DU, Hongguang
(College of Science, Beijing University of Chemical Technology)
,
LI, Ming
(College of Science, Beijing University of Chemical Technology)
,
ZUO, Hongjian
(College of Science, Beijing University of Chemical Technology)
,
LIU, Xiquan
(Beijing KBD Pharmaceutical Technology Development Ltd)
,
DU, Zhentao
(Beijing KBD Pharmaceutical Technology Development Ltd)
,
WANG, Shuming
(Beijing KBD Pharmaceutical Technology Development Ltd)
In this paper, the synthesis of tamsulosin hydrochloride from p-methoxyphenyl acetone was briefly reviewed.The starting material was chlorosulfonated with chlorosulfonic acid,and then aminolyzed by ammonia,the intermediate was reductively aminated with R-α-phenylethylamine,and then deprived of the b...
In this paper, the synthesis of tamsulosin hydrochloride from p-methoxyphenyl acetone was briefly reviewed.The starting material was chlorosulfonated with chlorosulfonic acid,and then aminolyzed by ammonia,the intermediate was reductively aminated with R-α-phenylethylamine,and then deprived of the benzyl group,followed by Holfmann amination,transformed the salt,and then obtained tamsulosin hydrochloride.All the compounds were characterized by elemental analysis,IR,~1HNMR and~(13)CNMR.
In this paper, the synthesis of tamsulosin hydrochloride from p-methoxyphenyl acetone was briefly reviewed.The starting material was chlorosulfonated with chlorosulfonic acid,and then aminolyzed by ammonia,the intermediate was reductively aminated with R-α-phenylethylamine,and then deprived of the benzyl group,followed by Holfmann amination,transformed the salt,and then obtained tamsulosin hydrochloride.All the compounds were characterized by elemental analysis,IR,~1HNMR and~(13)CNMR.
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