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[해외논문] Production and Characterization of Monoclonal Antibody to Botulinum Neurotoxin Type B Light Chain by Phage Display

Hybridoma : journal of molecular immunology and experimental and clinical immunotherapy, v.27 no.1, 2008년, pp.18 - 24  

Lee, Myung-Shin (Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea.) ,  Lee, Ji Chul (Interdisciplinary Program of Biochemical Engineering and Biotechnology, Seoul National University, Seoul, South Korea.) ,  Choi, Cha Yong (Interdisciplinary Program of Biochemical Engineering and Biotechnology, Seoul National University, Seoul, South Korea.) ,  Chung, Junho (Department of Biochemistry and Molecular Biology and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.)

Abstract AI-Helper 아이콘AI-Helper

A monoclonal antibody to the light chain of botulinum neurotoxin type B (BoNT/B) was generated and its protective activity was evaluated in vivo. A chimeric rabbit/human Fab library was generated using bone marrow and spleen cDNAs of rabbits immunized with the BoNT/B light chain, and three monoclona...

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