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Isolation and structure of a brain constituent that binds to the cannabinoid receptor

Science, v.258 no.5090 = no.5090, 1992년, pp.1946 - 1949  

Devane, WA (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Hanus, L (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Breuer, A (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Pertwee, RG (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Stevenson, LA (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Griffin, G (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Gibson, D (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Mandelbaum, A (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Etinger, A (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.) ,  Mechoulam, R (Department of Natural Products, Medical Faculty, Hebrew University, Jerusalem, Israel.)

Abstract ▼ AI-Helper 아이콘AI-Helper

Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has been named "anandamide," was determined by mass spectrometry and nuclear magnetic resonance spectroscopy...

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