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Protein Posttranslational Modifications: The Chemistry of Proteome Diversifications

Angewandte Chemie. international edition, v.44 no.45, 2005년, pp.7342 - 7372  

Walsh, Christopher T. (Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA, Fax: (+1) 617-432-0348) ,  Garneau-Tsodikova, Sylvie (Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA, Fax: (+1) 617-432-0348) ,  Gatto Jr., Gregory J. (Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA, Fax: (+1) 617-432-0348)

Abstract AI-Helper 아이콘AI-Helper

The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the number of proteins predicted by DNA coding capacities owing to directed posttranslational modifications. Enzymes dedicated to such protein modifications include 500 human protein kinases, 150 protein phosphatases...

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