[논문]Zusammenhang der NK-Zellaktivit？ gegen autologe Tumor- und K562-Zellen mit dem klinischen Verlauf unter Misteltherapie

Schink, M.; Tr？er, W.; Goyert, A.; Scheuerecker, H.; Selbmann, H.K.; Glaser, F.

doi:10.1159/000092624

Zusammenhang der NK-Zellaktivit？ gegen autologe Tumor- und K562-Zellen mit dem klinischen Verlauf unter Misteltherapie

Forschende Komplementärmedizin = Research in complementary medicine, v.13 no.3, 2006년, pp.147 - 155

Schink, M. (aForschungsabteilung, Verein Filderklinik e.V., Filderstadt,bKlinische Forschung Dr. Tr？er, Freiburg i.Br.,cAbteilung f？ Innere Medizin, dChirurgische Abteilung, Filderklinik, Filderstadt,eInstitut f？ Medizinische Informationsverarbeitung, Universit？ T？ingen, Deutschland) , Tr？er, W. (aForschungsabteilung, Verein Filderklinik e.V., Filderstadt,bKlinische Forschung Dr. Tr？er, Freiburg i.Br.,cAbteilung f？ Innere Medizin, dChirurgische Abteilung, Filderklinik, Filderstadt,eInstitut f？ Medizinische Informationsverarbeitung, Universit？ T？ingen, Deutschland) , Goyert, A. (aForschungsabteilung, Verein Filderklinik e.V., Filderstadt,bKlinische Forschung Dr. Tr？er, Freiburg i.Br.,cAbteilung f？ Innere Medizin, dChirurgische Abteilung, Filderklinik, Filderstadt,eInstitut f？ Medizinische Informationsverarbeitung, Universit？ T？ingen, Deutschland) , Scheuerecker, H. (aForschungsabteilung, Verein Filderklinik e.V., Filderstadt,bKlinische Forschung Dr. Tr？er, Freiburg i.Br.,cAbteilung f？ Innere Medizin, dChirur) , Selbmann, H.K. , Glaser, F.

Abstract ▼ AI-Helper

Suppression of NK cell activity is considered to bean unfavourable prognostic factor for tumour progression.There is proof that mistletoe extracts may increase NK cell activity.However, the inverse relation between an increase of NKcell activity and clinical progress of cancer has not been investigated.Aim and Design: The relation of NK cell activity andprogress of cancer in patients under therapy with mistletoe extractswas examined in a prospective, monocentric, cohortstudy. At the same time the in vitro killing of K562 cells and autologoustumour cells was compared. Patients and Methods:40 patients with operable cancer of the breast or colon were included.The patients did not receive any immunologically relevanttherapies except for mistletoe extracts. The absolute NKcell count in peripheral blood as well as the in vitro NK cell activitywere monitored for up to 2 years and compared with clinicaloutcome as well as quality of life. Results: The absolute NKcell count in peripheral blood increased within the observationperiod. Patients without progression had a significantly highermean activity of NK cells against K562 cells than patients withprogression. In the latter group, only stage IV patients showedreduced NK cell activity. The killing activity against autologoustumour cells was <5% in about 77.5% of the patients and couldnot be evaluated further. The NK cell activity against K562 cellswas not related to the number of NK cells. Conclusions: Wefound a relation between NK cell activity and the progression ofmalignant disease. In further studies the causality of this relationhas to be clarified. The establishment of NK cell activityagainst autologous tumour cells as a suitable parameter duringfollow-up was not successful.

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Zusammenhang der NK-Zellaktivit？ gegen autologe Tumor- und K562-Zellen mit dem klinischen Verlauf unter Misteltherapie

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