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Biochemical and biophysical research communications, v.340 no.4, 2006년, pp.1069 - 1077
Derouazi, M. (Laboratory of Cellular Biotechnology (LBTC), Institute of Biological Engineering and Biotechnology (IGBB), Faculty of Life Sciences, Ecole Polytechnique Fé) , Martinet, D. (dé) , Besuchet Schmutz, N. (rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland) , Flaction, R. (Laboratory of Cytogenetics, Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland) , Wicht, M. (Laboratory of Cytogenetics, Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland) , Bertschinger, M. (Laboratory of Cellular Biotechnology (LBTC), Institute of Biological Engineering and Biotechnology (IGBB), Faculty of Life Sciences, Ecole Polytechnique Fé) , Hacker, D.L. (dé) , Beckmann, J.S. (rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland) , Wurm, F.M. (Laboratory of Cytogenetics, Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland)
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AbstractThe dihydrofolate reductase-deficient Chinese hamster ovary (CHO) cell line DG44 is the dominant mammalian host for recombinant protein manufacturing, in large part because of the availability of a well-characterized genetic selection and amplification system. However, this cell line has not...
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