[논문]Effect of pantoprazole in older patients with erosive esophagitis

DeVault, K. R.; Morgenstern, D. M.; Lynn, R. B.; Metz, D. C.

doi:10.1111/j.1442-2050.2007.00642.x

Effect of pantoprazole in older patients with erosive esophagitis 원문보기

Diseases of the esophagus : official journal of the international society for diseases of the esophagus, v.20 no.5, 2007년, pp.411 - 415

DeVault, K. R. (Department of Medicine, Mayo Clinic College of Medicine, Jacksonville, Florida,) , Morgenstern, D. M. (Wyeth Research, Collegeville, Pennsylvania and) , Lynn, R. B. (Wyeth Research, Collegeville, Pennsylvania and) , Metz, D. C. (Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania, USA)

Abstract ▼ AI-Helper

SUMMARY. Several studies suggest that older adults with gastroesophageal reflux disease (GERD) are more likely to develop complications, including erosive esophagitis, but it is unclear whether erosive esophagitis is more difficult to treat in older patients. The purpose of this study was to determine if adults ≥ 65 years with erosive esophagitis are more difficult to treat than younger adults. The study was a post hoc analysis of two double-blind, randomized, multicenter trials of patients with erosive esophagitis. Patients received pantoprazole 40 mg once daily, nizatidine 150 mg twice daily or placebo. Patients were evaluated for endoscopic healing at 4 and 8 weeks. Patients recorded typical reflux symptoms using a daily diary to note presence or absence of symptoms. Results showed that 44, 13 and 11 patients ≥ 65 years and 210, 69, and 71 patients < 65 received pantoprazole 40 mg daily, nizatidine 150 mg twice daily, or placebo, respectively. Eighty-six percent (86%[76%, 97% CI]) of older and 83% (78%, 88% CI) of younger pantoprazole-treated patients were healed at 8 weeks; 46% (19%, 73% CI) and 35% (24%, 46% CI) of nizatidine-treated and 27% (1%, 54% CI) and 34% (23%, 45% CI) of placebo-treated were healed at 8 weeks. Median time to persistent absence of GERD-related symptoms was similar for older and younger patients treated with pantoprazole. We conclude that older patients with erosive esophagitis do not appear to have more difficult-to-treat disease. Erosive esophagitis is effectively healed and GERD symptoms are controlled in older patients using pantoprazole 40 mg daily.

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참고문헌 (24)

Scand J Gastroenterol Suppl 168 33 1989 Epidemiology of esophageal reflux disease
Rev Gastroenterol Disord 4 S16 2004 Gastroesophageal reflux disease in the elderly - a prevalent and severe disease
J Am Geriatr Soc 40 1209 1992 10.1111/j.1532-5415.1992.tb03643.x Prevalence and characteristics of symptomatic gastroesophageal reflux disease in the elderly

상세보기
Gastroenterology 102 895 1992 10.1016/0016-5085(92)90175-X Prevalence of gastrointestinal symptoms in the elderly: a population-based study

상세보기
The Esophagus 668 2005 Esophageal disease in older patients
Gastroenterol 112 1448 1997 10.1016/S0016-5085(97)70025-8 Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota

상세보기
Am J Gastroenterol 90 1053 1995 Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy

상세보기
Digestion 61 6 2000 10.1159/000007730 Gastroesophageal reflux disease: prevalence, clinical, endoscopic and histopathological findings in 1128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms

상세보기
J Am Geriatr Soc 46 1558 1998 10.1111/j.1532-5415.1998.tb01543.x Gastroesophageal reflux disease

상세보기
Am J Gastroenterol 98 35 2003 10.1111/j.1572-0241.2003.07188.x Failure of esophageal peristalsis in older patients: association with esophageal acid exposure

상세보기
Ann Intern Med 80 371 1974 10.7326/0003-4819-80-3-371 Esophageal function in elderly man. A new look at ‘presbyesophagus’

상세보기
Am J Gastroenterol 94 1795 1999 10.1111/j.1572-0241.1999.01208.x Deterioration of esophageal motility with age: a manometric study of 79 healthy subjects

상세보기
J Am Geriatr Soc 46 1534 1998 10.1111/j.1532-5415.1998.tb01538.x Aging, esophageal motility, and gastroesophageal reflux

상세보기
Am J Gastroenterol 95 3071 2000 10.1111/j.1572-0241.2000.03254.x Oral pantoprazole for erosive esophagitis: a placebo-controlled, randomized clinical trial. Pantoprazole US GERD Study Group

상세보기
Aliment Pharmacol Ther 16 2043 2002 10.1046/j.1365-2036.2002.01366.x Comparison of the efficacy of pantoprazole vs. nizatidine in the treatment of erosive esophagitis: a randomized, active-controlled, double-blind study

상세보기
Aliment Pharmacol Ther 17 1399 2003 10.1046/j.1365-2036.2003.01593.x Short- and long-term therapy for reflux esophagitis in the elderly: a multi-centre, placebo-controlled study with pantoprazole

상세보기
J Clin Gastroenterol 38 332 2004 10.1097/00004836-200404000-00007 40 mg pantoprazole and 40 mg esomeprazole are equivalent in the healing of esophageal lesions and relief from gastroesophageal reflux disease-related symptoms

상세보기
Gastroenterology 95 903 1988 10.1016/0016-5085(88)90162-X Healing and relapse of severe peptic esophagitis after treatment with omeprazole

상세보기
Am J Gastroenterol 92 2007 1997 Features of symptomatic gastroesophageal reflux disease in elderly patients

상세보기
Gut 41 594 1997 10.1136/gut.41.5.594 Associations between different forms of gastro-esophageal reflux disease

상세보기
Pharmacotherapy 17 938 1997 10.1002/j.1875-9114.1997.tb03784.x Identification, diagnosis, and treatment of acid-related diseases in the elderly: implications for long-term care

상세보기
Ann Pharmacother 29 1252 1995 10.1177/106002809502901212 Comparative role of omeprazole in the treatment of gastroesophageal reflux disease

상세보기
Age Ageing 23 121 1994 10.1093/ageing/23.2.121 Comparison of omeprazole and histamine H2-receptor antagonists in the treatment of elderly and young patients with reflux oesophagitis

상세보기
Drugs 42 138 1991 Omeprazole. An updated review of its pharmacology and therapeutic use in acid-related disorders

상세보기

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Effect of pantoprazole in older patients with erosive esophagitis 원문보기

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