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Elastin Peptides Activate Extracellular Signal-Regulated Kinase 1/2 via a Ras-Independent Mechanism Requiring Both p110γ/Raf-1 and Protein Kinase A/B-Raf Signaling in Human Skin Fibroblasts

Molecular pharmacology, v.67 no.4, 2005년, pp.1315 - 1324  

Duca, Laurent ,  Lambert, Elise ,  Debret, Romain ,  Rothhut, Bernard ,  Blanchevoye, Charlotte ,  Delacoux, Frédéric ,  Hornebeck, William ,  Martiny, Laurent ,  Debelle, Laurent

Abstract AI-Helper 아이콘AI-Helper

Elastin peptides (EPs) produced during cancer progression bind to the elastin binding protein (EBP) found at the surface of dermal fibroblasts, leading to the expression of collagenase-1 gene. The production of this enzyme involved in stromal reaction is caused by the sustained activation of the ext...

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