[논문]Clinical and economic outcomes of oral linezolid versus intravenous vancomycin in the treatment of MRSA-complicated, lower-extremity skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus

Sharpe, J. Neal; Shively, Eugene H.; Polk Jr., Hiram C.

doi:10.1016/j.amjsurg.2005.01.011

[해외논문] Clinical and economic outcomes of oral linezolid versus intravenous vancomycin in the treatment of MRSA-complicated, lower-extremity skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus

The American journal of surgery, v.189 no.4, 2005년, pp.425 - 428

Sharpe, J. Neal (SharpCare, LLC, 9505 Williamsburg Plaza, Suite 201, Louisville, KY 40222, USA) , Shively, Eugene H. (Department of Surgery, University of Louisville, Louisville, KY, USA) , Polk Jr., Hiram C. (Department of Surgery, University of Louisville, Louisville, KY, USA)

Abstract ▼ AI-Helper

AbstractBackgroundResistant bacteria often complicate the management of skin and soft tissue infections of the lower extremities. This open-label study compared oral linezolid and intravenous vancomycin for management of complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA).MethodsPatients aged 18 years or older with proven MRSA-related complicated skin and soft-tissue infections requiring surgical intervention were randomized to receive oral linezolid (n = 30) or intravenous vancomycin (n = 30) for 7 to 21 days. Clinical and microbiological outcomes, duration of hospitalization and drug treatment, and outpatient charges were determined.ResultsLinezolid was associated with greater rates of clinical cure and improvement (P = .015), a 3-day shorter median length of stay (P = .003), and reduced outpatient charges (P < .001). Vancomycin therapy was associated with more treatment failures and subsequent lower-extremity amputations (P = .011).ConclusionsClinical outcomes were significantly better with linezolid than with vancomycin. Additionally, linezolid was associated with reduced length of stay and outpatient charges.

Keyword

참고문헌 (10)

Diagn Microbiol Infect Dis Rennie 45 287 2003 10.1016/S0732-8893(02)00543-6 Occurrence and antimicrobial susceptibility patterns of pathogens isolated from skin and soft tissue infections

상세보기
Am J Respir Crit Care Med Rello 150 1545 1994 10.1164/ajrccm.150.6.7952612 Ventilator-associated pneumonia by Staphylococcus aureus

상세보기
Vnitr Lek Fejfarova 48 302 2002 Pathogen resistance and other risk factors in the frequency of lower limb amputations in patients with the diabetic foot syndrome [in Czech]
Ann Intern Med Saravolatz 96 11 1982 10.7326/0003-4819-96-1-11 Methicillin-resistant Staphylococcus aureus

상세보기
Antimicrob Agents Chemother Swaney 42 3251 1998 10.1128/AAC.42.12.3251 The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria

상세보기
Clin Infect Dis Stevens 34 1481 2002 10.1086/340353 Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections

상세보기
Stevens 2003 Poster presented at the 41st Annual Meeting of the Infectious Diseases Society of America Linezolid versus vancomycin for the treatment of suspected or proven methicillin-resistant Staphylococcus species infection
Weigelt 2003 Poster presented at the 41st Annual Meeting of the Infectious Diseases Society of America Linezolid vs vancomycin in the treatment of complicated skin and soft tissue infections
Weigelt 2003 Presented at the 41st Annual Meeting of the Infectious Diseases Society of America Linezolid reduces LOS when compared to vancomycin for complicated skin and soft tissue infections due to suspected or proven MRSA
Surg Infect (Larchmt) Li 4 57 2003 10.1089/109629603764655290 Effect of linezolid versus vancomycin on length of hospital stay in patients with complicated skin and soft tissue infections caused by known or suspected methicillin-resistant staphylococci

상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] Clinical and economic outcomes of oral linezolid versus intravenous vancomycin in the treatment of MRSA-complicated, lower-extremity skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus

Abstract ▼ AI-Helper

Keyword

참고문헌 (10)

이 논문을 인용한 문헌

활용도 분석정보

활용도 Top5 논문

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[해외논문] Clinical and economic outcomes of oral linezolid versus intravenous vancomycin in the treatment of MRSA-complicated, lower-extremity skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus

Abstract ▼ AI-Helper

Keyword

참고문헌 (10)

이 논문을 인용한 문헌

활용도 분석정보

활용도 Top5 논문 더보기

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

활용도 Top5 논문