[논문]Antiobesity Effects of Isaria sinclairii by Repeated Oral Treatment in Obese Zucker Rats Over a 4-Month Period

Ahn, Mi Young; Jee, Sang Deok; Lee, Byung Mu

doi:10.1080/15287390701428556

[해외논문] Antiobesity Effects of Isaria sinclairii by Repeated Oral Treatment in Obese Zucker Rats Over a 4-Month Period

Journal of toxicology and environmental health. Part A, v.70 no.15/16, 2007년, pp.1395 - 1401

Ahn, Mi Young (Department of Agricultural Biology, National Institute of Agricultural Science and Technology, Suwon, Republic of Korea) , Jee, Sang Deok (Department of Agricultural Biology, National Institute of Agricultural Science and Technology, Suwon, Republic of Korea) , Lee, Byung Mu (Division of Toxicology, College of Pharmacy, SungKyunKwan University, Suwon, Republic of Korea)

Abstract ▼ AI-Helper

In the present study, the antiobesity effects of Isaria sinclairii (I. sinclairii, a fungus cultured on silkworms) powder were investigated in obese (fa/fa) Zucker rats over 4 mo. Rats were given 5 or 10% (w/w) I. sinclairii powder (I. S.), 10% mulberry leaf powder, or 10% silkworm powder mixed with standard diet; a fifth (control) group was given standard diet alone. Dose-dependent decreases in rate of body weight gain were observed in the IS- treated groups after 2 wk of treatment. Interestingly, weights of abdominal adipose tissues surrounding the epididymides were markedly reduced by I. S., in parallel with an attenuated body weight gain. However, no significant differences were observed versus the control group in terms of urinalysis or ocular or histopathological examinations. In the serum, total cholesterol, trigyceride, bilirubin, and low-density lipoprotein (LDL) were significantly lower in the 10% I. S. group than control after 17 wk of treatment. The mulberry leaf diet (10%) significantly reduced serum bilirubin levels. Obese (fa/fa) Zucker rats displayed markedly elevated serum leptin levels (>24.6%) in the I. S. 5 and 10% groups compared with nontreated controls. Data suggest that I. sinclairii exerts an antiobesity effect in Zucker obese rats.

참고문헌 (20)

Sericulture and Entomology Research Ahn M. Y. 127 2001
Ahn, Mi Young, Ryu, Kang Sun, Jee, Sang Duck, Kim, Iksoo, Kim, Jin Won, Kim, Yeong Shik, Kim, Hyung Sik, Kim, In Sun, Kang, Se C., Koo, Hyun Jung, Park, Yo An, Choi, Sul Min, Yoo, Eun Jeong, Kwack, Seung Jun, Yoo, Sun Dong, Lee, Byung Mu. GENOTOXICITY EVALUATION OF Isaria sinclairii (ISE) EXTRACT. Journal of toxicology and environmental health. Part A, vol.67, no.23, 2037-2044.

상세보기
Andallu, Bondada, Varadacharyulu, N.Ch.. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clinica chimica acta, vol.338, no.1, 3-10.

상세보기
Asano, N., Yamashita, T., Yasuda, K., Ikeda, K., Kizu, H., Kameda, Y., Kato, A., Nash, R. J., Lee, H. S., Ryu, K. S.. Polyhydroxylated Alkaloids Isolated from Mulberry Trees (Morusalba L.) and Silkworms (Bombyx mori L.). Journal of agricultural and food chemistry, vol.49, no.9, 4208-4213.

상세보기
Yakugaku Zasshi Chen F. J. 476 115 1995 10.1248/yakushi1947.115.6_476

상세보기
Hall, John E., Crook, Errol D., Jones, Daniel W., Wofford, Marion R., Dubbert, Patricia M.. Mechanisms of Obesity-Associated Cardiovascular and Renal Disease. The American journal of the medical sciences, vol.324, no.3, 127-137.

상세보기
Jee, Sun Ha, Sull, Jae Woong, Park, Jungyong, Lee, Sang-Yi, Ohrr, Heechoul, Guallar, Eliseo, Samet, Jonathan M.. Body-Mass Index and Mortality in Korean Men and Women. The New England journal of medicine, vol.355, no.8, 779-787.

상세보기
Kim, Sun-Yeou, Gao, Jian Jun, Lee, Won-Chu, Ryu, Kang-Sun, Lee, Kang-Ro, Kim, Young-Choong. Antioxidative flavonoids from the Leaves of Morus alba. Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, vol.22, no.1, 81-85.

원문보기 상세보기
Arch. Latinoam. Nutr. Molero-Conejo E. 29 56 2006

상세보기
OH, Gi-Su, HONG, Kyung-Hwan, OH, Hyuncheol, PAE, Hyun-Ock, KIM, Il-Kwang, KIM, Na-Young, KWON, Tae-Oh, SHIN, Min-Kyo, CHUNG, Hun-Taeg. 4-Acetyl-12,13-epoxyl-9-trichothecene-3,15-diol Isolated from the Fruiting Bodies of Isaria japonica YASUDA Induces Apoptosis of Human Leukemia Cells (HL-60). Biological & pharmaceutical bulletin, vol.24, no.7, 785-789.

상세보기
Picard, Frédéric, Deshaies, Yves, Lalonde, Josée, Samson, Pierre, Richard, Denis. Topiramate Reduces Energy and Fat Gains in Lean (Fa/?) and Obese (fa/fa) Zucker Rats. Obesity research, vol.8, no.9, 656-663.

상세보기
Picó, Catalina, Sánchez, Juana, Oliver, Paula, Palou, Andreu. Leptin Production by the Stomach Is Up‐Regulated in Obese (fa/fa) Zucker Rats. Obesity research, vol.10, no.9, 932-938.

상세보기
Saito, M., Ueno, M., Ogino, S., Kubo, K., Nagata, J., Takeuchi, M.. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, vol.43, no.3, 411-419.

상세보기
Slawik, Marc, Vidal-Puig, Antonio J.. Lipotoxicity, overnutrition and energy metabolism in aging. Ageing research reviews, vol.5, no.2, 144-164.

상세보기
Takano, Fumihide, Yahagi, Nobuo, Yahagi, Remiko, Takada, Satoko, Yamaguchi, Masaya, Shoda, Satoko, Murase, Takeshi, Fushiya, Shinji, Ohta, Tomihisa. The liquid culture filtrates of Paecilomyces tenuipes (Peck) Samson (=Isaria japonica Yasuda) and Paecilomyces cicadae (Miquel) Samson (=Isaria sinclairii (Berk.) Llond) regulate Th1 and Th2 cytokine response in murine Peyer's patch cells in vitro and ex vivo. International immunopharmacology, vol.5, no.5, 903-916.

상세보기
Toblli, Jorge E., DeRosa, Graciela, Rivas, Carlos, Cao, Gabriel, Piorno, Pablo, Pagano, Patricia, Forcada, Pedro. Cardiovascular protective role of a low-dose antihypertensive combination in obese Zucker rats. Journal of hypertension, vol.21, no.3, 611-620.

상세보기
Ueda, Haruhiko, Takahara, Shiro, Itoh, Susumu, Nomi, Hayahito, Shibahara, Nobuhisa, Katsuoka, Yoji. Preoperative administration of FTY720 prolonged renal allograft survival. Transplant immunology, vol.14, no.1, 1-8.

상세보기
Life Sci. Wang G. J. 2767 73 2003
Wilkes, Jason J., Nelson, Elizabeth, Osborne, Melville, Demarest, Keith T., Olefsky, Jerrold M.. Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats. American journal of physiology, Endocrinology and metabolism, vol.288, no.3, E617-E624.

상세보기
Zhang, Yi, Scarpace, Philip J.. The role of leptin in leptin resistance and obesity. Physiology & behavior, vol.88, no.3, 249-256.

상세보기

LOADING...

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] Antiobesity Effects of Isaria sinclairii by Repeated Oral Treatment in Obese Zucker Rats Over a 4-Month Period

Abstract ▼ AI-Helper

참고문헌 (20)

이 논문을 인용한 문헌

연구과제 타임라인

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[해외논문] Antiobesity Effects of Isaria sinclairii by Repeated Oral Treatment in Obese Zucker Rats Over a 4-Month Period

Abstract ▼ AI-Helper

참고문헌 (20)

이 논문을 인용한 문헌

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트