dibromo-3-chloropropane (DBCP) 

  20. Toxicology Lag 56 273 1989 10.1016/0300-483X(89)90091-7 Role of P450 activity and glutathione levels on 1,2-dibromo-3-chloropropane tissue distribution, renal necrosis and in vivo DNA damage 

  21. Pharmacol. Toxicol. Søderlund 66 287 1990 10.1111/j.1600-0773.1990.tb00749.x Species differences in kidney necrosis and DNA damage, distribution and glutathione-dependent metabolism of 1,2-dibromo-3-chloropropane (DBCP) 

  22. Toxicol. Appl. Pharmacol. Omichinski 92 286 1988 10.1016/0041-008X(88)90388-2 Detection and mechanism of formation of the potent direct acting mutagen 2-bromoacrolein from 1,2-dibromo-3-chloropropane 

  23. Drug. Metab. Dispos. Eder 16 60 1988 Metabolism of 2,3-dichloro-1-propene in the rat. Consideration of bioactivation mechanisms 

  24. Mutat. Res. Rosen 78 113 1980 10.1016/0165-1218(80)90090-7 Mutagenic potency of haloacroleins and related compounds 

  25. Biochem. Pharmacol. Elfarra 33 3729 1984 10.1016/0006-2952(84)90032-7 Renal processing of glutathione conjugates. Role in nephrotoxicity 

  26. Biochem. Pharmacol. Elfarra 35 283 1986 10.1016/0006-2952(86)90527-7 Mechanism of S-(1,2-dichlorovinyl)-glutathione-induced nephrotoxicity 

  27. Toxicol. Lett. Lock 46 93 1989 10.1016/0378-4274(89)90120-3 Mechanism of nephrotoxic action due to organohalogenated compounds 

  28. Mutagenesis Omichinski 2 287 1987 10.1093/mutage/2.4.287 Synthesis and mutagenicity of selectively methylated analogues of tris (2,3-dibromo-propyl)phosphate and 1,2-dibromo-3-chloropropane 

  29. Biochem. Pharmacol. Dybing 26 729 1977 10.1016/0006-2952(77)90216-7 Metabolic activation of 2,4-diaminoanisole, a hair-dye component. I. Role of cytochrome P-450 metabolism in mutagenicity in vitro 

  30. J. Biol. Chem. Lowry 193 265 1951 10.1016/S0021-9258(19)52451-6 Protein measurement with the Folin phenol reagent 

  31. Mutat. Res. Ames 31 347 1975 10.1016/0165-1161(75)90046-1 Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test 

  32. Environ. Mutagen. Stolzenberg 2 59 1980 10.1002/em.2860020109 Mutagenicity of 2- and 3-carbon halogenated compounds in the Salmonella/mammalian-microsome test 

  33. Mutat. Res. Nakamura 66 373 1979 10.1016/0165-1218(79)90048-X The mutagenicity of halogenated alkanols and their phosphoric acid esters for Salmonella typhimurium 

  34. Mutat. Res. Saito-Suzuki 101 321 1982 10.1016/0165-1218(82)90125-2 Dominant lethal studies in rats with 1,2-dibromo-3-chloropropane and its structurally related compounds 

  35. Arch. Toxicol. Eder 60 182 1987 10.1007/BF00296977 The role of biotransformation in the genotoxicity of alkyl compounds 

  36. Drug Metabol. Disp. Zoetemelk 14 601 1986 Biotransformation of 1,2-dibromopropane in rats into four mercapturic acid derivatives 

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